Page last updated: 2024-10-31

metyrapone and Polycystic Ovarian Syndrome

metyrapone has been researched along with Polycystic Ovarian Syndrome in 12 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Research Excerpts

ExcerptRelevanceReference
"Serum androgen levels, including dehydroepiandrosterone sulphate (DHAS) which is thought to be solely of adrenal origin, are elevated in women with the polycystic ovarian syndrome."3.66Acth function in women with the polycystic ovarian syndrome. ( Butt, WR; Holder, G; Horrocks, PM; Kandeel, FR; Logan-Edwards, R; London, DR; Lynch, SS, 1983)
"Symptoms of hyperandrogenism are common in patients with Cushing's disease (CD), yet they are not sufficiently explained by androgen concentrations."1.7211-Oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing's disease. ( Adaway, JE; Auer, MK; Bidlingmaier, M; Braun, L; Hartmann, MF; Hawley, J; Keevil, B; Lottspeich, C; Nowotny, HF; Reincke, M; Reisch, N; Schilbach, K; Tschaidse, L; Vogel, F; Wudy, SA, 2022)
"BLA = bilateral adrenalectomy CD = Cushing disease CS = Cushing syndrome eCRF = electronic case report form MRI = magnetic resonance imaging PCOS = polycystic ovary syndrome."1.46BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY. ( Ayala, A; Biller, BMK; Bonert, V; Broder, MS; Carmichael, JD; Cherepanov, D; Eagan, M; Geer, EB; Gordon, MB; Hannoush, Z; Katznelson, L; Lalazar, Y; Lee, J; Manuylova, E; Neary, MP; Pulaski-Liebert, KJ; Said, Q; Shafiq, I; Surampudi, V; Swerdloff, RS, 2017)
"This study was undertaken to examine the role of adrenal androgen excess in the pathogenesis of polycystic ovary syndrome (PCOS) and, if such was present, to assess its reversibility using dexamethasone given in physiological dosage at night."1.27Adrenal abnormalities in polycystic ovary syndrome. ( Culliton, M; Cunningham, S; Loughlin, T; McKenna, TJ; Moore, A; Smyth, PP, 1986)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-199010 (83.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (8.33)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Nowotny, HF1
Braun, L1
Vogel, F1
Bidlingmaier, M1
Reincke, M1
Tschaidse, L1
Auer, MK1
Lottspeich, C1
Wudy, SA1
Hartmann, MF1
Hawley, J1
Adaway, JE1
Keevil, B1
Schilbach, K1
Reisch, N1
Geer, EB1
Shafiq, I1
Gordon, MB1
Bonert, V1
Ayala, A1
Swerdloff, RS1
Katznelson, L1
Lalazar, Y1
Manuylova, E1
Pulaski-Liebert, KJ1
Carmichael, JD1
Hannoush, Z1
Surampudi, V1
Broder, MS1
Cherepanov, D1
Eagan, M1
Lee, J1
Said, Q1
Neary, MP1
Biller, BMK1
KLEINFELDER, H1
HUSMAN, F1
FAGLIA, G1
D ALONZO, R1
NORBIATO, G1
ORTHMANN, G1
LIUZZI, A1
JOYEUX, R1
COLIN, R1
AMAR, E1
Sfikakis, AP1
Ikkos, DG1
Diamandopoulos, KN1
Horrocks, PM1
Kandeel, FR1
London, DR1
Butt, WR1
Lynch, SS1
Holder, G1
Logan-Edwards, R1
Wortsman, J1
Wehrenberg, WB1
Gavin, JR1
Allen, JP1
Loughlin, T1
Cunningham, S1
Moore, A1
Culliton, M1
Smyth, PP1
McKenna, TJ1
Fehér, T1
Thomas, JP1
Mills, IH1
Wilson, RJ1

Other Studies

12 other studies available for metyrapone and Polycystic Ovarian Syndrome

ArticleYear
11-Oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing's disease.
    European journal of endocrinology, 2022, Nov-01, Volume: 187, Issue:5

    Topics: Adrenocorticotropic Hormone; Androgens; Androstenedione; Androsterone; Cortisone; Dehydroepiandroste

2022
BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2017, Volume: 23, Issue:8

    Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectom

2017
[THE EXCRETION OF ADRENAL CORTEX STEROIDS IN PATIENTS WITH HIRSUTISM AFTER ORAL ADMINISTRATION OF METOPIRON].
    Klinische Wochenschrift, 1963, Dec-01, Volume: 41

    Topics: 17-Ketosteroids; Administration, Oral; Adrenal Cortex; Adrenal Cortex Hormones; Androsterone; Etioch

1963
[SIGNIFICANCE OF THE EVALUATION OF URINARY PREGNANTRIOL IN SOME ADRENAL ENDOCRINE DISORDERS: FINDINGS IN BASAL CONDITIONS AND AFTER TREATMENTS STIMULATING OR INHIBITING THE ADRENAL CORTEX].
    Archivio di patologia e clinica medica, 1964, Volume: 40

    Topics: Adolescent; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocortical Hyperfun

1964
[CLINICAL ASPECTS OF THE STEIN-LEVENTHAL SYNDROME].
    La Presse medicale, 1965, Feb-20, Volume: 73

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Clomiphene; Dexamethasone; Diagnosis; Female; Humans; Me

1965
Urinary oestrogen excretion after metyrapone administration to patients with the polycystic ovary syndrome.
    The Journal of endocrinology, 1967, Volume: 39, Issue:1

    Topics: 17-Ketosteroids; Adult; Amenorrhea; Dexamethasone; Estradiol; Estriol; Estrone; Feedback; Female; Hu

1967
Acth function in women with the polycystic ovarian syndrome.
    Clinical endocrinology, 1983, Volume: 19, Issue:2

    Topics: Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; And

1983
Elevated levels of plasma beta-endorphin and gamma 3-melanocyte stimulating hormone in the polycystic ovary syndrome.
    Obstetrics and gynecology, 1984, Volume: 63, Issue:5

    Topics: Adrenocorticotropic Hormone; Adult; beta-Endorphin; Dexamethasone; Endorphins; Female; Humans; Hydro

1984
Adrenal abnormalities in polycystic ovary syndrome.
    The Journal of clinical endocrinology and metabolism, 1986, Volume: 62, Issue:1

    Topics: 17-alpha-Hydroxyprogesterone; Adrenal Glands; Androgens; Dexamethasone; Estrogens; Female; Follicle

1986
Epiandrosterone excretion in man.
    The Journal of endocrinology, 1967, Volume: 38, Issue:3

    Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Cushing Syndrome; Fem

1967
Adrenocortical function in Stein-Leventhal syndrome.
    The Journal of clinical endocrinology and metabolism, 1968, Volume: 28, Issue:12

    Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Androstanes; Chemistry, Clin

1968
Endocrine studies in women with secondary amenorrhoea.
    Proceedings of the Royal Society of Medicine, 1969, Volume: 62, Issue:1

    Topics: Adolescent; Adult; Amenorrhea; Anorexia Nervosa; Basal Metabolism; Female; Gonadotropins; Humans; Io

1969