Page last updated: 2024-10-31

metyrapone and Heroin Dependence

metyrapone has been researched along with Heroin Dependence in 4 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Heroin Dependence: Strong dependence or addiction, both physiological and emotional, upon HEROIN.

Research Excerpts

ExcerptRelevanceReference
"In contrast to exaggerated HPA axis responsiveness reported in untreated heroin dependence, response to metyrapone was subnormal in heroin addicts maintained on buprenorphine."9.13Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence. ( Barr, CS; Heilig, M; Kakko, J; Lidström, J; Svanborg, KD; von Wachenfeldt, J, 2008)
"In contrast to exaggerated HPA axis responsiveness reported in untreated heroin dependence, response to metyrapone was subnormal in heroin addicts maintained on buprenorphine."5.13Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence. ( Barr, CS; Heilig, M; Kakko, J; Lidström, J; Svanborg, KD; von Wachenfeldt, J, 2008)
"The metyrapone test was administered to 15 former heroin addicts: 10 (8 male, 2 female) in steady-state methadone maintenance therapy (30 to 90 mg/d) and 5 (3 male, 2 female) in the final phase of a slow methadone dose reduction procedure (0 to 10 mg/d)."1.28Metyrapone-induced withdrawal symptoms. ( Hartman, N; Kennedy, JA; Khuri, E; Kreek, MJ; Sbriglio, R, 1990)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kakko, J1
von Wachenfeldt, J1
Svanborg, KD1
Lidström, J1
Barr, CS1
Heilig, M1
Schluger, JH1
Borg, L1
Ho, A1
Kreek, MJ2
Vescovi, PP1
Gerra, G1
Maninetti, L1
Pedrazzoni, M1
Michelini, M1
Pioli, G1
Girasole, G1
Caccavari, R1
Maestri, D1
Passeri, M1
Kennedy, JA1
Hartman, N1
Sbriglio, R1
Khuri, E1

Trials

1 trial available for metyrapone and Heroin Dependence

ArticleYear
Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence.
    Biological psychiatry, 2008, Jan-15, Volume: 63, Issue:2

    Topics: Adult; Affect; Asparagine; Buprenorphine; DNA Mutational Analysis; Drug Interactions; Enzyme Inhibit

2008

Other Studies

3 other studies available for metyrapone and Heroin Dependence

ArticleYear
Altered HPA axis responsivity to metyrapone testing in methadone maintained former heroin addicts with ongoing cocaine addiction.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 24, Issue:5

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Cocaine-Related Disorders; Female; Heroin Dependence

2001
Metyrapone effects on beta-endorphin, ACTH and cortisol levels after chronic opiate receptor stimulation in man.
    Neuropeptides, 1990, Volume: 15, Issue:3

    Topics: Adrenocorticotropic Hormone; Adult; beta-Endorphin; Heroin Dependence; Humans; Hydrocortisone; Male;

1990
Metyrapone-induced withdrawal symptoms.
    British journal of addiction, 1990, Volume: 85, Issue:9

    Topics: Adult; Female; Heroin Dependence; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Meth

1990