Page last updated: 2024-10-31

metyrapone and Obesity

metyrapone has been researched along with Obesity in 47 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

Excerpt	Relevance	Reference
" In 12 healthy men, 4-5 wk of rosiglitazone increased insulin sensitivity during insulin infusion but did not change 11beta-HSD1 mRNA or activity in sc adipose tissue, and insulin sensitization was unaffected by glucocorticoid blockade with a combination of metyrapone and RU38486."	5.12	Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men. ( Andrew, R; Homer, NZ; Karpe, F; Stimson, RH; Tan, GD; Wake, DJ; Walker, BR, 2007)
"Metyrapone treatment was associated with a significant decrease in plasma cortisol level; the cortisol nadir was 4."	2.71	Inhibition of cortisol biosynthesis decreases circulating leptin levels in obese humans. ( Dagogo-Jack, S; Tykodi, G; Umamaheswaran, I, 2005)

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	41 (87.23)	18.7374
1990's	1 (2.13)	18.2507
2000's	2 (4.26)	29.6817
2010's	3 (6.38)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Delivanis, DA	1
Athimulam, S	1
Bancos, I	1
Dey, A	1
Hao, S	1
Erion, JR	1
Wosiski-Kuhn, M	1
Stranahan, AM	1
Murphy, MO	1
Herald, JB	1
Wills, CT	1
Unfried, SG	1
Cohn, DM	1
Loria, AS	1
SIMKIN, B	1
ARCE, R	1
MESTMAN, JH	1
NELSON, DH	1
FERRARI, E	1
PIOTTI, LE	1
BENEDETTI, A	1
BUSONERA, G	1
GENOVA, R	1
OLIVI, O	1
BENATTI, C	1
PIETRAROSSA, N	1
SUMMERS, VK	1
SHEEHAN, HL	1
HIPKIN, LJ	1
DAVIS, JC	1
Dagogo-Jack, S	1
Tykodi, G	1
Umamaheswaran, I	1
Wake, DJ	1
Stimson, RH	1
Tan, GD	1
Homer, NZ	1
Andrew, R	1
Karpe, F	1
Walker, BR	1
Del Guercio, MJ	1
Pessina, S	1
Raux-Demay, MC	1
Girard, F	1
Wannarachue, N	1
Ruvalcaba, RH	1
Zurbrügg, RP	1
Croxson, MS	1
Hall, TD	1
Kletzky, OA	1
Jaramillo, JE	1
Nicoloff, JT	1
Neelon, FA	1
Goree, JA	1
Lebovitz, HE	1
Chmielowa, M	1
Walczak, M	1
Waligóra, A	1
Numano, A	1
Wynn, V	1
Bacchus, H	1
Weber, A	1
Gossmann, HH	1
Sako, T	1
Limaye, NR	1
Sarver, ME	1
Sabeh, G	3
Cohn, RE	1
Danowski, TS	3
Laron, Z	1
Karp, M	1
Nitzan, M	1
Pertzelan, A	1
Dondero, F	1
Negro, F	1
Isidori, A	1
Metcalf, MG	1
Angeli, A	1
Boccuzzi, G	1
Frairia, R	1
Bisbocci, D	1
Najjar, S	1
Ayash, MA	1
Tolis, G	1
Lewis, W	1
Verdy, M	1
Friesen, HG	1
Solomon, S	1
Pagalis, G	1
Pavlatos, F	1
Fessas, P	1
Rochefort, JG	1
Kley, HK	1
Krüskemper, HL	1
Laurent de Angulo, MS	1
van Gelderen, HH	1
Chen, R	1
Kenny, FM	3
Drash, AL	1
Nilsson, KO	1
Hökfelt, B	1
Laurian, L	1
Herzberg, M	1
Balas, L	1
Macmillan, DR	1
Kim, CB	1
Weisskopf, B	1
Haim, S	1
Benderly, A	1
Shafrir, A	1
Levy, J	1
Galli, V	1
Massolo, F	1
Fishman, MA	1
Peake, GT	1
Alley, RA	2
Narduzzi, JV	2
Weir, TF	1
McGowen, CH	1
Robbins, TJ	2
Tada, T	1
Garces, LY	1
Drash, A	1
Taylor, FH	1
Kreze, A	1
Lacková, E	1
Lisá, L	1
Jansa, M	1
Herbinger, W	2

Reviews

3 reviews available for metyrapone and Obesity

Article	Year
[METHODOLOGICAL DATA ON THE DYNAMIC EVALUATION OF THE DIENCEPHALON-ANTERIOR PITUITARY-ADRENAL CORTEX SYSTEM]. Archivio per le scienze mediche, 1964, Volume: 117 Topics: Acromegaly; Addison Disease; Adrenal Cortex; Adrenocorticotropic Hormone; Cushing Syndrome; Dexameth	1964
[Cushing syndrome in children]. Annales de pediatrie, 1993, Volume: 40, Issue:7 Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hor	1993
Hypothalamic-pituitary-adrenocortical regulation. A contribution to its assessment, development and disorders in infancy and childhood with special reference to plasma cortisol circadian rhythm. Monographs in paediatrics, 1976, Volume: 7 Topics: 17-Hydroxycorticosteroids; Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Anorexia Ner	1976

Trials

2 trials available for metyrapone and Obesity

Article	Year
Inhibition of cortisol biosynthesis decreases circulating leptin levels in obese humans. The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:9 Topics: Adult; Antimetabolites; C-Peptide; Circadian Rhythm; Cross-Over Studies; Female; Humans; Hydrocortis	2005
Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men. The Journal of clinical endocrinology and metabolism, 2007, Volume: 92, Issue:5 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adult; Aged; Cortisone; Cross-Over Studies; Double-Blin	2007

Other Studies

42 other studies available for metyrapone and Obesity

Article	Year
Modern Management of Mild Autonomous Cortisol Secretion. Clinical pharmacology and therapeutics, 2019, Volume: 106, Issue:6 Topics: 14-alpha Demethylase Inhibitors; Adrenal Cortex Neoplasms; Adrenal Insufficiency; Adrenalectomy; Adr	2019
Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes. Journal of neuroimmunology, 2014, Apr-15, Volume: 269, Issue:1-2 Topics: Animals; Diabetes Mellitus; Disease Models, Animal; Glucocorticoids; Inflammation Mediators; Male; M	2014
Postnatal treatment with metyrapone attenuates the effects of diet-induced obesity in female rats exposed to early-life stress. American journal of physiology. Endocrinology and metabolism, 2017, 02-01, Volume: 312, Issue:2 Topics: Animals; Animals, Newborn; Diet, High-Fat; Female; Male; Maternal Deprivation; Metyrapone; Obesity;	2017
Response of obese patients to an 11beta-hydroxylase inhibitor, methopyrapone (SU-4885). Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1962, Volume: 111 Topics: 17-Ketosteroids; Humans; Ketones; Metyrapone; Mixed Function Oxygenases; Obesity; Pyridines	1962
INHIBITION BY ESTROGEN ADMINISTRATION OF ADRENAL-PITUITARY RESPONSE TO METHOPYRAPONE. The Journal of clinical investigation, 1963, Volume: 42 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Diabetes Mellitus; Estrogens; Hypothyroidism; Ketones;	1963
[EFFECT OF A PROLONGED FAST ON HYPOPHYSIAL CORTICOTROPIN ACTIVITY IN SIMPLE OBESITY]. Minerva medica, 1964, Feb-21, Volume: 55 Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Fasting; Humans; Ketones; Metabolism; Metyrapone; Mine	1964
[PITUITARY-ADRENAL FUNCTION IN INFANTILE ESSENTIAL OBESITY. BIORHYTHM OF PLASMATIC CORTISOL AND THE METOPIRONE TEST]. Folia endocrinologica, 1964, Volume: 17 Topics: Adolescent; Blood Chemical Analysis; Child; Gigantism; Hydrocortisone; Ketones; Metyrapone; Mineralo	1964
DIFFERENTIAL DIAGNOSIS OF CUSHING'S SYNDROME AND OBESITY ASSOCIATED WITH STRIAE. Lancet (London, England), 1964, Nov-21, Volume: 2, Issue:7369 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Betamethasone; Cushing Synd	1964
[Changes in the urinary excretion of various corticosteroids induced by metopyrone in obese children]. Folia endocrinologica, 1966, Volume: 19, Issue:6 Topics: Adrenal Cortex Hormones; Child; Female; Humans; Male; Metyrapone; Obesity	1966
Hypogonadism in Prader-Willi syndrome. American journal of mental deficiency, 1975, Volume: 79, Issue:5 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Carbohyd	1975
Decreased serum thyrotropin induced by fasting. The Journal of clinical endocrinology and metabolism, 1977, Volume: 45, Issue:3 Topics: 17-Hydroxycorticosteroids; Adult; Fasting; Female; Humans; Hydrocortisone; Hypothyroidism; Iodine; M	1977
The primary empty sella: clinical and radiographic characteristics and endocrine function. Medicine, 1973, Volume: 52, Issue:1 Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Adult; Aged; Cholesterol; Female; Gonadotrop	1973
[ACTH reserve tests in obesity in childhood using the metopirone test]. Pediatria polska, 1966, Volume: 41, Issue:5 Topics: Adolescent; Adrenocorticotropic Hormone; Child; Child, Preschool; Female; Humans; Male; Metyrapone;	1966
[Study of urinary excretion of total 17-hydroxycorticosteroids among children. 3. Variations in urinary excretion of total 17-hydroxycorticosteroids by ACTH and metopirone loading in normal children and those with various diseases]. Nihon Shonika Gakkai zasshi. Acta paediatrica Japonica, 1966, Volume: 70, Issue:11 Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Asthma; Child, Preschool; Humans; Infant; Me	1966
The assessment of hypothalamic-pituitary-adrenocortical function in man. Proceedings of the Royal Society of Medicine, 1967, Volume: 60, Issue:9 Topics: Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Hydrocortisone; Insulin; Liver Diseas	1967
Sequential solvent extraction of urinary corticosteroids and its clinical application. Clinical chemistry, 1967, Volume: 13, Issue:10 Topics: 17-Hydroxycorticosteroids; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Adrenocorticotrop	1967
[Endoccinological changes as a result of obesity in juveniles]. Der Internist, 1968, Volume: 9, Issue:4 Topics: Adolescent; Adrenocorticotropic Hormone; Age Factors; Blood Glucose; Body Height; Body Weight; Cushi	1968
[Clinical studies on the stimulation and suppression of the pituitary-adrenocortical system. II. Studies on the pituitary-adrenocortical suppression test]. Nihon Naibunpi Gakkai zasshi, 1968, Dec-20, Volume: 44, Issue:9 Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Adult; C	1968
ACTH-excess and increased urinary pressor activity. Experimental medicine and surgery, 1967, Volume: 25, Issue:1 Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Biological Assay; Catechola	1967
The plasma 11-hydroxycorticosteroids responseto insulin-induced hypoglycaemia in children and adolescents. Acta endocrinologica, 1969, Volume: 60, Issue:3 Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Blood G	1969
[Pituitary corticotropin function in hypertonic obesity "with rose striae"]. Folia endocrinologica, 1970, Volume: 23, Issue:1 Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Diagnosis, Differential; Female; Humans; Hyper	1970
Rapid gas chromatographic assays for androsterone and etiocholanolone in urine. Clinical biochemistry, 1970, Volume: 3, Issue:4 Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amenorrhea; Androsterone; Chromatography, Gas; Dexam	1970
[Importance of the study of corticotropin circadian rhythm in the functional symptomatology of the ACTH-adrenal axis]. Minerva medica, 1974, Jun-16, Volume: 65, Issue:46 Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Anorexia Nervosa; Cir	1974
The Mauriac syndrome. Clinical pediatrics, 1974, Volume: 13, Issue:9 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Child; Depression, Chemical; Dexamethasone; Diabetes Mel	1974
Anterior pituitary function in the Prader-Labhart-Willi (PLW) syndrome. The Journal of clinical endocrinology and metabolism, 1974, Volume: 39, Issue:6 Topics: 17-Ketosteroids; Adolescent; Adult; Carbohydrate Metabolism, Inborn Errors; Chorionic Gonadotropin;	1974
[Performance and interpretation of a shortened metyrapone test]. Klinische Wochenschrift, 1972, Nov-15, Volume: 50, Issue:22 Topics: 11-Hydroxycorticosteroids; Acromegaly; Adolescent; Adult; Aged; Circadian Rhythm; Diabetes Mellitus;	1972
Comparative study of three tests for the assessment of hypothalamic-pituitary-adrenocortical function. Acta endocrinologica, 1972, Volume: 71, Issue:3 Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; Adolescent; Adrenal Glands; Adrenal Insufficie	1972
Cushing's disease in a boy: serial steroid and growth hormone studies. The Johns Hopkins medical journal, 1969, Volume: 125, Issue:3 Topics: 17-Hydroxycorticosteroids; Adrenalectomy; Arginine; Child; Cushing Syndrome; Dexamethasone; Diagnosi	1969
Influence of metyrapone on plasma concentrations of testosterone and androstenedione in man. Acta endocrinologica, 1971, Volume: 68, Issue:3 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Addison Disease; Administration, Oral; Adolescent; Adult	1971
Metopirone test in overweight subjects. Acta endocrinologica, 1966, Volume: 51, Issue:2 Topics: Adolescent; Adult; Female; Humans; Male; Metyrapone; Obesity	1966
Syndrome of growth resistance, obesity, and intellectual impairment with precocious puberty. Archives of disease in childhood, 1972, Volume: 47, Issue:251 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abnormalities, Multiple; Body Height; Body Weight; Child	1972
Alternate-day corticosteroid regimen. Dermatologica, 1971, Volume: 142, Issue:3 Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Glands; Adult; Aged; Body Weight; Child; Child, Presc	1971
[Evaluation of the function of the hypothalamus-hypophysis-adrenal gland system in obese children by means of the metopyrone and the lysine-8-vasopressin tests]. La Clinica pediatrica, 1969, Volume: 51, Issue:2 Topics: Adolescent; Adrenal Glands; Child; Child, Preschool; Fatty Acids, Nonesterified; Female; Humans; Hyd	1969
Paradoxical growth in a patient with the diencephalic syndrome. Pediatrics, 1970, Volume: 45, Issue:6 Topics: Arginine; Brain Neoplasms; Child; Child, Preschool; Diencephalon; Emaciation; Glioma; Glucose; Growt	1970
Hyperresponsiveness to metyrapone. Experimental medicine and surgery, 1967, Volume: 25, Issue:1 Topics: Adrenal Cortex Hormones; Anorexia Nervosa; Diabetes Mellitus; Growth; Growth Disorders; Humans; Hypo	1967
[Clinical studies on urinary 17-ketogenic steroid fractions. 3. SU-4885 test in normal subjects and the patients with various endocrine disorders]. Nihon Naibunpi Gakkai zasshi, 1968, Mar-20, Volume: 43, Issue:12 Topics: 17-Hydroxycorticosteroids; Acromegaly; Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland N	1968
Cortisol secretion rate during fasting of obese adolescent subjects. The Journal of clinical endocrinology and metabolism, 1968, Volume: 28, Issue:12 Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Glands; Child; Fasting; Female; Humans; Hydrocortison	1968
[Mutual relationship between obesity and hypertension. 3. Adrenocortical activity]. Bratislavske lekarske listy, 1968, Nov-05, Volume: 50, Issue:5 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Chromatography; Humans; Hypertension; Male; Methods; Met	1968
[Metopirone test in obese children]. Ceskoslovenska pediatrie, 1969, Volume: 24, Issue:1 Topics: 17-Hydroxycorticosteroids; Adolescent; Child; Female; Humans; Hypothalamo-Hypophyseal System; Male;	1969
Adrenocortical indices during fasting in obesity. The Journal of clinical endocrinology and metabolism, 1969, Volume: 29, Issue:3 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Body Weight; Corticos	1969
[Testing of pituitary-adrenocortical activity with metopirone in adiposis simplex]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1965, Volume: 71 Topics: Adrenal Glands; Adult; Female; Humans; Hydrocortisone; Metyrapone; Obesity; Pituitary Gland; Pituita	1965
[Testing of the hypophyseal-adrenal cortex activity with metopirone in adipositas simplex]. Wiener medizinische Wochenschrift (1946), 1966, Jun-18, Volume: 116, Issue:25 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Female; Humans; Metyrapone; Obesity; Pituitary-Adrenal F	1966