metyrapone has been researched along with Intraocular Pressure in 4 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the effect of a decrease in plasma cortisol level on intraocular pressure, 14 subjects with elevated ocular pressure were given oral metyrapone tartrate (an inhibitor of adrenal cortisol biosynthesis) and a placebo in a double-masked, two-period, crossover trial." | 5.06 | Decrease of ocular pressure with oral metyrapone. A double-masked crossover trial. ( Levi, L; Schwartz, B, 1987) |
| " This dosage resulted in partial adrenal suppression, manifested by reduced levels of plasma cortisol." | 1.26 | Topical corticosteroid therapy and pituitary-adrenal function. ( Becker, B; Krupin, T; Mandell, AI; Podos, SM, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schwartz, B | 2 |
| Wysocki, A | 1 |
| Qi, Y | 1 |
| Krupin, T | 1 |
| Mandell, AI | 1 |
| Podos, SM | 1 |
| Becker, B | 1 |
| Mito, T | 1 |
| Shiono, T | 1 |
| Kimura, R | 1 |
| Tamai, M | 1 |
| Levi, L | 1 |
2 trials available for metyrapone and Intraocular Pressure
| Article | Year |
|---|---|
The effect of oral metyrapone on aqueous humor dynamics in normal human eyes.
Topics: Administration, Oral; Adult; Anterior Chamber; Aqueous Humor; Female; Fluorophotometry; Humans; Hydr | 1990 |
Decrease of ocular pressure with oral metyrapone. A double-masked crossover trial.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Aged; Cortodoxone; Double-Blind Method; Drug Eval | 1987 |
2 other studies available for metyrapone and Intraocular Pressure
| Article | Year |
|---|---|
Decreased response of plasma cortisol to intravenous metyrapone in ocular hypertension and primary open-angle glaucoma.
Topics: Aged; Enzyme Inhibitors; Female; Glaucoma, Open-Angle; Humans; Hydrocortisone; Hypothalamo-Hypophyse | 2005 |
Topical corticosteroid therapy and pituitary-adrenal function.
Topics: Administration, Topical; Cortodoxone; Dexamethasone; Glaucoma; Humans; Hydrocortisone; Hypothalamus; | 1976 |