Page last updated: 2024-10-31

metyrapone and Neoplasms

metyrapone has been researched along with Neoplasms in 12 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"Imaging tests by CT/MRI identified the tumors in 8 of 16 (50%), in 4 of 11 (36%) and 4 of 6 (66."1.36Clinical features and management of ectopic ACTH syndrome at a single institute in Japan. ( Doi, M; Hirata, Y; Izumiyama, H; Sugiyama, T; Yoshimoto, T, 2010)
"The sensitivity of tumors to cyclophosphamide (CPA) and other anticancer prodrugs can be substantially enhanced by transduction of tumors with a prodrug-activating mammalian cytochrome P450 (CYP) enzyme in combination with the flavoenzyme P450 reductase."1.31Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors. ( Huang, Z; Waxman, DJ, 2001)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19909 (75.00)18.7374
1990's1 (8.33)18.2507
2000's1 (8.33)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Doi, M1
Sugiyama, T1
Izumiyama, H1
Yoshimoto, T1
Hirata, Y1
RIVADENEYRA, J1
MAGGIOLO, J1
CASTIGLIONI, CA1
OLIVIERI, E1
SOBOTA, JT1
REED, RJ1
WEST, CD1
KUMAGAI, LF1
SIMONS, EL1
DOMINGUEZ, OB1
BERLINER, DL1
KRIEGER, DT1
KOLODNY, H1
KRIEGER, HP1
BLEASEL, K1
LAZARUS, L1
Phlipponneau, M1
Lenne, F1
Proeschel, MF1
Girard, F1
Luton, JP1
Bertagna, X1
Huang, Z1
Waxman, DJ1
Stupfel, M1
Abe, K1
Gassel, WD1
Gerdes, H1
Littmann, KP1

Other Studies

12 other studies available for metyrapone and Neoplasms

ArticleYear
Clinical features and management of ectopic ACTH syndrome at a single institute in Japan.
    Endocrine journal, 2010, Volume: 57, Issue:12

    Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; Aged; Corticotropin-Releasing Hormone; D

2010
[INVESTIGATION OF THE BIOLOGICAL ACTIVITIES OF TRIAMCINOLONE DIACETATE IN PATIENTS WITH ADRENAL INSUFFICIENCY].
    Revista medica del Hospital General, 1964, Volume: 27

    Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenalectomy; Aldosterone; Blood; Blood Pressure; B

1964
[EXPLORATION OF THE ACTH HYPOPHYSEAL RESERVE WITH METOPIRONE IN DIFFERENT ENDOCRINOPATHIES].
    Anales de la Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay, 1963, Volume: 48

    Topics: 17-Ketosteroids; Acromegaly; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Clinical Lab

1963
MULTIPLE BRONCHIAL ADENOMAS, CUSHING'S SYNDROME AND HYPOKALEMIC ALKALOSIS. REPORT OF A CASE.
    Diseases of the chest, 1964, Volume: 46

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenalectomy; Adrenocorticotropic Hormone; Alk

1964
ADRENOCORTICAL CARCINOMA WITH FEMINIZATION AND HYPERTENSION ASSOCIATED WITH A DEFECT IN 11-BETA-HYDROXYLATION.
    The Journal of clinical endocrinology and metabolism, 1964, Volume: 24

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acne Vulgaris; Adrenal Cortex Hormones; Adrenal Gland Ne

1964
METHOPYRAPONE TESTS IN HYPOTHALAMIC-PITUITARY DISEASE.
    The Journal of clinical endocrinology and metabolism, 1964, Volume: 24

    Topics: Adrenocorticotropic Hormone; Brain Diseases; Brain Neoplasms; Diagnosis; Humans; Hypothalamic Diseas

1964
CRYOGENIC HYPOPHYSECTOMY.
    The Medical journal of Australia, 1965, Jul-24, Volume: 2, Issue:4

    Topics: Acromegaly; Betamethasone; Breast Neoplasms; Cryosurgery; Diabetic Retinopathy; Drug Therapy; Humans

1965
Plasma immunoreactive joining peptide in man: a new marker of proopiomelanocortin processing and corticotroph function.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:2

    Topics: Adrenocorticotropic Hormone; Adult; beta-Lipotropin; Chromatography, Gel; Circadian Rhythm; Dexameth

1993
Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors.
    Cancer gene therapy, 2001, Volume: 8, Issue:6

    Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Combined Modality Therapy; Cyclophosphamide

2001
Biorhythms in toxicology and pharmacology. I. Generalities, ultradian and circadian biorhythms.
    Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1975, Volume: 22, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Bacteria; Biological Clocks; Circadian Rhythm; Dexamethasone;

1975
[Correlation of ACTH and MSH in man].
    Nihon Naibunpi Gakkai zasshi, 1970, Volume: 46, Issue:8

    Topics: Addison Disease; Adrenocorticotropic Hormone; Cross Reactions; Cushing Syndrome; Hormones, Ectopic;

1970
[Case report on a female patient with 17- -hydroxylase deficiency].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1971, Volume: 77

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Androgen-Insensitivity Syndrome; Corticosteron

1971