mevalonic acid and Cell Transformation, Neoplastic

mevalonic acid has been researched along with Cell Transformation, Neoplastic in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (7.14)	18.7374
1990's	12 (42.86)	18.2507
2000's	2 (7.14)	29.6817
2010's	7 (25.00)	24.3611
2020's	5 (17.86)	2.80

Authors

Authors	Studies
Göbel, A; Hofbauer, LC; Rachner, TD; Riffel, RM	1
Aersilan, A; Gong, Y; Hashimoto, N; Kaneda, A; Kawakami, E; Kawauchi, S; Kinoshita, T; Nagano, H; Nakayama, A; Nishimura, M; Nohata, N; Rahmutulla, B; Sakuma, I; Seki, N; Shi, X; Tanaka, T; Yamagata, K; Yokoyama, M; Zhahara, SN	1
Chen, Y; Li, M; Li, X; Lu, Y; Yang, Y	1
He, F; Liu, H; Liu, Q; Pei, Q; Zhu, H	1
Göbel, A; Hofbauer, LC; Rachner, TD; Rauner, M	1
Bao, S; Dong, Z; Fang, X; Gimple, RC; Huang, Z; Hubert, CG; Kim, LJY; Lai, S; Mack, SC; Mahadev, V; Miller, TE; Prager, BC; Rich, JN; Shi, Y; Song, A; Wang, X; Wu, Q; Xie, Q; Yang, K; Zhou, W; Zhu, Z	1
Cai, Z; Chen, TW; Chin, E; Deng, YZ; Du, YN; Feng, D; Guan, DX; Huang, XX; Jiang, H; Li, DS; Liu, DP; Liu, LM; Ma, N; Qian, ZY; Rong, YF; Shang, YR; Shi, S; Wang, JJ; Wang, XF; Xie, D; Zhang, EB; Zhang, XL; Zhou, QL	1
Albarracin, CT; Bedrosian, I; Bhardwaj, A; Hunt, KK; Singh, H; Trinidad, CM	1
Dupont, S; Pocaterra, A; Santinon, G	1
Iwakuma, T; Iyer, SV; Padhye, S; Parrales, A; Ranjan, A; Roy, A; Weir, SJ	1
Boccadoro, M; Bosia, A; Cavallo, F; Coscia, M; Curcio, C; Forni, G; Holen, I; Iezzi, M; Massaia, M; Mönkkönen, H; Musiani, P; Pantaleoni, F; Quaglino, E; Riganti, C	1
Boutros, PC; Clendening, JW; El Ghamrasni, S; Hakem, A; Hakem, R; Jurisica, I; Khosravi, F; Martirosyan, A; Pandyra, A; Penn, LZ; Trentin, GA	1
Kapur, N; Kumar, R; Singh, RP	1
Cuthbert, JA; Lipsky, PE	1
Larsson, O	2
Ruch, RJ; Sigler, K	1
Klaunig, JE; Madhukar, BV; Ruch, RJ; Trosko, JE	1
Buss, JE; Cox, AD; Der, CJ; Graham, SM; Solski, PA	1
Brown, MS; Goldstein, JL; James, G	1
Hamilton, AD; McGuire, TF; Qian, Y; Sebti, SM; Vogt, A	1
Maume, BF; Maume, G; Mazet, JL; Osman, H	1
Elson, CE; Hadisusilo, S; He, L; Mo, H; Qureshi, AA	1
Lin, JK; Lin-Shiau, SY; Wang, IK	1
Cox, AD; Der, CJ	1
Bourne, JR; Buss, JE; Cochrane, CG; Der, CJ; Jackson, JH; Solski, PA	1
Maltese, WA; Sheridan, KM	1
Siperstein, MD	1

Reviews

6 review(s) available for mevalonic acid and Cell Transformation, Neoplastic

Article	Year
The mevalonate pathway in breast cancer biology. Cancer letters, 2022, 08-28, Volume: 542 Topics: Biology; Breast Neoplasms; Cell Transformation, Neoplastic; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid	2022
Cholesterol and beyond - The role of the mevalonate pathway in cancer biology. Biochimica et biophysica acta. Reviews on cancer, 2020, Volume: 1873, Issue:2 Topics: Antineoplastic Agents; Cell Proliferation; Cell Transformation, Neoplastic; Cholesterol; Clinical Trials as Topic; Disease Progression; Geranyltranstransferase; Humans; Hydroxymethylglutaryl CoA Reductases; Metabolic Networks and Pathways; Mevalonic Acid; Neoplasms; Protein Processing, Post-Translational; rho GTP-Binding Proteins; Sterol Regulatory Element Binding Proteins; Treatment Outcome	2020
Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways. Trends in cell biology, 2016, Volume: 26, Issue:4 Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Calcium-Binding Proteins; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; DNA-Binding Proteins; Feedback, Physiological; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Intracellular Signaling Peptides and Proteins; Mevalonic Acid; Nuclear Proteins; Phosphoproteins; Protein Serine-Threonine Kinases; Signal Transduction; TEA Domain Transcription Factors; TOR Serine-Threonine Kinases; Trans-Activators; Transcription Factors; Transcriptional Coactivator with PDZ-Binding Motif Proteins; YAP-Signaling Proteins	2016
Molecular regulation of cholesterol biosynthesis: implications in carcinogenesis. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2003, Volume: 22, Issue:2 Topics: Acyl Coenzyme A; Antineoplastic Agents; Cell Division; Cell Transformation, Neoplastic; Cholesterol; Humans; Mevalonic Acid; Proto-Oncogene Proteins c-raf; ras Proteins; Signal Transduction	2003
HMG-CoA reductase inhibitors: role in normal and malignant cells. Critical reviews in oncology/hematology, 1996, Volume: 22, Issue:3 Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Reference Values	1996
The ras/cholesterol connection: implications for ras oncogenicity. Critical reviews in oncogenesis, 1992, Volume: 3, Issue:4 Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cholesterol; Dimethylallyltranstransferase; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Mevalonic Acid; Molecular Sequence Data; Neoplasms; Palmitic Acid; Palmitic Acids; Polyisoprenyl Phosphates; Protein Processing, Post-Translational; Sequence Homology	1992

Other Studies

22 other study(ies) available for mevalonic acid and Cell Transformation, Neoplastic

Article	Year
MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway. Scientific reports, 2022, 11-02, Volume: 12, Issue:1 Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Mevalonic Acid; MicroRNAs; Tumor Suppressor Protein p53	2022
Antidiabetic drug metformin suppresses tumorigenesis through inhibition of mevalonate pathway enzyme HMGCS1. The Journal of biological chemistry, 2022, Volume: 298, Issue:12 Topics: Cell Line, Tumor; Cell Transformation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Synthase; Hypoglycemic Agents; Metformin; Mevalonic Acid; NF-E2-Related Factor 2	2022
Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis. Molecular carcinogenesis, 2023, Volume: 62, Issue:6 Topics: Animals; Carcinogenesis; Cell Transformation, Neoplastic; Colorectal Neoplasms; Mevalonic Acid; Mice; Mice, Nude; MicroRNAs; RNA, Circular; Tumor Suppressor Protein p53	2023
MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells. Cancer research, 2017, 09-15, Volume: 77, Issue:18 Topics: Animals; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Cell Proliferation; Cell Transformation, Neoplastic; Glioblastoma; Humans; Isocitrate Dehydrogenase; Mevalonic Acid; Mice; Mice, Inbred NOD; Mice, SCID; MicroRNAs; Neoplastic Stem Cells; Proto-Oncogene Proteins c-myc; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2017
Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. The Journal of experimental medicine, 2018, 01-02, Volume: 215, Issue:1 Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Transformation, Neoplastic; Cilia; Gene Expression Profiling; Humans; Male; Metabolic Networks and Pathways; Mevalonic Acid; Mice; NIH 3T3 Cells; Oncogenes; Pancreatic Neoplasms; Sterol Regulatory Element Binding Protein 2; TCF Transcription Factors	2018
The isomiR-140-3p-regulated mevalonic acid pathway as a potential target for prevention of triple negative breast cancer. Breast cancer research : BCR, 2018, 12-11, Volume: 20, Issue:1 Topics: Animals; Aspirin; Biomarkers, Tumor; Biosynthetic Pathways; Cell Line, Tumor; Cell Transformation, Neoplastic; Cholesterol; Feedback, Physiological; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Synthase; Mevalonic Acid; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Sequence Analysis, RNA; Triple Negative Breast Neoplasms; Up-Regulation; Xenograft Model Antitumor Assays	2018
DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. Nature cell biology, 2016, Volume: 18, Issue:11 Topics: Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; DNA; HSP40 Heat-Shock Proteins; Humans; Mevalonic Acid; Mutation; Protein Binding; Tumor Suppressor Protein p53; Ubiquitination	2016
Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. Journal of cellular and molecular medicine, 2010, Volume: 14, Issue:12 Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Diphosphonates; Female; Genes, erbB-2; Imidazoles; Interferon-gamma; Interleukin-10; Macrophages; Mammary Glands, Animal; Mammary Neoplasms, Animal; Metabolic Networks and Pathways; Mevalonic Acid; Mice; Mice, Inbred BALB C; Mice, Transgenic; Neovascularization, Pathologic; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Protein Prenylation; Vascular Endothelial Growth Factor A; Zoledronic Acid	2010
Dysregulation of the mevalonate pathway promotes transformation. Proceedings of the National Academy of Sciences of the United States of America, 2010, Aug-24, Volume: 107, Issue:34 Topics: Alternative Splicing; Animals; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Primers; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Male; Mevalonic Acid; Mice; Mice, SCID; Neoplasm Transplantation; RNA, Messenger; RNA, Neoplasm; Transplantation, Heterologous	2010
Suppression of the proliferation of Ras-transformed cells by fluoromevalonate, an inhibitor of mevalonate metabolism. Cancer research, 1995, Apr-15, Volume: 55, Issue:8 Topics: Animals; Carboxy-Lyases; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Cholesterol; DNA Replication; Genes, ras; Humans; Interleukin-3; Kinetics; Mevalonic Acid; Recombinant Proteins; Transfection; Tumor Cells, Cultured; Urinary Bladder Neoplasms	1995
Effect of virus-transformation and growth factor stimulation on isoprene biosynthesis in human fibroblasts: a correlation to cell growth. Cancer biochemistry biophysics, 1995, Volume: 14, Issue:4 Topics: Butadienes; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Culture Media; Dolichols; Fibroblasts; Hemiterpenes; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Pentanes; Platelet-Derived Growth Factor; Simian virus 40	1995
Growth inhibition of rat liver epithelial tumor cells by monoterpenes does not involve Ras plasma membrane association. Carcinogenesis, 1994, Volume: 15, Issue:4 Topics: Animals; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Cyclohexenes; Growth Inhibitors; In Vitro Techniques; Limonene; Liver; Lovastatin; Menthol; Mevalonic Acid; Proto-Oncogene Proteins p21(ras); Rats; Terpenes; Tumor Cells, Cultured	1994
Reversal of ras-induced inhibition of gap-junctional intercellular communication, transformation, and tumorigenesis by lovastatin. Molecular carcinogenesis, 1993, Volume: 7, Issue:1 Topics: Animals; Cell Communication; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Drug Interactions; Epithelial Cells; Genes, ras; Intercellular Junctions; Kinetics; Liver; Liver Neoplasms, Experimental; Lovastatin; Male; Mevalonic Acid; Phenotype; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344	1993
The carboxyl-terminal CXXX sequence of Gi alpha, but not Rab5 or Rab11, supports Ras processing and transforming activity. The Journal of biological chemistry, 1993, Jun-05, Volume: 268, Issue:16 Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cysteine; Genes, ras; GTP-Binding Proteins; Methionine; Mevalonic Acid; Mice; Molecular Sequence Data; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); rab5 GTP-Binding Proteins; Rats; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Transfection; Tritium	1993
Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. Proceedings of the National Academy of Sciences of the United States of America, 1996, Apr-30, Volume: 93, Issue:9 Topics: Alkyl and Aryl Transferases; Animals; Benzodiazepines; Cell Line; Cell Transformation, Neoplastic; Enzyme Inhibitors; Farnesyltranstransferase; Mevalonic Acid; Oligopeptides; Protein Prenylation; ras Proteins; Rats; Recombinant Fusion Proteins; Transfection; Transferases	1996
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. Oncogene, 1996, Nov-07, Volume: 13, Issue:9 Topics: Actins; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Diterpenes; DNA; Enzyme Inhibitors; Farnesol; Fibroblasts; G1 Phase; Genes, ras; GTP-Binding Proteins; Lovastatin; Methionine; Mevalonic Acid; Mice; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; rap GTP-Binding Proteins; ras Proteins; Resting Phase, Cell Cycle; S Phase; Transferases	1996
Geranylgeranyl as well as farnesyl moiety is transferred to Ras p21 overproduced in adrenocortical cells transformed by c-Ha-rasEJ oncogene. Biochemical and biophysical research communications, 1997, Feb-24, Volume: 231, Issue:3 Topics: Adrenal Cortex; Animals; Cell Transformation, Neoplastic; Mevalonic Acid; Protein Prenylation; Proto-Oncogene Proteins p21(ras); Rats	1997
Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. The Journal of nutrition, 1997, Volume: 127, Issue:5 Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Chromans; Dose-Response Relationship, Drug; Edible Grain; Female; Fruit; Melanoma, Experimental; Mevalonic Acid; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Norisoprenoids; Terpenes; Time Factors; Tumor Cells, Cultured; Vegetables; Vitamin E	1997
Suppression of invasion and MMP-9 expression in NIH 3T3 and v-H-Ras 3T3 fibroblasts by lovastatin through inhibition of ras isoprenylation. Oncology, 2000, Volume: 59, Issue:3 Topics: 3T3 Cells; Animals; Antineoplastic Agents; Cell Membrane; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Electrophoresis; Gene Expression; Genes, ras; Lovastatin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mevalonic Acid; Mice; Neoplasm Invasiveness; NF-kappa B; Promoter Regions, Genetic; Protein Prenylation; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-1; Transcription, Genetic	2000
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:8 Topics: Animals; Anticholesteremic Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Exons; Farnesol; Genetic Vectors; Humans; Lovastatin; Mevalonic Acid; Mice; Mutation; Oligonucleotide Probes; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Transfection	1990
Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis. Journal of cellular physiology, 1985, Volume: 125, Issue:3 Topics: Acetates; Acetylcholinesterase; Animals; Axons; Cell Cycle; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cholesterol; Cycloheximide; Glycoproteins; Growth Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Naphthalenes; Neuroblastoma; Terpenes	1985
Cholesterol and cancer. Transactions of the American Clinical and Climatological Association, 1970, Volume: 81 Topics: Aflatoxins; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cholesterol; Feedback; Glycolysis; Guinea Pigs; Humans; Leukemia, Experimental; Liver; Liver Neoplasms; Mevalonic Acid; Mice; Neoplasms, Experimental; Rats; Salmonidae	1970