mevalonic acid and Breast Neoplasms

mevalonic acid has been researched along with Breast Neoplasms in 57 studies

Research

Studies (57)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.75)	18.7374
1990's	4 (7.02)	18.2507
2000's	19 (33.33)	29.6817
2010's	25 (43.86)	24.3611
2020's	8 (14.04)	2.80

Authors

Authors	Studies
Bordel, S; Mikalayeva, V; Pankevičiūtė, M; Skeberdis, VA; Žvikas, V	1
Göbel, A; Hofbauer, LC; Rachner, TD; Riffel, RM	1
Anghel, R; Forsea, L; Gales, L; Georgescu, M; Mitrea, D; Mitrica, R; Serbanescu, L; Stanculescu, I; Stefanica, I; Trifanescu, O	1
Andrews, DW; Ba-Alawi, W; Branchard, E; Cescon, DW; Cruickshank, J; Gendoo, DMA; Gross, PL; Haibe-Kains, B; Longo, J; Penn, LZ; Schormann, W; Silvester, J; van Leeuwen, JE	1
Agarwal, M; Chen, A; Fan, Y; Jalali, A; Kondo, R; Li, BY; Liu, S; Minami, K; Siegel, A; Teli, M; Wang, L; Wang, Y; Yokota, H; Zhao, X	1
Akrap, N; Andersson, D; Buffa, F; Choudhry, H; Garre, E; Harris, A; Harrison, H; Jonasson, E; Landberg, G; Magnusson, Y; Rafnsdottir, S; Ragoussis, J; Ståhlberg, A; Walsh, CA	1
Billington, EO; Reid, IR	1
Brindisi, M; Cappello, AR; Fiorillo, M; Frattaruolo, L; Lisanti, MP; Sotgia, F	1
Branchard, E; Cescon, DW; Dennis, JW; Drake, RR; Elbaz, M; Longo, J; Penn, LZ; van Leeuwen, JE; Yu, R; Zhang, C	1
Azzolin, L; Bertolio, R; Bicciato, S; Del Sal, G; Ingallina, E; Lisek, K; Mano, M; Mantovani, F; Piccolo, S; Rosato, A; Scaini, D; Severino, LU; Sorrentino, G; Zannini, A	1
Bartella, L; Cappello, AR; Di Donna, L; Dolce, V; Fiorillo, M; Lisanti, MP; Peiris-Pagès, M; Sanchez-Alvarez, R; Sindona, G; Sotgia, F	1
Chatziioannou, A; Obasuyi, O; Pampalakis, G; Papadodima, O; Sotiropoulou, G; Zoumpourlis, V	1
Boutros, PC; Chan-Seng-Yue, M; Clendening, JW; Goard, CA; Haider, S; Lehner, R; Mullen, PJ; Penn, LZ; Quiroga, AD; Sendorek, DH; Wasylishen, AR	1
Chen, H; Fang, X; Huang, L; Jiang, Y; Li, N; Liu, Y; Mei, L; Sun, S; Wang, H; Wang, Z; Wu, Y; Zhang, F; Zhang, X; Zhang, Y; Zheng, Y	1
Cordenonsi, M; Del Sal, G; Dupont, S; Ingallina, E; Manfrin, A; Mano, M; Piazza, S; Piccolo, S; Rosato, A; Ruggeri, N; Sommaggio, R; Sorrentino, G; Specchia, V	1
Abbasi, T; Aggrawal, A; Bharati, IS; Chao, Y; Chien, S; Cong, X; Fogal, V; Jiang, P; Kapoor, S; Kesari, S; Mukthavaram, R; Nomura, N; Pastorino, S; Pingle, SC; Shetty, K; Teng, D; Vali, S	1
Dhople, VM; Kanugula, AK; Kotamraju, S; Ummanni, R; Völker, U	1
Buccione, R; Chaudhari, KR; Hyttinen, JM; Kaarniranta, K; Khandelwal, VK; Mitrofan, LM; Mönkkönen, J; Ravingerová, T	1
Bargonetti, J; Hendrickson, RC; Martin, C; Polotskaia, A; Qiu, WG; Reynoso, K; Xiao, G	1
Brown, KR; Ericson, E; Gebbia, M; Giaever, G; Goard, CA; Hart, T; Kalkat, M; Lang, KS; Moffat, J; Mullen, PJ; Nislow, C; Pandyra, AA; Penn, LZ; Pong, JT; Sharma, P; Yu, R	1
Browne, AJ; Göbel, A; Hofbauer, LC; Rachner, TD; Rauner, M; Thiele, S	1
Chan, CW; Goh, BC; Hartman, M; Lee, SC; Loh, X; Seah, S; Wang, T	1
Alizadeh, J; Barazeh, M; Kavousipour, S; Mokarram, P; Razban, V; Solomon, C	1
Browne, AJ; Göbel, A; Hofbauer, LC; Rachner, TD; Rauner, M; Thiele, S; Zinna, VM	1
Angeletti, M; Bonfili, L; Cecarini, V; Cocchioni, M; Cuccioloni, M; Eleuteri, AM; Mozzicafreddo, M; Nabissi, M; Santoni, G; Scuri, S	1
Deng, L; Ding, Y; Fan, J; Huang, B; Peng, Y	1
Bifulco, M; Laezza, C; Malfitano, AM; Pisanti, S	1
Cree, IA; Dexel, S; Fernando, A; Glaysher, S; Knight, LA; Kurbacher, CM; Reichelt, R; Reinhold, U	1
Auriola, S; Jauhiainen, M; Mönkkönen, H; Mönkkönen, J; Räikkönen, J	1
Auriola, S; Mönkkönen, H; Mönkkönen, J; Räikkönen, J	1
Boutros, PC; Clendening, JW; El Ghamrasni, S; Hakem, A; Hakem, R; Jurisica, I; Khosravi, F; Martirosyan, A; Pandyra, A; Penn, LZ; Trentin, GA	1
Cheng, G; Hauser, AD; Joseph, J; Kalyanaraman, B; Lopez, M; McAllister, D; Rowe, JJ; Sugg, SL; Williams, CL; Zielonka, J	1
Bargonetti, J; Barsotti, A; Bissell, MJ; Børresen-Dale, AL; Chicas, A; Freed-Pastor, WA; Langerød, A; Levine, AJ; Li, W; Lowe, SW; Mizuno, H; Moon, SH; Osborne, TF; Polotskaia, A; Prives, C; Rodriguez-Barrueco, R; Silva, JM; Tian, B; Zhao, X	1
Bertucci, F; Birnbaum, D; Cabaud, O; Cervera, N; Charafe-Jauffret, E; Finetti, P; Ginestier, C; Guille, A; Josselin, E; Larderet, G; Monville, F; Sebti, S; Viens, P; Wicinski, J	1
Gopalan, A; Kline, K; Sanders, BG; Yu, W	2
Angman, L; De Libero, G; Gober, HJ; Jenö, P; Kistowska, M; Mori, L	1
Mueck, AO; Seeger, H; Wallwiener, D	1
Awad, AB; Fink, CS; Williams, H	1
KORSH, G; TERNER, C	1
Coleman, RE; Evans, CA; Holen, I; Neville-Webbe, HL; Rostami-Hodjegan, A	1
Archer, MC; Duncan, RE; El-Sohemy, A	2
Coleman, RE; Evans, CA; Holen, I; Neville-Webbe, HL	1
Altundag, K; Bulut, N; Dincer, M; Harputluoglu, H	1
Golab, J; Issat, T; Jakóbisiak, M	1
Fujiwara, I; Magae, J; Mizuta, M; Mizuta, N; Nakajima, H; Sakaguchi, K; Sawai, K; Tsuruga, M; Yamagishi, H	1
Body, JJ; Chaboteaux, C; Durbecq, V; Journe, F; Larsimont, D; Laurent, G; Nonclercq, D	1
Harris, KW; Lehenkari, PP; Merrell, MA; Selander, KS; Wakchoure, S	1
Kalyanaraman, B; Kotamraju, S; Willams, CL; Williams, CL	1
Blegen, H; Larsson, O	1
Larsson, O	1
Carlberg, M; Hjertman, M; Larsson, O; Wejde, J	1
Miller, AC; Samid, D	1
Coleman, RE; Croucher, PI; Jagdev, SP; Rostami-H, A; Shipman, CM	1
Altucci, L; Bresciani, F; Cancemi, M; Cicatiello, L; Germano, D; Michalides, RJ; Pacilio, C; Petrizzi, VB; Salzano, S; Sperandio, C; Taya, Y; Weisz, A	1
Getz, B; Ingle, JN; Karpeisky, MY; Mikhailov, SN; Padyukova, NSh; Reinholz, GG; Sanders, ES; Spelsberg, TC	1

Reviews

6 review(s) available for mevalonic acid and Breast Neoplasms

Article	Year
The mevalonate pathway in breast cancer biology. Cancer letters, 2022, 08-28, Volume: 542 Topics: Biology; Breast Neoplasms; Cell Transformation, Neoplastic; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid	2022
Antidiabetics, Anthelmintics, Statins, and Beta-Blockers as Co-Adjuvant Drugs in Cancer Therapy. Medicina (Kaunas, Lithuania), 2022, Sep-07, Volume: 58, Issue:9 Topics: Adenosine Monophosphate; Adrenergic beta-Antagonists; Anthelmintics; Anti-Bacterial Agents; Antihypertensive Agents; Antimalarials; Antineoplastic Agents; Atorvastatin; Breast Neoplasms; Cholesterol; Diabetes Mellitus, Type 2; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Mebendazole; Metformin; Mevalonic Acid; Propranolol; Protein Kinases; Proto-Oncogene Proteins B-raf; Receptors, Adrenergic, beta-2; Tyrosine	2022
Benefits of Bisphosphonate Therapy: Beyond the Skeleton. Current osteoporosis reports, 2020, Volume: 18, Issue:5 Topics: Atherosclerosis; Bone Density Conservation Agents; Breast Neoplasms; Colorectal Neoplasms; Diphosphonates; Disease Progression; Endothelial Cells; Humans; Macrophages; Mevalonic Acid; Monocytes; Mortality; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protective Factors; Vascular Calcification	2020
Interconnection of Estrogen/Testosterone Metabolism and Mevalonate Pathway in Breast and Prostate Cancers. Current molecular pharmacology, 2017, Volume: 10, Issue:2 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cholesterol; Estradiol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mevalonic Acid; Prostatic Neoplasms; Signal Transduction; Testosterone	2017
Dietary factors and the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for breast cancer and development. Molecular nutrition & food research, 2005, Volume: 49, Issue:2 Topics: Animals; Breast Neoplasms; Cell Division; Cholesterol; Diet; Fatty Acids, Omega-3; Genistein; Homeostasis; Humans; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Plants; Terpenes	2005
Statins and cancer development. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2005, Volume: 14, Issue:8 Topics: Animals; Breast Neoplasms; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Pravastatin	2005

Other Studies

51 other study(ies) available for mevalonic acid and Breast Neoplasms

Article	Year
Contribution of branched chain amino acids to energy production and mevalonate synthesis in cancer cells. Biochemical and biophysical research communications, 2021, 12-31, Volume: 585 Topics: Acetoacetates; Algorithms; Amino Acids, Branched-Chain; Breast Neoplasms; Carbon; Cell Line; Cell Line, Tumor; Citric Acid Cycle; Energy Metabolism; Female; Humans; Leucine; MCF-7 Cells; Metabolic Flux Analysis; Metabolic Networks and Pathways; Mevalonic Acid; Mitochondria; Models, Biological	2021
Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins. Nature communications, 2022, 10-24, Volume: 13, Issue:1 Topics: Breast Neoplasms; Cadherins; Cholesterol; Clotrimazole; Dipyridamole; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Nelfinavir; Pharmacogenetics; Vemurafenib	2022
Pitavastatin slows tumor progression and alters urine-derived volatile organic compounds through the mevalonate pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:12 Topics: Animals; Bone Neoplasms; Breast Neoplasms; Cell Line; Cell Line, Tumor; Down-Regulation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Mevalonic Acid; Mice; Mice, Inbred BALB C; Osteoblasts; Quinolines; RAW 264.7 Cells; Volatile Organic Compounds	2019
The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer. PloS one, 2020, Volume: 15, Issue:7 Topics: Breast Neoplasms; Cell Line, Tumor; Cohort Studies; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroxymethylglutaryl-CoA Synthase; Lymph Nodes; Metabolic Networks and Pathways; Mevalonic Acid; Models, Biological; Neoplasm Invasiveness; Neoplastic Stem Cells	2020
Cholesterol and Mevalonate: Two Metabolites Involved in Breast Cancer Progression and Drug Resistance through the ERRα Pathway. Cells, 2020, 07-31, Volume: 9, Issue:8 Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Movement; Cholesterol; Disease Progression; Drug Resistance; ERRalpha Estrogen-Related Receptor; Female; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial; Mevalonic Acid; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Prognosis; Receptors, Estrogen; Signal Transduction	2020
Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced Cancer research, 2021, 05-15, Volume: 81, Issue:10 Topics: Adjuvants, Immunologic; Animals; Apoptosis; Breast Neoplasms; Cell Proliferation; Endoplasmic Reticulum; Epithelial-Mesenchymal Transition; Female; Fluvastatin; Gene Expression Regulation, Neoplastic; Glycosylation; Humans; Lung Neoplasms; Mevalonic Acid; Mice; Mice, SCID; Prognosis; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2021
Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis. Nature cell biology, 2018, Volume: 20, Issue:1 Topics: Actins; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Databases, Factual; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase 6; HSP90 Heat-Shock Proteins; Humans; Mechanotransduction, Cellular; Mevalonic Acid; Mice; Mice, SCID; Mutation; Protein Stability; Proteolysis; rhoA GTP-Binding Protein; Small Molecule Libraries; Tumor Suppressor Protein p53; Ubiquitin; Xenograft Model Antitumor Assays	2018
Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism. Biochimica et biophysica acta. Bioenergetics, 2018, Volume: 1859, Issue:9 Topics: Apoptosis; Biological Products; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Cells, Cultured; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Mitochondria; Neoplasm Metastasis; Neoplastic Stem Cells; Plant Oils; Prognosis; rho-Specific Guanine Nucleotide Dissociation Inhibitors; Signal Transduction; Survival Rate	2018
The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway. Oncotarget, 2014, May-15, Volume: 5, Issue:9 Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Proliferation; Cholesterol; Cholesterol, LDL; Fatty Acids; Female; Humans; Immunoenzyme Techniques; Kallikreins; Mevalonic Acid; Mice; Mice, SCID; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2014
Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells. Breast cancer research and treatment, 2014, Volume: 143, Issue:2 Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Fatty Acids, Monounsaturated; Female; Fluvastatin; Gene Expression; Gene Expression Profiling; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Indoles; MCF-7 Cells; Mevalonic Acid; Proto-Oncogene Proteins c-myc; Receptor, ErbB-2; RNA, Messenger	2014
Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proceedings of the National Academy of Sciences of the United States of America, 2014, Jan-07, Volume: 111, Issue:1 Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hippo Signaling Pathway; Humans; Hyaluronan Receptors; Mevalonic Acid; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Transplantation; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Simvastatin; Transcription Factors; YAP-Signaling Proteins	2014
Metabolic control of YAP and TAZ by the mevalonate pathway. Nature cell biology, 2014, Volume: 16, Issue:4 Topics: Active Transport, Cell Nucleus; Acyltransferases; Adaptor Proteins, Signal Transducing; Animals; Breast Neoplasms; Cell Proliferation; Drosophila melanogaster; Drosophila Proteins; Female; HCT116 Cells; HEK293 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent; Intracellular Signaling Peptides and Proteins; Mevalonic Acid; Mice; Nuclear Proteins; Phosphoproteins; Phosphorylation; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; RNA Interference; RNA, Small Interfering; Signal Transduction; Sterol Regulatory Element Binding Proteins; Trans-Activators; Transcription Factors; Transcription, Genetic; Tumor Suppressor Proteins; YAP-Signaling Proteins	2014
In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells. British journal of cancer, 2014, Oct-14, Volume: 111, Issue:8 Topics: Animals; Antineoplastic Agents; Autophagy; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Computer Simulation; Disease Models, Animal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Mevalonic Acid; Mice; Mice, Nude	2014
Fluvastatin mediated breast cancer cell death: a proteomic approach to identify differentially regulated proteins in MDA-MB-231 cells. PloS one, 2014, Volume: 9, Issue:9 Topics: Acyl Coenzyme A; Anticholesteremic Agents; Apoptosis; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Chromatography, High Pressure Liquid; Electrophoresis, Gel, Two-Dimensional; Epithelial-Mesenchymal Transition; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Indoles; Metabolic Networks and Pathways; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Proteome; Tandem Mass Spectrometry; Vimentin	2014
Oxidative stress plays an important role in zoledronic acid-induced autophagy. Physiological research, 2014, Volume: 63, Issue:Suppl 4 Topics: Autophagy; Bone Density Conservation Agents; Breast Neoplasms; Diphosphonates; Humans; Imidazoles; MCF-7 Cells; Mevalonic Acid; Oxidative Stress; Zoledronic Acid	2014
Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4. Proceedings of the National Academy of Sciences of the United States of America, 2015, Mar-17, Volume: 112, Issue:11 Topics: Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Chromatin; Cytoplasm; DNA Replication; Enzyme Inhibitors; Female; Humans; Isotope Labeling; Mevalonic Acid; Minichromosome Maintenance Complex Component 4; Mutant Proteins; Poly(ADP-ribose) Polymerases; Proliferating Cell Nuclear Antigen; Protein Stability; Protein Transport; Proteome; Proteomics; Signal Transduction; Transcription, Genetic; Tumor Suppressor Protein p53	2015
Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. Oncotarget, 2015, Sep-29, Volume: 6, Issue:29 Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dimethylallyltranstransferase; Farnesyltranstransferase; Fatty Acids, Monounsaturated; Female; Fluvastatin; Gene Expression Regulation, Neoplastic; Geranyltranstransferase; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Indoles; Lung Neoplasms; Mevalonic Acid; Neoplasms; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Sterol Regulatory Element Binding Protein 2	2015
Potentiated suppression of Dickkopf-1 in breast cancer by combined administration of the mevalonate pathway inhibitors zoledronic acid and statins. Breast cancer research and treatment, 2015, Volume: 154, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Atorvastatin; Breast Neoplasms; Cell Line, Tumor; Diphosphonates; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Mevalonic Acid; Mice, Nude; Osteoblasts; Rosuvastatin Calcium; Simvastatin; Xenograft Model Antitumor Assays; Zoledronic Acid	2015
Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. Oncotarget, 2016, Jan-19, Volume: 7, Issue:3 Topics: Adult; Aged; Apoptosis; Blotting, Western; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoenzyme Techniques; Mevalonic Acid; Middle Aged; Mitogen-Activated Protein Kinases; Neoplasm Grading; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Prognosis; Prospective Studies; Proto-Oncogene Proteins c-akt; Simvastatin; TOR Serine-Threonine Kinases; Tumor Cells, Cultured	2016
Combined inhibition of the mevalonate pathway with statins and zoledronic acid potentiates their anti-tumor effects in human breast cancer cells. Cancer letters, 2016, May-28, Volume: 375, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Atorvastatin; Biosynthetic Pathways; Breast Neoplasms; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Survival; Diphosphonates; Drug Synergism; Enzyme Activation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Mevalonic Acid; rho GTP-Binding Proteins; Zoledronic Acid	2016
Mangiferin blocks proliferation and induces apoptosis of breast cancer cells via suppression of the mevalonate pathway and by proteasome inhibition. Food & function, 2016, Oct-12, Volume: 7, Issue:10 Topics: Apoptosis; Biomarkers; Breast Neoplasms; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholesterol; Dose-Response Relationship, Drug; Female; Fibrinolysin; Humans; Mevalonic Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Xanthones	2016
Gamma-tocotrienol reverses multidrug resistance of breast cancer cells with a mechanism distinct from that of atorvastatin. The Journal of steroid biochemistry and molecular biology, 2017, Volume: 167 Topics: Antineoplastic Agents; Apoptosis; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Chromans; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Hydroxymethylglutaryl CoA Reductases; MCF-7 Cells; Membrane Potential, Mitochondrial; Mevalonic Acid; Reactive Oxygen Species; Vitamin E	2017
The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway. Endocrine-related cancer, 2008, Volume: 15, Issue:4 Topics: Actins; Amides; Arachidonic Acids; Blotting, Western; Breast Neoplasms; Cannabinoids; Cell Membrane; Cell Movement; Cytoskeleton; Cytosol; Female; Fluorescent Antibody Technique; Humans; Mevalonic Acid; Neoplasm Invasiveness; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction	2008
Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. BMC cancer, 2009, Jan-28, Volume: 9 Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diphosphonates; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Imidazoles; Indoles; Mevalonic Acid; Middle Aged; Ovarian Neoplasms; Signal Transduction; Tumor Cells, Cultured; Zoledronic Acid	2009
Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Oct-01, Volume: 877, Issue:27 Topics: Adenosine Triphosphate; Breast Neoplasms; Cell Line, Tumor; Chromatography, Liquid; Drug Stability; Hemiterpenes; Humans; Linear Models; Mevalonic Acid; Organophosphorus Compounds; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization	2009
Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. Biochemical pharmacology, 2010, Mar-01, Volume: 79, Issue:5 Topics: Adenosine Triphosphate; Anticarcinogenic Agents; Breast Neoplasms; Cell Line, Tumor; Diphosphonates; Down-Regulation; Drug Screening Assays, Antitumor; Farnesol; Female; Gene Expression Regulation, Neoplastic; Hemiterpenes; Humans; Imidazoles; Mevalonic Acid; Organophosphorus Compounds; Zoledronic Acid	2010
Dysregulation of the mevalonate pathway promotes transformation. Proceedings of the National Academy of Sciences of the United States of America, 2010, Aug-24, Volume: 107, Issue:34 Topics: Alternative Splicing; Animals; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Primers; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Male; Mevalonic Acid; Mice; Mice, SCID; Neoplasm Transplantation; RNA, Messenger; RNA, Neoplasm; Transplantation, Heterologous	2010
Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. Cancer biology & therapy, 2011, Oct-15, Volume: 12, Issue:8 Topics: Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Drug Synergism; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Mevalonic Acid; Mitochondria; Nitrogen Oxides; Organophosphorus Compounds; Reactive Oxygen Species	2011
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell, 2012, Jan-20, Volume: 148, Issue:1-2 Topics: Breast Neoplasms; Cell Line, Tumor; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metabolic Networks and Pathways; Mevalonic Acid; Mutation; Prenylation; Promoter Regions, Genetic; Simvastatin; Sterol Regulatory Element Binding Proteins; Tumor Suppressor Protein p53	2012
Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target. Stem cells (Dayton, Ohio), 2012, Volume: 30, Issue:7 Topics: Animals; Antineoplastic Agents; Benzamides; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Docetaxel; Female; Gene Expression Profiling; Humans; Mevalonic Acid; Mice; Mice, SCID; Neoplasms, Basal Cell; Neoplastic Stem Cells; Taxoids	2012
Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. Cancer letters, 2013, Feb-01, Volume: 329, Issue:1 Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mevalonic Acid; Polyisoprenyl Phosphates; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA, Small Interfering; Sesquiterpenes; Signal Transduction; Simvastatin; Transcription Factor CHOP	2013
Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol. Cancer letters, 2013, Jan-28, Volume: 328, Issue:2 Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Ceramides; Chromans; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Mevalonic Acid; Neoplastic Stem Cells; Retinal Dehydrogenase; Signal Transduction; Simvastatin; STAT3 Transcription Factor; Vitamin E	2013
Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells. The Journal of experimental medicine, 2003, Jan-20, Volume: 197, Issue:2 Topics: Breast Neoplasms; Cells, Cultured; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Immunotherapy; Lymphocyte Activation; Mevalonic Acid; Neoplasms; Phosphorylation; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocyte Subsets; Transfection; Tumor Cells, Cultured	2003
Statins can inhibit proliferation of human breast cancer cells in vitro. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2003, Volume: 111, Issue:1 Topics: Breast Neoplasms; Cell Division; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Tumor Cells, Cultured	2003
Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. The Journal of nutritional biochemistry, 2003, Volume: 14, Issue:2 Topics: Breast Neoplasms; Cell Division; Cholesterol; Humans; Mevalonic Acid; Mitogen-Activated Protein Kinases; Phytosterols; Protein Prenylation; Sitosterols; Tumor Cells, Cultured	2003
THE BIOSYNTHESIS OF GLYCERIDES IN HOMOGENATES OF NORMAL LACTATING MAMMARY GLAND AND OF MAMMARY TUMOR TISSUE OF THE MOUSE. Cancer research, 1963, Volume: 23 Topics: Animals; Breast; Breast Neoplasms; Carbon Isotopes; Fatty Acids; Female; Glucose; Glycerides; Hexokinase; Humans; Lactation; Lipid Metabolism; Mammary Glands, Animal; Mammary Glands, Human; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mevalonic Acid; Mice; Research	1963
Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. International journal of cancer, 2005, Jan-20, Volume: 113, Issue:3 Topics: Antibiotics, Antineoplastic; Apoptosis; Breast Neoplasms; Diphosphonates; Diterpenes; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Female; Humans; Imidazoles; Male; Mevalonic Acid; Prostatic Neoplasms; Time Factors; Tumor Cells, Cultured; Zoledronic Acid	2005
Mechanisms of the synergistic interaction between the bisphosphonate zoledronic acid and the chemotherapy agent paclitaxel in breast cancer cells in vitro. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2006, Volume: 27, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; BRCA1 Protein; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Diphosphonates; Dose-Response Relationship, Drug; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Imidazoles; Mevalonic Acid; Mutation; Paclitaxel; Signal Transduction; Time Factors; Zoledronic Acid	2006
Statins may decrease skeletal-related events in breast cancer patients with bone metastases. Medical hypotheses, 2006, Volume: 67, Issue:5 Topics: Acyl Coenzyme A; Apoptosis; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Cell Division; Cholesterol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neoplasm Metastasis; Osteoclasts	2006
Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway. Oncology reports, 2006, Volume: 16, Issue:6 Topics: Anticholesteremic Agents; Antineoplastic Agents; Berberine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Humans; Lovastatin; Mevalonic Acid	2006
Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. Cancer letters, 2007, Aug-08, Volume: 253, Issue:1 Topics: Antineoplastic Agents, Alkylating; Apoptosis; Breast Neoplasms; Diphosphonates; Drug Screening Assays, Antitumor; Humans; Imidazoles; Mevalonic Acid; Mitochondria; Polyisoprenyl Phosphates; Sesquiterpenes; Signal Transduction	2007
Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation. Breast cancer research and treatment, 2008, Volume: 107, Issue:1 Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Farnesol; Gene Silencing; Humans; Ligands; Mevalonic Acid; Microscopy, Fluorescence; Models, Genetic; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; Transcription Factors; Transcriptional Activation	2008
Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells. European journal of pharmacology, 2007, Sep-10, Volume: 570, Issue:1-3 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Diphosphonates; DNA; Humans; Lovastatin; Mevalonic Acid; Nitrogen; p38 Mitogen-Activated Protein Kinases; Polyisoprenyl Phosphates; rap1 GTP-Binding Proteins	2007
Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. Cancer research, 2007, Aug-01, Volume: 67, Issue:15 Topics: Anticholesteremic Agents; Antioxidants; Apoptosis; Arginase; Blotting, Western; Breast Neoplasms; Caspase 3; Cell Adhesion; Cell Cycle; Cells, Cultured; Colony-Forming Units Assay; Fatty Acids, Monounsaturated; Fluvastatin; Humans; In Situ Nick-End Labeling; Indoles; Mevalonic Acid; Nitric Oxide; Nitric Oxide Synthase Type II; Polyisoprenyl Phosphates; Protein Prenylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Simvastatin	2007
Inhibitory effect of mevalonate on the EGF mitogenic signaling pathway in human breast cancer cells in culture. Cancer biochemistry biophysics, 1994, Volume: 14, Issue:3 Topics: Breast Neoplasms; Cell Division; Cell Line; Culture Media, Serum-Free; Epidermal Growth Factor; ErbB Receptors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin-Like Growth Factor I; Kinetics; Lovastatin; Mevalonic Acid; Signal Transduction; Transcription, Genetic; Transforming Growth Factor alpha; Tumor Cells, Cultured	1994
Cell cycle-specific growth inhibition of human breast cancer cells induced by metabolic inhibitors. Glycobiology, 1993, Volume: 3, Issue:5 Topics: Antimetabolites; Breast Neoplasms; Cell Cycle; Cell Division; DNA, Neoplasm; Female; Glycosylation; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Mevalonic Acid; Neoplasm Proteins; Tumor Cells, Cultured; Tunicamycin	1993
Isoprenoid regulation of cell growth: identification of mevalonate-labelled compounds inducing DNA synthesis in human breast cancer cells depleted of serum and mevalonate. Journal of cellular physiology, 1993, Volume: 155, Issue:3 Topics: Blood; Breast Neoplasms; Cell Division; Chromatography, High Pressure Liquid; Culture Media; DNA; Dolichols; Glycosylation; Humans; Lovastatin; Mevalonic Acid; Tumor Cells, Cultured; Tunicamycin	1993
Tumor radiosensitization based on the use of inhibitors of the mevalonate pathway of cholesterol synthesis. Advances in experimental medicine and biology, 1997, Volume: 400B Topics: Adenocarcinoma; Brain Neoplasms; Breast Neoplasms; Cell Survival; Cholesterol; Cobalt Radioisotopes; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cyclohexenes; Dose-Response Relationship, Radiation; Female; Fibrosarcoma; Gamma Rays; Genes, ras; Glioblastoma; Humans; Limonene; Lung Neoplasms; Male; Mevalonic Acid; Prostatic Neoplasms; Radiation-Sensitizing Agents; Terpenes; Tumor Cells, Cultured	1997
The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel. British journal of cancer, 2001, Apr-20, Volume: 84, Issue:8 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Count; Diphosphonates; Dose-Response Relationship, Drug; Drug Synergism; Humans; Imidazoles; Mevalonic Acid; Paclitaxel; Time Factors; Tumor Cells, Cultured; Zoledronic Acid	2001
Inhibition of human breast cancer cell growth by blockade of the mevalonate-protein prenylation pathway is not prevented by overexpression of cyclin D1. Breast cancer research and treatment, 2001, Volume: 67, Issue:1 Topics: Animals; Breast Neoplasms; Cell Cycle; Cell Division; Cyclin D1; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neoplasm Proteins; Protein Prenylation; Rats; Simvastatin	2001
Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue. Breast cancer research and treatment, 2002, Volume: 71, Issue:3 Topics: Bone and Bones; Breast Neoplasms; Cell Differentiation; Diphosphonates; Dose-Response Relationship, Drug; Etidronic Acid; Female; Humans; Imidazoles; Lovastatin; Mevalonic Acid; Osteoblasts; Pregnancy; Structure-Activity Relationship; Tumor Cells, Cultured; Zoledronic Acid	2002