metyrapone has been researched along with Polycystic Ovary Syndrome in 12 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Polycystic Ovary Syndrome: A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serum androgen levels, including dehydroepiandrosterone sulphate (DHAS) which is thought to be solely of adrenal origin, are elevated in women with the polycystic ovarian syndrome." | 3.66 | Acth function in women with the polycystic ovarian syndrome. ( Butt, WR; Holder, G; Horrocks, PM; Kandeel, FR; Logan-Edwards, R; London, DR; Lynch, SS, 1983) |
| "Symptoms of hyperandrogenism are common in patients with Cushing's disease (CD), yet they are not sufficiently explained by androgen concentrations." | 1.72 | 11-Oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing's disease. ( Adaway, JE; Auer, MK; Bidlingmaier, M; Braun, L; Hartmann, MF; Hawley, J; Keevil, B; Lottspeich, C; Nowotny, HF; Reincke, M; Reisch, N; Schilbach, K; Tschaidse, L; Vogel, F; Wudy, SA, 2022) |
| "BLA = bilateral adrenalectomy CD = Cushing disease CS = Cushing syndrome eCRF = electronic case report form MRI = magnetic resonance imaging PCOS = polycystic ovary syndrome." | 1.46 | BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY. ( Ayala, A; Biller, BMK; Bonert, V; Broder, MS; Carmichael, JD; Cherepanov, D; Eagan, M; Geer, EB; Gordon, MB; Hannoush, Z; Katznelson, L; Lalazar, Y; Lee, J; Manuylova, E; Neary, MP; Pulaski-Liebert, KJ; Said, Q; Shafiq, I; Surampudi, V; Swerdloff, RS, 2017) |
| "This study was undertaken to examine the role of adrenal androgen excess in the pathogenesis of polycystic ovary syndrome (PCOS) and, if such was present, to assess its reversibility using dexamethasone given in physiological dosage at night." | 1.27 | Adrenal abnormalities in polycystic ovary syndrome. ( Culliton, M; Cunningham, S; Loughlin, T; McKenna, TJ; Moore, A; Smyth, PP, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (83.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Nowotny, HF | 1 |
| Braun, L | 1 |
| Vogel, F | 1 |
| Bidlingmaier, M | 1 |
| Reincke, M | 1 |
| Tschaidse, L | 1 |
| Auer, MK | 1 |
| Lottspeich, C | 1 |
| Wudy, SA | 1 |
| Hartmann, MF | 1 |
| Hawley, J | 1 |
| Adaway, JE | 1 |
| Keevil, B | 1 |
| Schilbach, K | 1 |
| Reisch, N | 1 |
| Geer, EB | 1 |
| Shafiq, I | 1 |
| Gordon, MB | 1 |
| Bonert, V | 1 |
| Ayala, A | 1 |
| Swerdloff, RS | 1 |
| Katznelson, L | 1 |
| Lalazar, Y | 1 |
| Manuylova, E | 1 |
| Pulaski-Liebert, KJ | 1 |
| Carmichael, JD | 1 |
| Hannoush, Z | 1 |
| Surampudi, V | 1 |
| Broder, MS | 1 |
| Cherepanov, D | 1 |
| Eagan, M | 1 |
| Lee, J | 1 |
| Said, Q | 1 |
| Neary, MP | 1 |
| Biller, BMK | 1 |
| KLEINFELDER, H | 1 |
| HUSMAN, F | 1 |
| FAGLIA, G | 1 |
| D ALONZO, R | 1 |
| NORBIATO, G | 1 |
| ORTHMANN, G | 1 |
| LIUZZI, A | 1 |
| JOYEUX, R | 1 |
| COLIN, R | 1 |
| AMAR, E | 1 |
| Sfikakis, AP | 1 |
| Ikkos, DG | 1 |
| Diamandopoulos, KN | 1 |
| Horrocks, PM | 1 |
| Kandeel, FR | 1 |
| London, DR | 1 |
| Butt, WR | 1 |
| Lynch, SS | 1 |
| Holder, G | 1 |
| Logan-Edwards, R | 1 |
| Wortsman, J | 1 |
| Wehrenberg, WB | 1 |
| Gavin, JR | 1 |
| Allen, JP | 1 |
| Loughlin, T | 1 |
| Cunningham, S | 1 |
| Moore, A | 1 |
| Culliton, M | 1 |
| Smyth, PP | 1 |
| McKenna, TJ | 1 |
| Fehér, T | 1 |
| Thomas, JP | 1 |
| Mills, IH | 1 |
| Wilson, RJ | 1 |
12 other studies available for metyrapone and Polycystic Ovary Syndrome
| Article | Year |
|---|---|
11-Oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing's disease.
Topics: Adrenocorticotropic Hormone; Androgens; Androstenedione; Androsterone; Cortisone; Dehydroepiandroste | 2022 |
BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY.
Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectom | 2017 |
[THE EXCRETION OF ADRENAL CORTEX STEROIDS IN PATIENTS WITH HIRSUTISM AFTER ORAL ADMINISTRATION OF METOPIRON].
Topics: 17-Ketosteroids; Administration, Oral; Adrenal Cortex; Adrenal Cortex Hormones; Androsterone; Etioch | 1963 |
[SIGNIFICANCE OF THE EVALUATION OF URINARY PREGNANTRIOL IN SOME ADRENAL ENDOCRINE DISORDERS: FINDINGS IN BASAL CONDITIONS AND AFTER TREATMENTS STIMULATING OR INHIBITING THE ADRENAL CORTEX].
Topics: Adolescent; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocortical Hyperfun | 1964 |
[CLINICAL ASPECTS OF THE STEIN-LEVENTHAL SYNDROME].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Clomiphene; Dexamethasone; Diagnosis; Female; Humans; Me | 1965 |
Urinary oestrogen excretion after metyrapone administration to patients with the polycystic ovary syndrome.
Topics: 17-Ketosteroids; Adult; Amenorrhea; Dexamethasone; Estradiol; Estriol; Estrone; Feedback; Female; Hu | 1967 |
Acth function in women with the polycystic ovarian syndrome.
Topics: Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; And | 1983 |
Elevated levels of plasma beta-endorphin and gamma 3-melanocyte stimulating hormone in the polycystic ovary syndrome.
Topics: Adrenocorticotropic Hormone; Adult; beta-Endorphin; Dexamethasone; Endorphins; Female; Humans; Hydro | 1984 |
Adrenal abnormalities in polycystic ovary syndrome.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Glands; Androgens; Dexamethasone; Estrogens; Female; Follicle | 1986 |
Epiandrosterone excretion in man.
Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Cushing Syndrome; Fem | 1967 |
Adrenocortical function in Stein-Leventhal syndrome.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Androstanes; Chemistry, Clin | 1968 |
Endocrine studies in women with secondary amenorrhoea.
Topics: Adolescent; Adult; Amenorrhea; Anorexia Nervosa; Basal Metabolism; Female; Gonadotropins; Humans; Io | 1969 |