mevalonic acid and Elevated Cholesterol

mevalonic acid has been researched along with Elevated Cholesterol in 60 studies

Research

Studies (60)

Timeframe	Studies, this research(%)	All Research%
pre-1990	26 (43.33)	18.7374
1990's	12 (20.00)	18.2507
2000's	12 (20.00)	29.6817
2010's	9 (15.00)	24.3611
2020's	1 (1.67)	2.80

Authors

Authors	Studies
Akhteruzzaman, S; Das, KC; Hossain, MU; Moniruzzaman, M; Salimullah, M	1
Guijarro, C	1
Chu, X; Gao, J; Li, D; Liu, J; Qiao, Y; Qiu, Y	1
Ghosh, M; Sengupta, A	1
Gee, RH; Johnston, JD; Malia, JM; Plant, KE; Plant, NJ; Spinks, JN	1
Kain, V; Kapadia, B; Misra, P; Saxena, U	1
Lahtela, J; Murtola, TJ; Syvälä, H; Tammela, TLj; Visakorpi, T	1
Saito, E; Sato, F; Seyama, Y; Wachi, H	1
Csont, T; Ferdinandy, P; Kocsis, GF; Murlasits, Z; Puskas, LG; Varga-Orvos, Z	1
Fukuda, A; Hirata, K; Ishida, T; Kojima, Y; Koshiyama, H; Kume, N; Rikitake, Y; Sun, L; Taniguchi, A; Toh, R; Yasuda, T	1
Chaiyaroj, SC; Chansrichavala, P; Chantharaksri, U; Ngaosuwankul, N; Sritara, P	1
Cai, Z; Hao, Q; Li, Y; Min, Y; Pan, J; Sheng, Y; Xia, Y; Zhou, W	1
Laufs, U	1
Kritchevsky, D; Tepper, SA	1
Gotto, AM; Vaughan, CJ	1
Behl, C; Moosmann, B	1
Han, KH; Hong, KH; Kim, JB; Kim, JJ; Ko, J; Pak, YK; Park, SW; Ryu, J	1
März, W; Scharnagl, H	1
Balogh, Z; Fóris, G; Fülöp, P; Koncsos, P; Kosztáczky, B; Paragh, G; Seres, I	1
Monger, EA; Nestel, PJ	1
Florén, CH; Nilsson, A	1
Lei, KY; Shao, MJ	1
Gagnon, RF; Pappu, AS; Stewart-Phillips, JL; Subang, MC; Subang, R	1
Lewis, LS	1
Dotti, MT; Federico, A; Lindenthal, B; Lütjohann, D; Simatupang, A; von Bergmann, K	1
De Paolis, P; Di Giulio, S; Lala, A; Menzinger, G; Scoppola, A	1
Caccese, D; Cortese, C; Lala, A; Menzinger, G; Motti, C; Scoppola, A	1
al-Shurbaji, A; Berglund, L; Humble, E; Lindenthal, B; Rudling, M	1
De Caterina, R; Lenzi, S	1
Adams-Huet, B; Blumenschein, S; Carter, NB; Grundy, SM; Laeis, P; Lindenthal, B; Lutjohann, D; Simatupang, A; Vega, GL; von Bergmann, J; von Bergmann, K	1
Breithardt, G; Schmidt, A; Sindermann, JR	1
Corsini, A	1
Boguslawski, W; Chmielewski, M; Nieweglowski, T; Rutkowski, B; Swierczynski, J	1
Ichihara, K; Satoh, K	1
Brown, MS; Goldstein, JL	4
Brannan, PG; Brown, MS; Goldstein, JL	1
Bersohn, I; Goldberg, RB; Kew, MC	1
Brown, MS; Faust, JR; Goldstein, JL	1
Brown, MS; Brunschede, GY; Dana, SE; Goldstein, JL	1
Eichelman, B; Qureshi, AA; Solomon, JK	1
Blankenhorn, DH; Kalra, VK	1
Edmond, J; Fogelman, AM; Popjåk, G	1
Edmond, J; Fogelman, AM; Popják, G; Seager, J	1
Buchwald, H	1
Anderson, JV; Besser, GM; Maher, VM; Scoppola, A; Thompson, GR; Trainer, PJ	1
Alberts, AW; Feingold, KR; Karkas, JD; Kwong, LK; Le, T; Peric-Golia, L; Wilson, DE	1
Alberts, AW; Beil, FU; Beisiegel, U; Eckardt, HG; Greten, H; Karkas, JD; Liou, R; Schrameyer-Wernecke, A; Till, AE	1
Bankhurst, AD; Cutts, JL	1
Illingworth, DR; Maher, VM; Pappu, A; Thompson, GR	1
Denisenko, TV; Dizhe, EB; Klimov, AN; Poliakova, ED; Vasil'eva, LE	1
Farré, G; Sablé-Amplis, R; Sicart, R	1
Feingold, KR; Fulford, MH; Golper, TA; Siperstein, MD	1
Kudchodkar, BJ; Sodhi, HS	1
Ellefson, RD; Karlson, AG; Thoen, CO	1
Edmond, J; Fogelman, AM; Polito, A; Popják, G	1
Miettinen, TA	1
Miettinen, TA; Penttilä, IM	1

Reviews

9 review(s) available for mevalonic acid and Elevated Cholesterol

Article	Year
Statins and prostate cancer prevention: where we are now, and future directions. Nature clinical practice. Urology, 2008, Volume: 5, Issue:7 Topics: Animals; Apoptosis; Cardiovascular Diseases; Cell Cycle; Comorbidity; Disease Progression; GTPase-Activating Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Meta-Analysis as Topic; Mevalonic Acid; Prostate-Specific Antigen; Prostatic Neoplasms; ras GTPase-Activating Proteins	2008
Beyond lipid-lowering: effects of statins on endothelial nitric oxide. European journal of clinical pharmacology, 2003, Volume: 58, Issue:11 Topics: Arteriosclerosis; Cholesterol; Clinical Trials as Topic; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Mevalonic Acid; Nitric Oxide; Oxidative Stress	2003
Update on statins: 2003. Circulation, 2004, Aug-17, Volume: 110, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Cholesterol, LDL; Creatine Kinase; Creatine Kinase, MM Form; Drug Interactions; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Inactivation, Metabolic; Isoenzymes; Male; Mevalonic Acid; Middle Aged; Models, Biological; Muscular Diseases; Prospective Studies; Protein Prenylation; Randomized Controlled Trials as Topic; Structure-Activity Relationship	2004
Selenoproteins, cholesterol-lowering drugs, and the consequences: revisiting of the mevalonate pathway. Trends in cardiovascular medicine, 2004, Volume: 14, Issue:7 Topics: Animals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Mevalonic Acid; Peroxisome Proliferator-Activated Receptors; Proteins; RNA, Transfer, Amino Acyl; Selenoproteins	2004
New lipid-lowering agents acting on LDL receptors. Current topics in medicinal chemistry, 2005, Volume: 5, Issue:3 Topics: Arteriosclerosis; Cholesterol, LDL; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Lipid Metabolism; Lipids; Mevalonic Acid; Receptors, LDL; Transcription, Genetic	2005
[Prevention and therapy of vascular damage and endothelial dysfunction with hypocholesteremic agents]. Giornale italiano di cardiologia, 1998, Volume: 28, Issue:2 Topics: Anticholesteremic Agents; Arteriosclerosis; Cholesterol; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Diet; Endothelium, Vascular; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Mevalonic Acid; Middle Aged; Physical Exertion; Primary Prevention; Simvastatin; Time Factors	1998
Fluvastatin: effects beyond cholesterol lowering. Journal of cardiovascular pharmacology and therapeutics, 2000, Volume: 5, Issue:3 Topics: Animals; Anticholesteremic Agents; Cholesterol, LDL; Coronary Disease; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hypercholesterolemia; Indoles; Mevalonic Acid; Muscle, Smooth, Vascular; Platelet Activation	2000
Disparity between angiographic regression and clinical event rates with hydrophobic statins. Lancet (London, England), 2002, Jun-22, Volume: 359, Issue:9324 Topics: Animals; Clinical Trials as Topic; Humans; Hydrophobic and Hydrophilic Interactions; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Mevalonic Acid; Myocardial Contraction; Signal Transduction; Ubiquinone	2002
Hyperlipidemia in coronary heart disease: a biochemical genetic approach. The Journal of laboratory and clinical medicine, 1975, Volume: 85, Issue:1 Topics: Alcohol Oxidoreductases; Cells, Cultured; Cholesterol; Coronary Disease; Enzyme Inhibitors; Fibroblasts; Glutarates; Heterozygote; Homozygote; Humans; Hypercholesterolemia; Hyperlipidemias; Lipoproteins, HDL; Lipoproteins, LDL; Mevalonic Acid; Protein Binding; Thyroid Function Tests; Time Factors	1975

Trials

3 trial(s) available for mevalonic acid and Elevated Cholesterol

Article	Year
Pitavastatin decreases the expression of endothelial lipase both in vitro and in vivo. Cardiovascular research, 2010, Jul-15, Volume: 87, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Animals; Cells, Cultured; Cholesterol, HDL; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipase; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Middle Aged; Polyisoprenyl Phosphates; Prospective Studies; Protein Kinase Inhibitors; Protein Prenylation; Quinolines; rho-Associated Kinases; rhoA GTP-Binding Protein; Time Factors; Transfection; Treatment Outcome	2010
Effect of lifibrol on the metabolism of low density lipoproteins and cholesterol. Journal of internal medicine, 1999, Volume: 246, Issue:1 Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Butanols; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydroxybenzoates; Hypercholesterolemia; Hypolipidemic Agents; Male; Mevalonic Acid; Middle Aged; Simvastatin; Single-Blind Method; Triglycerides	1999
Lovastatin versus bezafibrate: efficacy, tolerability, and effect on urinary mevalonate. Cardiology, 1990, Volume: 77 Suppl 4 Topics: Adult; Aged; Bezafibrate; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Mevalonic Acid; Middle Aged; Single-Blind Method	1990

Other Studies

48 other study(ies) available for mevalonic acid and Elevated Cholesterol

Article	Year
High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Inhibition of Cholesterol Biosynthesis. BioMed research international, 2022, Volume: 2022 Topics: Cholesterol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Mevalonic Acid; Polymorphism, Single Nucleotide	2022
PCSK9 Inhibitors, Statins, Low-Density Lipoprotein Cholesterol, Mevalonate Pathway, and Toxicity. JAMA cardiology, 2017, 10-01, Volume: 2, Issue:10 Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cholesterol, LDL; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Mevalonic Acid; Proprotein Convertase 9	2017
Multi-target-directed design, syntheses, and characterization of fluorescent bisphosphonate derivatives as multifunctional enzyme inhibitors in mevalonate pathway. Biochimica et biophysica acta, 2013, Volume: 1830, Issue:6 Topics: Animals; Cell Proliferation; Cell Survival; Diphosphonates; Enzyme Inhibitors; Fluorescent Dyes; Hypercholesterolemia; Mevalonic Acid; Molecular Docking Simulation; Neoplasms; Rats	2013
Protective role of phytosterol esters in combating oxidative hepatocellular injury in hypercholesterolemic rats. Pakistan journal of biological sciences : PJBS, 2013, Jan-15, Volume: 16, Issue:2 Topics: Acyl Coenzyme A; Animals; Antioxidants; Esters; Fatty Acids; Hypercholesterolemia; Lipid Metabolism; Liver; Liver Diseases; Liver Function Tests; Male; Malondialdehyde; Mevalonic Acid; Oxidative Stress; Phytosterols; Rats; Rats, Wistar	2013
Inhibition of prenyltransferase activity by statins in both liver and muscle cell lines is not causative of cytotoxicity. Toxicology, 2015, Mar-02, Volume: 329 Topics: Alkyl and Aryl Transferases; Cell Line, Tumor; Dimethylallyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver; Membrane Proteins; Mevalonic Acid; Muscle, Skeletal; Muscular Diseases; Prenylation; Protein Processing, Post-Translational; rap1 GTP-Binding Proteins; Simvastatin	2015
Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism. Scientific reports, 2015, Sep-08, Volume: 5 Topics: Cholesterol; Fatty Acids; Glucose; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Insulin; Insulin Resistance; Mevalonic Acid; PPAR gamma; Signal Transduction; Simvastatin	2015
7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cells. Journal of atherosclerosis and thrombosis, 2008, Volume: 15, Issue:3 Topics: Animals; Apoptosis; Calcium; Cattle; Cells, Cultured; DNA Fragmentation; Hypercholesterolemia; Ketocholesterols; Mevalonic Acid; Models, Biological; Myocytes, Smooth Muscle; Phenotype; Phosphates; rho-Associated Kinases; Signal Transduction	2008
Expression of genes related to oxidative/nitrosative stress in mouse hearts: effect of preconditioning and cholesterol diet. Medical science monitor : international medical journal of experimental and clinical research, 2010, Volume: 16, Issue:1 Topics: Analysis of Variance; Animals; Cholesterol, Dietary; DNA Primers; Gene Expression Regulation; Heart; Hypercholesterolemia; Ischemic Preconditioning, Myocardial; Male; Mevalonic Acid; Mice; Myocardium; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; Nitric Oxide Synthase; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; Xanthine Oxidase	2010
Atorvastatin affects TLR4 clustering via lipid raft modulation. International immunopharmacology, 2010, Volume: 10, Issue:8 Topics: Animals; Anti-Inflammatory Agents; Antibodies, Blocking; Atorvastatin; Cell Line; Heptanoic Acids; Humans; Hypercholesterolemia; Lipopolysaccharides; Membrane Microdomains; Mevalonic Acid; Mice; Precursor Cells, B-Lymphoid; Protein Transport; Pyrroles; Receptor Aggregation; Toll-Like Receptor 4	2010
Synthesis and anti-hypercholesterolemic evaluations of calcium salts of 4-substituted quinoline-based mevalonic acid. Chemical biology & drug design, 2011, Volume: 78, Issue:4 Topics: Animals; Anticholesteremic Agents; Calcium; Cholesterol; Hypercholesterolemia; Lipoproteins, LDL; Male; Mevalonic Acid; Quail; Quinolines; Salts	2011
INFLUENCE OF MEDIUM-CHAIN TRIGLYCERIDE (MCT) ON CHOLESTEROL METABOLISM IN RATS. The Journal of nutrition, 1965, Volume: 86, Issue:1 Topics: Acetates; Bile Acids and Salts; Cholesterol; Fatty Acids; Glycerides; Hypercholesterolemia; Lipid Metabolism; Lipoproteins; Mevalonic Acid; Organ Size; Rats; Research; Salts; Triglycerides	1965
HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. Circulation, 2005, Mar-22, Volume: 111, Issue:11 Topics: Anilides; Animals; Aorta; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Depression, Chemical; Diet, Atherogenic; Down-Regulation; Drug Evaluation, Preclinical; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Monocytes; Polyisoprenyl Phosphates; PPAR gamma; Rats; Rats, Sprague-Dawley; Receptors, CCR2; Receptors, Chemokine; RNA, Messenger; Rosiglitazone; Sesquiterpenes; Simvastatin; Thiazolidinediones	2005
Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. Neuropeptides, 2006, Volume: 40, Issue:5 Topics: Aged; Cell Separation; Cholesterol; Female; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; In Vitro Techniques; Ligands; Lovastatin; Male; Mevalonic Acid; Middle Aged; Monocytes; Neuropeptides; Signal Transduction; Stimulation, Chemical; Superoxides	2006
Turnover of plasma esterified cholesterol in normocholesterolemic and hypercholesterolemic subjects and its relation to body build. The Journal of clinical investigation, 1967, Volume: 46, Issue:6 Topics: Adult; Body Surface Area; Cholesterol; Coronary Disease; Humans; Hypercholesterolemia; Injections, Intravenous; Male; Mevalonic Acid; Middle Aged; Obesity; Tritium	1967
Effects of hypothyroidism and cholesterol feeding on the clearance of chylomicron remnants in vivo and by rat hepatocyte monolayers. European journal of clinical investigation, 1981, Volume: 11, Issue:1 Topics: Animals; Cells, Cultured; Cholesterol, Dietary; Cholic Acids; Chylomicrons; Hypercholesterolemia; Hypothyroidism; In Vitro Techniques; Lactones; Liver; Mevalonic Acid; Rats; Serum Albumin, Bovine	1981
Conversion of [2-14C] mevalonate into cholesterol, lanosterol and squalene in copper-deficient rats. The Journal of nutrition, 1980, Volume: 110, Issue:5 Topics: Animals; Cholesterol; Cholesterol Esters; Copper; Hypercholesterolemia; Kidney; Lanosterol; Liver; Male; Mevalonic Acid; Organ Size; Organ Specificity; Rats; Squalene	1980
Possible role of mevalonate in the hypercholesterolemia seen in experimental chronic renal failure. Nephron, 1995, Volume: 69, Issue:2 Topics: Animals; Cholesterol; Disease Models, Animal; Female; Hypercholesterolemia; Kidney Failure, Chronic; Mevalonic Acid; Mice; Mice, Inbred C57BL; Urea	1995
Statins, cholesterol, and mevalonate pathways? Lancet (London, England), 1996, Feb-24, Volume: 347, Issue:9000 Topics: Anticholesteremic Agents; Cholesterol; Coronary Disease; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Mevalonic Acid; Simvastatin	1996
Urinary excretion of mevalonic acid as an indicator of cholesterol synthesis. Journal of lipid research, 1996, Volume: 37, Issue:10 Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Cholestyramine Resin; Circadian Rhythm; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Mevalonic Acid; Middle Aged; Pravastatin; Reproducibility of Results; Simvastatin; Xanthomatosis, Cerebrotendinous	1996
Plasma mevalonate concentrations in uremic patients. Kidney international, 1997, Volume: 51, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Creatinine; Female; Humans; Hypercholesterolemia; Kidney Failure, Chronic; Lipids; Lipoproteins; Male; Mevalonic Acid; Middle Aged; Renal Dialysis; Uremia	1997
Apolipoprotein E genotype and cholesterogenesis in polygenic hypercholesterolemia. Metabolism: clinical and experimental, 1998, Volume: 47, Issue:1 Topics: Alleles; Apolipoproteins E; Cholesterol; Diet; Female; Genotype; Humans; Hypercholesterolemia; Lipids; Male; Mevalonic Acid; Middle Aged	1998
Hepatic cholesterol metabolism in experimental nephrotic syndrome. Lipids, 1998, Volume: 33, Issue:2 Topics: Animals; Cholesterol; Glomerular Filtration Rate; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Liver; Male; Mevalonic Acid; Nephrotic Syndrome; Puromycin Aminonucleoside; Rats; Rats, Sprague-Dawley; Receptors, LDL	1998
Upregulation of the interleukin-8 system in hypercholesterolemic patients. Does inhibition of the mevalonate pathway lower interleukin-8 levels in the vessel wall? Atherosclerosis, 2000, Volume: 150, Issue:2 Topics: Antibodies, Monoclonal; Arteriosclerosis; Biomarkers; Blood Vessels; Cell Division; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Interleukin-8; Mevalonic Acid; Muscle, Smooth, Vascular; Up-Regulation	2000
Diurnal rhythm of cholesterol biosynthesis in experimental chronic renal failure. Molecular and cellular biochemistry, 2001, Volume: 228, Issue:1-2 Topics: Animals; Body Weight; Cholesterol; Circadian Rhythm; Creatinine; Disease Models, Animal; Hypercholesterolemia; Intestinal Mucosa; Kidney Failure, Chronic; Liver; Male; Mevalonic Acid; Rats; Rats, Wistar; Urea	2001
3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human hair roots. Journal of lipid research, 1975, Volume: 16, Issue:1 Topics: Abetalipoproteinemia; Adolescent; Adult; Alcohol Oxidoreductases; Animals; Carbon Radioisotopes; Child; Cholestyramine Resin; Circadian Rhythm; Coenzymes; Female; Fibroblasts; Genotype; Hair; Humans; Hypercholesterolemia; Lipoproteins, LDL; Liver; Male; Mevalonic Acid; Middle Aged; Rats; Tritium	1975
Hypercholesterolaemia in primary cancer of the liver. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1975, Aug-23, Volume: 49, Issue:36 Topics: Acetates; Adult; Alkaline Phosphatase; Bilirubin; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cholestasis; Cholesterol; Cholesterol, Dietary; Feedback; Humans; Hypercholesterolemia; Liver; Liver Neoplasms; Male; Mevalonic Acid; Middle Aged	1975
Synthesis of ubiquinone and cholesterol in human fibroblasts: regulation of a branched pathway. Archives of biochemistry and biophysics, 1979, Volume: 192, Issue:1 Topics: Cells, Cultured; Cholesterol; Fibroblasts; Humans; Hypercholesterolemia; Kinetics; Lipoproteins, LDL; Mevalonic Acid; Skin; Ubiquinone	1979
Genetic heterogeneity in familial hypercholesterolemia: evidence for two different mutations affecting functions of low-density lipoprotein receptor. Proceedings of the National Academy of Sciences of the United States of America, 1975, Volume: 72, Issue:3 Topics: Adolescent; Adult; Cells, Cultured; Child; Child, Preschool; Cholesterol; Esters; Female; Fibroblasts; Heterozygote; Homozygote; Humans; Hypercholesterolemia; Infant, Newborn; Lipoproteins, LDL; Male; Mevalonic Acid; Middle Aged; Mutation; NADH, NADPH Oxidoreductases; Receptors, Drug; Skin	1975
L-histidine-induced facilitation of cholesterol biosynthesis in rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1978, Volume: 159, Issue:1 Topics: Acetates; Animals; Cholesterol; Dietary Fats; Histidine; Hypercholesterolemia; In Vitro Techniques; Liver; Male; Mevalonic Acid; Rats; Sterols	1978
Abnormal activation of sterol synthesis in lymphocytes of atherosclerotic-susceptible pigeons and heterozygous familial hypercholesterolemic patients. Biochimica et biophysica acta, 1976, Aug-23, Volume: 441, Issue:2 Topics: Acetates; Adult; Animals; Arteriosclerosis; Cholesterol; Columbidae; Cycloheximide; Humans; Hypercholesterolemia; Lipid Metabolism; Lymphocytes; Mevalonic Acid; Sterols	1976
Metabolism of mevalonate in rats and man not leading to sterols. The Journal of biological chemistry, 1975, Mar-10, Volume: 250, Issue:5 Topics: Adult; Aged; Animals; Bicarbonates; Carbon Dioxide; Cholesterol; Humans; Hypercholesterolemia; Male; Mevalonic Acid; Middle Aged; Rats; Sterols; Time Factors	1975
Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia. The Journal of biological chemistry, 1975, Mar-25, Volume: 250, Issue:6 Topics: Acetates; Adolescent; Adult; Alcohol Oxidoreductases; Enzyme Induction; Farnesol; Glutarates; Heterozygote; Humans; Hypercholesterolemia; Leukocytes; Lipids; Male; Mevalonic Acid; Middle Aged; Squalene; Sterols; Time Factors	1975
Cholesterol inhibition, cancer, and chemotherapy. Lancet (London, England), 1992, May-09, Volume: 339, Issue:8802 Topics: Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents; Cholesterol; Dogs; Drug Evaluation, Preclinical; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Lovastatin; Mevalonic Acid; Mice; Neoplasms; Neoplasms, Experimental; Rats	1992
Possible mechanism and treatment of o,p'DDD-induced hypercholesterolaemia. The Quarterly journal of medicine, 1992, Volume: 84, Issue:305 Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Cushing Syndrome; Cytochrome P-450 Enzyme System; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Mevalonic Acid; Middle Aged; Mitotane; Simvastatin	1992
Intestinal and hepatic cholesterogenesis in hypercholesterolemic dyslipidemia of experimental diabetes in dogs. Diabetes, 1991, Volume: 40, Issue:12 Topics: Animals; Body Weight; Cholesterol; Diabetes Mellitus, Experimental; Dogs; Female; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Insulin; Intestinal Mucosa; Intestine, Small; Lipoproteins; Liver; Male; Mevalonic Acid; Models, Biological; Organ Size	1991
Suppression of lymphoid cell function in vitro by inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by lovastatin. International journal of immunopharmacology, 1989, Volume: 11, Issue:8 Topics: Cytotoxicity, Immunologic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; In Vitro Techniques; Interferon-gamma; Interleukin-2; Lovastatin; Lymphocyte Activation; Lymphocytes; Mevalonic Acid; Mitogens	1989
Plasma mevalonate response in lovastatin-related myopathy. Lancet (London, England), 1989, Nov-04, Volume: 2, Issue:8671 Topics: Aged; Creatine Kinase; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Mevalonic Acid; Middle Aged; Muscular Diseases	1989
[Formation of mevalonic acid, sterols and bile acids from [1-14C]acetyl-CoA and [2-14C]malonyl-CoA in the liver of rabbits with experimental hypercholesterolemia]. Biokhimiia (Moscow, Russia), 1987, Volume: 52, Issue:2 Topics: Acetyl Coenzyme A; Acetyl-CoA Carboxylase; Animals; Bile Acids and Salts; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Hypercholesterolemia; Liver; Malonyl Coenzyme A; Mevalonic Acid; Rabbits; Sterols; Substrate Specificity	1987
Reduced synthesis and rapid esterification of cholesterol in the liver of hamsters with spontaneous hypercholesterolemia. Comparative biochemistry and physiology. B, Comparative biochemistry, 1987, Volume: 86, Issue:4 Topics: Acetates; Animals; Carbon Radioisotopes; Cholesterol; Cholesterol Esters; Cricetinae; Hypercholesterolemia; Ileum; Liver; Male; Mesocricetus; Mevalonic Acid	1987
The role of circulating mevalonate in nephrotic hypercholesterolemia in the rat. Journal of lipid research, 1986, Volume: 27, Issue:10 Topics: Animals; Cholesterol; Female; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; In Vitro Techniques; Liver; Mevalonic Acid; Nephrotic Syndrome; Rats; Rats, Inbred Strains	1986
Synthesis of cholesterol in hypercholesterolemia and its relationship to plasma trigylcerides. Metabolism: clinical and experimental, 1973, Volume: 22, Issue:7 Topics: Acetates; Body Weight; Carbon Isotopes; Cholesterol; Humans; Hypercholesterolemia; Lipoproteins, VLDL; Liver; Mevalonic Acid; Triglycerides; Tritium	1973
Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Proceedings of the National Academy of Sciences of the United States of America, 1974, Volume: 71, Issue:3 Topics: Adult; Alcohol Oxidoreductases; Binding Sites; Cells, Cultured; Child; Female; Fibroblasts; Glutarates; Homozygote; Humans; Hypercholesterolemia; Infant, Newborn; Iodine Radioisotopes; Kinetics; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Mevalonic Acid	1974
Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. The Journal of biological chemistry, 1974, Aug-25, Volume: 249, Issue:16 Topics: Alcohol Oxidoreductases; Binding Sites; Carbon Radioisotopes; Cell Membrane; Enzyme Repression; Fibroblasts; Glutarates; Homozygote; Humans; Hypercholesterolemia; Iodine Radioisotopes; Kinetics; Lipoproteins, LDL; Mevalonic Acid; Protein Binding; Receptors, Drug; Skin; Time Factors; Ultracentrifugation	1974
Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol. The Journal of biological chemistry, 1974, Nov-25, Volume: 249, Issue:22 Topics: Acetates; Alcohol Oxidoreductases; Carbon Radioisotopes; Cells, Cultured; Child; Cholesterol; Chromatography, Gas; Chromatography, Thin Layer; Female; Fibroblasts; Glutarates; Homozygote; Humans; Hypercholesterolemia; Infant, Newborn; Ketosteroids; Leucine; Lipids; Male; Mevalonic Acid; Protein Biosynthesis; Steroids; Structure-Activity Relationship; Tritium	1974
Mechanisms of changes in serum lipid-lipoprotein profiles in infectious disease: Mycobacterium bovis infection in rabbits. Mayo Clinic proceedings, 1972, Volume: 47, Issue:4 Topics: Animals; Carbon Isotopes; Cholesterol; Hypercholesterolemia; Injections, Intravenous; Lipoproteins; Mevalonic Acid; Mycobacterium bovis; Mycobacterium Infections; Rabbits	1972
Control of lipid metabolism in human leukocytes. The Journal of biological chemistry, 1973, Oct-10, Volume: 248, Issue:19 Topics: Acetates; Adult; Carbon Radioisotopes; Cholesterol; Cycloheximide; Digitonin; Fasting; Humans; Hypercholesterolemia; In Vitro Techniques; Leukocytes; Lipids; Mevalonic Acid; Middle Aged; Sterols; Triglycerides	1973
Effect of nicotinic acid on catabolism and synthesis of cholesterol in man. Clinica chimica acta; international journal of clinical chemistry, 1968, Volume: 20, Issue:1 Topics: Adult; Bile Acids and Salts; Cholesterol; Coronary Disease; Feces; Humans; Hypercholesterolemia; Hyperlipidemias; Mevalonic Acid; Middle Aged; Myocardial Infarction; Nicotinic Acids; Steroids; Triglycerides; Tritium	1968
Leucine and mevalonate as precursors of serum cholesterol in man. Acta medica Scandinavica, 1968, Volume: 184, Issue:3 Topics: Adult; Caproates; Carbon Isotopes; Cholesterol; Humans; Hypercholesterolemia; Hyperlipidemias; Leucine; Mevalonic Acid; Middle Aged; Triglycerides; Tritium	1968