mevalonic acid has been researched along with Apolipoprotein B-100, Familial Defective in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (24.14) | 18.7374 |
| 1990's | 15 (51.72) | 18.2507 |
| 2000's | 7 (24.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Illingworth, DR; Pappu, AS | 2 |
| Knight, BL; Naoumova, RP; O'Neill, FH; Patel, DD; Thompson, GR | 1 |
| Jones, PJ | 1 |
| Bacon, SP; Illingworth, DR; Pappu, AS | 1 |
| Cuthbert, JA; Lipsky, PE | 2 |
| Avigan, J; Mitchell, ED | 1 |
| Miettinen, TA | 1 |
| Jakober, B; Klass, C; Knisel, W; Naoumova, RP; Pfohl, M; Risler, T; Thompson, GR | 1 |
| Naoumova, RP; Thompson, GR; Watts, GF | 1 |
| Colette, C; Crastes De Paulet, A; Descomps, B; Farnier, M; Feillet, C; Monnier, LH; Percheron, C | 1 |
| Firth, JC; Marais, AD; Mountney, J; Naoumova, RP; Rendell, NB; Taylor, GW; Thompson, GR | 1 |
| Kameda-Takemura, K; Keno, Y; Matsuzawa, Y; Nakagawa, T; Nakamura, T; Nakata, A; Nozaki, S; Tokunaga, K; Yamashita, S | 1 |
| Abu-Muhana, O; Dunn, S; Naoumova, RP; Neuwirth, C; Rallidis, L; Rendell, NB; Taylor, GW; Thompson, GR | 1 |
| Firth, JC; Marais, AD; Naoumova, RP; Neuwirth, CK; Penny, C; Thompson, GR | 1 |
| Kim, KD; Naoumova, RP; Neuwirth, C; Niththyananthan, S; Rendell, NB; Taylor, GW; Thompson, GR | 1 |
| Axelson, M; Dunn, S; Naoumova, RP; Neuwirth, CK; O'Neill, FH; Taylor, GW; Thompson, GR | 1 |
| Black, DM; Firth, JC; Heinonen, TM; Illingworth, DR; Kotze, MJ; Marais, AD; Pappu, AS; Pilcher, GJ; Raal, FJ | 1 |
| Endo, M; Harada-Shiba, M; Hori, H; Imai, T; Ito, T; Kato, H; Kawaguchi, A; Kubo, H; Mikami, Y; Oi, K; Sakai, S; Sato, I; Suzuki, Y; Yamamoto, A | 1 |
| Bourbon, M; Knight, BL; Naoumova, RP; Neuwirth, CK; O'Neill, FH; Patel, DD; Soutar, AK; Taylor, GW; Thompson, GR | 1 |
| Nilsson, J | 1 |
| Aloe, N; Augeri, C; Avola, F; Carta, G; Cavagnaro, A; De Grandi, R; Del Nero, E; Gianfreda, M; Magro, GP; Mazzarello, GP | 1 |
| Harada-Shiba, M; Kawakami, M; Kojima, S; Miyake, Y; Tajima, S; Tsushima, M; Yamamoto, A; Yokoyama, S | 1 |
| Illingworth, DR; Pappu, AS; Prihoda, JS; Smith, FE | 1 |
| Angelin, B; Berglund, L; Dallner, G; Elmberger, PG; Eriksson, M; Kalén, A; Lund, E; Reihnér, E | 1 |
| Hagemenas, FC; Illingworth, DR; Pappu, AS | 1 |
| Bacon, S; Illingworth, DR; Pappu, AS | 1 |
| Avigan, J; Beg, ZH; Reznikov, DC | 1 |
2 review(s) available for mevalonic acid and Apolipoprotein B-100, Familial Defective
| Article | Year |
|---|---|
Statin rebound effect?
Topics: Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Mevalonic Acid; Recurrence; Up-Regulation | 2003 |
Role of cholesterol in regulating apolipoprotein B secretion by the liver.
Topics: Acyl Coenzyme A; Animals; Apolipoproteins B; Bile; Cholesterol; Cholesterol Esters; Humans; Hyperlipoproteinemia Type II; Lipid Metabolism; Lipoproteins; Lipoproteins, VLDL; Liver; Mevalonic Acid | 1996 |
10 trial(s) available for mevalonic acid and Apolipoprotein B-100, Familial Defective
| Article | Year |
|---|---|
Treatment with atorvastatin alters the ratio of interleukin-12/interleukin-10 gene expression [corrected].
Topics: Adult; Anticholesteremic Agents; Atorvastatin; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Heptanoic Acids; Humans; Hyperlipoproteinemia Type II; Interleukin-10; Interleukin-12; Interleukin-12 Subunit p35; Leukocytes, Mononuclear; Lipids; Male; Mevalonic Acid; Middle Aged; Protein Subunits; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Single-Blind Method | 2003 |
Acute and chronic effects on cholesterol biosynthesis of LDL-apheresis with or without concomitant HMG-CoA reductase inhibitor therapy.
Topics: Adult; Blood Component Removal; Cholesterol; Cholesterol, LDL; Cholesterol, VLDL; Coronary Disease; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Male; Mevalonic Acid; Middle Aged | 1994 |
Comparative effects of simvastatin and pravastatin on cholesterol synthesis in patients with primary hypercholesterolemia.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Liver; Lovastatin; Male; Mevalonic Acid; Middle Aged; Pravastatin; Simvastatin; Treatment Outcome; Triglycerides | 1995 |
Effects of pravastatin on plasma and urinary mevalonate concentrations in subjects with familial hypercholesterolaemia: a comparison of morning and evening administration.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Hyperlipoproteinemia Type II; Male; Mevalonic Acid; Middle Aged; Pravastatin | 1996 |
Prolonged inhibition of cholesterol synthesis explains the efficacy of atorvastatin.
Topics: Anticholesteremic Agents; Atorvastatin; Cholesterol; Cholesterol, LDL; Creatinine; Enzyme Inhibitors; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Male; Mevalonic Acid; Middle Aged; Pyrroles | 1997 |
Decreased production of low density lipoprotein by atorvastatin after apheresis in homozygous familial hypercholesterolemia.
Topics: Adolescent; Adult; Anticholesteremic Agents; Apolipoproteins B; Atorvastatin; Blood Component Removal; Cholesterol, LDL; Combined Modality Therapy; Enzyme Inhibitors; Female; Heptanoic Acids; Homozygote; Humans; Hyperlipoproteinemia Type II; Kinetics; Lipids; Lipoproteins, LDL; Male; Mevalonic Acid; Pyrroles | 1997 |
Effect of inhibiting HMG-CoA reductase on 7 alpha-hydroxy-4-cholesten-3-one, a marker of bile acid synthesis: contrasting findings in patients with and without prior up-regulation of the latter pathway.
Topics: Anticholesteremic Agents; Atorvastatin; Bile Acids and Salts; Biomarkers; Cholestenones; Female; Heptanoic Acids; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Jejunoileal Bypass; Lipids; Lipoproteins; Male; Mevalonic Acid; Middle Aged; Pyrroles; Up-Regulation | 1999 |
Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia.
Topics: Adolescent; Adult; Anticholesteremic Agents; Atorvastatin; Biomarkers; Child; Child, Preschool; Cholesterol; Cholesterol, LDL; DNA; DNA Mutational Analysis; Female; Heptanoic Acids; Homozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Male; Mevalonic Acid; Mutation; Polymorphism, Single-Stranded Conformational; Prognosis; Pyrroles; Receptors, LDL | 2000 |
Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia.
Topics: Anticholesteremic Agents; Atorvastatin; Cholestenones; Cholesterol, LDL; Cholestyramine Resin; Colestipol; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hyperlipoproteinemia Type II; Male; Mevalonic Acid; Middle Aged; Mutation; Pyrroles; Receptors, LDL; RNA, Messenger | 2001 |
The effects of simvastatin on plasma lipoproteins and cholesterol homeostasis in patients with heterozygous familial hypercholesterolaemia.
Topics: Adult; Anticholesteremic Agents; Cholesterol; Clinical Trials as Topic; Heterozygote; Homeostasis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; In Vitro Techniques; Leukocytes, Mononuclear; Lipoproteins; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Receptors, LDL; Simvastatin | 1990 |
17 other study(ies) available for mevalonic acid and Apolipoprotein B-100, Familial Defective
| Article | Year |
|---|---|
The effects of lovastatin and simvastatin on the diurnal periodicity of plasma mevalonate concentrations in patients with heterozygous familial hypercholesterolemia.
Topics: Adult; Analysis of Variance; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Circadian Rhythm; Female; Heterozygote; Humans; Hyperlipoproteinemia Type II; Lovastatin; Mevalonic Acid; Middle Aged; Periodicity; Probability; Prospective Studies; Sampling Studies; Simvastatin; Urinalysis | 2002 |
Residual effects of lovastatin and simvastatin on urinary mevalonate excretions in patients with familial hypercholesterolemia.
Topics: Adult; Anticholesteremic Agents; Cholesterol, LDL; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Lovastatin; Male; Mevalonic Acid; Middle Aged; Simvastatin | 2003 |
Modulation of human lymphocyte responses by low density lipoproteins (LDL): enhancement but not immunosuppression is mediated by LDL receptors.
Topics: Child; DNA Replication; Female; Humans; Hyperlipoproteinemia Type II; Immunosuppression Therapy; Lipoproteins, LDL; Lovastatin; Lymphocyte Activation; Lymphocytes; Mevalonic Acid; Naphthalenes; Phytohemagglutinins; Receptors, Cell Surface; Receptors, LDL | 1984 |
Control of phosphorylation and decarboxylation of mevalonic acid and its metabolites in cultured human fibroblasts and in rat liver in vivo.
Topics: Animals; Carboxy-Lyases; Cells, Cultured; Culture Media; Decarboxylation; Fibroblasts; Humans; Hydroxymethylglutaryl CoA Reductases; Hyperlipoproteinemia Type II; Lipids; Liver; Male; Mevalonic Acid; Phosphorylation; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Rats | 1981 |
Effects of neomycin alone and in combination with cholestyramine on serum methyl sterols and conversion of acetate and mevalonate to cholesterol.
Topics: Acetates; Cholesterol; Cholestyramine Resin; Feces; Humans; Hyperlipoproteinemia Type II; Mevalonic Acid; Neomycin; Steroids; Sterols | 1982 |
Plasma mevalonic acid, an index of cholesterol synthesis in vivo, and responsiveness to HMG-CoA reductase inhibitors in familial hypercholesterolaemia.
Topics: Adult; Aged; Anticholesteremic Agents; Atorvastatin; Cholesterol; Coronary Disease; Enzyme Inhibitors; Female; Heptanoic Acids; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Lipids; Lipoproteins, LDL; Lovastatin; Male; Mevalonic Acid; Middle Aged; Pravastatin; Pyrroles; Simvastatin | 1996 |
Cholesterol synthesis is increased in mixed hyperlipidaemia.
Topics: Adult; Apolipoproteins E; Cholesterol; Cholesterol, LDL; Fasting; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hyperlipidemias; Hyperlipoproteinemia Type II; Male; Mevalonic Acid; Phenotype; Triglycerides | 1998 |
The effect of atorvastatin on serum lipids and lipoproteins in patients with homozyous familial hypercholesterolemia undergoing LDL-apheresis therapy.
Topics: Adolescent; Adult; Anticholesteremic Agents; Apolipoproteins; Atorvastatin; Blood Component Removal; Female; Heptanoic Acids; Homozygote; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoprotein(a); Lipoproteins; Lipoproteins, LDL; Lymphocytes; Male; Mevalonic Acid; Middle Aged; Pyrroles; Receptors, LDL | 2000 |
Nobel seminar: Molecular medicine--cell biology in disease. The mevalonate pathway--a link between cellular cholesterol homeostasis and growth regulation.
Topics: Cell Division; Humans; Hyperlipoproteinemia Type II; Mevalonic Acid; Receptors, LDL | 1992 |
[The clinical evaluation of the hypocholesterolemic effects of an inhibitor of cholesterol synthesis: mevalonic acid].
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Drug Evaluation; Female; Humans; Hyperlipoproteinemia Type II; Male; Mevalonic Acid; Middle Aged; Triglycerides | 1992 |
Siblings with normal LDL receptor activity and severe hypercholesterolemia.
Topics: Adolescent; Adult; Child; Cholesterol; Female; Humans; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Male; Mevalonic Acid; Middle Aged; Plasmapheresis; Receptors, LDL | 1992 |
The influence of simvastatin on adrenal corticosteroid production and urinary mevalonate during adrenocorticotropin stimulation in patients with heterozygous familial hypercholesterolemia.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Anticholesteremic Agents; Heterozygote; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Lovastatin; Mevalonic Acid; Middle Aged; Simvastatin | 1991 |
Effects of pravastatin and cholestyramine on products of the mevalonate pathway in familial hypercholesterolemia.
Topics: Adult; Aged; Cholesterol; Cholestyramine Resin; Dolichols; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Male; Mevalonic Acid; Middle Aged; Pravastatin; Ubiquinone | 1991 |
Reduction in plasma low-density lipoprotein cholesterol and urinary mevalonic acid by lovastatin in patients with heterozygous familial hypercholesterolemia.
Topics: Adult; Aged; Cholesterol, LDL; Dose-Response Relationship, Drug; Female; Humans; Hyperlipoproteinemia Type II; Kinetics; Lovastatin; Male; Mevalonic Acid; Middle Aged | 1989 |
Contrasting effects of lovastatin and cholestyramine on low-density lipoprotein cholesterol and 24-hour urinary mevalonate excretion in patients with heterozygous familial hypercholesterolemia.
Topics: Adult; Cholesterol, LDL; Cholestyramine Resin; Drug Therapy, Combination; Female; Heterozygote; Humans; Hyperlipoproteinemia Type II; Lovastatin; Male; Mevalonic Acid | 1989 |
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by reversible phosphorylation: modulation of enzymatic activity by low density lipoprotein, sterols, and mevalonolactone.
Topics: Acetates; AMP-Activated Protein Kinases; Cells, Cultured; Fibroblasts; Fluorides; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Ketocholesterols; Lipid Metabolism; Lipoproteins, LDL; Mevalonic Acid; Multienzyme Complexes; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Complex; Sterols; Water | 1986 |
Assessment of functional low-density lipoprotein receptor activity on lymphocytes of normal subjects and patients with familial hypercholesterolemia.
Topics: Cell Division; Cholesterol, LDL; Heterozygote; Homozygote; Humans; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Lovastatin; Lymphocytes; Mevalonic Acid; Receptors, LDL | 1988 |