metyrapone has been researched along with Puberty, Precocious in 10 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Puberty, Precocious: Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Medroxyprogesterone (MPA) is a progestin with no clinically detectable estrogenic and androgenic properties used in the treatment of sexual precocity." | 1.25 | Adverse effects of large doses of medroxyprogesterone (MPA) in idiopathic isosexual precocity. ( French, FS; Richman, RA; Underwood, LE; Van Wyk, JJ, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| FAGLIA, G | 1 |
| D ALONZO, R | 1 |
| NORBIATO, G | 1 |
| ORTHMANN, G | 1 |
| LIUZZI, A | 1 |
| IORI, E | 1 |
| Tecilazich, D | 1 |
| Rosenwirth, D | 1 |
| Tonini, G | 1 |
| Mangiarotti-Marchi, MA | 1 |
| Laron, Z | 1 |
| Karp, M | 1 |
| Nitzan, M | 1 |
| Pertzelan, A | 1 |
| Mathews, JH | 1 |
| Abrams, CA | 1 |
| Morishima, A | 1 |
| Richman, RA | 1 |
| Underwood, LE | 1 |
| French, FS | 1 |
| Van Wyk, JJ | 1 |
| Hamilton, W | 1 |
| Gray, CE | 1 |
| Nakazawa, S | 1 |
| Ueki, K | 1 |
| Macmillan, DR | 1 |
| Kim, CB | 1 |
| Weisskopf, B | 1 |
| Fishman, MA | 1 |
| Peake, GT | 1 |
1 trial available for metyrapone and Puberty, Precocious
| Article | Year |
|---|---|
Pituitary-adrenal function in ten patients receiving medroxyprogesterone acetate for true precocious puberty.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Child; Child, Preschool; Clinical Trials as | 1970 |
9 other studies available for metyrapone and Puberty, Precocious
| Article | Year |
|---|---|
[SIGNIFICANCE OF THE EVALUATION OF URINARY PREGNANTRIOL IN SOME ADRENAL ENDOCRINE DISORDERS: FINDINGS IN BASAL CONDITIONS AND AFTER TREATMENTS STIMULATING OR INHIBITING THE ADRENAL CORTEX].
Topics: Adolescent; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocortical Hyperfun | 1964 |
[CONTRIBUTION TO THE FUNCTIONAL STUDY OF THE PITUITARY-ADRENAL AXIS WITH METHOPYRAPONE (2-METHYL-1,2-BIS(3-PYRIDYL)-1-PROPANONE)].
Topics: Adolescent; Adrenal Glands; Adrenocortical Hyperfunction; Child; Cushing Syndrome; Hirsutism; Humans | 1964 |
[Auxological problems in a case of virilizing adenoma of the adrenal gland].
Topics: 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Child; Child, Preschool; Dexamethasone; Growth Di | 1977 |
The plasma 11-hydroxycorticosteroids responseto insulin-induced hypoglycaemia in children and adolescents.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Blood G | 1969 |
Adverse effects of large doses of medroxyprogesterone (MPA) in idiopathic isosexual precocity.
Topics: Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Body Height; Body Weight; Bone D | 1971 |
Urinary pregnanediol and pregnanetriol in the salt-losing and nonsalt-losing forms of C-21-hydroxylase deficiency.
Topics: Adolescent; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldosterone; Child; Child, Pr | 1972 |
[Endocrine, water and electrolyte abnormalities of craniopharyngioma (author's transl)].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Cortex; Adrenocorticotropic Hormone; | 1974 |
Syndrome of growth resistance, obesity, and intellectual impairment with precocious puberty.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abnormalities, Multiple; Body Height; Body Weight; Child | 1972 |
Paradoxical growth in a patient with the diencephalic syndrome.
Topics: Arginine; Brain Neoplasms; Child; Child, Preschool; Diencephalon; Emaciation; Glioma; Glucose; Growt | 1970 |