metyrapone has been researched along with Hypokalemia in 18 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ruling out other causes, paraneoplastic hypercortisolism was diagnosed." | 1.51 | Hypokalaemic metabolic alkalosis, hypertension and diabetes: what is the link. ( Cathomas, R; Fehr, T; Kamber, N; Vögelin, M, 2019) |
| "Imaging tests by CT/MRI identified the tumors in 8 of 16 (50%), in 4 of 11 (36%) and 4 of 6 (66." | 1.36 | Clinical features and management of ectopic ACTH syndrome at a single institute in Japan. ( Doi, M; Hirata, Y; Izumiyama, H; Sugiyama, T; Yoshimoto, T, 2010) |
| "Aldosterone levels were subnormal but as yet there has been no evidence of overproduction of other mineralocorticoids by chemical analysis or by bioassay of plasma and urinary extracts." | 1.26 | A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. ( Bradlow, HL; Gunczler, P; Levine, LS; New, MI; Ramirez, LC; Rauh, W; Rösler, A; Ulick, S; Zanconato, G, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (77.78) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Saishouji, F | 1 |
| Maeda, S | 1 |
| Hamada, H | 1 |
| Kimura, N | 1 |
| Tamanoi, A | 1 |
| Nishida, S | 1 |
| Sakaguchi, M | 1 |
| Igata, M | 1 |
| Yokoo, K | 1 |
| Kawakami, F | 1 |
| Araki, E | 1 |
| Kondo, T | 1 |
| Pivonello, R | 1 |
| Simeoli, C | 1 |
| Di Paola, N | 1 |
| Colao, A | 1 |
| Vögelin, M | 1 |
| Cathomas, R | 1 |
| Kamber, N | 1 |
| Fehr, T | 1 |
| Doi, M | 1 |
| Sugiyama, T | 1 |
| Izumiyama, H | 1 |
| Yoshimoto, T | 1 |
| Hirata, Y | 1 |
| SOBOTA, JT | 1 |
| REED, RJ | 1 |
| MINDER, E | 1 |
| MARKOFF, NG | 1 |
| NEHER, R | 1 |
| KAHNT, FW | 1 |
| CRANE, MG | 1 |
| HARRIS, JJ | 1 |
| HERBER, R | 1 |
| Ulick, S | 1 |
| Levine, LS | 1 |
| Gunczler, P | 1 |
| Zanconato, G | 1 |
| Ramirez, LC | 1 |
| Rauh, W | 1 |
| Rösler, A | 1 |
| Bradlow, HL | 1 |
| New, MI | 2 |
| Stoner, E | 1 |
| DiMartino-Nardi, J | 1 |
| Cotonat, J | 1 |
| Mertens, HG | 1 |
| Lurati, M | 1 |
| Führ, J | 1 |
| Miura, K | 1 |
| Morimoto, Y | 1 |
| Hiwada, K | 1 |
| Nanahoshi, M | 1 |
| Yano, S | 1 |
| Kumagai, A | 1 |
| Yamamura, Y | 1 |
| Koto, K | 1 |
| Uda, H | 1 |
| Okano, K | 1 |
| Yamane, G | 1 |
| Streeten, DH | 1 |
| Speller, PJ | 1 |
| Koller, F | 1 |
| Thorens, B | 1 |
| Riondel, AM | 1 |
| Scholer, D | 1 |
| Colby, HD | 1 |
| Skelton, FR | 1 |
| Brownie, AC | 1 |
| Guinet, P | 1 |
| Mornex, R | 1 |
| Revol, A | 1 |
| Bertrand, J | 1 |
| Veyrat, A | 1 |
| Dorsit, G | 1 |
| Adlin, EV | 1 |
| Channick, BJ | 1 |
2 reviews available for metyrapone and Hypokalemia
| Article | Year |
|---|---|
Cushing's disease: adrenal steroidogenesis inhibitors.
Topics: Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Hypokalemia; Ketoconazole; Male; Mety | 2022 |
[Adrenal cortex function tests and their interpretation].
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Aldosterone; Androg | 1969 |
16 other studies available for metyrapone and Hypokalemia
| Article | Year |
|---|---|
Ectopic ACTH-producing neuroendocrine tumor occurring with large recurrent metastatic pheochromocytoma: a case report.
Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aged, 80 and over; Cat | 2022 |
Hypokalaemic metabolic alkalosis, hypertension and diabetes: what is the link.
Topics: Alkalosis; Cushing Syndrome; Diabetes Mellitus; Female; Humans; Hypertension; Hypokalemia; Metyrapon | 2019 |
Clinical features and management of ectopic ACTH syndrome at a single institute in Japan.
Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; Aged; Corticotropin-Releasing Hormone; D | 2010 |
MULTIPLE BRONCHIAL ADENOMAS, CUSHING'S SYNDROME AND HYPOKALEMIC ALKALOSIS. REPORT OF A CASE.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenalectomy; Adrenocorticotropic Hormone; Alk | 1964 |
[A SURGICALLY TREATED CASE OF CONN'S SYNDROME. CLINICAL, HISTOLOGICAL AND BIOCHEMICAL FINDINGS].
Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Alkalosis; Humans; Hyperal | 1964 |
PRIMARY ALDOSTERONISM DUE TO AN ADRENAL CARCINOMA.
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Alkalosis; Blood; Drug Therapy; Hyperaldosteronism | 1965 |
A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Aldosterone; Child; Cortisone; Humans; Hydro | 1979 |
Apparent mineralocorticoid excess causing hypertension and hypokalemia in children.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Aldosterone; Child; Child, Preschool; Female; Humans; Hydroco | 1986 |
[Influence of metopirone on the reactions of adaptation to water loading in the normal or adrenalectomized dog].
Topics: Adaptation, Physiological; Adrenalectomy; Animals; Diuresis; Dogs; Glucocorticoids; Hypokalemia; Hyp | 1967 |
Primary periodic paralysis associated with hyperkalemic and hypokalemic attacks and with hemolytic bilirubinemia.
Topics: Acetazolamide; Adolescent; Adrenocorticotropic Hormone; Adult; Aldosterone; Bilirubin; Dexamethasone | 1968 |
Cushing's syndrome caused by malignant tumor in the scrotum: clinical, pathologic and biochemical studies.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Rest Tumor; Adrenocorticotropic Hormone; Androst | 1971 |
The role of mineralocorticoids in the pathogenesis of hypokalemic periodic paralysis.
Topics: Adult; Aldosterone; Angiotensin II; Desoxycorticosterone; Humans; Hydrocortisone; Hyperaldosteronism | 1974 |
[Proceedings: Cushing's syndrome in hypernephroid carcinoma; normalization of the cortisol value, hypokalemia and hypertension under metopirone].
Topics: Adenocarcinoma; Cushing Syndrome; Humans; Hydrocortisone; Hypertension; Hypokalemia; Kidney Neoplasm | 1974 |
Metopirone-induced hypertension in the rat.
Topics: Adrenal Glands; Animals; Blood Pressure; Body Weight; Desoxycorticosterone; Female; Hypernatremia; H | 1970 |
[2 cases of Cushing's disease with a hypokalemic alkalosis syndrome].
Topics: Adrenalectomy; Adult; Alkalosis; Calcium; Cushing Syndrome; Female; Humans; Hypokalemia; Metyrapone; | 1967 |
Effects of prolonged inhibition of 11 beta-hydroxylase in the dog.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Animals; Blood; Blood Pressure; Chromatogr | 1966 |