metyrapone has been researched along with Stomach Ulcer in 11 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The results revealed that 100 mg/kg nimesulide produces gastric ulceration in adrenalectomized rats, which is prevented by prednisolone and adrenaline." | 3.74 | Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats. ( Cadirci, E; Gocer, F; Hacimuftuoglu, A; Halici, Z; Keles, S; Suleyman, H, 2007) |
| "Metyrapone pretreatment allowed us to prevent the acute corticosterone response to CRF and avoid the lasting effects of glucocorticoid deficiency." | 1.40 | [Metyrapone effect on gastroprotective action of corticotropin-releasing factor administered centrally against indomethacin-induced gastric injury]. ( Bagaeva, TR; Filaretova, LP; Miazina, MA, 2014) |
| "Metyrapone pretreatment shortly inhibited corticosterone rise, caused by ischemic preconditioning, and prevented the gastroprotective action of ischemic preconditioning." | 1.35 | Ischemic preconditioning attenuates gastric ischemia-reperfusion injury through involvement of glucocorticoids. ( Bagaeva, T; Bobryshev, P; Filaretova, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Filaretova, LP | 4 |
| Bagaeva, TR | 3 |
| Morozova, OIu | 1 |
| Miazina, MA | 1 |
| Amagase, K | 1 |
| Takeuchi, K | 1 |
| Bobryshev, P | 1 |
| Bagaeva, T | 1 |
| Filaretova, L | 1 |
| Bagaeva, TP | 1 |
| Bobryshev, PIu | 1 |
| Komkova, OP | 1 |
| Suleyman, H | 1 |
| Halici, Z | 1 |
| Cadirci, E | 1 |
| Hacimuftuoglu, A | 1 |
| Keles, S | 1 |
| Gocer, F | 1 |
| Stamford, W | 1 |
| Smoke, R | 1 |
| Rettura, G | 1 |
| Levenson, SM | 1 |
| Seifter, E | 1 |
| Murison, R | 1 |
| Overmier, JB | 1 |
| Hellhammer, DH | 1 |
| Carmona, M | 1 |
| Hirano, T | 1 |
| Kohút, A | 1 |
| Nicák, A | 1 |
| Van Nostrand, DM | 1 |
| Nicoloff, DM | 1 |
11 other studies available for metyrapone and Stomach Ulcer
| Article | Year |
|---|---|
[Gastroprotective action of corticotropin-releasing factor (CRF): involvement of glucocorticoids and CRF receptors type 2].
Topics: Animals; Antimetabolites; Cold Temperature; Corticosterone; Corticotropin-Releasing Hormone; Gastric | 2012 |
[Metyrapone effect on gastroprotective action of corticotropin-releasing factor administered centrally against indomethacin-induced gastric injury].
Topics: Animals; Corticosterone; Corticotropin-Releasing Hormone; Gastric Mucosa; Glucocorticoids; Indometha | 2014 |
Contribution of glucocorticoids to protective influence of preconditioning mild stress against stress-induced gastric erosions.
Topics: Adrenalectomy; Animals; Conditioning, Psychological; Corticosterone; Cyclooxygenase Inhibitors; Gluc | 2008 |
Ischemic preconditioning attenuates gastric ischemia-reperfusion injury through involvement of glucocorticoids.
Topics: Adrenalectomy; Animals; Celiac Artery; Corticosterone; Enzyme Inhibitors; Gastric Mucosa; Hormone An | 2009 |
[Role of glucocorticoids and capsaicin-sensitive neurons in gastroprotective effect of ischemic preconditioning].
Topics: Adrenalectomy; Animals; Capsaicin; Corticosterone; Ischemic Preconditioning; Male; Metyrapone; Neuro | 2012 |
Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats.
Topics: Adrenalectomy; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; alpha- | 2007 |
Stress ulcer prevention by metyrapone.
Topics: Acute Disease; Animals; Gastritis; Male; Metyrapone; Rats; Stomach Ulcer; Stress, Physiological; Vit | 1975 |
Hypothalamo-pituitary-adrenal manipulations and stress ulcerations in rats.
Topics: Animals; Corticosterone; Corticotropin-Releasing Hormone; Hypothalamo-Hypophyseal System; Male; Mety | 1989 |
[Changes in plasma ACTH activity by oral administration of SU-4485].
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aneurysm; Animals; Circad | 1967 |
[Stomach ulcer induced by phenylbutazone and its course in adult rats].
Topics: Adrenal Glands; Adrenalectomy; Animals; Epinephrine; Metyrapone; Phenylbutazone; Promethazine; Propr | 1972 |
Effect of prolonged inhibition of 11-beta-hydroxylase on gastric secretion, ulcer provocation, and parietal cell population of the dog.
Topics: Adrenal Glands; Animals; Body Weight; Dogs; Gastric Juice; Gastric Mucosa; Histamine; Metyrapone; Mi | 1968 |