Page last updated: 2024-10-31

metyrapone and Hirsutism

metyrapone has been researched along with Hirsutism in 20 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Hirsutism: A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.

Research Excerpts

ExcerptRelevanceReference
"BLA = bilateral adrenalectomy CD = Cushing disease CS = Cushing syndrome eCRF = electronic case report form MRI = magnetic resonance imaging PCOS = polycystic ovary syndrome."1.46BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY. ( Ayala, A; Biller, BMK; Bonert, V; Broder, MS; Carmichael, JD; Cherepanov, D; Eagan, M; Geer, EB; Gordon, MB; Hannoush, Z; Katznelson, L; Lalazar, Y; Lee, J; Manuylova, E; Neary, MP; Pulaski-Liebert, KJ; Said, Q; Shafiq, I; Surampudi, V; Swerdloff, RS, 2017)
"Metyrapone was used in the long-term management of 13 patients with pituitary-dependent bilateral adrenal hyperplasia (Cushing's disease)."1.26Metyrapone in long-term management of Cushing's disease. ( Besser, GM; Edwards, CR; Jeffcoate, WJ; Jones, AE; Rees, LH; Tomlin, S, 1977)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199018 (90.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Geer, EB1
Shafiq, I1
Gordon, MB1
Bonert, V1
Ayala, A1
Swerdloff, RS1
Katznelson, L1
Lalazar, Y1
Manuylova, E1
Pulaski-Liebert, KJ1
Carmichael, JD1
Hannoush, Z1
Surampudi, V1
Broder, MS1
Cherepanov, D1
Eagan, M1
Lee, J1
Said, Q1
Neary, MP1
Biller, BMK1
Syed, AA1
Demssi, YN1
KLEINFELDER, H1
HUSMAN, F1
IORI, E1
Moore, A1
Magee, F1
Cunningham, S1
Culliton, M1
McKenna, TJ3
Tourniaire, J2
Pugeat, M1
Darsy, P1
Forest, MG1
de Peretti, E1
Bertrand, J1
Jeffcoate, WJ1
Rees, LH1
Tomlin, S1
Jones, AE1
Edwards, CR1
Besser, GM1
Van't Hoff, W1
Bicknell, EJ1
Horrocks, PM1
Fleetwood, JA2
Inthuprapa, M1
Hall, R2
Lorber, DL1
Rabinowitz, D1
Maroulis, GB1
Manlimos, FS1
Garza, R1
Abraham, GE1
Cunningham, SK1
Loughlin, T1
Bertagna, X1
Girard, F1
Fehér, T1
Few, JD1
Limaye, NR1
Sarver, ME1
Sabeh, G1
Cohn, RE1
Danowski, TS1
Metcalf, MG1
Schaison, G1
Leigh, RJ1
Smith, PA1
Tamm, J1
Voigt, KD1
Tuft, L1
Marks, AD1
Channick, BJ1

Other Studies

20 other studies available for metyrapone and Hirsutism

ArticleYear
BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2017, Volume: 23, Issue:8

    Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectom

2017
Medical image. Adrenocortical carcinoma presenting with hirsutism: an uncommon cause of a common complaint.
    The New Zealand medical journal, 2014, Mar-07, Volume: 127, Issue:1390

    Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Antimetabolites; Diagnosis, Differential; Fatal

2014
[THE EXCRETION OF ADRENAL CORTEX STEROIDS IN PATIENTS WITH HIRSUTISM AFTER ORAL ADMINISTRATION OF METOPIRON].
    Klinische Wochenschrift, 1963, Dec-01, Volume: 41

    Topics: 17-Ketosteroids; Administration, Oral; Adrenal Cortex; Adrenal Cortex Hormones; Androsterone; Etioch

1963
[CONTRIBUTION TO THE FUNCTIONAL STUDY OF THE PITUITARY-ADRENAL AXIS WITH METHOPYRAPONE (2-METHYL-1,2-BIS(3-PYRIDYL)-1-PROPANONE)].
    Endocrinologia e scienza della costituzione, 1964, Volume: 28

    Topics: Adolescent; Adrenal Glands; Adrenocortical Hyperfunction; Child; Cushing Syndrome; Hirsutism; Humans

1964
Adrenal abnormalities in idiopathic hirsutism.
    Clinical endocrinology, 1983, Volume: 18, Issue:4

    Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Function Tests; Adrenal Glands; Adrenocorticotropic Hormon

1983
Strategic approach of hyperandrogenism in women.
    Hormone research, 1983, Volume: 18, Issue:1-3

    Topics: Adrenocorticotropic Hormone; Androgens; Catheterization; Chorionic Gonadotropin; Dehydroepiandroster

1983
[Comparison of plasma testosterone (T), androstenedione (A) and dhea variations after métopirone in 10 normal and 12 hirsute women (author's transl)].
    Annales d'endocrinologie, 1977, Volume: 38, Issue:6

    Topics: Administration, Oral; Androstenedione; Dehydroepiandrosterone; Female; Hirsutism; Humans; Metyrapone

1977
Metyrapone in long-term management of Cushing's disease.
    British medical journal, 1977, Jul-23, Volume: 2, Issue:6081

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Hirsutism; Humans; Male; M

1977
Urinary pregnanetriol excretion in hirsutism.
    Clinica chimica acta; international journal of clinical chemistry, 1977, Oct-15, Volume: 80, Issue:2

    Topics: Adrenalectomy; Adrenocorticotropic Hormone; Adult; Female; Hirsutism; Humans; Metyrapone; Middle Age

1977
Plasma pregnenolone and 17-OH-pregnenolone in hirsute amenorrhoeic patients.
    Acta endocrinologica, 1978, Volume: 87, Issue:3

    Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticot

1978
Serum cortisol and 11-desoxycortisol levels in hirsute premenopausal women.
    Obstetrics and gynecology, 1976, Volume: 48, Issue:4

    Topics: 17-Hydroxycorticosteroids; Adult; Chromatography; Cortodoxone; Female; Hirsutism; Humans; Hydrocorti

1976
Plasma pro-opiomelanocortin fragments and adrenal steroids following administration of metyrapone to normal and hirsute women.
    Journal of endocrinological investigation, 1988, Volume: 11, Issue:4

    Topics: Administration, Oral; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androstenedion

1988
Epiandrosterone excretion in man.
    The Journal of endocrinology, 1967, Volume: 38, Issue:3

    Topics: 17-Ketosteroids; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Cushing Syndrome; Fem

1967
A simple method for the separate estimation of 11-deoxy and 11-oxygenated 17-hydroxycortico-steroids in human urine.
    The Journal of endocrinology, 1968, Volume: 41, Issue:2

    Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adr

1968
ACTH-excess and increased urinary pressor activity.
    Experimental medicine and surgery, 1967, Volume: 25, Issue:1

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Biological Assay; Catechola

1967
Rapid gas chromatographic assays for androsterone and etiocholanolone in urine.
    Clinical biochemistry, 1970, Volume: 3, Issue:4

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amenorrhea; Androsterone; Chromatography, Gas; Dexam

1970
[Late-appearing congenital adrenal hyperplasia. Apropos of 3 cases of 11 beta hydroxylase deficiency].
    Annales de medecine interne, 1974, Volume: 125, Issue:2

    Topics: Adrenal Gland Diseases; Adrenocorticotropic Hormone; Adult; Androgens; Dexamethasone; Female; Hirsut

1974
Evidence for an underlying adrenocortical abnormality in hirsute women.
    Clinical endocrinology, 1974, Volume: 3, Issue:4

    Topics: Adrenal Cortex Function Tests; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Female; Hirsutism

1974
The effect of metopirone on the urinary excretion of testosterone and epitestosterone in normal males treated with HCG or cyproterone and in hirsute females.
    Acta endocrinologica, 1971, Volume: 67, Issue:1

    Topics: Adolescent; Adult; Androgen Antagonists; Chorionic Gonadotropin; Female; Hirsutism; Humans; Male; Me

1971
Long-term corticosteroid therapy in chronic intractable asthmatic patients.
    Annals of allergy, 1971, Volume: 29, Issue:6

    Topics: 17-Hydroxycorticosteroids; Adult; Aged; Asthma; Blood Coagulation Tests; Blood Glucose; Body Weight;

1971