metyrapone has been researched along with Pregnancy in 181 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To control hypercortisolism, the patient was treated with metyrapone." | 6.41 | Recurrent ACTH-independent Cushing's syndrome in multiple pregnancies and its treatment with metyrapone. ( Dokoupilová, M; Hána, V; Marek, J; Plavka, R, 2001) |
| "The ketoconazole was shift to metyrapone but afterwards ketoconazole was added again." | 5.46 | A successful case of pregnancy in a woman with ACTH-independent Cushing's syndrome treated with ketoconazole and metyrapone. ( Michalak, R; Zieleniewski, W, 2017) |
| "Hypercortisolism was successfully controlled with metyrapone, which was started at 8 weeks of gestation." | 5.33 | Cushing's syndrome during pregnancy secondary to adrenal adenoma: metyrapone treatment and laparoscopic adrenalectomy. ( Blanco, C; Maqueda, E; Rodriguez, A; Rubio, JA, 2006) |
| "The hypercortisolism was controlled with metyrapone until elective delivery of the fetus by Caesarean section at 34 weeks gestation because of a decline in growth." | 5.29 | ACTH-independent Cushing's syndrome in pregnancy with spontaneous resolution after delivery: control of the hypercortisolism with metyrapone. ( Close, CF; Mann, MC; Taylor, KG; Watts, JF, 1993) |
| " Maternal treatment with dexamethasone on day 15 of pregnancy mimicked the stress effect and reproduced the AI and AHR outcomes, whereas blockade of the stress-induced corticosterone surge with metyrapone pretreatment of pregnant mice abrogated the effect." | 3.80 | Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids. ( Fedulov, AV; Kobzik, L; Lim, R, 2014) |
| "To determine whether prenatal dietary protein deprivation results in a reduction in nephron number and hypertension in offspring by exposure to maternal glucocorticoids, we administered metyrapone to rats fed either a 6% or 20% protein diet to inhibit glucocorticoid production and compared the offspring to rats that were the product of mothers fed either a 6% or 20% protein diet during the last half of pregnancy." | 3.77 | Evidence that prenatal programming of hypertension by dietary protein deprivation is mediated by fetal glucocorticoid exposure. ( Baum, M; Gattineni, J; Habib, S; Twombley, K, 2011) |
| " The corticosteroid synthesis inhibitor metyrapone was injected daily during days 14-19 of pregnancy, without (n = 6) and with commensurate administration of cortisol (n = 6)." | 3.73 | Lack of effect of metyrapone and exogenous cortisol on early porcine conceptus development. ( Christenson, RK; Klemcke, HG; Vallet, JL, 2006) |
| "The hypothalamic-pituitary-adrenal axis is hyporesponsive to stress in late pregnancy, exemplified as reduced adrenocorticotropic hormone (ACTH) and corticosterone responses to restraint, but the mechanisms are unknown." | 3.70 | Attenuation of hypothalamic-pituitary-adrenal axis stress responses in late pregnancy: changes in feedforward and feedback mechanisms. ( Douglas, AJ; Johnstone, HA; Landgraf, R; Neumann, ID; Russell, JA; Seckl, JR; Wigger, A, 2000) |
| " Replacement of corticosterone during pregnancy had no effect upon the blood pressures and GPDH activities of male offspring, but it reversed the effects of metyrapone in female offspring." | 3.69 | Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis. ( Langley-Evans, SC, 1997) |
| "The disturbance of corticosteroids balance of female rats on the 16 and 18 days of pregnancy by injections of exogenous corticosterone or methopyrone--blocker of endogenous hormone formation--decreased both body weight and activity of the rate-limiting catecholamine synthesising enzyme--tyrosine hydroxylase (TH) in the stem half of the 21 day fetal brain." | 3.68 | [The catecholamine system in rat fetal brain with a disrupted corticosteroid balance]. ( Dygalo, NN; Kalinina, TS; Naumenko, EV, 1991) |
| "Fetal and neonatal hypoadrenalism was induced by treating rat mothers with metyrapone from day 12 of pregnancy to day 7 postnatally." | 3.68 | Perinatal hypoadrenalism in the rat does not alter glucose tolerance and insulin secretory response to glucose. ( Eriksson, UJ; Karlsson, MG; Swenne, I, 1990) |
| " A regimen of twice daily metyrapone injections (10 mg/100 gm body weight), results in marked depression of serum corticosterone in pregnant and in fetal rats without surgical trauma and stress." | 3.68 | Fetal and maternal levels of corticosterone and ACTH after pharmacological adrenalectomy. ( Baram, TZ; Schultz, L, 1990) |
| "Pregnancy-induced Cushing's syndrome is exceptionally rare with fewer than ten cases reported in the world literature and none in Australia or New Zealand." | 2.48 | Pregnancy-induced Cushing's syndrome in recurrent pregnancies: case report and literature review. ( Achong, N; D'Emden, M; Fagermo, N; Mortimer, R, 2012) |
| "The most common cause of endogenous Cushing's disease in children older than 7 years is ACTH-dependent Cushing's disease (85%)." | 2.45 | [Cushing's syndrome: special issues]. ( Goñi Iriarte, MJ, 2009) |
| "To control hypercortisolism, the patient was treated with metyrapone." | 2.41 | Recurrent ACTH-independent Cushing's syndrome in multiple pregnancies and its treatment with metyrapone. ( Dokoupilová, M; Hána, V; Marek, J; Plavka, R, 2001) |
| "The ketoconazole was shift to metyrapone but afterwards ketoconazole was added again." | 1.46 | A successful case of pregnancy in a woman with ACTH-independent Cushing's syndrome treated with ketoconazole and metyrapone. ( Michalak, R; Zieleniewski, W, 2017) |
| "Maternal food restriction (MFR) causes intrauterine growth restriction, a known risk factor for developing chronic lung disease." | 1.42 | Metyrapone alleviates deleterious effects of maternal food restriction on lung development and growth of rat offspring. ( Khorram, O; Li, Y; Paek, DS; Rehan, VK; Sakurai, R; Saraswat, A; Torday, JS, 2015) |
| "Pretreatment with metyrapone counteracted effects produced by LPS, including hormonal and behavioral responses in lactating rats." | 1.39 | Corticosterone synthesis inhibitor metyrapone preserves changes in maternal behavior and neuroendocrine responses during immunological challenge in lactating rats. ( Antunes-Rodrigues, J; Elias, LL; Giusti-Paiva, A; Vilela, FC, 2013) |
| "Pregnancy was confirmed by transrectal ultrasonography between Days 28-30 after insemination." | 1.38 | Effects of cortisol on pregnancy rate and corpus luteum function in heifers: an in vivo study. ( Acosta, TJ; Bah, MM; Duong, HT; Jankowska, K; Majewska, M; Okuda, K; Piotrowska-Tomala, KK; Sinderewicz, E; Skarzynski, DJ, 2012) |
| "The metyrapone treatment produced no changes in GAD activity at PN23, but induced an important increase in this activity at PN90." | 1.34 | Role of maternal corticosterone in the development and maturation of the aminoacidergic systems of the rat brain. ( Garcia-Montojo, M; González, JC; Lecumberri, M; Leret, ML, 2007) |
| "Metyrapone pretreatment did not affect oxytocin-induced/-stimulated lung fluid absorption, while completely blocking IL-1beta-induced/-stimulated fluid absorption." | 1.33 | Oxytocin-induced labor augments IL-1beta-stimulated lung fluid absorption in fetal guinea pig lungs. ( Bhattacharjee, R; Folkesson, HG; Li, T; Nair, PK; Ye, X, 2005) |
| "Hypercortisolism was successfully controlled with metyrapone, which was started at 8 weeks of gestation." | 1.33 | Cushing's syndrome during pregnancy secondary to adrenal adenoma: metyrapone treatment and laparoscopic adrenalectomy. ( Blanco, C; Maqueda, E; Rodriguez, A; Rubio, JA, 2006) |
| "When metyrapone was infused from 137/138 days gestation, there was a significant decrease in plasma cortisol concentrations by +6 h, which was followed by an increase back to pre-infusion values." | 1.32 | The effect of intrafetal infusion of metyrapone on arterial blood pressure and on the arterial blood pressure response to angiotensin II in the sheep fetus during late gestation. ( Coulter, CL; McMillen, IC; Robinson, JS; Warnes, KE, 2003) |
| "The hypercortisolism was controlled with metyrapone until elective delivery of the fetus by Caesarean section at 34 weeks gestation because of a decline in growth." | 1.29 | ACTH-independent Cushing's syndrome in pregnancy with spontaneous resolution after delivery: control of the hypercortisolism with metyrapone. ( Close, CF; Mann, MC; Taylor, KG; Watts, JF, 1993) |
| "Carbon monoxide was equally effective in the intact ductus and the ductus denuded of endothelium, whereas cytochrome P-450 inhibitors were marginally less effective in the latter preparation." | 1.28 | Lamb ductus venosus: evidence of a cytochrome P-450 mechanism in its contractile tension. ( Adeagbo, AS; Breen, CA; Coceani, F; Cutz, E; Lees, JG; Olley, PM, 1990) |
| "Metyrapone was also a relaxant agent, and its action was greater at low than at high PO2." | 1.27 | Cytochrome P 450-linked monooxygenase: involvement in the lamb ductus arteriosus. ( Coceani, F; Hamilton, NC; Labuc, J; Olley, PM, 1984) |
| "Metyrapone was approximately 150 times less potent than indomethacin." | 1.25 | The influence of metyrapone on the synthesis and release of prostaglandins from the pregnant rat uterus in vitro. ( Parnham, MJ; Sneddon, JM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 124 (68.51) | 18.7374 |
| 1990's | 18 (9.94) | 18.2507 |
| 2000's | 21 (11.60) | 29.6817 |
| 2010's | 17 (9.39) | 24.3611 |
| 2020's | 1 (0.55) | 2.80 |
| Authors | Studies |
|---|---|
| Nemoto, T | 1 |
| Nakakura, T | 1 |
| Kakinuma, Y | 1 |
| Chuang, TD | 1 |
| Sakurai, R | 3 |
| Gong, M | 1 |
| Khorram, O | 4 |
| Rehan, VK | 3 |
| Li, Y | 2 |
| Corral, J | 1 |
| Saraswat, A | 2 |
| Husain, S | 1 |
| Dhar, A | 1 |
| Torday, JS | 2 |
| Durrant, LM | 1 |
| Buchholz, JN | 1 |
| Pearce, WJ | 1 |
| Lim, R | 1 |
| Fedulov, AV | 1 |
| Kobzik, L | 1 |
| Paek, DS | 1 |
| Murphy, MO | 1 |
| Herald, JB | 1 |
| Wills, CT | 1 |
| Unfried, SG | 1 |
| Cohn, DM | 1 |
| Loria, AS | 1 |
| Zieleniewski, W | 1 |
| Michalak, R | 1 |
| Cohade, C | 1 |
| Broussaud, S | 1 |
| Louiset, E | 1 |
| Bennet, A | 1 |
| Huyghe, E | 1 |
| Caron, P | 1 |
| Goñi Iriarte, MJ | 1 |
| Leret, ML | 3 |
| Rua, C | 1 |
| Garcia-Montojo, M | 2 |
| Lecumberri, M | 2 |
| González, JC | 2 |
| Erhuma, A | 1 |
| McMullen, S | 2 |
| Langley-Evans, SC | 3 |
| Bennett, AJ | 1 |
| Bogdarina, I | 1 |
| Haase, A | 1 |
| Langley-Evans, S | 1 |
| Clark, AJ | 1 |
| Habib, S | 1 |
| Gattineni, J | 1 |
| Twombley, K | 1 |
| Baum, M | 1 |
| Cui, K | 1 |
| Luheshi, GN | 1 |
| Boksa, P | 1 |
| Bronstein, MD | 1 |
| Paraiba, DB | 1 |
| Jallad, RS | 1 |
| Alexander, BN | 1 |
| Fewell, JE | 1 |
| Schiemer, R | 1 |
| Latibeaudiere, M | 1 |
| Close, C | 1 |
| Fox, R | 1 |
| Duong, HT | 1 |
| Piotrowska-Tomala, KK | 1 |
| Acosta, TJ | 1 |
| Bah, MM | 1 |
| Sinderewicz, E | 1 |
| Majewska, M | 1 |
| Jankowska, K | 1 |
| Okuda, K | 1 |
| Skarzynski, DJ | 1 |
| Achong, N | 1 |
| D'Emden, M | 1 |
| Fagermo, N | 1 |
| Mortimer, R | 1 |
| Vilela, FC | 1 |
| Antunes-Rodrigues, J | 1 |
| Elias, LL | 1 |
| Giusti-Paiva, A | 1 |
| Lim, WH | 1 |
| Torpy, DJ | 1 |
| Jeffries, WS | 1 |
| Smith, JT | 1 |
| Waddell, BJ | 2 |
| Shaw, JA | 1 |
| Pearson, DW | 1 |
| Krukowski, ZH | 1 |
| Fisher, PM | 1 |
| Bevan, JS | 1 |
| Lubin, V | 1 |
| Gautier, JF | 1 |
| Antoine, JM | 1 |
| Beressi, JP | 1 |
| Vexiau, P | 1 |
| HEINEN, G | 1 |
| BUCHHEIT, H | 1 |
| OERTEL, GW | 1 |
| JARVINEN, PA | 1 |
| PESONEN, S | 1 |
| VAANANEN, P | 1 |
| CASTREN, O | 2 |
| KALLIOMAEKI, JL | 2 |
| PEKKARINEN, A | 2 |
| RUPONEN, S | 2 |
| SOIVA, K | 2 |
| GILES, C | 1 |
| GRIFFITHS, K | 1 |
| KERNOHAN, RJ | 1 |
| HOLMDAHL, TH | 1 |
| Warnes, KE | 2 |
| Coulter, CL | 3 |
| Robinson, JS | 2 |
| McMillen, IC | 2 |
| Beck, P | 2 |
| Eaton, CJ | 1 |
| Young, IS | 1 |
| Kupperman, HS | 1 |
| Miyoshi, T | 1 |
| Otsuka, F | 1 |
| Suzuki, J | 1 |
| Inagaki, K | 1 |
| Takeda, M | 1 |
| Kano, Y | 1 |
| Yamashita, T | 1 |
| Ogura, T | 1 |
| Date, I | 1 |
| Tanaka, Y | 1 |
| Hashimoto, K | 1 |
| Makino, H | 1 |
| Nair, PK | 1 |
| Li, T | 1 |
| Bhattacharjee, R | 1 |
| Ye, X | 1 |
| Folkesson, HG | 1 |
| Klemcke, HG | 1 |
| Vallet, JL | 1 |
| Christenson, RK | 1 |
| Franklin, SO | 1 |
| Jimenez, R | 1 |
| Blanco, C | 1 |
| Maqueda, E | 1 |
| Rubio, JA | 1 |
| Rodriguez, A | 1 |
| Tixier-Vidal, A | 1 |
| Assenmacher, I | 1 |
| Birnbaum, SJ | 1 |
| Lye, SJ | 3 |
| Challis, JR | 3 |
| Bialik, RJ | 1 |
| Pappas, BA | 1 |
| Roberts, DC | 1 |
| Salinas, ME | 1 |
| Arias, F | 1 |
| Yamamoto, M | 2 |
| Arishima, K | 2 |
| Eguchi, Y | 2 |
| Mochizuki, K | 2 |
| Kaelin, AC | 1 |
| Cummings, AJ | 1 |
| Kremers, P | 1 |
| Gielen, JE | 1 |
| Coceani, F | 2 |
| Hamilton, NC | 1 |
| Labuc, J | 1 |
| Olley, PM | 2 |
| Badawy, SZ | 1 |
| Notman, DD | 1 |
| Sunderlin, FS | 1 |
| Springer, JM | 1 |
| Streeten, DH | 1 |
| Omar, MM | 1 |
| Marshall, LD | 1 |
| Brien, TG | 1 |
| Gormley, MJ | 1 |
| Hadden, DR | 1 |
| Kennedy, TL | 1 |
| Montgomery, DA | 1 |
| Murnaghan, GA | 1 |
| Sheridan, B | 1 |
| Mirkes, PE | 1 |
| Greenaway, JC | 1 |
| Saito, H | 1 |
| Naminohira, S | 1 |
| Sakai, T | 1 |
| Ueno, K | 1 |
| Kitagawa, H | 1 |
| Nogami, H | 2 |
| Tachibana, T | 1 |
| Sangild, PT | 2 |
| Hilsted, L | 1 |
| Nexø, E | 1 |
| Fowden, AL | 1 |
| Silver, M | 1 |
| Burton, PJ | 1 |
| Lawrence, MS | 1 |
| Sapolsky, RM | 1 |
| Close, CF | 1 |
| Mann, MC | 1 |
| Watts, JF | 1 |
| Taylor, KG | 1 |
| Goldsmith, PC | 1 |
| Mesiano, S | 1 |
| Voytek, CC | 1 |
| Martin, MC | 1 |
| Mason, JI | 1 |
| Jaffe, RB | 1 |
| Bordone, L | 1 |
| Schrott, LM | 1 |
| Sparber, SB | 1 |
| Prieur, B | 1 |
| Bismuth, J | 1 |
| Delaval, E | 1 |
| Antonio, MT | 1 |
| Arahuetes, RM | 1 |
| Kasperlik-Zaluska, AA | 1 |
| Szczupacka, I | 1 |
| Leszczynska-Bystrzanowska, J | 1 |
| Drus-Przybyszewska, G | 1 |
| Johnstone, HA | 1 |
| Wigger, A | 1 |
| Douglas, AJ | 1 |
| Neumann, ID | 1 |
| Landgraf, R | 1 |
| Seckl, JR | 1 |
| Russell, JA | 1 |
| Hána, V | 1 |
| Dokoupilová, M | 1 |
| Marek, J | 1 |
| Plavka, R | 1 |
| Blondeau, B | 1 |
| Lesage, J | 1 |
| Czernichow, P | 1 |
| Dupouy, JP | 4 |
| Bréant, B | 1 |
| Matsubara, M | 1 |
| Harigaya, T | 1 |
| Klinger, W | 1 |
| Muller, D | 1 |
| Prochukhanov, RA | 1 |
| Rostovtseva, TI | 1 |
| Kotas, RV | 2 |
| Kling, OR | 2 |
| Hassani, M | 1 |
| Joss, EE | 1 |
| Townsley, JD | 1 |
| Groos, G | 1 |
| Tharandt, L | 1 |
| Benker, G | 1 |
| Zäh, W | 1 |
| Hackenberg, K | 1 |
| Reinwein, D | 1 |
| Birkenhäger, JC | 1 |
| Upton, GV | 1 |
| Seldenrath, HJ | 1 |
| Krieger, DT | 1 |
| Tashjian, AH | 1 |
| Iwai, K | 1 |
| Honda, H | 1 |
| Patt, JA | 2 |
| Eberhart, RJ | 2 |
| Wolf, AS | 1 |
| Musch, K | 1 |
| Fehm, HL | 1 |
| Lauritzen, C | 2 |
| Parnham, MJ | 4 |
| Pelkonen, O | 2 |
| Sneddon, JM | 2 |
| Dybing, E | 1 |
| Thorgeirsson, SS | 1 |
| Canick, JA | 1 |
| Ryan, KJ | 1 |
| Mitskevich, MS | 1 |
| Rumiantseva, ON | 1 |
| Schmid, R | 1 |
| McDonagh, AF | 1 |
| Milković, K | 3 |
| Romić, R | 1 |
| Paunović, J | 2 |
| Milković, S | 3 |
| Vidyasagar, D | 2 |
| Chernick, V | 2 |
| Klepac, R | 1 |
| Baram, TZ | 2 |
| Schultz, L | 2 |
| Dygalo, NN | 1 |
| Kalinina, TS | 1 |
| Naumenko, EV | 1 |
| Piersma, AH | 1 |
| van Aerts, LA | 1 |
| Verhoef, A | 1 |
| Garbis-Berkvens, JM | 1 |
| Robinson, JE | 1 |
| Peereboom-Stegeman, JH | 1 |
| Peters, PW | 1 |
| Karlsson, MG | 1 |
| Eriksson, UJ | 1 |
| Swenne, I | 1 |
| Adeagbo, AS | 1 |
| Breen, CA | 1 |
| Cutz, E | 1 |
| Lees, JG | 1 |
| MacNiven, E | 1 |
| de Catanzaro, D | 1 |
| Takebe, K | 1 |
| Yang, HY | 1 |
| Namkung, MJ | 1 |
| Juchau, MR | 1 |
| Dobrović-Jenik, D | 1 |
| Rose, JC | 1 |
| Turner, CS | 1 |
| Ray, D | 1 |
| Rawashdeh, N | 1 |
| Oglesby, LA | 1 |
| Ebron, MT | 1 |
| Beyer, PE | 1 |
| Carver, BD | 1 |
| Kavlock, RJ | 1 |
| Heitkemper, MM | 1 |
| Marotta, SF | 1 |
| Howlett, TA | 1 |
| Rees, LH | 1 |
| Mitchell, BF | 1 |
| Lukash, L | 1 |
| Welsh, J | 1 |
| Peruzović, M | 1 |
| Pasanen, M | 1 |
| Taskinen, T | 1 |
| Sotaniemi, EA | 1 |
| Kairaluoma, M | 1 |
| Mukhtar, H | 1 |
| Athar, M | 1 |
| Bickers, DR | 1 |
| Connell, JM | 1 |
| Cordiner, J | 1 |
| Davies, DL | 1 |
| Fraser, R | 1 |
| Frier, BM | 1 |
| McPherson, SG | 1 |
| David, GF | 1 |
| Ramaswami, LS | 2 |
| Haddock, L | 1 |
| Vega, LA | 1 |
| Aguiló, F | 1 |
| Rodríguez, O | 1 |
| Kaul, DK | 1 |
| Bergheim, P | 1 |
| Rathgen, GH | 1 |
| Netter, KJ | 1 |
| Reiss, M | 1 |
| Wakoh, T | 1 |
| Hillman, JC | 1 |
| Pearse, JJ | 1 |
| Daley, N | 1 |
| Reiss, JM | 1 |
| Carlon, N | 1 |
| Michaels, RH | 1 |
| Kenny, FM | 1 |
| Geloso, JP | 1 |
| Basset, JC | 1 |
| Gillette, DD | 1 |
| Filkins, M | 1 |
| Arvay, A | 1 |
| Takács, J | 1 |
| Spellacy, WN | 2 |
| Cohen, WD | 1 |
| Tanaka, T | 1 |
| Yagi, T | 1 |
| van Kampen, EJ | 1 |
| Hoek, W | 1 |
| Wynn, V | 1 |
| Bacchus, H | 1 |
| Okada, S | 1 |
| Scommegna, A | 1 |
| Nedoss, BR | 1 |
| Chattoraj, SC | 1 |
| Miura, K | 1 |
| Berson, SA | 1 |
| Yalow, RS | 1 |
| Dickey, RP | 1 |
| Thompson, JP | 1 |
| Kubo, N | 1 |
| Faglia, G | 1 |
| Travaglini, P | 1 |
| Neri, V | 1 |
| Farrari, C | 1 |
| Gattinoni, L | 1 |
| Acerbi, L | 1 |
| Künzel, W | 1 |
| Maeyama, M | 1 |
| Nakagawa, T | 2 |
| Martin, MM | 1 |
| Martin, AL | 1 |
| Hellman, L | 1 |
| Bradlow, HL | 1 |
| Zumoff, B | 1 |
| Oakey, RE | 2 |
| Heys, RF | 2 |
| Kićović, P | 1 |
| Subotić, Z | 1 |
| Popović, D | 1 |
| Givens, JR | 1 |
| Fort, AT | 1 |
| Leigh, JH | 1 |
| Northrop, G | 1 |
| Ditzler, J | 1 |
| Ryan, WG | 1 |
| Wilbanks, GD | 1 |
| Jorgensen, PI | 1 |
| Sele, V | 1 |
| Buus, O | 1 |
| Damkjoer, M | 1 |
| Yamada, S | 1 |
| Parvez, H | 2 |
| Parvez, S | 2 |
| Bachmann, R | 1 |
| Gennser, G | 1 |
| Hökfelt, B | 1 |
| Nilsson, KO | 1 |
| Sternby, NH | 1 |
| Thompson, EA | 1 |
| Siiteri, PK | 1 |
| Goldman, AS | 1 |
| Okamoto, K | 1 |
| Husslein, H | 2 |
| Stöger, H | 1 |
| Roffi, J | 1 |
| Gates, RB | 1 |
| Friesen, H | 1 |
| Samaan, NA | 1 |
| Clary, JJ | 1 |
| Stokinger, HE | 1 |
| Herrera Justiniano, E | 1 |
| Díaz Gálvez, M | 1 |
| Rodríguez de Quesada, B | 1 |
| Aznar Reig, A | 1 |
| Hubl, W | 1 |
| Stahl, F | 1 |
| Freymann, E | 1 |
| Büchner, M | 1 |
| Turksoy, RN | 1 |
| Salimi, R | 1 |
| Jones, GS | 1 |
| Jones, JE | 1 |
| Graham, NA | 1 |
| Seal, US | 1 |
| Caffarena, EL | 1 |
| Jadresic, A | 1 |
| Arias, G | 1 |
| Maira, J | 1 |
| Lennon, H | 1 |
| Donoso, F | 1 |
| Nielsen, MD | 1 |
| Binder, C | 1 |
| Starup, J | 1 |
| Bird, CC | 1 |
| Crawford, AM | 1 |
| Currie, AR | 1 |
| Stirling, BF | 1 |
| Yussman, MA | 1 |
| Taymor, ML | 1 |
| D'Alberton, A | 1 |
| Reschini, E | 1 |
| Shimao, S | 1 |
| Wiqvist, N | 1 |
| Diczfalusy, E | 1 |
| Solomon, S | 1 |
| Carlson, KL | 1 |
| Schade, SL | 1 |
| Gómez-Vargas, E | 1 |
| Zárate, A | 1 |
| Karchmer, S | 1 |
| Domínguez, H | 1 |
| Janata, J | 1 |
| Stárka, L | 1 |
15 reviews available for metyrapone and Pregnancy
| Article | Year |
|---|---|
Ectopic Cushing's syndrome due to a pheochromocytoma: a new case in the post-partum and review of literature.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Cushing Syndrome; Female; Humans; Insulin; Metyrapone | 2009 |
[Cushing's syndrome: special issues].
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adult; Child; Cush | 2009 |
Management of pituitary tumors in pregnancy.
Topics: Dopamine Agonists; Female; Humans; Ketoconazole; Metyrapone; Pituitary Neoplasms; Pregnancy; Pregnan | 2011 |
Pregnancy-induced Cushing's syndrome in recurrent pregnancies: case report and literature review.
Topics: Adrenocorticotropic Hormone; Adult; Australia; Cushing Syndrome; Enzyme Inhibitors; Female; Humans; | 2012 |
The medical management of Cushing's syndrome during pregnancy.
Topics: Adrenalectomy; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole; Metyrapone; Pre-Eclam | 2013 |
[Cushing's syndrome during pregnancy].
Topics: Adrenal Cortex Neoplasms; Adult; Anti-Inflammatory Agents; Antimetabolites; Cushing Syndrome; Dexame | 2002 |
Human corticosteroid binding globulin.
Topics: Adrenal Cortex Diseases; Adrenal Cortex Hormones; Age Factors; Animals; Chemical Phenomena; Chemistr | 1981 |
Recurrent ACTH-independent Cushing's syndrome in multiple pregnancies and its treatment with metyrapone.
Topics: Abortion, Therapeutic; Adolescent; Adrenal Glands; Cesarean Section; Cushing Syndrome; Female; Fetal | 2001 |
Growth hormone deficiency in childhood. Evaluation of diagnostic procedures.
Topics: Adolescent; Adrenocorticotropic Hormone; Anthropometry; Birth Weight; Bone Development; Child; Child | 1975 |
[Determination of serum (and urinary) 17-hydroxycorticosteroids and 17-ketosteroids].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Adolescent; Adrenocorticotropic Hormone | 1976 |
The enzymatic formation of bilirubin.
Topics: Animals; Benzopyrenes; Bile Pigments; Bilirubin; Cytochrome P-450 Enzyme System; Female; Heme; Human | 1975 |
Is it possible to diagnose pituitary-dependent Cushing's disease?
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hor | 1985 |
Recent advances in human steroid metabolism.
Topics: Adrenocorticotropic Hormone; Aldosterone; Carbon Isotopes; Dexamethasone; Estriol; Etiocholanolone; | 1970 |
Spontaneous hypertension in rats.
Topics: Adrenal Medulla; Animals; Antihypertensive Agents; Aorta; Arteries; Autonomic Agents; Body Weight; C | 1969 |
[The clinical picture and therapy of Sheehan's syndrome (author's transl)].
Topics: Addison Disease; Amenorrhea; Anorexia Nervosa; Celiac Disease; Cortisone; Diagnosis, Differential; F | 1974 |
166 other studies available for metyrapone and Pregnancy
| Article | Year |
|---|---|
Elevated blood pressure in high-fat diet-exposed low birthweight rat offspring is most likely caused by elevated glucocorticoid levels due to abnormal pituitary negative feedback.
Topics: Animals; Birth Weight; Blood Pressure; Corticosterone; Diet, High-Fat; Feedback, Physiological; Fema | 2020 |
Role of miR-29 in mediating offspring lung phenotype in a rodent model of intrauterine growth restriction.
Topics: Animals; Extracellular Matrix Proteins; Female; Fetal Growth Retardation; Glucocorticoids; Lung; Mal | 2018 |
Metyrapone blocks maternal food restriction-induced changes in female rat offspring lung development.
Topics: Age Factors; Animal Nutritional Physiological Phenomena; Animals; Caloric Restriction; Female; Gesta | 2014 |
Maternal food restriction modulates cerebrovascular structure and contractility in adult rat offspring: effects of metyrapone.
Topics: Age Factors; Animals; Calcium; Caloric Restriction; Cardiovascular Diseases; Cerebrovascular Circula | 2014 |
Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Corticosterone; Disease Susceptibility; Female; Glucocor | 2014 |
Metyrapone alleviates deleterious effects of maternal food restriction on lung development and growth of rat offspring.
Topics: Age Factors; Animals; Bronchopulmonary Dysplasia; Caloric Restriction; Cell Differentiation; Cells, | 2015 |
Postnatal treatment with metyrapone attenuates the effects of diet-induced obesity in female rats exposed to early-life stress.
Topics: Animals; Animals, Newborn; Diet, High-Fat; Female; Male; Maternal Deprivation; Metyrapone; Obesity; | 2017 |
A successful case of pregnancy in a woman with ACTH-independent Cushing's syndrome treated with ketoconazole and metyrapone.
Topics: Adult; Cushing Syndrome; Drug Therapy, Combination; Female; Humans; Ketoconazole; Metyrapone; Pregna | 2017 |
Influence of metyrapone treatment during pregnancy on the development and maturation of brain monoaminergic systems in the rat.
Topics: Animals; Brain; Brain Chemistry; Corticosterone; Dopamine; Enzyme Inhibitors; Female; Male; Metyrapo | 2009 |
Feeding pregnant rats a low-protein diet alters the hepatic expression of SREBP-1c in their offspring via a glucocorticoid-related mechanism.
Topics: Adrenalectomy; Animals; Cells, Cultured; Dexamethasone; Diet, Protein-Restricted; Dietary Proteins; | 2009 |
Glucocorticoid effects on the programming of AT1b angiotensin receptor gene methylation and expression in the rat.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Blood Pressure; Dexamethasone | 2010 |
Evidence that prenatal programming of hypertension by dietary protein deprivation is mediated by fetal glucocorticoid exposure.
Topics: Animals; Blood Pressure; Dexamethasone; Diet, Protein-Restricted; Female; Fetus; Hypertension; Kidne | 2011 |
Effects of endogenous glucocorticoid secretion on the interleukin-6 response to bacterial endotoxin in pregnant and non-pregnant rats.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Corticosterone; Enzyme Inhibitors; Femal | 2011 |
Metyrapone restores the febrile response to Escherichia coli LPS in pregnant rats.
Topics: Animals; Body Temperature; Body Temperature Regulation; Corticosterone; Enzyme Inhibitors; Escherich | 2011 |
Type 2 diabetes identified in pregnancy secondary to Cushing's syndrome.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Cushing Syndrome; Diabetes Mellitus, Type 2 | 2011 |
Effects of cortisol on pregnancy rate and corpus luteum function in heifers: an in vivo study.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Administration, Intravaginal; Animals; Animals, Inbred | 2012 |
Corticosterone synthesis inhibitor metyrapone preserves changes in maternal behavior and neuroendocrine responses during immunological challenge in lactating rats.
Topics: Animals; Corticosterone; Enzyme Inhibitors; Female; Immunity, Innate; Immunologic Techniques; Lactat | 2013 |
Leptin receptor expression in the rat placenta: changes in ob-ra, ob-rb, and ob-re with gestational age and suppression by glucocorticoids.
Topics: Animals; Carbenoxolone; Dexamethasone; Enzyme Inhibitors; Female; Fetal Growth Retardation; Gene Exp | 2002 |
Cushing's syndrome during pregnancy: curative adrenalectomy at 31 weeks gestation.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Cushing Syndrome; Female; Gestational A | 2002 |
[Studies with adrenostatic Su 4885 (Metopirone) in pregnancy].
Topics: Edema; Female; Ketones; Metyrapone; Pregnancy; Pregnancy Complications; Pyridines | 1963 |
[On the effect of Metopirone on the secretion of corticotropin and on the exretion of hormones of the adrenal cortex in hyperemesis gravidarum].
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Female; Humans; Hyperemesis Gr | 1962 |
ADRENOCORTICOTROPHIC HORMONE RESERVE OF THE ANTERIOR PITUITARY GLAND AFTER SEVERE POSTPARTUM HAEMORRHAGE.
Topics: Adrenocorticotropic Hormone; Female; Humans; Hypopituitarism; Metyrapone; Mineralocorticoid Receptor | 1963 |
INHIBITION OF THE AROMATIZING ACTIVITY OF HUMAN PLACENTA BY SU 4885.
Topics: Carbon Isotopes; Chromatography; Cricetinae; Estradiol; Estrone; Female; Metabolism; Metyrapone; Min | 1964 |
PITUITARY CORTICOTROPIN RESERVE AFTER SEVERE POSTPARTUM HAEMORRHAGE.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Female; Hemorrhage; Humans; Ketones; Metyrapon | 1964 |
METYRAPONE AND ACUTE ADRENAL INSUFFICIENCY.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Arthritis; Arthritis, Rheumatoid; F | 1964 |
EFFECTS OF ADMINISTRATION OF METOPIRON AND OF DELIVERY ON HUMAN PLASMA CORTICOTROPHIN.
Topics: Adenoma; Adenoma, Chromophobe; Adrenocorticotropic Hormone; Blood; Delivery, Obstetric; Female; Huma | 1965 |
The effect of intrafetal infusion of metyrapone on arterial blood pressure and on the arterial blood pressure response to angiotensin II in the sheep fetus during late gestation.
Topics: Adrenocorticotropic Hormone; Angiotensin II; Animals; Antimetabolites; Blood Gas Analysis; Blood Glu | 2003 |
Differential actions of metyrapone on the fetal pituitary-adrenal axis in the sheep fetus in late gestation.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; 3-Hydroxysteroid Dehydrogenases; Adrenal Glands; Adreno | 2004 |
Maternal low-protein diet in rat pregnancy programs blood pressure through sex-specific mechanisms.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Blood Pressure; Corticosterone; Diet, Protein- | 2005 |
Metyrapone response in pregnancy.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Female; Ge | 1968 |
Periodic secretion of adrenocorticotropin in a patient with Cushing's disease manifested during pregnancy.
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Corticotropin-Releasing Hormone; Female; Humans; Hydroc | 2005 |
Oxytocin-induced labor augments IL-1beta-stimulated lung fluid absorption in fetal guinea pig lungs.
Topics: Absorption; Amiloride; Animals; Enzyme Activation; Enzyme Inhibitors; Epinephrine; Extravascular Lun | 2005 |
Lack of effect of metyrapone and exogenous cortisol on early porcine conceptus development.
Topics: Aldosterone; Animals; Drug Combinations; Embryonic Development; Female; Hydrocortisone; Maternal-Fet | 2006 |
Increases in preproenkephalin mRNA levels in the Syrian hamster: the influence of glucocorticoids is dependent on age and tissue.
Topics: Adrenal Glands; Age Factors; Animals; Animals, Newborn; Corpus Striatum; Cricetinae; Dose-Response R | 2006 |
Cushing's syndrome during pregnancy secondary to adrenal adenoma: metyrapone treatment and laparoscopic adrenalectomy.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Cushing Syndrome; Enzyme Inhibitors; Female; | 2006 |
Role of maternal corticosterone in the development and maturation of the aminoacidergic systems of the rat brain.
Topics: Aging; Amino Acids; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Corticost | 2007 |
[Cytologic study of the prehypophysis of the pigeon during brooding time and lactation].
Topics: Animals; Birds; Female; Lactation; Male; Metyrapone; Pituitary Gland; Pregnancy; Thyroxine | 1966 |
Thermographic and hormonal studies of the placenta in abdominal pregnancy.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Chorionic Gonadotropin; Female; Humans; Metyrapon | 1967 |
In vivo adrenocorticotropin (1-24)-induced accumulation of cyclic adenosine monophosphate by ovine fetal adrenal cells is inhibited by concomitant infusion of metopirone.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Cosyntropin; Cycl | 1984 |
Neonatal 6-hydroxydopamine prevents adaptation to chemical disruption of the pituitary-adrenal system in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Avoidance Learning; Brain Stem; Cerebral Cor | 1984 |
Effects of ethanol on alcohol dehydrogenase and microsomal ethanol oxidative system activities in fetal mice.
Topics: Alcohol Oxidoreductases; Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Ethanol; Fe | 1984 |
Analysis of metopirone-induced hypertrophy of adrenals in fetal rats encephalectomized in utero.
Topics: Adrenal Glands; Animals; Decerebrate State; Female; Fetus; Gestational Age; Humans; Hypertrophy; Met | 1984 |
Gravimetric and histologic changes in fetal adrenals following maternal adrenalectomy and metopirone injection in the rat.
Topics: Adrenal Glands; Adrenalectomy; Animals; Feedback; Female; Hypertrophy; Maternal-Fetal Exchange; Mety | 1983 |
Differential inhibition of human placental monooxygenase activity: evidence for multiple forms of 7-ethoxycoumarin O-deethylase.
Topics: 7-Alkoxycoumarin O-Dealkylase; Benzoflavones; Dimethyl Sulfoxide; Epilepsy; Female; Humans; Metyrapo | 1984 |
Mono-oxygenase expression in primary foetal-rat hepatocytes in culture.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enz | 1983 |
Cytochrome P 450-linked monooxygenase: involvement in the lamb ductus arteriosus.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Ductus Arteriosus; Female; Guinea Pigs; In | 1984 |
Hypothalamic-pituitary function following bromocriptine therapy in patients with prolactinomas.
Topics: Adenoma; Adult; Bromocriptine; Female; Humans; Hypothalamo-Hypophyseal System; Infertility, Female; | 1982 |
Cushing's syndrome in pregnancy--treatment with metyrapone.
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Cushing Syndrome; Female; Humans; Metyrapone; Pregnancy; Pr | 1982 |
Teratogenicity of chlorambucil in rat embryos in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Chlorambucil; Cyclophosphamide; Dose-Respon | 1982 |
Drug metabolism and fetal toxicity: changes in fetal toxicity of aminopyrine by variation of drug metabolizing enzyme activity in mice.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cobalt; Female; Fetal Death; M | 1981 |
Dexamethasone induces advanced growth hormone expression in the fetal rat pituitary gland in vivo.
Topics: Animals; Blotting, Northern; Dexamethasone; Female; Fetus; Growth Hormone; Immunohistochemistry; In | 1993 |
Vaginal birth versus elective caesarean section: effects on gastric function in the neonate.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Animals, Newborn; Cesarean Section; Female; Ga | 1995 |
11 beta-Hydroxysteroid dehydrogenase in the rat placenta: developmental changes and the effects of altered glucocorticoid exposure.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Animals; Corticosterone; Dexamethasone; Female; Gestational A | 1994 |
Glucocorticoids accelerate ATP loss following metabolic insults in cultured hippocampal neurons.
Topics: Adenosine Triphosphate; Adrenalectomy; Animals; Cell Hypoxia; Cells, Cultured; Female; Fetus; Glucoc | 1994 |
ACTH-independent Cushing's syndrome in pregnancy with spontaneous resolution after delivery: control of the hypercortisolism with metyrapone.
Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Delivery, Obstetric; Female; Humans; Hydrocort | 1993 |
Stimulation of gastric proteases in the neonatal pig by a rise in adrenocortical secretion at parturition.
Topics: Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Animals, Newborn; Chymosin; En | 1995 |
Functional maturation of the primate fetal adrenal in vivo. II. Ontogeny of corticosteroid synthesis is dependent upon specific zonal expression of 3 beta-hydroxysteroid dehydrogenase/isomerase.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Cholesterol Side-Chain Cleavage Enzyme; Female; Ge | 1996 |
Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis.
Topics: Animals; Blood Pressure; Corticosterone; Diet, Protein-Restricted; Female; Glucocorticoids; Glycerol | 1997 |
Ontogeny of glucocorticoid receptors in the hyperstriatum-hippocampus-parahippocampal area and optic tectum of the embryonic chicken (Gallus domesticus) brain.
Topics: Animals; Antibody Specificity; Brain; Chick Embryo; Chickens; Corticosterone; Cytosol; DNA; Female; | 1997 |
Effects of adrenal steroid hormones on mitochondrial maturation during the late fetal period.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Aldosterone; Animals; Dexamethasone; DNA, Mitochondrial; Ele | 1998 |
Effect of metyrapone administration in pregnant rats on monoamine concentration in fetal brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Glands; Animals; Biogenic Monoamines; Brain; Dopamine; Enzym | 1998 |
Pregnancy-dependent Cushing's syndrome in three pregnancies.
Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans; Hydrocortisone; Metyrapone; Pr | 2000 |
Attenuation of hypothalamic-pituitary-adrenal axis stress responses in late pregnancy: changes in feedforward and feedback mechanisms.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adrenalectomy; Adrenocorticotropic Hormone; Aminoglutet | 2000 |
Glucocorticoids impair fetal beta-cell development in rats.
Topics: Adrenal Glands; Adrenalectomy; Animals; Corticosterone; Female; Fetal Blood; Fetal Growth Retardatio | 2001 |
Effects of diethylstilbestrol on the cytogenesis of prolactin cells in the pars distalis of the pituitary gland of the mouse.
Topics: Animals; Animals, Newborn; Diethylstilbestrol; Enzyme Inhibitors; Estrogens, Non-Steroidal; Female; | 2001 |
Developmental aspects of xenobiotic transformation.
Topics: Aminopyrine; Aniline Compounds; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Cytochro | 1976 |
[Structuro-metabolic mechanisms for integrating several endocrine organs].
Topics: 11-Hydroxycorticosteroids; Adrenal Cortex; Adrenocorticotropic Hormone; Alkaline Phosphatase; Animal | 1979 |
Influence of glucocorticoid administration and inhibition on fetal baboon pulmonary maturity and the amniotic fluid L/S ratio.
Topics: Amniotic Fluid; Animals; Dexamethasone; Estrone; Female; Fetus; Haplorhini; Lung; Lung Volume Measur | 1979 |
[Role played by the adrenal cortex on the luteotrophic action of estrogens during the rat estrus cycle].
Topics: Adrenal Cortex; Animals; Dexamethasone; Estradiol; Estrus; Female; Metyrapone; Pregnancy; Progestero | 1978 |
Utilization of dehydroepiandrosterone and its sulphate for oestrogen production by pregnant baboons (Papio papio).
Topics: Adrenocorticotropic Hormone; Animals; Betamethasone; Estradiol; Estrogens; Estrone; Female; Haplorhi | 1976 |
[Diagnostic problems in Cushing's syndrome during pregnancy].
Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans; Hydrocortisone; Metyrapone; Pr | 1976 |
Medullary thyroid carcinoma: ectopic production of peptides with ACTH-like, corticotrophin releasing factor-like and prolactin production-stimulating activities.
Topics: Adrenocorticotropic Hormone; Antigens; Biological Assay; Calcitonin; Carcinoma; Corticotropin-Releas | 1976 |
Effects of metyrapone and ACTH on intestinal absorption of immunoreactive bovine IgG in cesarean-derived pigs.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Animals, Newborn; Cattle; Colostrum; Female; H | 1976 |
Total and differential leukocyte counts in cesarean-derived newborn pigs following treatment with ACTH or metyrapone.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Animals, Newborn; Cesarean Section; Female; Hy | 1977 |
[Studies on hyperemesis gravidarum (author's transl)].
Topics: Adrenocorticotropic Hormone; Female; Humans; Hydrocortisone; Hyperemesis Gravidarum; Metyrapone; Pit | 1978 |
Metyrapone: a possible tool in investigating the role of endogenous corticosteroids in inflammation.
Topics: Adrenal Cortex Hormones; Animals; Chronic Disease; Female; In Vitro Techniques; Inflammation; Metyra | 1977 |
Differential inhibition of aryl hydrocarbon hydroxylase in human foetal liver, adrenal gland and placenta*.
Topics: Adrenal Glands; Aminopyrine; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; | 1977 |
The influence of metyrapone on the synthesis and release of prostaglandins from the pregnant rat uterus in vitro.
Topics: Animals; Female; Indomethacin; Metyrapone; Pregnancy; Pregnancy, Animal; Prostaglandin-Endoperoxide | 1975 |
Metabolic activation of 2,4-diamino-anisole, a hair-dye component--I. Role of cytochrome p-450 metabolism in mutagenicity in vitro.
Topics: Animals; Anisoles; Aroclors; Coloring Agents; Cytochrome P-450 Enzyme System; Female; Fetus; Flavono | 1977 |
The effect of metyrapone on uterine prostaglandin output and smooth muscle activity.
Topics: Animals; Female; Ileum; In Vitro Techniques; Isoproterenol; Metyrapone; Muscle, Smooth; Papaverine; | 1976 |
Cytochrome P-450 and the aromatization of 16alpha-hydroxytestosterone and androstenedione by human placental microsomes.
Topics: Androstenedione; Aromatase; Carbon Monoxide; Cytochrome P-450 Enzyme System; Female; Humans; Hydroxy | 1976 |
[Effect of metopirone and glucocorticoids on the glycogen content in the adrenals of rat fetuses].
Topics: Adrenal Glands; Animals; Dexamethasone; Female; Fetus; Gestational Age; Glucocorticoids; Glycogen; H | 1976 |
Endocrine influences on pulmonary maturation and the lecithin/sphingomyelin ratio in the fetal baboon.
Topics: Adrenal Cortex; Amniotic Fluid; Animals; Dexamethasone; Disease Models, Animal; Female; Fetus; Gesta | 1975 |
Failure of the metopirone (Su4885) suppressed fetal adrenal glands to maintain corticosterone concentration of adrenalectomized pregnant rats.
Topics: Adrenal Glands; Adrenalectomy; Animals; Corticosterone; Depression, Chemical; Female; Fetus; Materna | 1975 |
Proceedings: Metyrapone inhibits prostaglandin synthesis and release from the pregnant rat uterus in vitro.
Topics: Animals; Depression, Chemical; Female; In Vitro Techniques; Metyrapone; Pregnancy; Prostaglandins; R | 1975 |
Effect of metopirone on the synthesis of lung surfactant in does and fetal rabbits.
Topics: Animals; Cortisone; Depression, Chemical; DNA; Female; Fetus; Gestational Age; Lung; Maternal-Fetal | 1975 |
Steroidogenesis of the fetal adrenal gland in vitro: influence of metopirone applied in vivo and in vitro.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Female; Gestational Age; Metyrapone; Pregnancy; Pr | 1975 |
CRH gene expression in the fetal rat is not increased after pharmacological adrenalectomy.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Animals; Corticotropin-Releasing Hormone; Female; Fetus; | 1992 |
[The catecholamine system in rat fetal brain with a disrupted corticosteroid balance].
Topics: Adrenal Cortex Hormones; Animals; Body Weight; Brain; Catecholamines; Corticosterone; DNA; Female; F | 1991 |
Biotransformation of cyclophosphamide in post-implantation rat embryo culture using maternal hepatocytes in co-culture.
Topics: Animals; Biotransformation; Cells, Cultured; Cyclophosphamide; Embryo, Mammalian; Female; Liver; Mal | 1991 |
Perinatal hypoadrenalism in the rat does not alter glucose tolerance and insulin secretory response to glucose.
Topics: Adrenal Insufficiency; Animals; Animals, Newborn; Body Weight; Corticosterone; Female; Fetus; Glucos | 1990 |
Fetal and maternal levels of corticosterone and ACTH after pharmacological adrenalectomy.
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Body Weight; Corticosterone; Fe | 1990 |
Lamb ductus venosus: evidence of a cytochrome P-450 mechanism in its contractile tension.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ductus | 1990 |
Reversal of stress-induced pregnancy blocks in mice by progesterone and metyrapone.
Topics: Animals; Embryo Loss; Fear; Female; Fetal Death; Metyrapone; Mice; Mice, Inbred C57BL; Pregnancy; Pr | 1990 |
[Clinical significance of urinary 17-hydroxycorticoid and its component analysis in endocrine tests of the adrenal cortex].
Topics: 17-Hydroxycorticosteroids; Addison Disease; Adolescent; Adrenal Cortex Function Tests; Adrenal Hyper | 1989 |
Immunodetection, immunoinhibition, immunoquantitation and biochemical analyses of cytochrome P-450IA1 in tissues of the ratoffceptus during the progression of organogenesis.
Topics: 2-Acetylaminofluorene; Amnion; Animals; Benzo(a)pyrene; Benzoflavones; Chorion; Cytochrome P-450 Enz | 1989 |
Regulation of fetal Na+/K+-ATPase in rat kidney by corticosteroids.
Topics: 4-Nitrophenylphosphatase; Adrenal Cortex Hormones; Adrenalectomy; Animals; Ca(2+) Mg(2+)-ATPase; Des | 1988 |
Evidence that cortisol inhibits basal adrenocorticotropin secretion in the sheep fetus by 0.70 gestation.
Topics: Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Carbon Dioxide; Female; Fetal Blood; Fetus; | 1988 |
Co-culture of rat embryos and hepatocytes: in vitro detection of a proteratogen.
Topics: Animals; Biotransformation; Cells, Cultured; Ectogenesis; Embryo, Mammalian; Female; Liver; Metyrapo | 1986 |
Effects of corticosterone and metyrapone on gastrointestinal neurotransmitter enzyme activities.
Topics: Acetylcholinesterase; Animals; Choline O-Acetyltransferase; Corticosterone; Digestive System; Female | 1986 |
Androstenedione metabolism in the late gestation sheep fetus.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Androstenedione; Animals; Estrone; Female; Fetal Blood; | 1986 |
Ovine fetal adrenal maturation at term and during fetal ACTH administration: evidence that the modulating effect of cortisol may involve cAMP.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Cosyntropin; Cyclic | 1986 |
Prenatal ACTH and corticosteroids, development and behavior in rat.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Avoidance Learning; Behavior, Animal; | 1986 |
Inhibitor panel studies of human hepatic and placental cytochrome P-450-associated monooxygenase activities.
Topics: Aminoglutethimide; Animals; Benzoflavones; Cimetidine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enz | 1988 |
Cytochrome P-450 dependent metabolism of testosterone in rat skin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Female; Metyrapone; Microsom | 1987 |
Pregnancy complicated by Cushing's syndrome: potential hazard of metyrapone therapy. Case report.
Topics: Adult; Cushing Syndrome; Female; Humans; Hypertension; Metyrapone; Pregnancy; Pregnancy Complication | 1985 |
The pituitary gland of the North Indian langur (Presbytis entellus entellus Dufrèsne).
Topics: Animals; Cadmium; Castration; Estradiol; Female; Haplorhini; India; Lactation; Male; Menstruation; M | 1971 |
Adrenocortical, thyroidal and human growth hormone reserve in Sheehan's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aldosterone; Arginine; Estrogens; Female; Growth Hormone; | 1972 |
Cytology of the pituitary gland of the Indian desert gerbil Meriones hurrianae Jerdon.
Topics: Animals; Basophils; Cadmium; Castration; Estrus; Female; Gerbillinae; Gonadotropins, Pituitary; Indi | 1974 |
Interaction of drugs and steroids with human placental microsomes.
Topics: Acetanilides; Amphetamine; Anaerobiosis; Androgens; Aniline Compounds; Anisoles; Carbon Monoxide; Cy | 1973 |
Endocrine investigations into mongolism.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; | 1965 |
[Cytology of the anterior lobe of the hypophysis of the dog].
Topics: Adrenocorticotropic Hormone; Animals; Dogs; Estrus; Female; Follicle Stimulating Hormone; Growth Hor | 1967 |
Postnatal growth retardation in congenital rubella.
Topics: 17-Hydroxycorticosteroids; Body Height; Body Weight; Cephalometry; Child, Preschool; Female; Gestati | 1969 |
Role of adrenal glands in development of foetal rat kidney Na-K-ATPase.
Topics: Adenosine Triphosphatases; Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Female; Gestational | 1974 |
Factors affecting antibody transfer in the newborn puppy.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Antibodies; Dogs; Female; Hydrocortisone; Im | 1966 |
The influence of hormone changes during pregnancy on the velocity of collagen aging.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Castration; Chorionic Gonadotropin; Collagen; Estradiol | 1965 |
Clomiphene treatment of prolonged secondary amenorrhea associated with pituitary gonadotropin deficiency.
Topics: 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Amenorrhea; Clomiphene; Female; Gon | 1967 |
[Studies on the relationship between lactation and corticoids, with special reference to urinary 11-deoxy-17 KGS and 11-oxy-17 KGS].
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Dehydroepiandrosterone; Diuresis; Female; Humans; Hydr | 1966 |
[Pituitary-adrenocortical function of women following Gestagen administration].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Cont | 1967 |
Urinary steroid spectrum by gas chromatography.
Topics: 17-Ketosteroids; Addison Disease; Adrenocorticotropic Hormone; Androgens; Breast Neoplasms; Chemistr | 1967 |
The assessment of hypothalamic-pituitary-adrenocortical function in man.
Topics: Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Hydrocortisone; Insulin; Liver Diseas | 1967 |
Sequential solvent extraction of urinary corticosteroids and its clinical application.
Topics: 17-Hydroxycorticosteroids; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenocorticotrop | 1967 |
[Study of focal epilepsy].
Topics: Adrenocorticotropic Hormone; Animals; Brain; Child, Preschool; Electroencephalography; Female; Human | 1967 |
Maternal urinary estriol excretion after dehydroepiandrosterone-sulfate infusion and adrenal stimulation and suppression.
Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Dehydroepiandrosterone; Dexamethasone; | 1968 |
[Patterns of adrenal steroids present in the blood].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aldosterone; Blood Proteins; Corticosterone; C | 1967 |
Radioimmunoassay of ACTH in plasma.
Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Con | 1968 |
Effect of ACTH and metyrapone on estriol, 17-hydroxycorticosteroid, 17-ketosteroid, pregnanediol and pregnanetriol excretion late in pregnancy.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Body Weight; Estriol | 1969 |
[Fractional determination of 4 types of neutral steroid glucuronides (11-deoxy-C-19 steroid, 11-deoxy-C-21 steroid, 11-oxy-C-19 steroid, 11-oxy-C-21 steroid) and 3 types of steroid glucuronides (11-deoxy-neutral steroid, pregnanediol, 11-oxy-neutral stero
Topics: Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Castration; | 1969 |
Occurrence of a virilizing syndrome with 21-hydroxylase deficiency after pregnancy.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hor | 1969 |
[Analytical studies of steroid hormones in hyperemesis gravidarum].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Body Weight; Chorion | 1969 |
Effects of ACTH, metopirone and dexamethasone on maternal urinary steroid excretion in late pregnancy.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Adult; Dexamethasone; Estradiol; Estriol; Es | 1970 |
Simultaneous determination of cortisol and corticosterone in urine.
Topics: Adrenal Gland Diseases; Adrenal Glands; Adrenocorticotropic Hormone; Child; Circadian Rhythm; Cortic | 1970 |
Regulation of the production of oestrogen precursors in the foetus.
Topics: 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Androgens; Anencephaly; Estrogens; Fem | 1970 |
[Effect of ACTH, metopirone and dexamethasone on urinary steroid excretion of pregnant women in the latter stage of pregnancy].
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Dexamethasone; Estradiol; Estrone; Female; G | 1970 |
Interrelationships between maternal and fetal pituitary-adrenal axis.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Dehydroepiandrosterone; Est | 1970 |
Effect of norgestrel in combination with ethinyl oestradiol on the human pituitary-adrenal axis.
Topics: 17-Hydroxycorticosteroids; Administration, Oral; Adrenocorticotropic Hormone; Contraceptives, Oral; | 1968 |
[Response of the hypothalamo-hypophyseal complex of the rat fetus to a blocking of corticosteroid biosynthesis by metopirone. Infleunce of cortisol].
Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Age Factors; Animals; Body Wei | 1971 |
Estriol excretion profiles in narcotic-addicted pregnant women.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Age Fact | 1972 |
[Corticostimulating activity of rat fetus hypophysis after maternal adrenalectomy and metopirone injections during gestation].
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Age Factors; Animals; Corticosterone; Fe | 1972 |
Detailed hormonal studies during and after pregnancy in a previously hypophysectomized patient.
Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Chorionic | 1973 |
[Urinary 6beta-hydroxycortisol. II. Urinary 6beta-hydroxycortisol in different diseases and after administration of drugs].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Carcinoma; Cushing Syndrome; F | 1973 |
The rate limiting control of enzymes monoamine oxidase and catechol-O-methyl transferase in the foetus and the adult by adreno-cortical hormones.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Animal | 1973 |
Steroid studies in a case of ovarian hyperluteinization with virilism in two consecutive pregnancies.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; An | 1974 |
The involvement of human placental microsomal cytochrome P-450 in aromatization.
Topics: Aminoglutethimide; Androstenedione; Animals; Binding Sites; Binding, Competitive; Carbon Monoxide; C | 1974 |
Experimental model of congenital adrenal cortical hyperplasia produced in utero with an inhibitor of 11-beta-steroid hydroxylase.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Animals; Corticosteron | 1967 |
Sites of the negative feedback action of corticosteroids on the hypothalamo-hypophisial system of the rat fetus.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Binding Sites; Body Weight; Corticosterone; Desoxy | 1974 |
[Prolonged pregnancy in rats treated with metopirone].
Topics: Adrenal Cortex Hormones; Animals; Body Weight; Female; Fetus; Labor, Obstetric; Metyrapone; Pregnanc | 1972 |
Inappropriate lactation and amenorrhoea: pathological and diagnostic considerations.
Topics: Adolescent; Adult; Amenorrhea; Arginine; Autopsy; Blood Glucose; Clomiphene; Estrogens; Female; Gona | 1973 |
Placental transfer of metopirone.
Topics: Animals; Female; Fluorometry; Injections, Subcutaneous; Maternal-Fetal Exchange; Metyrapone; Pregnan | 1972 |
The mechanism of delayed biologic response following beryllium exposure.
Topics: Adrenal Insufficiency; Adrenalectomy; Animals; Beryllium; Body Weight; Bone and Bones; Chemical and | 1973 |
[Plasma levels of 11-hydroxy and 11-desoxycorticoids in the metopirone test].
Topics: 11-Hydroxycorticosteroids; Addison Disease; Adult; Female; Humans; Hypopituitarism; Hypothalamo-Hypo | 1973 |
[A simple method for the determination of 11-desoxycortisol in small amounts of plasma using competitive protein binding analysis].
Topics: Animals; Binding, Competitive; Chromatography, Thin Layer; Corticosterone; Dogs; Evaluation Studies | 1973 |
Pituitary-adrenal responsiveness during microdose norethindrone therapy.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Contraceptives, Oral; Female; Humans; Metyrapone; | 1972 |
The adreno-ovarian physiology in the rat treated with metopirone and corticosterone.
Topics: Abortion, Spontaneous; Adrenal Glands; Animals; Corticosterone; Estrus; Female; Infertility, Female; | 1971 |
Pituitary factors affecting androgen production by the foetal adrenal.
Topics: Adrenal Glands; Androgens; Anencephaly; Estrogens; Female; Fetus; Humans; Hydrocephalus; Hypothalamo | 1969 |
Excretion of urinary free amino acids in Cushing's syndrome.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Amino | 1969 |
[Postpartum hypopituitarism: Sheehan's syndrome].
Topics: Adolescent; Adult; Female; Gonadotropins; Humans; Hypopituitarism; Metyrapone; Pituitary-Adrenal Fun | 1969 |
Urinary excretion of different corticosteroid-metabolites in oral contraception and pregnancy.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Contraceptives, Oral; Corticosterone; Dysmenorrhea; Fema | 1969 |
Protection from the embryopathic effects of 7-hydroxymethyl-12-methylbenz(a)anthracene by 2-methyl-1,2-bis-(3-pyridyl)1-propanone(metopirone, Ciba) and beta-diethylaminoethyldiphenyl-n-propyl acetate (SKF 525-A).
Topics: Abnormalities, Drug-Induced; Adrenal Glands; Animals; Benz(a)Anthracenes; Embryo, Mammalian; Female; | 1970 |
Ovulation inhibition with a long-acting injectable contraceptive. IV. Return of reproductive function after discontinuation.
Topics: Adult; Clomiphene; Contraceptive Agents; Delayed-Action Preparations; Estradiol; Female; Follicle St | 1970 |
[On the amenorrhea-galactorrhea syndrome].
Topics: Amenorrhea; Female; Growth Hormone; Humans; Hydrocortisone; Insulin; Lactation Disorders; Metyrapone | 1970 |
The effect of Metopirone (SU-4885) on the metabolism of progesterone by the perfused previable human fetus.
Topics: Adrenal Glands; Chromatography; Desoxycorticosterone; Female; Fetus; Humans; Intestinal Mucosa; Live | 1968 |
Human growth hormone studies in patients with galactorrhea (Ahumada-del Castillo syndrome).
Topics: 17-Hydroxycorticosteroids; Adult; Amenorrhea; Blood Glucose; Fasting; Female; Growth Hormone; Humans | 1968 |
[Forbes-Albright syndrome and the pituitary reserve. Study by the methopyrone test].
Topics: Adult; Amenorrhea; Female; Humans; Kidney Function Tests; Lactation Disorders; Metyrapone; Pituitary | 1968 |
[Steroid examinations in the Chiari-Frommel syndrome].
Topics: 17-Ketosteroids; Adult; Chiari-Frommel Syndrome; Chromatography, Paper; Female; Gonadal Steroid Horm | 1968 |
[Sheehan's syndrome].
Topics: Amenorrhea; Cortisone; Diagnosis, Differential; Female; Humans; Hypopituitarism; Metyrapone; Pituita | 1966 |