metyrapone and Liver Neoplasms
metyrapone has been researched along with Liver Neoplasms in 6 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Liver Neoplasms: Tumors or cancer of the LIVER.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metyrapone treatment is therefore unlikely to result in the induction of CYP1A1 but may induce the expression of CYP3A4 in humans." | 1.31 | Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4. ( Harvey, JL; Maurel, P; Paine, AJ; Wright, MC, 2000) |
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Kondo, T | 1 |
| Matsuyama, R | 1 |
| Ashihara, H | 1 |
| Matsuo, Y | 1 |
| Sasaki, K | 1 |
| Goto, R | 1 |
| Ono, K | 1 |
| Takaki, Y | 1 |
| Honda, Y | 1 |
| Iyama, K | 1 |
| Kawashima, J | 1 |
| Motoshima, H | 1 |
| Tsuruzoe, K | 1 |
| Miyamura, N | 1 |
| Araki, E | 1 |
| Harvey, JL | 1 |
| Paine, AJ | 1 |
| Maurel, P | 1 |
| Wright, MC | 1 |
| Spence, RW | 1 |
| Burns-Cox, CJ | 1 |
| Fandrey, J | 1 |
| Seydel, FP | 1 |
| Siegers, CP | 1 |
| Jelkmann, W | 1 |
| Dearfield, KL | 1 |
| Jacobson-Kram, D | 1 |
| Huber, BE | 1 |
| Williams, JR | 1 |
| Lacassagne, A | 1 |
| Hurst, L | 1 |
Other Studies
6 other studies available for metyrapone and Liver Neoplasms
| Article | Year |
|---|---|
A case of ectopic adrenocorticotropic hormone-producing pancreatic neuroendocrine tumor with multiple liver metastases.
Topics: Adrenocorticotropic Hormone; Chemoembolization, Therapeutic; Female; Hormones, Ectopic; Humans; Hydr | 2010 |
Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Line; Cytochrome P-450 CYP1A1; Cytochrome P-450 | 2000 |
ACTH-secreting 'apudoma' of gallbladder.
Topics: Adenocarcinoma; Adrenocorticotropic Hormone; Adult; Autopsy; Cushing Syndrome; Dexamethasone; Diagno | 1975 |
Role of cytochrome P450 in the control of the production of erythropoietin.
Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoi | 1990 |
Induction of sister chromatid exchanges in human and rat hepatoma cell lines by cyclophosphamide and phosphoramide mustard and the effects of cytochrome P-450 inhibitors.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; | 1986 |
[Metopirone does not inhibit cancerization of the rat liver by p-dimethylaminoazobenzene].
Topics: Animals; In Vitro Techniques; Liver Neoplasms; Metyrapone; Neoplasms, Experimental; p-Dimethylaminoa | 1965 |