metyrapone has been researched along with Seizures in 11 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Metyrapone, an inhibitor of corticosterone synthesis, completely abolished seizures in GAERS, and seizures remained suppressed for >2 h." | 8.31 | Metyrapone abolishes spike-wave discharge seizures in genetic absence epilepsy rats from Strasbourg by reducing stress hormones. ( Dezsi, G; Harris, G; Jones, NC; O'Brien, TJ; Ozturk, E; Paul, C, 2023) |
| "Cerebral ischemia and seizures can induce considerable GC secretion." | 5.29 | Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures. ( Brooke, SM; Craddock, SD; Mattson, MP; Pettigrew, LC; Phares, C; Sapolsky, RM; Smith-Swintosky, VL, 1996) |
| " Metyrapone, an inhibitor of corticosterone synthesis, completely abolished seizures in GAERS, and seizures remained suppressed for >2 h." | 4.31 | Metyrapone abolishes spike-wave discharge seizures in genetic absence epilepsy rats from Strasbourg by reducing stress hormones. ( Dezsi, G; Harris, G; Jones, NC; O'Brien, TJ; Ozturk, E; Paul, C, 2023) |
| " Rats were microinfused with the excitotoxin kainic acid in order to induce status epilepticus seizures; this insult caused a significant GC stress-response." | 3.67 | Chemical adrenalectomy reduces hippocampal damage induced by kainic acid. ( Sapolsky, RM; Stein, BA, 1988) |
| "Cerebral ischemia and seizures can induce considerable GC secretion." | 1.29 | Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures. ( Brooke, SM; Craddock, SD; Mattson, MP; Pettigrew, LC; Phares, C; Sapolsky, RM; Smith-Swintosky, VL, 1996) |
| "Susceptibility to audiogenic seizures can be induced in some strains of resistant mice by exposure to an initial auditory stimulus (acoustic priming)." | 1.26 | Pharmacogenetic differences in audiogenic seizure priming of C57BL/6Bg and DBA/1Bg-asr mice. ( Cowen, JS; Maxson, SC; Sze, PY, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Dezsi, G | 1 |
| Ozturk, E | 1 |
| Harris, G | 1 |
| Paul, C | 1 |
| O'Brien, TJ | 1 |
| Jones, NC | 1 |
| COLLE, E | 1 |
| ULSTROM, RA | 1 |
| Smith-Swintosky, VL | 1 |
| Pettigrew, LC | 1 |
| Sapolsky, RM | 2 |
| Phares, C | 1 |
| Craddock, SD | 1 |
| Brooke, SM | 1 |
| Mattson, MP | 1 |
| Koch, CA | 1 |
| Bornstein, SR | 1 |
| Pacak, K | 1 |
| Chrousos, GP | 1 |
| Sarac, MS | 1 |
| Zieske, AW | 1 |
| Lindberg, I | 1 |
| Desbois, JC | 1 |
| Delepine, N | 1 |
| Techenet, J | 1 |
| Gueris, J | 1 |
| Herrault, A | 1 |
| Berel, A | 1 |
| Lehr, PR | 1 |
| Gayet, J | 1 |
| Maxson, SC | 1 |
| Cowen, JS | 1 |
| Sze, PY | 1 |
| Stein, BA | 1 |
| Roe, TF | 1 |
| Kogut, MD | 1 |
11 other studies available for metyrapone and Seizures
| Article | Year |
|---|---|
Metyrapone abolishes spike-wave discharge seizures in genetic absence epilepsy rats from Strasbourg by reducing stress hormones.
Topics: Animals; Corticosterone; Desoxycorticosterone; Disease Models, Animal; Electroencephalography; Epile | 2023 |
KETOTIC HYPOGLYCEMIA.
Topics: Acidosis; Carbohydrate Metabolism; Child; Diet; Glycogen; Humans; Hypoglycemia; Ketones; Metyrapone; | 1964 |
Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Glucocorticoids; Hippocampus; Male; Metyrapone; Neu | 1996 |
How does metyrapone decrease seizures?
Topics: Animals; Anticonvulsants; Child; Humans; Metyrapone; Rats; Seizures | 1998 |
The lethal form of Cushing's in 7B2 null mice is caused by multiple metabolic and hormonal abnormalities.
Topics: Adrenocorticotropic Hormone; Animals; Blood Glucose; Cause of Death; Corticosterone; Cushing Syndrom | 2002 |
[Lack of ACTH responsiveness in children and paroxysmal central nervous system manifestations. Study of nine cases of isolated ACTH deficiency (author's transl)].
Topics: Adolescent; Adrenocorticotropic Hormone; Child; Child, Preschool; Female; Humans; Hypoglycemia; Male | 1979 |
Inhibition by metyrapone of convulsions and storage of brain glycogen in mice induced by methionine sulfoximine (MSO).
Topics: Animals; Brain; Dose-Response Relationship, Drug; Glycogen; Male; Methionine Sulfoximine; Metyrapone | 1977 |
Pharmacogenetic differences in audiogenic seizure priming of C57BL/6Bg and DBA/1Bg-asr mice.
Topics: Acoustic Stimulation; Aminooxyacetic Acid; Animals; Brain Chemistry; Cycloheximide; Female; gamma-Am | 1977 |
Chemical adrenalectomy reduces hippocampal damage induced by kainic acid.
Topics: Adrenal Cortex; Animals; Electroencephalography; Glucocorticoids; Hippocampus; Kainic Acid; Male; Me | 1988 |
Hypopituitarism and ketotic hypoglycemia.
Topics: Acetone; Acidosis; Arginine; Body Height; Body Weight; Child; Fatty Acids, Nonesterified; Female; Gl | 1971 |
Medical grand rounds from the University of Alabama Medical Center.
Topics: Adrenocorticotropic Hormone; Adult; Drinking; Humans; Male; Metyrapone; Pituitary Diseases; Pituitar | 1967 |