metyrapone has been researched along with Sepsis in 4 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used the overnight metyrapone stimulation test to investigate the diagnostic value of the standard cosyntropin stimulation test, and the prevalence of sepsis-associated adrenal insufficiency." | 3.73 | Diagnosis of adrenal insufficiency in severe sepsis and septic shock. ( Abe, E; Alvarez, JC; Annane, D; Boudou, P; Ibrahim, F; Maxime, V, 2006) |
| " For example, a marked fall in systemic blood pressure and dynamic lung compliance is seen in both models, but in the present gram-positive sepsis model, much less interleukin-8 and tumor necrosis factor-alpha are produced." | 3.70 | Synergistic septicemic action of the gram-positive bacterial cell wall components peptidoglycan and lipoteichoic acid in the pig in vivo. ( Alving, K; Middelveld, RJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Annane, D | 1 |
| Maxime, V | 1 |
| Ibrahim, F | 1 |
| Alvarez, JC | 1 |
| Abe, E | 1 |
| Boudou, P | 1 |
| Middelveld, RJ | 1 |
| Alving, K | 1 |
| Grant, JM | 1 |
| Yeo, JD | 1 |
| Loridan, L | 1 |
| Senior, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Total, Salivary and Calculated Free Cortisol Levels in Patients With Severe Sepsis[NCT02589431] | 46 participants (Actual) | Observational | 2009-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for metyrapone and Sepsis
| Article | Year |
|---|---|
Diagnosis of adrenal insufficiency in severe sepsis and septic shock.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Aged; Cosyntropin; Female; Humans; Hydrocortison | 2006 |
Synergistic septicemic action of the gram-positive bacterial cell wall components peptidoglycan and lipoteichoic acid in the pig in vivo.
Topics: Animals; Drug Synergism; Endothelin-1; Endotoxins; Female; Hydrocortisone; Interleukin-8; Leukocyte | 2000 |
Studies o the levels of 17 hydroxy-corticoids in 24-hour specimens of urine from five quadriplegic patients and two paraplegic patients admitted to the Royal North Shore Hospital, Sydney.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Female; H | 1968 |
Cushing's syndrome in infancy.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abnormalities, Multiple; Adenoma; Adrenal Gland Neoplasm | 1969 |