metyrapone has been researched along with Hyperplasia in 49 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A diagnosis of preclinical Cushing's disease was made, and she was treated with 11-hydroxylase inhibitor metyrapone." | 5.34 | Preclinical Cushing's disease characterized by massive adrenal hyperplasia and hormonal changes after three years of metyrapone therapy. ( Nomura, K; Ohmori, K; Ohmori, N; Takano, K, 2007) |
| "Treatment with metyrapone thus appears a good therapy for AIMAH, but its effectiveness has not, to our knowledge, been studied." | 5.31 | Rational, effective metyrapone treatment of ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH). ( Nomura, K; Obara, T; Omori, K; Omori, N; Takano, K, 2001) |
| "Aldosterone excretion was high, normal, or low in each of the three types of Cushing's syndrome." | 5.26 | Deoxycorticosterone and aldosterone excretion in Cushing's syndrome. ( Cassar, J; Joplin, GF; Kelly, WF; Loizou, S; Mashiter, K, 1980) |
| "Subnormal plasma 11-deoxycortisol (compound S) responses to metyrapone were found in patients with adrenal insufficiency or with Cushing syndrome caused by adrenal tumors and in those receiving long-term glucocorticoid or diphenylhydantoin sodium therapy." | 3.65 | Single-dose metyrapone test: review of a four-year experience. ( Jubiz, W; Meikle, AW; Spiger, M; Tylor, FH; West, CD, 1975) |
| "A diagnosis of preclinical Cushing's disease was made, and she was treated with 11-hydroxylase inhibitor metyrapone." | 1.34 | Preclinical Cushing's disease characterized by massive adrenal hyperplasia and hormonal changes after three years of metyrapone therapy. ( Nomura, K; Ohmori, K; Ohmori, N; Takano, K, 2007) |
| "Treatment with metyrapone thus appears a good therapy for AIMAH, but its effectiveness has not, to our knowledge, been studied." | 1.31 | Rational, effective metyrapone treatment of ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH). ( Nomura, K; Obara, T; Omori, K; Omori, N; Takano, K, 2001) |
| "Familial Cushing's syndrome is rare, and when it occurs, it is usually associated with primary micronodular dysplasia." | 1.29 | Familial adrenocorticotropin-independent Cushing's syndrome with bilateral macronodular adrenal hyperplasia. ( Aron, DC; Engeland, WC; Findlay, JC; Sheeler, LR, 1993) |
| "Aldosterone excretion was high, normal, or low in each of the three types of Cushing's syndrome." | 1.26 | Deoxycorticosterone and aldosterone excretion in Cushing's syndrome. ( Cassar, J; Joplin, GF; Kelly, WF; Loizou, S; Mashiter, K, 1980) |
| "Six nonadrenalectomized patients with pituitary tumors showed similar abnormalities of ACTH regulation." | 1.25 | Studies of ACTH secretion control in 116 cases of Cushing's syndrome. ( Binoux, M; Girard, F; Gourmelen, M; Luton, JP; Raux, MC, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (87.76) | 18.7374 |
| 1990's | 3 (6.12) | 18.2507 |
| 2000's | 2 (4.08) | 29.6817 |
| 2010's | 1 (2.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yoshida, M | 1 |
| Umeda, H | 1 |
| Iwama, S | 1 |
| Nakayama, S | 1 |
| Miyata, M | 1 |
| Ogawa, K | 1 |
| Maeda, H | 1 |
| Oiso, Y | 1 |
| CLEVELAND, WW | 1 |
| NIKEZIC, M | 1 |
| MIGEON, CJ | 1 |
| QUENUM, A | 1 |
| SOLA, OH | 1 |
| VILANOVA, D | 1 |
| HOFFMAN, C | 1 |
| KOSANIK, M | 1 |
| WAINER, AC | 1 |
| Ohmori, N | 1 |
| Nomura, K | 2 |
| Ohmori, K | 1 |
| Takano, K | 2 |
| Mahesh, VB | 1 |
| McDonough, PG | 1 |
| Greenblatt, RB | 1 |
| Cassar, J | 1 |
| Loizou, S | 1 |
| Kelly, WF | 1 |
| Mashiter, K | 1 |
| Joplin, GF | 1 |
| Findlay, JC | 1 |
| Sheeler, LR | 1 |
| Engeland, WC | 1 |
| Aron, DC | 1 |
| Hayashi, Y | 1 |
| Takeda, Y | 1 |
| Kaneko, K | 1 |
| Koyama, H | 1 |
| Aiba, M | 1 |
| Ikeda, U | 1 |
| Shimada, K | 1 |
| Omori, N | 1 |
| Omori, K | 1 |
| Obara, T | 1 |
| Besser, GM | 1 |
| Jeffcoate, WJ | 1 |
| Raux, MC | 1 |
| Binoux, M | 3 |
| Luton, JP | 2 |
| Gourmelen, M | 1 |
| Girard, F | 3 |
| Delaney, JP | 1 |
| Solomkin, JS | 1 |
| Jacobson, ME | 1 |
| Doe, RP | 1 |
| Dluhy, RG | 1 |
| Spiger, M | 1 |
| Jubiz, W | 2 |
| Meikle, AW | 2 |
| West, CD | 2 |
| Tylor, FH | 1 |
| Menéndez Torre, EL | 1 |
| López Carballo, MT | 1 |
| Rodríguez Erdozain, R | 1 |
| Urbieta Echezarreta, M | 1 |
| Lafita Tejedor, J | 1 |
| Forga Llenas, L | 1 |
| Makino, S | 1 |
| Hashimoto, K | 2 |
| Sugiyama, M | 1 |
| Hirasawa, R | 1 |
| Takao, T | 1 |
| Ota, Z | 2 |
| Saegusa, M | 1 |
| Ohashi, T | 2 |
| Omori, H | 2 |
| Watanobe, H | 1 |
| Kawagishi, T | 1 |
| Hirai, Y | 1 |
| Sato, T | 1 |
| Tsutsui, M | 1 |
| Kamata, Y | 1 |
| Takebe, K | 2 |
| Kawada, Y | 1 |
| Murakami, K | 1 |
| Hattori, T | 1 |
| Suemaru, S | 1 |
| Kageyama, J | 1 |
| Hayata, S | 1 |
| Del Conte, E | 1 |
| Giusti, G | 1 |
| Toccafondi, R | 1 |
| Tarquini, B | 1 |
| Brackett, NC | 1 |
| Koppel, M | 1 |
| Randall, RE | 1 |
| Nixon, WP | 1 |
| Materazzi, F | 1 |
| Minozzi, M | 1 |
| Faggiano, M | 1 |
| Salerno, M | 1 |
| Lombardi, G | 1 |
| Nunziata, V | 1 |
| Sparks, LL | 1 |
| Smilo, RP | 1 |
| Pavlatos, FC | 1 |
| Forsham, PH | 1 |
| Bethge, H | 1 |
| Bayer, JM | 1 |
| Winkelmann, W | 1 |
| Mozziconacci, P | 1 |
| Rayyis, SS | 2 |
| Bethune, JE | 2 |
| Weiss, ER | 1 |
| Nelson, DH | 1 |
| New, MI | 1 |
| Seaman, MP | 1 |
| Hall, R | 1 |
| Smith, PA | 1 |
| Harkness, RA | 1 |
| Smart, GA | 1 |
| Imura, H | 1 |
| Matsukura, S | 1 |
| Gourmelen-Combourieu, M | 1 |
| Pham-Huu-Trung, MT | 1 |
| Tyler, FH | 1 |
| Silvestrini, F | 1 |
| D'Alonzo, R | 1 |
| Donald, RA | 1 |
| Espiner, EA | 1 |
| Beaven, DW | 1 |
| Schaison, G | 1 |
| Steinbeck, AW | 1 |
| Theile, HM | 1 |
| Choi, Y | 1 |
| Werk, EE | 1 |
| Sholiton, LJ | 1 |
| Franks, RC | 1 |
| Poulsen, JE | 1 |
| Asfeldt, VH | 1 |
| Kellen, JA | 1 |
| Sizonenko, PC | 1 |
| Doret, AM | 1 |
| Riondel, AM | 1 |
| Paunier, L | 1 |
| Sendrail, M | 1 |
| Gleizes, L | 1 |
| Sendrail-Pesqué, M | 1 |
| Chkili, T | 1 |
| Fabre, MT | 1 |
| Vassal, D | 1 |
| Matthews, JI | 1 |
| Fariss, BL | 1 |
| Chertow, BS | 1 |
| Howard, WB | 1 |
| Tietze, HU | 1 |
| Zurbrugg, R | 1 |
| Zuppinger, K | 1 |
| Joss, E | 1 |
| Käser, H | 1 |
| Tada, T | 1 |
| Adlin, EV | 1 |
| Channick, BJ | 1 |
1 review available for metyrapone and Hyperplasia
| Article | Year |
|---|---|
[ACTH--how to read its figures].
Topics: Addison Disease; Adrenocorticotropic Hormone; Biological Assay; Blood Chemical Analysis; Circadian R | 1971 |
1 trial available for metyrapone and Hyperplasia
| Article | Year |
|---|---|
Experience with a rapid oral metyrapone test and the plasma ACTH content in determining the cause of Cushing's syndrome.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Diseases; Adrenal Gla | 1969 |
47 other studies available for metyrapone and Hyperplasia
| Article | Year |
|---|---|
Assessment of long-term efficacy and safety of metyrapone monotherapy in a patient with ACTH-independent macronodular adrenal hyperplasia.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aged; Cushing Syndrome; Dose-Response Relationship, Dru | 2012 |
Response to an 11beta-hydroxylase inhibitor (SU-4885) in males with adrenal hyperplasia and in their parents.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Enzyme Inhibitors; Humans; Hyperplasia; Male; Metyr | 1962 |
[ACTION OF METOPIRONE (SU-4885) ON THE PITUITARY-ADRENOCORTICAL AXIS OF CRICETOMYS GAMBIANUS].
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Ascorbic Acid; Histology; Hyperplasia; Hypertrophy; Lip | 1964 |
[ADRENAL CORTEX HYPERPLASIA ASSOCIATED WITH HYPERTROPHY OF THE THYMUS GLAND AND ACANTHOSIS NIGICANS IN A CHILD].
Topics: Acanthosis Nigricans; Adrenal Cortex; Adrenal Gland Diseases; Adrenocortical Hyperfunction; Adrenoco | 1964 |
Preclinical Cushing's disease characterized by massive adrenal hyperplasia and hormonal changes after three years of metyrapone therapy.
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adrenal Glands; Adrenocorticotropic Hormone; Aged; Antime | 2007 |
Endocrine studies in a patient with virilism, ovarian stromal hyperplasia, and endometrial carcinoma.
Topics: Adult; Androgens; Carcinoma; Dexamethasone; Endometrium; Estrogens; Female; Humans; Hyperplasia; Hys | 1967 |
Deoxycorticosterone and aldosterone excretion in Cushing's syndrome.
Topics: Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenal Glands; Adult; Aged; Aldosterone; Carcinoma; | 1980 |
Familial adrenocorticotropin-independent Cushing's syndrome with bilateral macronodular adrenal hyperplasia.
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormon | 1993 |
A case of Cushing's syndrome due to ACTH-independent bilateral macronodular hyperplasia associated with excessive secretion of mineralocorticoids.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aged; Aldosterone; Cushing Syndrome; Dexamethasone; Glu | 1998 |
Rational, effective metyrapone treatment of ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH).
Topics: Adrenal Glands; Cushing Syndrome; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Humans; Hydrocortiso | 2001 |
Endocrine and metabolic diseases. Adrenal diseases.
Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Insuffici | 1976 |
Studies of ACTH secretion control in 116 cases of Cushing's syndrome.
Topics: Adrenal Gland Diseases; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Biological Assay; Cushi | 1975 |
Surgical management of Cushing's syndrome.
Topics: Adenoma; Adolescent; Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocorticotropic Ho | 1978 |
Adrenal function testing.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Horm | 1978 |
Single-dose metyrapone test: review of a four-year experience.
Topics: Adenoma, Chromophobe; Adolescent; Adrenal Cortex Neoplasms; Adrenal Gland Diseases; Adrenal Glands; | 1975 |
[ACTH-independent Cushing's syndrome due to bilateral macronodular adrenal hyperplasia with empty sella turcica and anterior panhypopituitarism].
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aged; Cushing Syndrome; Empty Sella Syndrome; Humans; H | 1992 |
Cushing's syndrome due to huge nodular adrenocortical hyperplasia with fluctuation of urinary 17-OHCS excretion.
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex; Cushing Syndrome; Dexamethasone; Humans; Hydrocortisone; | 1989 |
Cushing's syndrome presenting the coexistence of a pituitary corticotrophic cell hyperplasia and a unilateral functional adrenal adenoma.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Circadian Rhythm; Cush | 1985 |
Cortisol responsiveness to insulin-induced hypoglycemia in Cushing's syndrome with huge nodular adrenocortical hyperplasia.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Angiotensin II; Arginine Vasopressin; Circadian Rhythm; | 1986 |
The corticotroph cells of the anterior pituitary gland of a reptile: Cnemidophorus l. lemniscatus (Sauria, Teiidae).
Topics: Adrenocorticotropic Hormone; Animals; Hyperplasia; Hypertrophy; Lizards; Male; Metyrapone; Pituitary | 1969 |
Nycthemeral rhythm of plasma cortisol levels in the Cushing's syndrome associated with hyperplasia of adrenal cortex, before and after treatment of hypophyseal suppression with ultrasonic technique.
Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Adult; Circadian Rhy | 1967 |
Hyperplasia of the juxtaglomerular complex with secondary aldosteronism without hypertension (Bartter's syndrome).
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Aldosterone; Ammonium Chloride; Angiotensin II; Bicarb | 1968 |
[Reichstein's S substance in humans].
Topics: Adenocarcinoma; Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; A | 1966 |
[Functional exploration of the adrenal cortex in basal and dynamic conditions in hypercorticism of the Cushing type].
Topics: 17-Ketosteroids; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocortical Hyperfu | 1968 |
Diagnosis of Cushing's syndrome. The differentiation between adrenocortical hyperplasia and adrenocrotical adenoma by means of lysine-vasopressin.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone | 1969 |
[Problems raised by fluorometric determination of plasma cortisol in congenital hyperplasia of adrenal glands].
Topics: Adrenal Gland Diseases; Adrenocorticotropic Hormone; Child; Child, Preschool; Chromatography; Chroma | 1969 |
Radioimmunoassayable ACTH in dexamethasone nonsuppressible Cushing's syndrome.
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Chemistry, Clinical; Cushing Syndr | 1969 |
Evaluation of stimulation and suppression tests in the etiological diagnosis of Cushing's syndrome.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Ang | 1969 |
Secretion rates of cortisol and aldosterone precursors in various forms of congenital adrenal hyperplasia.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hor | 1970 |
A study of the parents of patients with congenital adrenal hyperplasia: detection of the heterozygote.
Topics: Adrenal Gland Diseases; Adrenocorticotropic Hormone; Female; Genes, Recessive; Heterozygote; Humans; | 1970 |
[Study of plasma ACTH in 100 human lysine-vasopressin tests].
Topics: Addison Disease; Adolescent; Adrenal Gland Diseases; Adrenal Glands; Adrenalectomy; Adrenocorticotro | 1971 |
Dilantin and metyrapone: a clinically significant example of enzyme induction.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Animals; Depression, Chemical; Endoplasmic R | 1970 |
[Behavior of adrenocorticotropic internal secretions in Cushing's syndrome].
Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Circadian Rhythm; Cu | 1970 |
Measurement of pituitary hormones: clinical applications. 2. Corticotrophin.
Topics: Addison Disease; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Circadian Rhythm; Cushing Synd | 1972 |
[Late-appearing congenital adrenal hyperplasia. Apropos of 3 cases of 11 beta hydroxylase deficiency].
Topics: Adrenal Gland Diseases; Adrenocorticotropic Hormone; Adult; Androgens; Dexamethasone; Female; Hirsut | 1974 |
The adrenal cortex (excluding aldosteronism).
Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex; Adrenal Gland Diseases; Adrenal Glands; Adrenocort | 1974 |
Cushing's syndrome with dual pituitary-adrenal control.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Cushin | 1970 |
Screening tests for congenital adrenal hyperplasia.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Binding | 1972 |
Diagnostic and therapeutic problems in spontaneous Cushing's syndrome. A review with five case reports.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenalectomy; Adult; Circadian Rhythm; | 1972 |
Temporal rhythm in the response of urinary 17-OHCS to metopirone in Cushing's syndrome due to bilateral adrenal hyperplasia.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Circadian Rhythm; Cushing Syndrome; Feedback; Female; Hum | 1973 |
Failure of metopirone to protect rats from adrenal hypertension induced by 7,12-dimethylbenz (alpha) anthracene.
Topics: Adrenal Glands; Animals; Benz(a)Anthracenes; Female; Hyperplasia; Hypertension; Hypertrophy; Mammary | 1973 |
Cushing's syndrome due to bilateral adrenal cortical hyperplasia in a 13-year old girl: successful treatment with op'DDD'.
Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Gland Diseases; Body Height; Body Weig | 1974 |
[Attempted experimental chronic block of adrenal cortex hormone synthesis during growth].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal | 1969 |
Adrenal adenoma with variable response to dexamethasone suppression and metyrapone stimulation.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocortical Hyperfun | 1972 |
[Cortisol regulation in childhood hypoglycemia with adrenal medulla dysfunction].
Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenal Medulla; | 1970 |
[Clinical studies on urinary 17-ketogenic steroid fractions. 3. SU-4885 test in normal subjects and the patients with various endocrine disorders].
Topics: 17-Hydroxycorticosteroids; Acromegaly; Adenoma; Adolescent; Adrenal Cortex Hormones; Adrenal Gland N | 1968 |
Effects of prolonged inhibition of 11 beta-hydroxylase in the dog.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Animals; Blood; Blood Pressure; Chromatogr | 1966 |