metyrapone has been researched along with Epilepsy in 8 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (75.00) | 18.7374 |
1990's | 2 (25.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kaelin, AC | 1 |
Cummings, AJ | 1 |
Krugers, HJ | 2 |
Kemper, RH | 1 |
Korf, J | 2 |
Ter Horst, GJ | 1 |
Knollema, S | 1 |
Maslam, S | 1 |
Van Vuuren, SM | 1 |
Joƫls, M | 1 |
Few, JD | 1 |
Asfeldt, VH | 1 |
Buhl, J | 1 |
Meikle, AW | 2 |
Jubiz, W | 2 |
Matsukura, S | 1 |
West, CD | 2 |
Tyler, FH | 2 |
Szeberenyi, S | 1 |
Tacconi, MT | 1 |
Garattini, S | 1 |
8 other studies available for metyrapone and Epilepsy
Article | Year |
---|---|
Differential inhibition of human placental monooxygenase activity: evidence for multiple forms of 7-ethoxycoumarin O-deethylase.
Topics: 7-Alkoxycoumarin O-Dealkylase; Benzoflavones; Dimethyl Sulfoxide; Epilepsy; Female; Humans; Metyrapo | 1984 |
Metyrapone reduces rat brain damage and seizures after hypoxia-ischemia: an effect independent of modulation of plasma corticosterone levels?
Topics: Animals; Blood Glucose; Body Temperature; Brain Damage, Chronic; Brain Ischemia; Corticosterone; Epi | 1998 |
Postischemic steroid modulation: effects on hippocampal neuronal integrity and synaptic plasticity.
Topics: Action Potentials; Animals; Brain Ischemia; Corticosterone; Dexamethasone; Electrophysiology; Epilep | 1999 |
A simple method for the separate estimation of 11-deoxy and 11-oxygenated 17-hydroxycortico-steroids in human urine.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adr | 1968 |
Inhibitory effect of diphenylhydantoin on the feedback control of corticotrophin release.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; | 1969 |
Effect of diphenylhydantoin on the metabolism of metyrapone and release of ACTH in man.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Depression, Chemical; Epilepsy; Humans; Hydr | 1969 |
Dilantin and metyrapone: a clinically significant example of enzyme induction.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Animals; Depression, Chemical; Endoplasmic R | 1970 |
Increased metabolism of metyrapone in rats pretreated with diphenylhydantoin or phenobarbital.
Topics: Adrenal Glands; Animals; Biotransformation; Chromatography, Thin Layer; Enzyme Induction; Epilepsy; | 1969 |