Page last updated: 2024-10-31

metyrapone and Epilepsy

metyrapone has been researched along with Epilepsy in 8 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19906 (75.00)18.7374
1990's2 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kaelin, AC1
Cummings, AJ1
Krugers, HJ2
Kemper, RH1
Korf, J2
Ter Horst, GJ1
Knollema, S1
Maslam, S1
Van Vuuren, SM1
Joƫls, M1
Few, JD1
Asfeldt, VH1
Buhl, J1
Meikle, AW2
Jubiz, W2
Matsukura, S1
West, CD2
Tyler, FH2
Szeberenyi, S1
Tacconi, MT1
Garattini, S1

Other Studies

8 other studies available for metyrapone and Epilepsy

ArticleYear
Differential inhibition of human placental monooxygenase activity: evidence for multiple forms of 7-ethoxycoumarin O-deethylase.
    Biochemical pharmacology, 1984, Feb-01, Volume: 33, Issue:3

    Topics: 7-Alkoxycoumarin O-Dealkylase; Benzoflavones; Dimethyl Sulfoxide; Epilepsy; Female; Humans; Metyrapo

1984
Metyrapone reduces rat brain damage and seizures after hypoxia-ischemia: an effect independent of modulation of plasma corticosterone levels?
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1998, Volume: 18, Issue:4

    Topics: Animals; Blood Glucose; Body Temperature; Brain Damage, Chronic; Brain Ischemia; Corticosterone; Epi

1998
Postischemic steroid modulation: effects on hippocampal neuronal integrity and synaptic plasticity.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1999, Volume: 19, Issue:10

    Topics: Action Potentials; Animals; Brain Ischemia; Corticosterone; Dexamethasone; Electrophysiology; Epilep

1999
A simple method for the separate estimation of 11-deoxy and 11-oxygenated 17-hydroxycortico-steroids in human urine.
    The Journal of endocrinology, 1968, Volume: 41, Issue:2

    Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adr

1968
Inhibitory effect of diphenylhydantoin on the feedback control of corticotrophin release.
    Acta endocrinologica, 1969, Volume: 61, Issue:3

    Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult;

1969
Effect of diphenylhydantoin on the metabolism of metyrapone and release of ACTH in man.
    The Journal of clinical endocrinology and metabolism, 1969, Volume: 29, Issue:12

    Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Depression, Chemical; Epilepsy; Humans; Hydr

1969
Dilantin and metyrapone: a clinically significant example of enzyme induction.
    Transactions of the American Clinical and Climatological Association, 1970, Volume: 81

    Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Animals; Depression, Chemical; Endoplasmic R

1970
Increased metabolism of metyrapone in rats pretreated with diphenylhydantoin or phenobarbital.
    Endocrinology, 1969, Volume: 85, Issue:3

    Topics: Adrenal Glands; Animals; Biotransformation; Chromatography, Thin Layer; Enzyme Induction; Epilepsy;

1969