metyrapone has been researched along with Heroin Dependence in 4 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Heroin Dependence: Strong dependence or addiction, both physiological and emotional, upon HEROIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In contrast to exaggerated HPA axis responsiveness reported in untreated heroin dependence, response to metyrapone was subnormal in heroin addicts maintained on buprenorphine." | 9.13 | Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence. ( Barr, CS; Heilig, M; Kakko, J; Lidström, J; Svanborg, KD; von Wachenfeldt, J, 2008) |
| "In contrast to exaggerated HPA axis responsiveness reported in untreated heroin dependence, response to metyrapone was subnormal in heroin addicts maintained on buprenorphine." | 5.13 | Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence. ( Barr, CS; Heilig, M; Kakko, J; Lidström, J; Svanborg, KD; von Wachenfeldt, J, 2008) |
| "The metyrapone test was administered to 15 former heroin addicts: 10 (8 male, 2 female) in steady-state methadone maintenance therapy (30 to 90 mg/d) and 5 (3 male, 2 female) in the final phase of a slow methadone dose reduction procedure (0 to 10 mg/d)." | 1.28 | Metyrapone-induced withdrawal symptoms. ( Hartman, N; Kennedy, JA; Khuri, E; Kreek, MJ; Sbriglio, R, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kakko, J | 1 |
| von Wachenfeldt, J | 1 |
| Svanborg, KD | 1 |
| Lidström, J | 1 |
| Barr, CS | 1 |
| Heilig, M | 1 |
| Schluger, JH | 1 |
| Borg, L | 1 |
| Ho, A | 1 |
| Kreek, MJ | 2 |
| Vescovi, PP | 1 |
| Gerra, G | 1 |
| Maninetti, L | 1 |
| Pedrazzoni, M | 1 |
| Michelini, M | 1 |
| Pioli, G | 1 |
| Girasole, G | 1 |
| Caccavari, R | 1 |
| Maestri, D | 1 |
| Passeri, M | 1 |
| Kennedy, JA | 1 |
| Hartman, N | 1 |
| Sbriglio, R | 1 |
| Khuri, E | 1 |
1 trial available for metyrapone and Heroin Dependence
| Article | Year |
|---|---|
Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence.
Topics: Adult; Affect; Asparagine; Buprenorphine; DNA Mutational Analysis; Drug Interactions; Enzyme Inhibit | 2008 |
3 other studies available for metyrapone and Heroin Dependence
| Article | Year |
|---|---|
Altered HPA axis responsivity to metyrapone testing in methadone maintained former heroin addicts with ongoing cocaine addiction.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Cocaine-Related Disorders; Female; Heroin Dependence | 2001 |
Metyrapone effects on beta-endorphin, ACTH and cortisol levels after chronic opiate receptor stimulation in man.
Topics: Adrenocorticotropic Hormone; Adult; beta-Endorphin; Heroin Dependence; Humans; Hydrocortisone; Male; | 1990 |
Metyrapone-induced withdrawal symptoms.
Topics: Adult; Female; Heroin Dependence; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Meth | 1990 |