mevalonic acid and Aging

mevalonic acid has been researched along with Aging in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199021 (55.26)18.7374
1990's5 (13.16)18.2507
2000's8 (21.05)29.6817
2010's4 (10.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bardenheier, A; Bening-Abu-Shach, U; Boxem, M; Broday, L; Ching, K; Chou, TF; Koorman, T; Mishra, P; Podolsky, L; Sapir, A; Sternberg, PW; Tsur, A1
Eckert, GP; Hooff, GP; Müller, WE; Wood, WG1
Bentinger, M; Dallner, G; Tekle, M1
Du, CQ; Han, J; Hu, SJ; Jiang, DM1
Bergamini, E; Cavallini, G; Marino, M; Pallottini, V; Trentalance, A1
Dallner, G; Olsson, J; Turunen, M1
Haratake, A; Horikoshi, T; Komiya, A; Uchiwa, H; Watanabe, S1
Aguilera, JA; Arce, V; Garcia-Peregrin, E; Linares, A; Marco, C1
Paul, I; Rosenfeld, RS; Spaet, TH1
Kritchevsky, D; Malhotra, S; Scott, DA1
Edlund, C; Kristensson, K; Söderberg, M1
Allen, CM; Dugan, JM1
Aberg, F; Andersson, M; Appelkvist, EL; Edlund, C; Teclebrhan, H1
Haratake, A; Hirano, S; Ikenaga, K; Katoh, N; Uchiwa, H; Yasuno, H1
Dallner, G; Sindelar, PJ1
Papapoulos, SE1
Bergamini, E; Cavallini, G; D'Eramo, C; Marino, M; Pallottini, V; Trentalance, A1
Chojnacki, T; Dallner, G; Sindelar, P; Swiezewska, E; Turunen, M1
Garcia-Martinez, J; Garcia-Peregrin, E; Segovia, JL; Suarez, MD1
Ramachandran, CK; Shah, SN2
Koga, M; Takeuchi, N; Tanaka, F; Uchida, K; Yamaguchi, Y; Yamamura, Y1
Howton, MM; Siperstein, MD; Wiley, MH1
Nakamura, H1
Dallner, G; Edlund, C; Kristensson, K; Söderberg, M1
Bolaños, JP; Medina, JM; Williamson, DH1
Aguilera, JA; Arce, V; Garcia-Molina, V; Garcia-Peregrin, E; Linares, A; Rodriguez-Vico, F1
Hahn, P1
Choi, YS; Ide, T; Sugano, M; Tomari, Y1
Conti Devirgiliis, L; Leoni, S; Mangiantini, MT; Spagnuolo, S; Trentalance, A; Valbonesi, M1
Johnson, RC; Shah, SN1
Kabara, JJ1
Aexel, RT; Jones, JP; Nicholas, HJ; Ramsey, RB1
McNamara, DJ1
Chevallier, F; Sérougne-Gautheron, C1
Kandutsch, AA; Saucier, SE1
Jones, JP; Naqvi, SH; Nicholas, HJ; Ramsey, RB2

Reviews

7 review(s) available for mevalonic acid and Aging

ArticleYear
Isoprenoids, small GTPases and Alzheimer's disease.
    Biochimica et biophysica acta, 2010, Volume: 1801, Issue:8

    Topics: Aging; Alzheimer Disease; Animals; Cholesterol; Humans; Metabolic Networks and Pathways; Mevalonic Acid; Models, Biological; Monomeric GTP-Binding Proteins; Nerve Degeneration; Protein Prenylation; Terpenes

2010
Coenzyme Q--biosynthesis and functions.
    Biochemical and biophysical research communications, 2010, May-21, Volume: 396, Issue:1

    Topics: Aging; Humans; Mevalonic Acid; Mitochondria; Mitochondrial Diseases; Ubiquinone

2010
Metabolism and function of coenzyme Q.
    Biochimica et biophysica acta, 2004, Jan-28, Volume: 1660, Issue:1-2

    Topics: Aging; Animals; Biological Transport; Diet; Escherichia coli; Half-Life; Humans; Mevalonic Acid; Models, Animal; Oxidation-Reduction; Terpenes; Tissue Distribution; Ubiquinone

2004
Regulation of ubiquinone metabolism.
    Free radical biology & medicine, 2000, Volume: 29, Issue:3-4

    Topics: Aging; Animals; Antioxidants; Diet; Dolichols; Half-Life; Humans; Lipid Metabolism; Liver; Liver Neoplasms; Mevalonic Acid; Oxidative Stress; Ubiquinone

2000
Catabolic and anabolic signals in bone: therapeutic implications.
    Current opinion in clinical nutrition and metabolic care, 2001, Volume: 4, Issue:3

    Topics: Aging; Bone and Bones; Bone Diseases, Metabolic; Bone Remodeling; Bone Resorption; Diphosphonates; Humans; Mevalonic Acid; Signal Transduction; Tumor Necrosis Factor-alpha

2001
Regulatory aspects of coenzyme Q metabolism.
    Free radical research, 2002, Volume: 36, Issue:4

    Topics: Aging; Eukaryotic Cells; Humans; Mevalonic Acid; Peroxisomes; Ubiquinone

2002
A critical review of brain cholesterol metabolism.
    Progress in brain research, 1973, Volume: 40, Issue:0

    Topics: Age Factors; Aging; Animals; Brain; Carbon Radioisotopes; Cholesterol; DNA; Dogs; Humans; In Vitro Techniques; Mevalonic Acid; Mice; Microsomes; Neurochemistry; Neuroglia; Neurons; Rabbits; Rats; Water

1973

Other Studies

31 other study(ies) available for mevalonic acid and Aging

ArticleYear
Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Sep-16, Volume: 111, Issue:37

    Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cytosol; Humans; Hydroxymethylglutaryl-CoA Synthase; Lysine; Metabolic Networks and Pathways; Mevalonic Acid; Mitochondria; Models, Biological; Mutation; Phenotype; Proteasome Endopeptidase Complex; Protein Binding; Protein Interaction Maps; Protein Transport; Sumoylation; Ubiquitin

2014
Alteration of enzyme expressions in mevalonate pathway: possible role for cardiovascular remodeling in spontaneously hypertensive rats.
    Circulation journal : official journal of the Japanese Circulation Society, 2011, Volume: 75, Issue:6

    Topics: Age Factors; Aging; Alkyl and Aryl Transferases; Analysis of Variance; Animals; Aorta, Thoracic; Blood Pressure; Blotting, Western; Cholesterol, HDL; Cholesterol, LDL; Disease Models, Animal; Farnesyl-Diphosphate Farnesyltransferase; Farnesyltranstransferase; Geranyltranstransferase; Hydroxymethylglutaryl CoA Reductases; Hypertension; Liver; Male; Mevalonic Acid; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Ventricular Remodeling

2011
Age-related changes of isoprenoid biosynthesis in rat liver and brain.
    Biogerontology, 2003, Volume: 4, Issue:6

    Topics: Aging; Animals; Brain; Caloric Restriction; Cholesterol; Dolichols; Eating; Hydroxymethylglutaryl CoA Reductases; Liver; Male; Mevalonic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Terpenes

2003
Acceleration of de novo cholesterol synthesis in the epidermis influences desquamation of the stratum corneum in aged mice.
    Skin pharmacology and physiology, 2006, Volume: 19, Issue:5

    Topics: Aging; Animals; Cholesterol; DNA; Epidermis; Hydrogen-Ion Concentration; Mevalonic Acid; Mice; Mice, Hairless

2006
Postnatal development of the sterol and nonsterol mevalonate metabolism in chick liver and kidneys. Effect of cholesterol feeding.
    Annals of nutrition & metabolism, 1984, Volume: 28, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Chickens; Cholesterol; Cholesterol Esters; Cholesterol, Dietary; Diet; Kidney; Liver; Male; Mevalonic Acid; Sterols

1984
Long-term effects of deendothelialization of rabbit aorta: in vitro synthesis of DNA, protein, and lipid.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1983, Volume: 173, Issue:3

    Topics: Acetates; Aging; Animals; Aorta; Catheterization; Cholesterol; DNA; Endothelium; Leucine; Lipids; Male; Mevalonic Acid; Protein Biosynthesis; Rabbits; Thymidine

1983
Cholesterol synthesis in tissues of young and old Fisher 344 and Sprague-Dawley rats.
    Experimental gerontology, 1980, Volume: 15, Issue:5

    Topics: Acetates; Aging; Animals; Cholesterol; Colon; Kidney; Liver; Male; Mevalonic Acid; Rats; Rats, Inbred F344; Rats, Inbred Strains; Spleen

1980
Isoprenoids in aging and neurodegeneration.
    Neurochemistry international, 1994, Volume: 25, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Animals; Brain Chemistry; Cells, Cultured; Cholesterol; Dolichol Phosphates; Dolichols; Humans; Lipid Metabolism; Mevalonic Acid; Middle Aged; Nerve Degeneration; Polyisoprenyl Phosphates; Rats; Ubiquinone

1994
Changes in protein prenylation and prenyltransferase activity in the rat seminiferous epithelium during early stages of spermatogenesis.
    Biology of reproduction, 1995, Volume: 53, Issue:4

    Topics: Aging; Alkyl and Aryl Transferases; Amino Acid Sequence; Animals; Dimethylallyltranstransferase; Male; Meiosis; Mevalonic Acid; Molecular Sequence Data; Protein Prenylation; Rats; Seminiferous Epithelium; Sexual Maturation; Spermatogenesis; Spermatozoa; Substrate Specificity; Testis; Transferases

1995
Age-dependent modifications in the metabolism of mevalonate pathway lipids in rat brain.
    Mechanisms of ageing and development, 1995, Nov-03, Volume: 85, Issue:1

    Topics: Aging; Alkyl and Aryl Transferases; Animals; Animals, Newborn; Brain; Cholesterol; Dolichol Phosphates; Dolichols; Farnesyl-Diphosphate Farnesyltransferase; In Vitro Techniques; Lipid Metabolism; Male; Mevalonic Acid; Phospholipids; Rats; Rats, Sprague-Dawley; Transferases

1995
Topical mevalonic acid stimulates de novo cholesterol synthesis and epidermal permeability barrier homeostasis in aged mice.
    The Journal of investigative dermatology, 2000, Volume: 114, Issue:2

    Topics: Administration, Topical; Aging; Animals; Cell Membrane Permeability; Cholesterol; Fatty Acids, Nonesterified; Homeostasis; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Mice; Mice, Hairless; Skin

2000
Age-related changes of cholesterol and dolichol biosynthesis in rat liver.
    Mechanisms of ageing and development, 2002, Apr-30, Volume: 123, Issue:8

    Topics: Aging; Animals; Cholesterol; Dolichols; Hydroxymethylglutaryl CoA Reductases; Liver; Male; Mevalonic Acid; Rats; Rats, Sprague-Dawley

2002
Mevalonate phosphorylation in the neonatal chick liver.
    Biochemical and biophysical research communications, 1976, Sep-07, Volume: 72, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Chickens; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Mevalonic Acid; Phosphotransferases; Subcellular Fractions

1976
Decarboxylation of mevalonate pyrophosphate is one rate-limiting step in hepatic cholesterol synthesis in suckling and weaned rats.
    Biochemical and biophysical research communications, 1976, Mar-08, Volume: 69, Issue:1

    Topics: Aging; Animals; Cholesterol; Cholesterol, Dietary; Female; Kinetics; Lactation; Liver; Mevalonic Acid; Organophosphorus Compounds; Phosphotransferases; Pregnancy; Rats

1976
Studies on mevalonate kinase, phosphomevalonate kinase and pyrophosphomevalonate decarboxylase in developing rat brain.
    Journal of neurochemistry, 1977, Volume: 28, Issue:4

    Topics: Aging; Animals; Brain; Carboxy-Lyases; Kinetics; Mevalonic Acid; Phosphotransferases; Rats

1977
Impairment of hepatic cholesterol synthesis from squalene and the function of hepatic sterol carrier protein system by ageing.
    Experimental gerontology, 1978, Volume: 13, Issue:1-2

    Topics: Aging; Animals; Carrier Proteins; Cholesterol; Cytosol; In Vitro Techniques; Liver; Male; Mevalonic Acid; Microsomes, Liver; Rats; Squalene; Sterols

1978
The quantitative role of the kidneys in the in vivo metabolism of mevalonate.
    The Journal of biological chemistry, 1977, Jan-25, Volume: 252, Issue:2

    Topics: Aging; Animals; Brain; Cholesterol; Intestinal Mucosa; Kidney; Kinetics; Liver; Lung; Male; Mevalonic Acid; Muscles; Nephrectomy; Organ Specificity; Rats; Skin; Spleen; Testis

1977
[Effect of vitamin E on the alteration of the cholesterol metabolism with the aging of mice (author's transl)].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1976, Volume: 51, Issue:4

    Topics: Acetates; Aging; Animals; Cholesterol; Fatty Acids; Feces; Kidney; Lipid Metabolism; Liver; Male; Mevalonic Acid; Mice; Proteins; Vitamin E

1976
Ubiquinone, dolichol, and cholesterol metabolism in aging and Alzheimer's disease.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 1992, Volume: 70, Issue:6

    Topics: Aged; Aging; Alzheimer Disease; Brain Chemistry; Cholesterol; Dolichol Phosphates; Dolichols; Fatty Acids; Humans; Membrane Lipids; Mevalonic Acid; Middle Aged; Phosphatidylinositols; Phospholipids; Ubiquinone

1992
Inhibition of sterol but not fatty acid synthesis by valproate in developing rat brain in vivo.
    The Biochemical journal, 1990, Nov-15, Volume: 272, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Brain; Fatty Acids; Kinetics; Mevalonic Acid; Rats; Rats, Inbred Strains; Reference Values; Sterols; Tritium; Valproic Acid

1990
Age-related changes in the mevalonate metabolism in vivo in chick kidneys.
    Archives internationales de physiologie et de biochimie, 1988, Volume: 96, Issue:2

    Topics: Aging; Animals; Chickens; Cholesterol; Kidney; Lanosterol; Lipids; Male; Mevalonic Acid; Squalene

1988
2-14C-mevalonate oxidation during rat development.
    Biology of the neonate, 1986, Volume: 49, Issue:3

    Topics: Aging; Animals; Animals, Suckling; Carbon Dioxide; Carbon Radioisotopes; Female; Kidney; Male; Mevalonic Acid; Oxidation-Reduction; Rats; Rats, Inbred Strains; Sex Factors; Weaning

1986
Effects of short-term cholestyramine feeding on cholesterol metabolism in differently aged rats.
    Mechanisms of ageing and development, 1987, Volume: 41, Issue:1-2

    Topics: Aging; Animals; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Cholesterol Esters; Cholestyramine Resin; Hydroxymethylglutaryl CoA Reductases; Kinetics; Liver; Male; Mevalonic Acid; Rats; Rats, Inbred Strains; Sterol O-Acyltransferase; Triglycerides

1987
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevalonate and cholesterol in isolated rat hepatocytes during perinatal development.
    Cellular and molecular biology, 1986, Volume: 32, Issue:3

    Topics: Aging; Animals; Cholesterol; Female; Hydroxymethylglutaryl CoA Reductases; Liver; Mevalonic Acid; Microsomes, Liver; Pregnancy; Rats

1986
Metabolism of intracerebrally injected mevalonate in brain of suckling and young adult rats.
    Neurochemical research, 1985, Volume: 10, Issue:5

    Topics: Aging; Animal Population Groups; Animals; Animals, Suckling; Brain; Chemical Precipitation; Digitonin; Fatty Acids; Kinetics; Lipid Metabolism; Mevalonic Acid; Rats; Squalene; Sterols; Terpenes

1985
Lipid biosynthesis in neuron-enriched and glial-enriched fractions of rat brain: ganglioside biosynthesis.
    Life sciences. Pt. 1: Physiology and pharmacology, 1972, Mar-15, Volume: 11, Issue:6

    Topics: Acetates; Aging; Animals; Brain; Carbon Isotopes; Gangliosides; Glycolipids; Lipids; Mevalonic Acid; Neuraminic Acids; Neuroglia; Neurons; Phospholipids; Rats; Serine

1972
Design and application of a special feeder for studying enzymes of the late suckling period.
    Analytical biochemistry, 1973, Volume: 51, Issue:2

    Topics: Aging; Alcohol Oxidoreductases; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Equipment and Supplies; Female; Liver; Mevalonic Acid; Microsomes, Liver; Rats; Weaning

1973
Time course of biosynthetic cholesterol in the adult rat brain.
    Biochimica et biophysica acta, 1973, Aug-23, Volume: 316, Issue:2

    Topics: Aging; Animals; Brain; Carbon Radioisotopes; Centrifugation, Density Gradient; Cerebellum; Cholesterol; Chromatography, Gas; Male; Mevalonic Acid; Myelin Sheath; Organ Size; Rats; Time Factors

1973
Sterol and fatty acid synthesis in developing brains of three myelin-deficient mouse mutants.
    Biochimica et biophysica acta, 1972, Jan-27, Volume: 260, Issue:1

    Topics: Acetates; Aging; Alcohol Oxidoreductases; Animals; Brain; Carbon Dioxide; Carbon Isotopes; Central Nervous System Diseases; Cholesterol; Fasting; Fatty Acids; Male; Mevalonic Acid; Mice; Mutation; Myelin Sheath; Neuromuscular Diseases; Sterols

1972
The biosynthesis of cholesterol and other sterols by brain tissue. II. A comparison of in vitro and in vivo methods.
    Lipids, 1971, Volume: 6, Issue:4

    Topics: Acetates; Aging; Animals; Animals, Newborn; Brain; Carbon Isotopes; Cell-Free System; Chemical Precipitation; Cholesterol; Chromatography; Chromatography, Thin Layer; Esters; Female; Injections; Injections, Intraperitoneal; Liver; Male; Mevalonic Acid; Microsomes; Radionuclide Imaging; Rats; Saponins; Sodium; Squalene; Sterols

1971
The biosynthesis of cholesterol and other sterols by brain tissue. I. Subcellular biosynthesis in vitro.
    Lipids, 1971, Volume: 6, Issue:3

    Topics: Acetates; Adenosine Triphosphate; Aging; Animals; Brain; Carbon Isotopes; Cholestanes; Cholesterol; Chromatography; Chromatography, Thin Layer; Digitalis Glycosides; Female; Glucose; Liver; Magnesium; Male; Mevalonic Acid; Microsomes; Microsomes, Liver; Mitochondria; Rats; Squalene; Sterols; Swine; Vitamin D

1971