metyrapone has been researched along with Hypertension in 57 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "All Wistar rats showed hypertension when they were given heat-stress and administered metyrapone (200 micrograms/kg/day), a cholesterol-11-beta-hydroxylase inhibitor." | 7.67 | [Hypertension in rats caused by metyrapone and heat-stress treatment]. ( Arakawa, K, 1985) |
| "The effect of 5 to 9 days of metyrapone administration (400 mg/m2 every 4 h) on aldosterone, deoxycorticosterone, plasma renin activity, electrolyte balance, and blood pressure was investigated in 2 normotensive siblings (one of whom showed limited ACTH reserve), in 3 patients with hypertension and dexamethasone-suppressible hyperaldosteronism, and in a hypertensive patient with primary hyperaldosteronism due to bilateral adrenal hyperplasia." | 7.66 | Mineralocorticoid and metabolic response to metyrapone on normotensive children and children with dexamethasone-suppressible and primary hyperaldosteronism. ( Levine, LS; New, MI; Sonino, N, 1981) |
| "Treatment with metyrapone thus appears a good therapy for AIMAH, but its effectiveness has not, to our knowledge, been studied." | 5.31 | Rational, effective metyrapone treatment of ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH). ( Nomura, K; Obara, T; Omori, K; Omori, N; Takano, K, 2001) |
| "To determine whether prenatal dietary protein deprivation results in a reduction in nephron number and hypertension in offspring by exposure to maternal glucocorticoids, we administered metyrapone to rats fed either a 6% or 20% protein diet to inhibit glucocorticoid production and compared the offspring to rats that were the product of mothers fed either a 6% or 20% protein diet during the last half of pregnancy." | 3.77 | Evidence that prenatal programming of hypertension by dietary protein deprivation is mediated by fetal glucocorticoid exposure. ( Baum, M; Gattineni, J; Habib, S; Twombley, K, 2011) |
| " Replacement of corticosterone during pregnancy had no effect upon the blood pressures and GPDH activities of male offspring, but it reversed the effects of metyrapone in female offspring." | 3.69 | Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis. ( Langley-Evans, SC, 1997) |
| "All Wistar rats showed hypertension when they were given heat-stress and administered metyrapone (200 micrograms/kg/day), a cholesterol-11-beta-hydroxylase inhibitor." | 3.67 | [Hypertension in rats caused by metyrapone and heat-stress treatment]. ( Arakawa, K, 1985) |
| "The effect of 5 to 9 days of metyrapone administration (400 mg/m2 every 4 h) on aldosterone, deoxycorticosterone, plasma renin activity, electrolyte balance, and blood pressure was investigated in 2 normotensive siblings (one of whom showed limited ACTH reserve), in 3 patients with hypertension and dexamethasone-suppressible hyperaldosteronism, and in a hypertensive patient with primary hyperaldosteronism due to bilateral adrenal hyperplasia." | 3.66 | Mineralocorticoid and metabolic response to metyrapone on normotensive children and children with dexamethasone-suppressible and primary hyperaldosteronism. ( Levine, LS; New, MI; Sonino, N, 1981) |
| "Chronic hypertension has been produced in mongrel dogs by the long-term oral administration of metyrapone (100 mg/kg per day)." | 3.65 | Multifactorial analysis of chronic hypertension induced by electrolyte-active steroids in trained, unanesthetized dogs. ( Bravo, EL; Dustan, HP; Tarazi, RC, 1977) |
| "The blood pressure elevation of primary aldosteronism is caused by excessive production of the known mineralocorticoid, aldosterone." | 2.64 | Are there unknown mineralocorticoids in low-renin essential hypertension? ( Hollifield, JW; Island, DP; Liddle, GW; Sennett, JA; Slaton, PE; Wilson, HM; Yarbro, L, 1977) |
| "Ruling out other causes, paraneoplastic hypercortisolism was diagnosed." | 1.51 | Hypokalaemic metabolic alkalosis, hypertension and diabetes: what is the link. ( Cathomas, R; Fehr, T; Kamber, N; Vögelin, M, 2019) |
| "BLA = bilateral adrenalectomy CD = Cushing disease CS = Cushing syndrome eCRF = electronic case report form MRI = magnetic resonance imaging PCOS = polycystic ovary syndrome." | 1.46 | BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY. ( Ayala, A; Biller, BMK; Bonert, V; Broder, MS; Carmichael, JD; Cherepanov, D; Eagan, M; Geer, EB; Gordon, MB; Hannoush, Z; Katznelson, L; Lalazar, Y; Lee, J; Manuylova, E; Neary, MP; Pulaski-Liebert, KJ; Said, Q; Shafiq, I; Surampudi, V; Swerdloff, RS, 2017) |
| "The baby girl underwent medical treatment of Cushing's syndrome with metyrapone which was followed by a rapid recovery." | 1.42 | Neonatal McCune-Albright syndrome with systemic involvement: a case report. ( Dias, P; Gouveia, R; Lourenço, R; Oliveira, G; Sousa, AB, 2015) |
| "Imaging tests by CT/MRI identified the tumors in 8 of 16 (50%), in 4 of 11 (36%) and 4 of 6 (66." | 1.36 | Clinical features and management of ectopic ACTH syndrome at a single institute in Japan. ( Doi, M; Hirata, Y; Izumiyama, H; Sugiyama, T; Yoshimoto, T, 2010) |
| "Treatment with metyrapone thus appears a good therapy for AIMAH, but its effectiveness has not, to our knowledge, been studied." | 1.31 | Rational, effective metyrapone treatment of ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH). ( Nomura, K; Obara, T; Omori, K; Omori, N; Takano, K, 2001) |
| "The hypothesis that hyperaldosteronism is not the sole cause of hypertension in dexamethasone-suppressible hyperaldosteronsim was tested in an 18-year-old male." | 1.26 | Evidence for an unidentified ACTH-induced steroid hormone causing hypertension. ( Levine, LS; New, MI; Peterson, RE; Saenger, P, 1976) |
| "The hypertension was alleviated by the administeration of dexamethasone in 2 of 3 patients with 17 alpha-hydroxylase deficiency." | 1.26 | Hypertension induced by adrenocortical dysfunction--hypertension in 17 alpha-hydroxylase deficiency and metopirone-induced hypertension. ( Kato, E; Kitajima, W; Kondo, K; Konishi, K; Matsuki, S; Nakamura, R; Ohguro, T; Oka, M; Ozawa, Y; Saito, I; Saruta, T; Yamagami, K, 1978) |
| "Aldosterone levels were subnormal but as yet there has been no evidence of overproduction of other mineralocorticoids by chemical analysis or by bioassay of plasma and urinary extracts." | 1.26 | A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. ( Bradlow, HL; Gunczler, P; Levine, LS; New, MI; Ramirez, LC; Rauh, W; Rösler, A; Ulick, S; Zanconato, G, 1979) |
| "The Metyrapone-treated animals developed severe hypertension with greatly elevated serum creatin phosphokinase, glucose, BUN and cholesterol levels." | 1.26 | Metyrapone-induced cardiovascular degenerative changes in non-arteriosclerotic and arteriosclerotic rats. ( Greenberg, BP; Wexler, BC, 1978) |
| "Medroxyprogesterone (MPA) is a progestin with no clinically detectable estrogenic and androgenic properties used in the treatment of sexual precocity." | 1.25 | Adverse effects of large doses of medroxyprogesterone (MPA) in idiopathic isosexual precocity. ( French, FS; Richman, RA; Underwood, LE; Van Wyk, JJ, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (77.19) | 18.7374 |
| 1990's | 2 (3.51) | 18.2507 |
| 2000's | 3 (5.26) | 29.6817 |
| 2010's | 7 (12.28) | 24.3611 |
| 2020's | 1 (1.75) | 2.80 |
| Authors | Studies |
|---|---|
| Nemoto, T | 1 |
| Nakakura, T | 1 |
| Kakinuma, Y | 1 |
| Geer, EB | 1 |
| Shafiq, I | 1 |
| Gordon, MB | 1 |
| Bonert, V | 1 |
| Ayala, A | 1 |
| Swerdloff, RS | 1 |
| Katznelson, L | 1 |
| Lalazar, Y | 1 |
| Manuylova, E | 1 |
| Pulaski-Liebert, KJ | 1 |
| Carmichael, JD | 1 |
| Hannoush, Z | 1 |
| Surampudi, V | 1 |
| Broder, MS | 1 |
| Cherepanov, D | 1 |
| Eagan, M | 1 |
| Lee, J | 1 |
| Said, Q | 1 |
| Neary, MP | 1 |
| Biller, BMK | 1 |
| Vögelin, M | 1 |
| Cathomas, R | 1 |
| Kamber, N | 1 |
| Fehr, T | 1 |
| Delivanis, DA | 1 |
| Athimulam, S | 1 |
| Bancos, I | 1 |
| Ito, K | 1 |
| Hirooka, Y | 1 |
| Sunagawa, K | 1 |
| Lourenço, R | 1 |
| Dias, P | 1 |
| Gouveia, R | 1 |
| Sousa, AB | 1 |
| Oliveira, G | 1 |
| Habib, S | 1 |
| Gattineni, J | 1 |
| Twombley, K | 1 |
| Baum, M | 1 |
| Doi, M | 1 |
| Sugiyama, T | 1 |
| Izumiyama, H | 1 |
| Yoshimoto, T | 1 |
| Hirata, Y | 1 |
| Vozarova, B | 1 |
| Weyer, C | 1 |
| Snitker, S | 1 |
| Gautier, JF | 1 |
| Cizza, G | 1 |
| Chrousos, G | 1 |
| Ravussin, E | 1 |
| Tataranni, PA | 1 |
| TORIGAI, T | 1 |
| FUKUCHI, S | 2 |
| HANADA, M | 1 |
| TAKAHASHI, H | 1 |
| IDEMURA, H | 1 |
| KUMAGAI, T | 1 |
| ARMASCRUZ, R | 1 |
| GOMEZ, R | 1 |
| MARDONES, J | 1 |
| PLAZADELOSREYES, M | 1 |
| HOFFMEISTER, W | 1 |
| WEST, CD | 1 |
| KUMAGAI, LF | 1 |
| SIMONS, EL | 1 |
| DOMINGUEZ, OB | 1 |
| BERLINER, DL | 1 |
| RAPP, JP | 1 |
| CRANE, MG | 1 |
| HARRIS, JJ | 1 |
| HERBER, R | 1 |
| Shibata, H | 1 |
| Haruyama, K | 1 |
| Yamazaki, M | 1 |
| Toki, T | 1 |
| Oberfield, SE | 1 |
| Levine, LS | 4 |
| Carey, RM | 1 |
| Greig, F | 1 |
| Ulick, S | 2 |
| New, MI | 6 |
| Nakamura, J | 1 |
| Yakata, M | 1 |
| Sonino, N | 1 |
| Langley-Evans, SC | 1 |
| Omori, N | 1 |
| Nomura, K | 1 |
| Omori, K | 1 |
| Takano, K | 1 |
| Obara, T | 1 |
| Peterson, RE | 1 |
| Saenger, P | 1 |
| Honda, M | 1 |
| Ueda, Y | 1 |
| Tsuchiya, M | 1 |
| Izumi, Y | 1 |
| Watanabe, H | 1 |
| Shiratsuchi, T | 1 |
| Hatano, M | 1 |
| Saruta, T | 1 |
| Nakamura, R | 1 |
| Saito, I | 1 |
| Kondo, K | 1 |
| Ohguro, T | 1 |
| Yamagami, K | 1 |
| Kitajima, W | 1 |
| Oka, M | 1 |
| Konishi, K | 1 |
| Ozawa, Y | 1 |
| Kato, E | 1 |
| Matsuki, S | 1 |
| Gunczler, P | 1 |
| Zanconato, G | 1 |
| Ramirez, LC | 1 |
| Rauh, W | 1 |
| Rösler, A | 1 |
| Bradlow, HL | 1 |
| Hollifield, JW | 1 |
| Slaton, PE | 1 |
| Wilson, HM | 1 |
| Sennett, JA | 1 |
| Yarbro, L | 1 |
| Island, DP | 1 |
| Liddle, GW | 2 |
| Wexler, BC | 1 |
| Greenberg, BP | 1 |
| Tarazi, RC | 2 |
| Bravo, EL | 1 |
| Dustan, HP | 1 |
| Loewenstein, JE | 1 |
| Kolebinov, N | 1 |
| Grigorova-Racheva, R | 1 |
| Vasileva, B | 1 |
| Kishi, K | 1 |
| Kinouchi, T | 1 |
| Shimizu, N | 1 |
| Yoshida, H | 1 |
| Stoner, E | 1 |
| DiMartino-Nardi, J | 1 |
| Connell, JM | 1 |
| Cordiner, J | 1 |
| Davies, DL | 1 |
| Fraser, R | 1 |
| Frier, BM | 1 |
| McPherson, SG | 1 |
| Arakawa, K | 1 |
| Temple, TE | 1 |
| Nagano, T | 1 |
| Miura, K | 2 |
| Miura, S | 1 |
| Hasui, K | 1 |
| Seaman, MP | 1 |
| Tamura, M | 1 |
| Richman, RA | 1 |
| Underwood, LE | 1 |
| French, FS | 1 |
| Van Wyk, JJ | 1 |
| Schaison, G | 1 |
| Okamoto, K | 1 |
| Koller, F | 1 |
| Thorens, B | 1 |
| Riondel, AM | 1 |
| Scholer, D | 1 |
| Kley, HK | 1 |
| Krüskemper, HL | 1 |
| Kellen, JA | 1 |
| Torikai, T | 1 |
| Marks, AD | 2 |
| Adlin, EV | 2 |
| Channick, BJ | 3 |
| Colby, HD | 2 |
| Skelton, FR | 2 |
| Brownie, AC | 1 |
| Tuft, L | 1 |
| Kreze, A | 1 |
| Brownie, A | 1 |
| Nickerson, PA | 1 |
| Molteni, A | 1 |
| Gallant, S | 1 |
8 reviews available for metyrapone and Hypertension
| Article | Year |
|---|---|
[DRUGS INHIBITING ALDOSTERONE SECRETION AND ALDOSTERONE ANTAGONISTS].
Topics: Aldosterone; Edema; Heparinoids; Hypertension; Ketones; Metyrapone; Mineralocorticoid Receptor Antag | 1963 |
[Corticosterone-producing adrenal tumor].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Corticosterone; Diagnosis, Differential; Humans; Hy | 2006 |
Hemodynamic role of extracellular fluid in hypertension.
Topics: Animals; Blood Volume; Cardiac Output; Disease Models, Animal; Extracellular Space; Hemodynamics; Ho | 1976 |
Inhibitors of adrenal steroid biosynthesis.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Aminoglutethimide | 1970 |
[Adrenal cortex function tests and their interpretation].
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Aldosterone; Androg | 1969 |
[New endocrine disorders attracting current interest--adrenal system].
Topics: Addison Disease; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocorticotropic Ho | 1969 |
Spontaneous hypertension in rats.
Topics: Adrenal Medulla; Animals; Antihypertensive Agents; Aorta; Arteries; Autonomic Agents; Body Weight; C | 1969 |
[Aspect of hormones and hypertension].
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Age Factors; Aged; Aldosterone; Blood Pressure; Catechol | 1969 |
2 trials available for metyrapone and Hypertension
| Article | Year |
|---|---|
Effect of cortisol on muscle sympathetic nerve activity in Pima Indians and Caucasians.
Topics: Adult; Anti-Inflammatory Agents; Cross-Over Studies; Enzyme Inhibitors; Humans; Hydrocortisone; Hype | 2003 |
Are there unknown mineralocorticoids in low-renin essential hypertension?
Topics: Aminoglutethimide; Blood Pressure; Clinical Trials as Topic; Humans; Hyperaldosteronism; Hypertensio | 1977 |
47 other studies available for metyrapone and Hypertension
| Article | Year |
|---|---|
Elevated blood pressure in high-fat diet-exposed low birthweight rat offspring is most likely caused by elevated glucocorticoid levels due to abnormal pituitary negative feedback.
Topics: Animals; Birth Weight; Blood Pressure; Corticosterone; Diet, High-Fat; Feedback, Physiological; Fema | 2020 |
BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY.
Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectom | 2017 |
Hypokalaemic metabolic alkalosis, hypertension and diabetes: what is the link.
Topics: Alkalosis; Cushing Syndrome; Diabetes Mellitus; Female; Humans; Hypertension; Hypokalemia; Metyrapon | 2019 |
Modern Management of Mild Autonomous Cortisol Secretion.
Topics: 14-alpha Demethylase Inhibitors; Adrenal Cortex Neoplasms; Adrenal Insufficiency; Adrenalectomy; Adr | 2019 |
Corticosterone-activated mineralocorticoid receptor contributes to salt-induced sympathoexcitation in pressure overload mice.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Adrenalectomy; Aldosterone; Animals; Corticosterone; Hy | 2014 |
Neonatal McCune-Albright syndrome with systemic involvement: a case report.
Topics: Cafe-au-Lait Spots; Cushing Syndrome; Diagnosis, Differential; Failure to Thrive; Fatal Outcome; Fem | 2015 |
Evidence that prenatal programming of hypertension by dietary protein deprivation is mediated by fetal glucocorticoid exposure.
Topics: Animals; Blood Pressure; Dexamethasone; Diet, Protein-Restricted; Female; Fetus; Hypertension; Kidne | 2011 |
Clinical features and management of ectopic ACTH syndrome at a single institute in Japan.
Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; Aged; Corticotropin-Releasing Hormone; D | 2010 |
[NATRIURETIC DRUGS].
Topics: Acetazolamide; Aldosterone; Ascites; Chlorothiazide; Dexamethasone; Diabetes Insipidus; Diuresis; Di | 1963 |
[PATHOPHYSIOLOGY AND CLINICAL ASPECTS OF SECONDARY ALDOSTERONISM AND ITS TREATMENT].
Topics: Adrenocorticotropic Hormone; Aldosterone; Ascites; Body Fluids; Classification; Dexamethasone; Extra | 1964 |
ADRENOCORTICAL CARCINOMA WITH FEMINIZATION AND HYPERTENSION ASSOCIATED WITH A DEFECT IN 11-BETA-HYDROXYLATION.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acne Vulgaris; Adrenal Cortex Hormones; Adrenal Gland Ne | 1964 |
EFFECT OF AN ALDOSTERONE ANTAGONIST ON ELECTROLYTES AND JUXTAGLOMERULAR GRANULARITY IN ADRENAL REGENERATION HYPERTENSION.
Topics: Adrenal Glands; Angiotensins; Blood; Blood Pressure; Electrolytes; Hypertension; Juxtaglomerular App | 1964 |
PRIMARY ALDOSTERONISM DUE TO AN ADRENAL CARCINOMA.
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Alkalosis; Blood; Drug Therapy; Hyperaldosteronism | 1965 |
Two cases of low-renin hypertension thought to be due to excessive secretion of unknown mineralocorticoid.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aldosterone; Blood P | 1982 |
Metabolic and blood pressure responses to hydrocortisone in the syndrome of apparent mineralocorticoid excess.
Topics: Adrenocorticotropic Hormone; Aldosterone; Blood Pressure; Child; Female; Humans; Hydrocortisone; Hyd | 1983 |
Clinical evaluation of the liquid-chromatographic determination of urinary free cortisol.
Topics: Adolescent; Adrenal Gland Diseases; Adult; Age Factors; Chromatography, High Pressure Liquid; Dexame | 1983 |
Mineralocorticoid and metabolic response to metyrapone on normotensive children and children with dexamethasone-suppressible and primary hyperaldosteronism.
Topics: Aldosterone; Child; Desoxycorticosterone; Electrolytes; Female; Humans; Hyperaldosteronism; Hyperten | 1981 |
Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis.
Topics: Animals; Blood Pressure; Corticosterone; Diet, Protein-Restricted; Female; Glucocorticoids; Glycerol | 1997 |
Rational, effective metyrapone treatment of ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH).
Topics: Adrenal Glands; Cushing Syndrome; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Humans; Hydrocortiso | 2001 |
Evidence for an unidentified ACTH-induced steroid hormone causing hypertension.
Topics: 18-Hydroxydesoxycorticosterone; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aldoste | 1976 |
Pathogenesis of essential hypertension with low renin: responses of plasma renin activity to various stimulation tests in essential hypertension.
Topics: Adrenocorticotropic Hormone; Adult; Angiotensin II; Circadian Rhythm; Dexamethasone; Humans; Hyperte | 1978 |
Hypertension induced by adrenocortical dysfunction--hypertension in 17 alpha-hydroxylase deficiency and metopirone-induced hypertension.
Topics: Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Animals; Cushing Syndrome; Deso | 1978 |
A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Aldosterone; Child; Cortisone; Humans; Hydro | 1979 |
Metyrapone-induced cardiovascular degenerative changes in non-arteriosclerotic and arteriosclerotic rats.
Topics: Adrenal Glands; Animals; Arteries; Arteriosclerosis; Blood Urea Nitrogen; Body Weight; Cardiovascula | 1978 |
Multifactorial analysis of chronic hypertension induced by electrolyte-active steroids in trained, unanesthetized dogs.
Topics: Acebutolol; Aldosterone; Animals; Chronic Disease; Clonidine; Corticosterone; Diet, Sodium-Restricte | 1977 |
Testing adrenal function--1975.
Topics: Adolescent; Adrenal Cortex Function Tests; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal | 1975 |
[Changes in the corticosteroids and their alpha-ketol metabolites in the urine of hypertension patients treated with metopirons].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aldosterone; Circadian Rhythm; Cortodoxone; Desoxycortic | 1975 |
[Animal models of various hypertensions].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenocorticotropic Hormone; Androgens; Angiotensin II; Animals; C | 1992 |
[Clinical significance of serum 11-deoxycorticosterone analysis in endocrine tests of the adrenal cortex].
Topics: Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Desoxycorticosterone; Dexamethasone; Hum | 1989 |
Apparent mineralocorticoid excess causing hypertension and hypokalemia in children.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Aldosterone; Child; Child, Preschool; Female; Humans; Hydroco | 1986 |
Pregnancy complicated by Cushing's syndrome: potential hazard of metyrapone therapy. Case report.
Topics: Adult; Cushing Syndrome; Female; Humans; Hypertension; Metyrapone; Pregnancy; Pregnancy Complication | 1985 |
[Hypertension in rats caused by metyrapone and heat-stress treatment].
Topics: Animals; Brain; Disease Models, Animal; Dopamine; Hot Temperature; Hypertension; Male; Metyrapone; P | 1985 |
[Urinary excretion of pregnanetriol in various internal diseases].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Hyperplasia, Congenital; Adrenalecto | 1966 |
[Diurnal variation of plasma cortisol concentration in patients with various diseases and negative feedback mechanism of the pituitary-adrenal axis].
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Central Nervous Sys | 1969 |
Secretion rates of cortisol and aldosterone precursors in various forms of congenital adrenal hyperplasia.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hor | 1970 |
[Adrenal function in urological patients].
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adu | 1971 |
Adverse effects of large doses of medroxyprogesterone (MPA) in idiopathic isosexual precocity.
Topics: Adrenal Glands; Adrenal Insufficiency; Adrenocorticotropic Hormone; Body Height; Body Weight; Bone D | 1971 |
[Late-appearing congenital adrenal hyperplasia. Apropos of 3 cases of 11 beta hydroxylase deficiency].
Topics: Adrenal Gland Diseases; Adrenocorticotropic Hormone; Adult; Androgens; Dexamethasone; Female; Hirsut | 1974 |
[Proceedings: Cushing's syndrome in hypernephroid carcinoma; normalization of the cortisol value, hypokalemia and hypertension under metopirone].
Topics: Adenocarcinoma; Cushing Syndrome; Humans; Hydrocortisone; Hypertension; Hypokalemia; Kidney Neoplasm | 1974 |
[Performance and interpretation of a shortened metyrapone test].
Topics: 11-Hydroxycorticosteroids; Acromegaly; Adolescent; Adult; Aged; Circadian Rhythm; Diabetes Mellitus; | 1972 |
Failure of metopirone to protect rats from adrenal hypertension induced by 7,12-dimethylbenz (alpha) anthracene.
Topics: Adrenal Glands; Animals; Benz(a)Anthracenes; Female; Hyperplasia; Hypertension; Hypertrophy; Mammary | 1973 |
Effect of metyrapone on plasma renin activity in dogs.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Dexamethasone; Diet, Sodium-Restricted; Disease Model | 1971 |
Metopirone-induced hypertension in the rat.
Topics: Adrenal Glands; Animals; Blood Pressure; Body Weight; Desoxycorticosterone; Female; Hypernatremia; H | 1970 |
Long-term corticosteroid therapy in chronic intractable asthmatic patients.
Topics: 17-Hydroxycorticosteroids; Adult; Aged; Asthma; Blood Coagulation Tests; Blood Glucose; Body Weight; | 1971 |
[Mutual relationship between obesity and hypertension. 3. Adrenocortical activity].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Chromatography; Humans; Hypertension; Male; Methods; Met | 1968 |
Adrenal cortical dysfunction as a basis for experimental hypertensive disease.
Topics: Adrenal Glands; Adrenocortical Hyperfunction; Anabolic Agents; Androgens; Animals; Blood Pressure; F | 1969 |
Effects of prolonged inhibition of 11 beta-hydroxylase in the dog.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Animals; Blood; Blood Pressure; Chromatogr | 1966 |