metyrapone has been researched along with Hypothyroidism in 23 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 58-yr-old woman had frequent hypoglycemic attacks, undetectable levels of plasma cortisol, ACTH, and beta-lipotropin, and deficient responses of these hormones after insulin induced-hypoglycemia and metyrapone." | 3.66 | Anaphylactic shock after synthetic adrenocorticotropin-(1-18) in a patient with isolated adrenocorticotropin and beta-lipotropin deficiency. ( Hashimoto, K; Ofuji, T; Takahara, J; Takaya, Y; Yunoki, S, 1980) |
| "Subnormal plasma 11-deoxycortisol (compound S) responses to metyrapone were found in patients with adrenal insufficiency or with Cushing syndrome caused by adrenal tumors and in those receiving long-term glucocorticoid or diphenylhydantoin sodium therapy." | 3.65 | Single-dose metyrapone test: review of a four-year experience. ( Jubiz, W; Meikle, AW; Spiger, M; Tylor, FH; West, CD, 1975) |
| "Hypothyroidism is known to lead to a certain degree of functional insufficiency of the adrenal gland by affecting both the hypophyseal axis and peripheral metabolism of cortisol." | 1.29 | [Hypothalamic-pituitary-adrenal function in primary hypothyroidism]. ( Bakiri, F; Benmiloud, M, 1994) |
| " Responses of LH and FSH to LH-RH improved markedly after a long term administration of LH-RH for a period of one month in 2 patients with gonadotropin deficiency." | 1.25 | Hypothalamic-pituitary functions in patients with idiopathic pituitary dwarfism. ( Demura, H; Demura, R; Jujo, K; Maeda, T; Odagiri, E; Shizume, K; Suda, T; Takano, K, 1975) |
| "In 17 patients with primary hypothyroidism, plasma TSH levels fell significantly during treatment to a mean of 54% of control (range 23-96%)." | 1.25 | The effect of glucocorticoids on thyrotropin secretion. ( Utiger, RD; Wilber, JF, 1969) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (95.65) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MESTMAN, JH | 1 |
| NELSON, DH | 1 |
| BLIZZARD, RM | 1 |
| TOUYABOGGIANO, JJ | 1 |
| MEDOC, J | 1 |
| SARVER, ME | 1 |
| SABEH, G | 1 |
| FETTERMAN, GH | 1 |
| WALD, N | 1 |
| DANOWSKI, TS | 1 |
| Davison, K | 1 |
| Roth, M | 1 |
| Gibson, A | 1 |
| KAPLAN, NM | 1 |
| Hashimoto, K | 1 |
| Takahara, J | 1 |
| Takaya, Y | 1 |
| Yunoki, S | 1 |
| Ofuji, T | 1 |
| Yoshida, T | 1 |
| Arai, T | 1 |
| Sugano, J | 1 |
| Yarita, H | 1 |
| Yanagisawa, H | 1 |
| Bakiri, F | 1 |
| Benmiloud, M | 1 |
| Weiss, RB | 1 |
| Yamamoto, T | 1 |
| Ogihara, T | 1 |
| Miyai, K | 1 |
| Kumahara, Y | 1 |
| Hirata, Y | 1 |
| Demura, R | 1 |
| Jujo, K | 1 |
| Takano, K | 1 |
| Odagiri, E | 1 |
| Maeda, T | 1 |
| Suda, T | 1 |
| Demura, H | 1 |
| Shizume, K | 1 |
| Croxson, MS | 1 |
| Hall, TD | 1 |
| Kletzky, OA | 1 |
| Jaramillo, JE | 1 |
| Nicoloff, JT | 1 |
| Spiger, M | 1 |
| Jubiz, W | 1 |
| Meikle, AW | 1 |
| West, CD | 1 |
| Tylor, FH | 1 |
| Siegel, ET | 1 |
| Kubo, N | 1 |
| Hasui, K | 1 |
| Spark, RF | 1 |
| Minozzi, M | 1 |
| Faggiano, M | 1 |
| Lombardi, G | 1 |
| Carella, C | 1 |
| Criscuolo, T | 1 |
| Oliver, C | 1 |
| Vague, P | 1 |
| Zachmann, M | 1 |
| Völlmin, JA | 1 |
| Zagalak, M | 1 |
| Kley, HK | 1 |
| Krüskemper, HL | 1 |
| Wilber, JF | 1 |
| Utiger, RD | 1 |
| Blunck, W | 1 |
| Bierich, JR | 1 |
23 other studies available for metyrapone and Hypothyroidism
| Article | Year |
|---|---|
INHIBITION BY ESTROGEN ADMINISTRATION OF ADRENAL-PITUITARY RESPONSE TO METHOPYRAPONE.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Diabetes Mellitus; Estrogens; Hypothyroidism; Ketones; | 1963 |
THE DIFFERENTIAL DIAGNOSIS AND TREATMENT OF SHORT STATURE AT ADOLESCENCE.
Topics: Adolescent; Body Height; Bone and Bones; Child; Diagnosis, Differential; Dwarfism; Estrogens; Glucos | 1964 |
[HYPOPHYSARY COMA IN SHEEHAN'S SYNDROME. ANATOMOCLINICAL STUDY].
Topics: Adrenal Insufficiency; Coma; Desoxycorticosterone; Diagnosis, Differential; Female; Humans; Hydrocor | 1963 |
FRACTIONAL HYPOPITUITARISM WITH GIANTISM AND NORMAL SELLA TURCICA.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Chromosome Aberrations; Fluids and Secretions; G | 1964 |
PREMATURELY AGED APPEARANCE AND SIMULATED ENDOCRINE DISORDER IN CHRONIC ANXIETY.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Anxi | 1964 |
METHOPYRAPONE TEST IN PRIMARY HYPOTHYROIDISM.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Diagnosis, Differential; Hypothyroidism; Keton | 1965 |
Anaphylactic shock after synthetic adrenocorticotropin-(1-18) in a patient with isolated adrenocorticotropin and beta-lipotropin deficiency.
Topics: Adrenocorticotropic Hormone; Anaphylaxis; beta-Lipotropin; Female; Humans; Hydrocortisone; Hypoglyce | 1980 |
Isolated ACTH deficiency accompanied by 'primary hypothyroidism' and hyperprolactinaemia.
Topics: Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Gonadotropin-Releasing Hormone; Humans | 1983 |
[Hypothalamic-pituitary-adrenal function in primary hypothyroidism].
Topics: Adrenocorticotropic Hormone; Adult; Autoimmune Diseases; Cosyntropin; Female; Humans; Hydrocortisone | 1994 |
Primary empty sella syndrome.
Topics: Adrenocorticotropic Hormone; Cerebrospinal Fluid Rhinorrhea; Humans; Hypopituitarism; Hypothyroidism | 1975 |
Co-existent primary hypothyroidism and isolated ACTH deficiency.
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Follicle Stimulating Hormone; Gonadotropin-Releasing H | 1976 |
Hypothalamic-pituitary functions in patients with idiopathic pituitary dwarfism.
Topics: Adolescent; Adult; Arginine; Child; Cortodoxone; Dwarfism, Pituitary; Follicle Stimulating Hormone; | 1975 |
Decreased serum thyrotropin induced by fasting.
Topics: 17-Hydroxycorticosteroids; Adult; Fasting; Female; Humans; Hydrocortisone; Hypothyroidism; Iodine; M | 1977 |
Single-dose metyrapone test: review of a four-year experience.
Topics: Adenoma, Chromophobe; Adolescent; Adrenal Cortex Neoplasms; Adrenal Gland Diseases; Adrenal Glands; | 1975 |
Assessment of pituitary-adrenal gland function in the dog.
Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Animals; Diabetes Mellitus; Do | 1968 |
[Fractional determination of 4 types of neutral steroid glucuronides (11-deoxy-C-19 steroid, 11-deoxy-C-21 steroid, 11-oxy-C-19 steroid, 11-oxy-C-21 steroid) and 3 types of steroid glucuronides (11-deoxy-neutral steroid, pregnanediol, 11-oxy-neutral stero
Topics: Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Castration; | 1969 |
[Diurnal variation of plasma cortisol concentration in patients with various diseases and negative feedback mechanism of the pituitary-adrenal axis].
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Central Nervous Sys | 1969 |
Simplified assessment of pituitary-adrenal reserve. Measurement of serum 11-deoxycortisol and cortisol after metyrapone.
Topics: Acromegaly; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Biotransformation; Child; Child, P | 1971 |
Somatotrophic and corticotrophic functions in primary hypothyroidism before and after thyroxine treatment.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arginine; Child; Female; Growth Ho | 1973 |
Urinary steroid dynamics after a single dose of metyrapone.
Topics: 17-Ketosteroids; Administration, Oral; Adolescent; Adrenocorticotropic Hormone; Adult; Child; Child, | 1974 |
[Performance and interpretation of a shortened metyrapone test].
Topics: 11-Hydroxycorticosteroids; Acromegaly; Adolescent; Adult; Aged; Circadian Rhythm; Diabetes Mellitus; | 1972 |
The effect of glucocorticoids on thyrotropin secretion.
Topics: Animals; Depression, Chemical; Dexamethasone; Humans; Hydrocortisone; Hypothyroidism; Metyrapone; Mi | 1969 |
[Differentiated evaluation of metopirone test by thin layer chromatography].
Topics: Addison Disease; Adrenal Cortex Hormones; Adult; Child; Child, Preschool; Chromatography, Thin Layer | 1968 |