metyrapone has been researched along with Innate Inflammatory Response in 15 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metyrapone (MT) has been used clinically to decrease glucocorticoid levels in human and animal studies." | 5.36 | Evidence that metyrapone in the presence of inflammation modulates cytokine mRNA expression. ( Andersen, ML; Benatti, BB; Casati, MZ; Nociti, FH; Peruzzo, DC; Tufik, S, 2010) |
| "Metyrapone (MET) was used to inhibit GC synthesis, and RU486 to block GC actions." | 1.40 | Essential roles of endogenous glucocorticoids and TNF/TNFR1 in promoting bone-marrow eosinopoiesis in ovalbumin-sensitized, airway-challenged mice. ( Almeida da Silva, CL; Gaspar-Elsas, MI; Lopes, RS; Luz, RA; Masid-de-Brito, D; Queto, T; Vieira, BM; Xavier-Elsas, P, 2014) |
| "Metyrapone (MT) has been used clinically to decrease glucocorticoid levels in human and animal studies." | 1.36 | Evidence that metyrapone in the presence of inflammation modulates cytokine mRNA expression. ( Andersen, ML; Benatti, BB; Casati, MZ; Nociti, FH; Peruzzo, DC; Tufik, S, 2010) |
| "Acute hyperglycemia was induced by IP injection of dextrose 30 minutes before ischemia." | 1.33 | Why does acute hyperglycemia worsen the outcome of transient focal cerebral ischemia? Role of corticosteroids, inflammation, and protein O-glycosylation. ( Bargalló, N; Chamorro, A; Falcón, C; Martín, A; Planas, AM; Rojas, S, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Masid-de-Brito, D | 1 |
| Xavier-Elsas, P | 1 |
| Luz, RA | 1 |
| Queto, T | 1 |
| Almeida da Silva, CL | 1 |
| Lopes, RS | 1 |
| Vieira, BM | 1 |
| Gaspar-Elsas, MI | 1 |
| Zhang, S | 1 |
| Shen, Z | 1 |
| Hu, G | 1 |
| Liu, R | 1 |
| Zhang, X | 1 |
| Peruzzo, DC | 1 |
| Benatti, BB | 1 |
| Andersen, ML | 1 |
| Tufik, S | 1 |
| Casati, MZ | 1 |
| Nociti, FH | 1 |
| Vukelic, S | 1 |
| Stojadinovic, O | 1 |
| Pastar, I | 1 |
| Rabach, M | 1 |
| Krzyzanowska, A | 1 |
| Lebrun, E | 1 |
| Davis, SC | 1 |
| Resnik, S | 1 |
| Brem, H | 1 |
| Tomic-Canic, M | 1 |
| Strausbaugh, HJ | 2 |
| Green, PG | 2 |
| Dallman, MF | 2 |
| Levine, JD | 3 |
| RILEY, RF | 1 |
| COLEMAN, MK | 1 |
| HOKAMA, Y | 1 |
| Martín, A | 1 |
| Rojas, S | 1 |
| Chamorro, A | 1 |
| Falcón, C | 1 |
| Bargalló, N | 1 |
| Planas, AM | 1 |
| Miao, FJ | 1 |
| Jänig, W | 1 |
| Farsky, SP | 1 |
| Sannomiya, P | 2 |
| Garcia-Leme, J | 2 |
| Parnham, MJ | 1 |
| Bhattacharya, SK | 1 |
| Das, N | 1 |
| Rao, PJ | 1 |
| Anteghini, HJ | 1 |
| Vianna, ES | 1 |
| Kowalczyk-Bronisz, SH | 1 |
15 other studies available for metyrapone and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Essential roles of endogenous glucocorticoids and TNF/TNFR1 in promoting bone-marrow eosinopoiesis in ovalbumin-sensitized, airway-challenged mice.
Topics: Animals; Bone Marrow; Corticosterone; Eosinophilia; Eosinophils; Female; Glucocorticoids; Inflammati | 2014 |
Effects of endogenous glucocorticoids on allergic inflammation and T(H)1 /T(H)2 balance in airway allergic disease.
Topics: Animals; Bone Marrow; Cell Count; Concanavalin A; Corticosterone; Eosinophils; Glucocorticoids; Immu | 2009 |
Evidence that metyrapone in the presence of inflammation modulates cytokine mRNA expression.
Topics: Animals; Base Sequence; Biomarkers; Body Weight; Cytokines; DNA Primers; Gene Expression Profiling; | 2010 |
Cortisol synthesis in epidermis is induced by IL-1 and tissue injury.
Topics: Adrenocorticotropic Hormone; Animals; Enzyme Inhibitors; Epidermis; Hormones; Humans; Hydrocortisone | 2011 |
Repeated, non-habituating stress suppresses inflammatory plasma extravasation by a novel, sympathoadrenal dependent mechanism.
Topics: Adrenal Medulla; Adrenalectomy; Analysis of Variance; Animals; Body Weight; Bradykinin; Capillary Pe | 2003 |
EFFECTS OF DRUGS ON CX-PROTEIN RESPONSES IN THE RABBIT.
Topics: Adrenalectomy; Animals; Blood; C-Reactive Protein; Carbon Tetrachloride Poisoning; Inflammation; Lag | 1964 |
Why does acute hyperglycemia worsen the outcome of transient focal cerebral ischemia? Role of corticosteroids, inflammation, and protein O-glycosylation.
Topics: Adrenal Cortex Hormones; Animals; Antimetabolites; Disease Progression; Glycosylation; Hyperglycemia | 2006 |
Negative feedback neuroendocrine control of the inflammatory response in rats.
Topics: Adrenal Glands; Afferent Pathways; Animals; Arthritis, Experimental; Bradykinin; Electric Stimulatio | 1995 |
Secreted glucocorticoids regulate leukocyte-endothelial interactions in inflammation. A direct vital microscopic study.
Topics: Adrenalectomy; Animals; CD18 Antigens; Cell Adhesion; Cycloheximide; Dactinomycin; Endothelium, Vasc | 1995 |
Repeated, but not acute, stress suppresses inflammatory plasma extravasation.
Topics: Adrenocorticotropic Hormone; Animals; Bradykinin; Capillary Permeability; Corticosterone; Hypothalam | 1999 |
Metyrapone: a possible tool in investigating the role of endogenous corticosteroids in inflammation.
Topics: Adrenal Cortex Hormones; Animals; Chronic Disease; Female; In Vitro Techniques; Inflammation; Metyra | 1977 |
Effect of pre-existing inflammation on carrageenan-induced paw oedema in rats.
Topics: Adrenalectomy; Animals; Carrageenan; Edema; Hydroxydopamines; Inflammation; Male; Metyrapone; Oxidop | 1987 |
Involvement of lymphocytes in non-immune inflammation: dual effect of glucocorticoids.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Carrageenan; Glucocorticoids; Inflammation; Leukopenia; Lym | 1985 |
Glucosteroids in immunologically specific and nonspecific inflammatory processes.
Topics: Adrenalectomy; Animals; Arthritis; Benzene; Blood Cell Count; Brain; Carrageenan; Dermatitis, Contac | 1972 |