metyrapone has been researched along with Disease Models, Animal in 39 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Metyrapone, an inhibitor of corticosterone synthesis, completely abolished seizures in GAERS, and seizures remained suppressed for >2 h." | 8.31 | Metyrapone abolishes spike-wave discharge seizures in genetic absence epilepsy rats from Strasbourg by reducing stress hormones. ( Dezsi, G; Harris, G; Jones, NC; O'Brien, TJ; Ozturk, E; Paul, C, 2023) |
| "The status epilepticus (SE) induced by lithium-pilocarpine is a well characterized rodent model of the human temporal lobe epilepsy (TLE) which is accompanied by severe brain damage." | 7.85 | Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model. ( Bankstahl, JP; Bascuñana, P; Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MA; Shiha, AA; Silván, Á, 2017) |
| " We characterized the pharmacokinetic/pharmacodynamic relationships of a prototypical ASI, (+)-(5R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile hydrochloride (CGS020286A, FAD286, FAD) and compared these profiles to those of the 11beta-hydroxylase inhibitor metyrapone (MET) in two rodent models of secondary hyperaldosteronism and corticosteronism." | 7.76 | Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone. ( Beil, M; Fu, F; Hu, CW; Jeng, AY; Liang, G; Rigel, DF, 2010) |
| "All Wistar rats showed hypertension when they were given heat-stress and administered metyrapone (200 micrograms/kg/day), a cholesterol-11-beta-hydroxylase inhibitor." | 7.67 | [Hypertension in rats caused by metyrapone and heat-stress treatment]. ( Arakawa, K, 1985) |
| " Metyrapone, an inhibitor of corticosterone synthesis, completely abolished seizures in GAERS, and seizures remained suppressed for >2 h." | 4.31 | Metyrapone abolishes spike-wave discharge seizures in genetic absence epilepsy rats from Strasbourg by reducing stress hormones. ( Dezsi, G; Harris, G; Jones, NC; O'Brien, TJ; Ozturk, E; Paul, C, 2023) |
| "The status epilepticus (SE) induced by lithium-pilocarpine is a well characterized rodent model of the human temporal lobe epilepsy (TLE) which is accompanied by severe brain damage." | 3.85 | Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model. ( Bankstahl, JP; Bascuñana, P; Delgado, M; Fernández de la Rosa, R; García-García, L; Gomez, F; Pozo, MA; Shiha, AA; Silván, Á, 2017) |
| "The aim of this study was to determine the effects of previous administration of metyrapone (met) on the acute lung injury (ALI) induced by caecal ligation and puncture (CLP) and to explore met's relationship with endogenous glucocorticoids (GCs) as measured by inflammatory, oxidative and functional parameters." | 3.81 | Inhibition of endogenous glucocorticoid synthesis aggravates lung injury triggered by septic shock in rats. ( Incerpi, EK; Oliveira, LM; Pereira, EM; Soncini, R, 2015) |
| " We characterized the pharmacokinetic/pharmacodynamic relationships of a prototypical ASI, (+)-(5R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile hydrochloride (CGS020286A, FAD286, FAD) and compared these profiles to those of the 11beta-hydroxylase inhibitor metyrapone (MET) in two rodent models of secondary hyperaldosteronism and corticosteronism." | 3.76 | Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone. ( Beil, M; Fu, F; Hu, CW; Jeng, AY; Liang, G; Rigel, DF, 2010) |
| "In the process of developing a model of Escherichia coli endotoxin-induced acute lung injury and shock in specific pathogen-free pigs, the effects of pretreatment with metyrapone (a cortisol-synthesis inhibitor) were examined." | 3.70 | Effect of cortisol-synthesis inhibition on endotoxin-induced porcine acute lung injury, shock, and nitric oxide production. ( Alving, K; Bergman, D; Middelveld, RJ; Wanecek, M; Weitzberg, E, 1999) |
| " In ovalbumin-sensitized guinea pigs, challenged with low doses of ovalbumin, we observed an immediate bronchoconstriction, a late-phase bronchopulmonary eosinophilia but no late-phase bronchoconstriction." | 3.68 | Chasing the elusive animal model of late-phase bronchoconstriction: studies in dogs, guinea pigs and rats. ( Fidler, SF; Griffin, RL; Reid, MS; Richards, IM; Shields, SK, 1992) |
| "All Wistar rats showed hypertension when they were given heat-stress and administered metyrapone (200 micrograms/kg/day), a cholesterol-11-beta-hydroxylase inhibitor." | 3.67 | [Hypertension in rats caused by metyrapone and heat-stress treatment]. ( Arakawa, K, 1985) |
| "Chronic hypertension has been produced in mongrel dogs by the long-term oral administration of metyrapone (100 mg/kg per day)." | 3.65 | Multifactorial analysis of chronic hypertension induced by electrolyte-active steroids in trained, unanesthetized dogs. ( Bravo, EL; Dustan, HP; Tarazi, RC, 1977) |
| "Glucocorticoids (GCs) are used for acute respiratory distress syndrome (ARDS) to improve or prevent lung injury." | 1.48 | Glucocorticoid receptor gene expression in a CLP-induced ARDS-like rat model treated with dexamethasone and metyrapone. ( Barchuk, AR; Incerpi, EK; Ramos Lopes, AC; Ruginsk, SG; Soncini, R; Vieira, J, 2018) |
| "Maternal food restriction (MFR) causes intrauterine growth restriction, a known risk factor for developing chronic lung disease." | 1.42 | Metyrapone alleviates deleterious effects of maternal food restriction on lung development and growth of rat offspring. ( Khorram, O; Li, Y; Paek, DS; Rehan, VK; Sakurai, R; Saraswat, A; Torday, JS, 2015) |
| "Allopregnanolone and THDOC were measured using liquid chromatography-mass spectroscopy (LC-MS/MS) in the prefrontal cortex and amygdala in the brains from these rats." | 1.42 | A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats. ( Dhungana, S; Goeders, NE; Guerin, GF; Runyon, SP; Schmoutz, CD, 2015) |
| "Propranolol is a non-selective β adrenergic receptor blocker which antagonises the anti-inflammatory effect of non-steroidal anti-inflammatory drugs via the β1 and β2 adrenergic receptors." | 1.37 | Effects of epinephrine and cortisol on the analgesic activity of metyrosine in rats. ( Akcay, F; Albayrak, Y; Karatay, S; Polat, B; Saglam, MB; Suleyman, H; Uslu, T; Yildirim, K, 2011) |
| "Pretreatment with metyrapone (100 m a g , intraperitoneal)1 h before inescapable stress (40 2mA tail shocks delivered over a 1-h period) (IS)blocked the acute plasma corticosterone response to IS." | 1.31 | Pharmacological suppression of corticosterone secretion in response to a physical stressor does not prevent the delayed persistent increase in circulating basal corticosterone concentration. ( Beck, KD; Beldowicz, D; Brennan, FX; Moldow, RL; Ottenweller, JE; Servatius, RJ; Zhug, G, 2001) |
| "Pretreatment with metyrapone (a corticosterone synthesis inhibitor 150 mg/kg i." | 1.27 | Central serotonergic responses and behavioural adaptation to repeated immobilisation: the effect of the corticosterone synthesis inhibitor metyrapone. ( Curzon, G; Dickinson, SL; Kennett, GA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (23.08) | 18.7374 |
| 1990's | 7 (17.95) | 18.2507 |
| 2000's | 9 (23.08) | 29.6817 |
| 2010's | 11 (28.21) | 24.3611 |
| 2020's | 3 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Dezsi, G | 1 |
| Ozturk, E | 1 |
| Harris, G | 1 |
| Paul, C | 1 |
| O'Brien, TJ | 1 |
| Jones, NC | 1 |
| Bencze, M | 1 |
| Vavřínová, A | 1 |
| Zicha, J | 1 |
| Behuliak, M | 1 |
| García-García, L | 1 |
| Shiha, AA | 1 |
| Fernández de la Rosa, R | 1 |
| Delgado, M | 1 |
| Silván, Á | 1 |
| Bascuñana, P | 1 |
| Bankstahl, JP | 1 |
| Gomez, F | 1 |
| Pozo, MA | 1 |
| Soncini, R | 2 |
| Vieira, J | 1 |
| Ramos Lopes, AC | 1 |
| Ruginsk, SG | 1 |
| Incerpi, EK | 2 |
| Barchuk, AR | 1 |
| Dey, A | 1 |
| Hao, S | 1 |
| Erion, JR | 1 |
| Wosiski-Kuhn, M | 1 |
| Stranahan, AM | 1 |
| Paek, DS | 1 |
| Sakurai, R | 1 |
| Saraswat, A | 1 |
| Li, Y | 1 |
| Khorram, O | 1 |
| Torday, JS | 1 |
| Rehan, VK | 1 |
| Oliveira, LM | 1 |
| Pereira, EM | 1 |
| Keller, SM | 1 |
| Schreiber, WB | 1 |
| Stanfield, BR | 1 |
| Knox, D | 1 |
| Schmoutz, CD | 1 |
| Guerin, GF | 1 |
| Runyon, SP | 1 |
| Dhungana, S | 1 |
| Goeders, NE | 1 |
| Simola, N | 1 |
| Di Chiara, G | 1 |
| Daniels, WM | 1 |
| Schallert, T | 1 |
| Morelli, M | 1 |
| Rigel, DF | 1 |
| Fu, F | 1 |
| Beil, M | 1 |
| Hu, CW | 1 |
| Liang, G | 1 |
| Jeng, AY | 1 |
| Milot, MR | 1 |
| Plamondon, H | 1 |
| Lorivel, T | 1 |
| Gras, M | 1 |
| Hilber, P | 1 |
| Albayrak, Y | 1 |
| Saglam, MB | 1 |
| Yildirim, K | 1 |
| Karatay, S | 1 |
| Polat, B | 1 |
| Uslu, T | 1 |
| Suleyman, H | 1 |
| Akcay, F | 1 |
| Moldow, RL | 1 |
| Beck, KD | 1 |
| Zhug, G | 1 |
| Beldowicz, D | 1 |
| Brennan, FX | 1 |
| Ottenweller, JE | 1 |
| Servatius, RJ | 1 |
| Cordero, MI | 1 |
| Kruyt, ND | 1 |
| Merino, JJ | 1 |
| Sandi, C | 1 |
| Georén, S | 1 |
| Ahnblad, P | 1 |
| Stjärne, P | 1 |
| Wikström, AC | 1 |
| Stierna, P | 2 |
| Tahera, Y | 1 |
| Meltser, I | 1 |
| Johansson, P | 1 |
| Bian, Z | 1 |
| Hansson, AC | 1 |
| Canlon, B | 1 |
| Pedersen, WA | 1 |
| McMillan, PJ | 1 |
| Kulstad, JJ | 1 |
| Leverenz, JB | 1 |
| Craft, S | 1 |
| Haynatzki, GR | 1 |
| Li, X | 1 |
| Rana, SN | 1 |
| Schwacha, MG | 1 |
| Chaudry, IH | 1 |
| Choudhry, MA | 1 |
| Conrad, CD | 1 |
| Mauldin-Jourdain, ML | 1 |
| Hobbs, RJ | 1 |
| Mesripour, A | 1 |
| Hajhashemi, V | 1 |
| Rabbani, M | 1 |
| Fornhem, C | 2 |
| Lundberg, JM | 1 |
| Alving, K | 2 |
| Nagai, H | 2 |
| Iwama, T | 2 |
| Mori, H | 1 |
| Nishida, H | 1 |
| Takatsu, K | 1 |
| Iikura, Y | 1 |
| Middelveld, RJ | 1 |
| Wanecek, M | 1 |
| Bergman, D | 1 |
| Weitzberg, E | 1 |
| Bonta, IL | 1 |
| Adolfs, MJ | 1 |
| Parnham, MJ | 1 |
| Tarazi, RC | 2 |
| Bravo, EL | 1 |
| Dustan, HP | 1 |
| Kling, OR | 1 |
| Kotas, RV | 1 |
| Richards, IM | 1 |
| Griffin, RL | 1 |
| Shields, SK | 1 |
| Reid, MS | 1 |
| Fidler, SF | 1 |
| Kishi, K | 1 |
| Suda, H | 1 |
| Koda, A | 1 |
| Trulson, ME | 1 |
| Ulissey, MJ | 1 |
| Sasaki, H | 1 |
| Yanai, M | 1 |
| Shimura, S | 1 |
| Okayama, H | 1 |
| Aikawa, T | 1 |
| Sasaki, T | 1 |
| Takishima, T | 1 |
| Arakawa, K | 1 |
| Kennett, GA | 1 |
| Dickinson, SL | 1 |
| Curzon, G | 1 |
| Marks, AD | 1 |
| Adlin, EV | 1 |
| Channick, BJ | 1 |
1 review available for metyrapone and Disease Models, Animal
| Article | Year |
|---|---|
Hemodynamic role of extracellular fluid in hypertension.
Topics: Animals; Blood Volume; Cardiac Output; Disease Models, Animal; Extracellular Space; Hemodynamics; Ho | 1976 |
38 other studies available for metyrapone and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Metyrapone abolishes spike-wave discharge seizures in genetic absence epilepsy rats from Strasbourg by reducing stress hormones.
Topics: Animals; Corticosterone; Desoxycorticosterone; Disease Models, Animal; Electroencephalography; Epile | 2023 |
Pharmacological suppression of endogenous glucocorticoid synthesis attenuated blood pressure and heart rate response to acute restraint in Wistar rats.
Topics: Adrenalectomy; Aminoglutethimide; Animals; Antimetabolites; Aromatase Inhibitors; Blood Pressure; Di | 2020 |
Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model.
Topics: Animals; Astrocytes; Autoradiography; Brain; Carbazoles; Carrier Proteins; Disease Models, Animal; E | 2017 |
Glucocorticoid receptor gene expression in a CLP-induced ARDS-like rat model treated with dexamethasone and metyrapone.
Topics: Animals; Cecum; Corticosterone; Dexamethasone; Disease Models, Animal; Gene Expression Regulation; L | 2018 |
Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes.
Topics: Animals; Diabetes Mellitus; Disease Models, Animal; Glucocorticoids; Inflammation Mediators; Male; M | 2014 |
Metyrapone alleviates deleterious effects of maternal food restriction on lung development and growth of rat offspring.
Topics: Age Factors; Animals; Bronchopulmonary Dysplasia; Caloric Restriction; Cell Differentiation; Cells, | 2015 |
Inhibition of endogenous glucocorticoid synthesis aggravates lung injury triggered by septic shock in rats.
Topics: Acute Lung Injury; Animals; Corticosterone; Disease Models, Animal; Down-Regulation; Enzyme Inhibito | 2015 |
Inhibiting corticosterone synthesis during fear memory formation exacerbates cued fear extinction memory deficits within the single prolonged stress model.
Topics: Animals; Conditioning, Psychological; Corticosterone; Cues; Disease Models, Animal; Enzyme Inhibitor | 2015 |
A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Desoxycorticosterone; Disease Models, Animal; Do | 2015 |
Priming of rotational behavior by a dopamine receptor agonist in Hemiparkinsonian rats: movement-dependent induction.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Apomorphi | 2009 |
Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone.
Topics: Adrenal Glands; Aldosterone; Animals; Blood Pressure; Blood Proteins; Chromatography, Liquid; Cortic | 2010 |
How right is the righting reflex? The risk of false positives in neuroprotection studies using behavioral measures to certify forebrain ischemia.
Topics: Animals; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Memory Disor | 2010 |
Effects of corticosterone synthesis inhibitor metyrapone on anxiety-related behaviors in Lurcher mutant mice.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Cerebellum; Corticosterone; Disease Models | 2010 |
Effects of epinephrine and cortisol on the analgesic activity of metyrosine in rats.
Topics: Adrenergic beta-Antagonists; alpha-Methyltyrosine; Analgesics; Animals; Carrageenan; Chromatography, | 2011 |
Pharmacological suppression of corticosterone secretion in response to a physical stressor does not prevent the delayed persistent increase in circulating basal corticosterone concentration.
Topics: Animals; Biomarkers; Circadian Rhythm; Corticosterone; Disease Models, Animal; Electric Stimulation; | 2001 |
Glucocorticoid involvement in memory formation in a rat model for traumatic memory.
Topics: Animals; Biomarkers; Conditioning, Psychological; Corticosterone; Disease Models, Animal; Electrosho | 2002 |
Significance of endogenous glucocorticoid sensitivity for airway eosinophilia in a murine model of allergy.
Topics: Administration, Intranasal; Airway Resistance; Animals; Asthma; Bone Marrow; Bronchi; Disease Models | 2005 |
NF-kappaB mediated glucocorticoid response in the inner ear after acoustic trauma.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Auditory Threshold; Blotting, Northern; Disease | 2006 |
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Behavior, Anim | 2006 |
A novel role for IL-18 in corticosterone-mediated intestinal damage in a two-hit rodent model of alcohol intoxication and injury.
Topics: Alcoholic Intoxication; Animals; Burns; Caspase 1; Caspase Inhibitors; Chemokine CXCL1; Chemokines, | 2006 |
Metyrapone reveals that previous chronic stress differentially impairs hippocampal-dependent memory.
Topics: Animals; Atrophy; Behavior, Animal; Chronic Disease; Conditioning, Psychological; Corticosterone; Cu | 2001 |
Metyrapone and mifepristone reverse recognition memory loss induced by spontaneous morphine withdrawal in mice.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Glucocorticoids; Hormone Antagonists; Injections | 2008 |
Allergen-induced late-phase airways obstruction in the pig: the role of endogenous cortisol.
Topics: Airway Obstruction; Airway Resistance; Allergens; Animals; Catecholamines; Disease Models, Animal; E | 1995 |
Increase in respiratory resistance after exercise in conscious guinea pigs. As a model for exercise-induced asthma.
Topics: Airway Resistance; Animals; Asthma, Exercise-Induced; Bronchoalveolar Lavage Fluid; Disease Models, | 1995 |
Allergen-induced late airways reactions in the pig. Influence of endogenous and exogenous glucocorticoids.
Topics: Allergens; Amino Acid Sequence; Animals; Antimicrobial Cationic Peptides; Ascaris suum; Asthma; Bloo | 1995 |
Effect of cortisol-synthesis inhibition on endotoxin-induced porcine acute lung injury, shock, and nitric oxide production.
Topics: Acid-Base Imbalance; Animals; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Disease Models, Anim | 1999 |
Distribution and further studies on the activity of prostaglandin E in chronic granulomatous inflammation.
Topics: Animals; Bucladesine; Carbon Radioisotopes; Carrageenan; Disease Models, Animal; Granulomatous Disea | 1979 |
Multifactorial analysis of chronic hypertension induced by electrolyte-active steroids in trained, unanesthetized dogs.
Topics: Acebutolol; Aldosterone; Animals; Chronic Disease; Clonidine; Corticosterone; Diet, Sodium-Restricte | 1977 |
Endocrine influences on pulmonary maturation and the lecithin/sphingomyelin ratio in the fetal baboon.
Topics: Adrenal Cortex; Amniotic Fluid; Animals; Dexamethasone; Disease Models, Animal; Female; Fetus; Gesta | 1975 |
Chasing the elusive animal model of late-phase bronchoconstriction: studies in dogs, guinea pigs and rats.
Topics: Animals; Ascaris; Bronchi; Bronchial Hyperreactivity; Disease Models, Animal; Dogs; Guinea Pigs; Met | 1992 |
[Animal models of various hypertensions].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenocorticotropic Hormone; Androgens; Angiotensin II; Animals; C | 1992 |
Effects of NZ-107 on bronchoconstriction in guinea pigs.
Topics: Albuterol; Animals; Asthma; Bronchoconstriction; Cromolyn Sodium; Disease Models, Animal; Guinea Pig | 1992 |
Low doses of L-tryptophan are lethal in rats with adrenal insufficiency.
Topics: Adrenal Insufficiency; Adrenalectomy; Animals; Corticosterone; Disease Models, Animal; Lethal Dose 5 | 1987 |
Late asthmatic response to Ascaris antigen challenge in dogs treated with metyrapone.
Topics: Airway Resistance; Allergens; Animals; Antigens, Helminth; Ascaris; Asthma; Bronchoalveolar Lavage F | 1987 |
[Hypertension in rats caused by metyrapone and heat-stress treatment].
Topics: Animals; Brain; Disease Models, Animal; Dopamine; Hot Temperature; Hypertension; Male; Metyrapone; P | 1985 |
Central serotonergic responses and behavioural adaptation to repeated immobilisation: the effect of the corticosterone synthesis inhibitor metyrapone.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Body Weight; Corticosterone; Disease Models, A | 1985 |
Effect of metyrapone on plasma renin activity in dogs.
Topics: Animals; Blood Pressure; Desoxycorticosterone; Dexamethasone; Diet, Sodium-Restricted; Disease Model | 1971 |