mevalonic acid and Innate Inflammatory Response

Topics: Cholesterol; Humans; Inflammation; Lipid Metabolism; Mevalonic Acid; T-Lymphocytes, Regulatory

Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide

Topics: Anti-Inflammatory Agents; Anticholesteremic Agents; Atherosclerosis; Blood Coagulation; Cardiovascular Diseases; Cerebral Hemorrhage; Cholesterol; Diabetes Mellitus, Type 2; Endothelium, Vascular; Fibrinolytic Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Inflammation; Mevalonic Acid; Musculoskeletal Diseases

Topics: Animals; Anti-Inflammatory Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immune System; Immune System Diseases; Immunologic Factors; Inflammation; Mevalonic Acid; Signal Transduction

Topics: Cholesterol; GTP Phosphohydrolases; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mevalonate Kinase Deficiency; Mevalonic Acid; Signal Transduction

Topics: Animals; Cholesterol; Glucose; Hepatocytes; Humans; Hyperglycemia; Inflammation; Metabolic Networks and Pathways; Mevalonic Acid

Topics: Cardiovascular System; Chemical and Drug Induced Liver Injury; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipid Metabolism; Mevalonic Acid; Muscular Diseases; Nervous System Diseases; Rhabdomyolysis; Risk Assessment; Risk Factors; Signal Transduction

Topics: Anticholesteremic Agents; Biomarkers, Pharmacological; C-Reactive Protein; Cholesterol, LDL; Communicable Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mevalonic Acid; Monocytes; Risk Assessment; Signal Transduction; T-Lymphocytes; Venous Thrombosis

Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mevalonic Acid; Monomeric GTP-Binding Proteins; Plaque, Atherosclerotic; Pravastatin; Primary Prevention; Randomized Controlled Trials as Topic; Secondary Prevention

Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cytokines; Drug Design; Hereditary Autoinflammatory Diseases; Humans; Inflammasomes; Inflammation; Mevalonate Kinase Deficiency; Mevalonic Acid

Topics: Adipose Tissue; Animals; Antioxidants; Blood Vessels; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Inflammation; Lipid Metabolism; Metabolic Networks and Pathways; Mevalonic Acid; Models, Biological; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Platelet Activation; Reactive Oxygen Species; Translational Research, Biomedical; Vasculitis

Topics: Enzyme Activation; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Mevalonate Kinase Deficiency; Mevalonic Acid; Phosphotransferases (Alcohol Group Acceptor); Polyisoprenyl Phosphates; rac1 GTP-Binding Protein; Rare Diseases

Topics: Cholesterol; Diterpenes; Familial Mediterranean Fever; Farnesol; Humans; Inflammation; Mevalonic Acid; Models, Biological; Mutation; Phosphotransferases (Alcohol Group Acceptor); Polyisoprenyl Phosphates; Syndrome

Topics: Adjuvants, Immunologic; Animals; Arteriosclerosis; Cell Line; Cholesterol; Clinical Trials as Topic; Guanosine Triphosphate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interferon-gamma; Mevalonic Acid; Models, Biological; T-Lymphocytes; Transplantation

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Diabetic Angiopathies; Diabetic Nephropathies; Endothelium, Vascular; Enzyme Induction; GTP Phosphohydrolases; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Insulin Resistance; Mevalonic Acid; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Protein Prenylation; Protein Processing, Post-Translational; Rabbits; Rats; Rhabdomyolysis; Signal Transduction; Terpenes

Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosphate; Adsorption; Adult; Africa, Eastern; Aged; Air Pollutants; Air Pollution; Air Pollution, Indoor; Alcohol Drinking; Allergens; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Anti-Bacterial Agents; Antibodies; Antibodies, Immobilized; Antigen Presentation; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Aptamers, Nucleotide; Asthma; Asthma, Exercise-Induced; Atrophy; Autophagy; Azoospermia; Bacillus cereus; Bacterial Infections; Beclin-1; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biofouling; Biological Monitoring; Biomarkers; Biomarkers, Tumor; Biosensing Techniques; Blastocyst; Bone Neoplasms; Bone Regeneration; Bronchoconstriction; Burkitt Lymphoma; C9orf72 Protein; Campylobacter; Campylobacter Infections; Campylobacter jejuni; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cardiomyopathies; Caregivers; Carmine; Case-Control Studies; Catalysis; Cattle; Cause of Death; CCAAT-Enhancer-Binding Protein-alpha; CD8-Positive T-Lymphocytes; Cefepime; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cell Transdifferentiation; Chelating Agents; Chemical and Drug Induced Liver Injury, Chronic; Chemoradiotherapy, Adjuvant; Child; Child, Preschool; China; Chlorquinaldol; Cholangiocarcinoma; Cholera; Chromatin; Clinical Trials as Topic; Cognitive Dysfunction; Cohort Studies; Colonic Neoplasms; Colorectal Neoplasms; Colorimetry; Cooking; Coordination Complexes; COVID-19; Creatinine; CRISPR-Cas Systems; Critical Care; Critical Illness; Cross-Sectional Studies; Cryopreservation; Cryoprotective Agents; Cysteine; Cytokines; Device Removal; Diet; Diet, High-Fat; Diet, Mediterranean; Dietary Supplements; Dimethyl Sulfoxide; Dipeptides; Disease Models, Animal; Dithiothreitol; DNA; DNA Repeat Expansion; DNA, Bacterial; DNA, Complementary; Dopamine; Electrochemical Techniques; Electrodes; Endocannabinoids; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Enzyme-Linked Immunosorbent Assay; Erlotinib Hydrochloride; Escherichia coli; Escherichia coli O157; Esophageal Neoplasms; Esophagitis, Peptic; Ethylene Glycol; Europium; Exanthema; Fallopian Tubes; Feces; Female; Fertilization in Vitro; Fluoresceins; Fluorescent Dyes; Follicle Stimulating Hormone; Follow-Up Studies; Food Microbiology; Forced Expiratory Volume; Forkhead Transcription Factors; Frontotemporal Dementia; G-Quadruplexes; Galactose; Gastroenteritis; Gastrointestinal Diseases; Gastrointestinal Microbiome; Gastrointestinal Neoplasms; Gastrointestinal Tract; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genital Neoplasms, Female; Genome-Wide Association Study; Genome, Viral; Genomics; Genotype; Glucose; Glutathione; Glycerol; Gold; Graphite; GTPase-Activating Proteins; Heat-Shock Proteins; Heme Oxygenase-1; Hepacivirus; Hepatitis C; Hepatocytes; Histamine; Histocompatibility Antigens Class II; Hoarseness; Hospice and Palliative Care Nursing; Humans; Hydrogen; Hydrogen Peroxide; Hydrogen Sulfide; Hydroxybenzoates; Hydroxyl Radical; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperthermia, Induced; Hysteroscopy; Immunoassay; Indigo Carmine; Inflammation; Inflammatory Bowel Diseases; Insulin Resistance; Intensive Care Units; Interleukin-11; Interleukin-6; Interleukins; Iodine Radioisotopes; Iran; Iridium; Islets of Langerhans; Kinetics; Lactation; Lactobacillus; Lactobacillus plantarum; Lamins; Latin America; Lead; Lectins; Leukopenia; Ligands; Limit of Detection; Lipopolysaccharides; Lipoprotein Lipase; Liver; Liver Cirrhosis; Liver Neoplasms; Lolium; Luminescent Measurements; Luminol; Lung; Luteinizing Hormone; Macrophages; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Malnutrition; Maltose; Manganese Compounds; Maternal Nutritional Physiological Phenomena; Melatonin; Metabolic Engineering; Metal Nanoparticles; Metallocenes; Metaplasia; Methicillin-Resistant Staphylococcus aureus; Methylation; Mevalonic Acid; Mexico; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbial Sensitivity Tests; Microbiota; MicroRNAs; Milk; Mitomycin; Molecular Diagnostic Techniques; Molecular Docking Simulation; Monte Carlo Method; Moringa oleifera; Multiple Sclerosis; Muscle Strength; Muscle, Skeletal; Nanocomposites; Nanotubes, Carbon; Neoadjuvant Therapy; Neoplasms; Neurodegenerative Diseases; Neurotransmitter Agents; NF-E2-Related Factor 2; Nickel; Nitrogen Dioxide; Non-alcoholic Fatty Liver Disease; Nucleic Acid Amplification Techniques; Nucleic Acid Hybridization; Nucleocapsid Proteins; Nutritional Status; Obesity; Osteogenesis; Osteosarcoma; Oxidation-Reduction; Oxides; Oxygen; Oxyquinoline; Pain; Palliative Care; Pancreatic Neoplasms; Pandemics; Particulate Matter; Peroxidase; Peroxidases; Phagocytosis; Phaseolus; Photothermal Therapy; Point-of-Care Systems; Polyethyleneimine; Polymers; Polymorphism, Single Nucleotide; Polysomnography; Postoperative Complications; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Prevalence; Printing, Three-Dimensional; Probability; Probiotics; Prognosis; Prophages; Prospective Studies; Proteomics; Proto-Oncogene Proteins; Pseudomonas aeruginosa; Pseudomonas putida; Pulmonary Disease, Chronic Obstructive; Pulmonary Embolism; Pyridines; Pyrroles; Quality of Life; Quinolones; Rabbits; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Receptors, Histamine; Receptors, Histamine H2; Recombinases; Rectal Neoplasms; Reperfusion Injury; Respiration; Respiratory Function Tests; Respiratory Rate; Respiratory Sounds; Retrospective Studies; rho GTP-Binding Proteins; Risk Assessment; Risk Factors; RNA; RNA, Messenger; RNA, Ribosomal, 16S; Robotic Surgical Procedures; Running; Rural Population; Saccharomyces cerevisiae; Salpingectomy; Sarcopenia; SARS-CoV-2; Seeds; Semen; Sensitivity and Specificity; Sepsis; Shock, Septic; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Skin Neoplasms; Sleep Apnea, Obstructive; Soil; Spain; Spectrum Analysis, Raman; Sperm Retrieval; Spermatozoa; Spirometry; Staphylococcus aureus; STAT3 Transcription Factor; Stereoisomerism; Sterilization, Tubal; Stroke Volume; Sulfadiazine; Sulfites; Superoxide Dismutase; Surface Plasmon Resonance; tau Proteins; Testis; Testosterone; Thioredoxin-Disulfide Reductase; Thyroid Neoplasms; Thyroidectomy; Trans-Activators; Transcription Factor AP-1; Treatment Outcome; Triazoles; Triclosan; Trifluridine; Tumor Microenvironment; Tumor Necrosis Factor-alpha; United States; Uracil; Vagina; Vegetables; Ventricular Function, Left; Ventricular Pressure; Vibrio cholerae; Vietnam; Virulence; Vital Capacity; Vitrification; Walking; Water; Water Pollutants, Radioactive; Whole Genome Sequencing; Wind; YAP-Signaling Proteins; Zeolites; Zinc Oxide

Topics: Alendronate; Animals; Anti-Inflammatory Agents; Apoptosis; Autophagy; Biosynthetic Pathways; Cell Death; Cell Shape; Farnesyl-Diphosphate Farnesyltransferase; Inflammation; Interleukin-6; Lipopolysaccharides; Macrophages; Mevalonate Kinase Deficiency; Mevalonic Acid; Mice; Mitochondria; Oxazepines; Piperidines; RAW 264.7 Cells; Tumor Necrosis Factor-alpha

Topics: Animals; Cells, Cultured; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoglobulin E; Inflammation; Interleukin-33; Interleukin-6; Killer Cells, Natural; Macrophages; Mast Cells; Mevalonic Acid; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Peritonitis; Prenylation; Stem Cell Factor; Terpenes; Transcription Factor RelA; Transcription, Genetic; Tumor Necrosis Factor-alpha

Topics: Animals; Fibrosis; Humans; Inflammasomes; Inflammation; Liver; Liver Cirrhosis; Mevalonic Acid; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Rats

Topics: Androgens; Animals; Female; Gene Expression; Inflammation; Interleukin-1beta; Lipopolysaccharides; Mevalonic Acid; Polycystic Ovary Syndrome; Rats, Sprague-Dawley; Theca Cells

Topics: Animals; Asthma; Atherosclerosis; Cell Line; Cholesterol; Disease Models, Animal; Exosomes; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Mevalonic Acid; Mice; Mice, Inbred BALB C; Monocytes; Simvastatin

Topics: Acetyl Coenzyme A; Cells, Cultured; Cellular Reprogramming; Epigenesis, Genetic; Humans; Immunity, Innate; Immunologic Memory; Inflammation; Interleukin-1beta; Liver X Receptors; Mevalonic Acid; Monocytes; Mycobacterium bovis; Phenotype; Signal Transduction

Topics: Cholesterol; Cholesterol, LDL; COVID-19; COVID-19 Drug Treatment; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immune System; Immunity, Innate; Inflammation; Lipoproteins, LDL; Mevalonic Acid; Models, Theoretical; Oxidation-Reduction; Oxidative Stress; Selenoproteins

Topics: Apoptosis; Autophagy; Cell Line, Tumor; Humans; Hydroxycholesterols; Inflammation; Interleukin-1beta; Lovastatin; Mevalonic Acid; Protein Prenylation; Signal Transduction

Topics: Glioblastoma; Humans; Inflammation; Mevalonate Kinase Deficiency; Mevalonic Acid; Oxidative Stress; Phenotype; Phosphotransferases (Alcohol Group Acceptor); Reactive Oxygen Species

Topics: Adaptor Proteins, Signal Transducing; Age of Onset; Animals; Carrier Proteins; Cell Proliferation; Cholesterol; CTLA-4 Antigen; Forkhead Transcription Factors; Immune Tolerance; Inducible T-Cell Co-Stimulator Protein; Inflammation; Interleukin-2; Lipid Metabolism; Mechanistic Target of Rapamycin Complex 1; Mevalonic Acid; Mice; Multiprotein Complexes; Proteins; Receptors, Antigen, T-Cell; Regulatory-Associated Protein of mTOR; Signal Transduction; Survival Rate; T-Lymphocytes, Regulatory; TOR Serine-Threonine Kinases

Topics: Acyl Coenzyme A; Alkyl and Aryl Transferases; Animals; Aorta; Atherosclerosis; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Farnesyltranstransferase; Female; Geranylgeranyl-Diphosphate Geranylgeranyltransferase; Geranyltranstransferase; Glucose; Inflammation; Lipids; Mevalonic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular

Topics: Animals; Apoptosis; Cell Line; Coculture Techniques; Cytokines; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipopolysaccharides; Lovastatin; Membrane Potential, Mitochondrial; Mevalonate Kinase Deficiency; Mevalonic Acid; Mice; Microglia; Neurons

Topics: Animals; Asthma; Biosynthetic Pathways; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mevalonic Acid; Mice; Mice, Inbred BALB C; Simvastatin

Topics: Alendronate; Carrier Proteins; Child; Female; Humans; Inflammation; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Metabolic Networks and Pathways; Mevalonate Kinase Deficiency; Mevalonic Acid; NLR Family, Pyrin Domain-Containing 3 Protein; Up-Regulation; Young Adult

Topics: Alendronate; Animals; Apoptosis; Biomarkers; Biosynthetic Pathways; Caspase 1; Caspase 3; Caspase Inhibitors; Cell Line; Cell Survival; Enzyme Activation; Inflammation; Interleukin-1beta; Lipopolysaccharides; Mevalonic Acid; Mice; Monocytes; Necrosis; Oligopeptides; Terpenes

Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Animals; Biological Availability; Biosynthetic Pathways; Calcitriol; CD4-Positive T-Lymphocytes; Encephalomyelitis, Autoimmune, Experimental; Female; Guinea Pigs; Immunosuppression Therapy; Inflammation; Lovastatin; Lymphoid Tissue; Mevalonic Acid; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Spinal Cord; Steroid Hydroxylases; Vitamin D; Vitamin D3 24-Hydroxylase

Topics: Aged; Bone Resorption; Cell Proliferation; Cell Survival; Cells, Cultured; Culture Media; Diterpenes; Farnesol; Femur Head; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-1beta; Interleukin-6; Mevalonic Acid; Middle Aged; Osteoblasts; Osteoporosis; Osteoprotegerin; Pyrimidines; RNA, Messenger; Rosuvastatin Calcium; Sulfonamides; Terpenes

Topics: Alkaline Phosphatase; Atorvastatin; Calcinosis; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mevalonic Acid; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Polyisoprenyl Phosphates; Pyridines; Pyrroles; Sesquiterpenes

Topics: Amino Acid Chloromethyl Ketones; Antibodies; Atorvastatin; Caspase 1; CD28 Antigens; CD3 Complex; Cells, Cultured; Enzyme Activation; Heptanoic Acids; Humans; Inflammation; Interferon-gamma; Interleukin-1; Interleukin-12; Interleukin-18; Mevalonic Acid; Mitosis; Monocytes; Pyrroles; Simvastatin; Solubility; T-Lymphocytes

Topics: Anti-Inflammatory Agents; Bodily Secretions; Diphosphonates; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-1beta; Leukocytes, Mononuclear; Mevalonic Acid; Pamidronate; Phosphotransferases (Alcohol Group Acceptor); Protein Prenylation; Simvastatin; Terpenes

Topics: Alendronate; Animals; Bone Density Conservation Agents; Clodronic Acid; Female; Histidine Decarboxylase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-1alpha; Interleukin-1beta; Liposomes; Liver; Lung; Macrophages; Mevalonic Acid; Mice; Mice, Knockout; Peritoneal Cavity; Spleen; T-Lymphocytes; Tumor Necrosis Factor-alpha

Topics: Bone Marrow Transplantation; Cholesterol; Fever; Humans; Inflammation; Metabolism, Inborn Errors; Mevalonic Acid; Phosphotransferases (Alcohol Group Acceptor); Protein Prenylation; Transplantation, Homologous; Ubiquinone

Topics: Biomarkers; Bone Marrow Transplantation; Child, Preschool; Cytokines; Failure to Thrive; Fever; Humans; Inflammation; Male; Metabolism, Inborn Errors; Mevalonic Acid; Mutation, Missense; Phosphotransferases (Alcohol Group Acceptor); Transplantation, Homologous

Topics: C-Reactive Protein; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Mevalonic Acid; Monocytes; NF-kappa B; Polyisoprenyl Phosphates; Receptors, IgG; RNA, Small Interfering; Sesquiterpenes; Simvastatin; Umbilical Veins; Up-Regulation; Vascular Cell Adhesion Molecule-1

Topics: Animals; Benzamides; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl CoA Reductases; Inflammation; Lovastatin; Methionine; Mevalonic Acid; Myelin Sheath; Nerve Growth Factors; Neuroglia; Oligodendroglia; Polyisoprenyl Phosphates; ras Proteins; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Spinal Cord; Wound Healing

Topics: Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Atorvastatin; Carrageenan; Edema; Heptanoic Acids; Hindlimb; Inflammation; Male; Mevalonic Acid; Mice; Pyrroles; Rats; Rats, Wistar

Topics: Animals; Chromatography, High Pressure Liquid; Dexamethasone; Dolichol Phosphates; Dolichols; Inflammation; Liver; Male; Mevalonic Acid; Microsomes, Liver; Polyisoprenyl Phosphates; Rats; Rats, Inbred Strains; Turpentine