Compounds > metyrapone
Page last updated: 2024-10-31

metyrapone and Diabetes Mellitus

metyrapone has been researched along with Diabetes Mellitus in 30 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

Research Excerpts

ExcerptRelevanceReference
"Active Cushing's syndrome is associated with insulin resistance induced by the high and prolonged circulating level of glucocorticoids."2.46Management of diabetes mellitus in Cushing's syndrome. ( Munir, A; Newell-Price, J, 2010)
"Ruling out other causes, paraneoplastic hypercortisolism was diagnosed."1.51Hypokalaemic metabolic alkalosis, hypertension and diabetes: what is the link. ( Cathomas, R; Fehr, T; Kamber, N; Vögelin, M, 2019)
"Imaging tests by CT/MRI identified the tumors in 8 of 16 (50%), in 4 of 11 (36%) and 4 of 6 (66."1.36Clinical features and management of ectopic ACTH syndrome at a single institute in Japan. ( Doi, M; Hirata, Y; Izumiyama, H; Sugiyama, T; Yoshimoto, T, 2010)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199026 (86.67)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vögelin, M1
Cathomas, R1
Kamber, N1
Fehr, T1
Dey, A1
Hao, S1
Erion, JR1
Wosiski-Kuhn, M1
Stranahan, AM1
Munir, A1
Newell-Price, J1
Doi, M1
Sugiyama, T1
Izumiyama, H1
Yoshimoto, T1
Hirata, Y1
DE MARTINIS, C1
MESTMAN, JH1
NELSON, DH1
TAKEDA, R1
MIYAHO, S1
MORIMOTO, S1
HASUI, K2
KANEDA, M2
NAGANO, T1
YOKOYAMA, T1
FERRARI, E2
MAZZI, C1
PIOTTI, LE1
LENTLE, BC1
THOMAS, JP1
MCCULLAGH, EP1
FELDSTEIN, MA1
TWEED, DC1
DOHN, DF1
DITZEL, J1
Nakamura, J1
Yakata, M1
Schade, DS1
Eaton, RP1
Standefer, J1
Szybiński, Z1
Sieradzki, J1
Korzeniowska, D1
Siegel, ET1
Miura, K1
Weber, A1
Gossmann, HH1
Limaye, NR1
Sarver, ME1
Sabeh, G2
Cohn, RE1
Danowski, TS2
Bates, RW1
Garrison, MM1
Nishida, S1
Nakajima, T1
Hatemi, H1
Oker, C1
Sukyasyan, A1
Bağriaçik, N1
Bozhadzhieva, E1
Konstantinov, N1
Rachev, R1
Koev, D1
Chankova, P1
Najjar, S1
Ayash, MA1
Kley, HK1
Krüskemper, HL1
Grinberg, R1
Mazar, S1
Bossolo, PA1
Alley, RA1
Narduzzi, JV1
Weir, TF1
McGowen, CH1
Robbins, TJ1
Lukács, K1
Földvári, M1
Rohoska, J1

Reviews

2 reviews available for metyrapone and Diabetes Mellitus

ArticleYear
Management of diabetes mellitus in Cushing's syndrome.
    Neuroendocrinology, 2010, Volume: 92 Suppl 1

    Topics: Cushing Syndrome; Diabetes Mellitus; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Insulin Resista

2010
[SIGNIFICANCE OF PITUITARY AND ADRENAL CORTEX HORMONES IN DIABETES MELLITUS].
    Nihon rinsho. Japanese journal of clinical medicine, 1964, Apr-10, Volume: 22

    Topics: Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Blood Chemical A

1964

Other Studies

28 other studies available for metyrapone and Diabetes Mellitus

ArticleYear
Hypokalaemic metabolic alkalosis, hypertension and diabetes: what is the link.
    BMJ case reports, 2019, Jan-18, Volume: 12, Issue:1

    Topics: Alkalosis; Cushing Syndrome; Diabetes Mellitus; Female; Humans; Hypertension; Hypokalemia; Metyrapon

2019
Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes.
    Journal of neuroimmunology, 2014, Apr-15, Volume: 269, Issue:1-2

    Topics: Animals; Diabetes Mellitus; Disease Models, Animal; Glucocorticoids; Inflammation Mediators; Male; M

2014
Clinical features and management of ectopic ACTH syndrome at a single institute in Japan.
    Endocrine journal, 2010, Volume: 57, Issue:12

    Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; Aged; Corticotropin-Releasing Hormone; D

2010
[Changes in glucose tolerance after Metopirone in normal and diabetic subjects. Preliminary observations].
    Bollettino della Societa italiana di biologia sperimentale, 1963, Mar-31, Volume: 39

    Topics: Carbohydrate Metabolism; Diabetes Mellitus; Glucose Tolerance Test; Humans; Ketones; Metyrapone; Min

1963
INHIBITION BY ESTROGEN ADMINISTRATION OF ADRENAL-PITUITARY RESPONSE TO METHOPYRAPONE.
    The Journal of clinical investigation, 1963, Volume: 42

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Diabetes Mellitus; Estrogens; Hypothyroidism; Ketones;

1963
[PITUITARY CORTICOTROPIN RESERVE AND RESPONSIVENESS IN THE LIDDLE TEST IN DIABETES MELLITUS].
    Archivio per le scienze mediche, 1964, Volume: 117

    Topics: Adrenocorticotropic Hormone; Diabetes Mellitus; Metabolism; Metyrapone; Pharmacology; Physiology; Pi

1964
ADRENAL FUNCTION AND THE COMPLICATIONS OF DIABETES MELLITUS.
    Lancet (London, England), 1964, Sep-12, Volume: 2, Issue:7359

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Blood Chemical Analysis; Carbon Isotopes; Cush

1964
A STUDY OF PITUITARY FUNCTION AFTER INTRASELLAR IMPLANTATION OF 90YTTRIUM.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Basal Metabolism; Breast Neoplasms; Cushing

1965
CLINICAL ASSESSMENT OF THE PERORAL METOPIRONE TEST.
    Acta medica Scandinavica, 1965, Volume: 178

    Topics: Adenoma; Adenoma, Chromophobe; Adrenalectomy; Adrenocorticotropic Hormone; Cushing Syndrome; Diabete

1965
Clinical evaluation of the liquid-chromatographic determination of urinary free cortisol.
    Clinical chemistry, 1983, Volume: 29, Issue:5

    Topics: Adolescent; Adrenal Gland Diseases; Adult; Age Factors; Chromatography, High Pressure Liquid; Dexame

1983
Modulation of basal ketone body concentration by cortisol in diabetic man.
    The Journal of clinical endocrinology and metabolism, 1978, Volume: 47, Issue:3

    Topics: Adult; Diabetes Mellitus; Female; Humans; Hydrocortisone; Insulin; Ketone Bodies; Kinetics; Male; Me

1978
[Growth hormone secretion following metopirone administration].
    Polskie Archiwum Medycyny Wewnetrznej, 1975, Volume: 53, Issue:6

    Topics: Adolescent; Adult; Diabetes Mellitus; Female; Growth Hormone; Humans; Male; Metyrapone; Middle Aged;

1975
[Pituitary-adrenal function in diabetes].
    Nihon Naibunpi Gakkai zasshi, 1967, Jan-20, Volume: 42, Issue:10

    Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Chr

1967
Assessment of pituitary-adrenal gland function in the dog.
    American journal of veterinary research, 1968, Volume: 29, Issue:1

    Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Animals; Diabetes Mellitus; Do

1968
[Patterns of adrenal steroids present in the blood].
    Nihon Naibunpi Gakkai zasshi, 1967, Oct-20, Volume: 43, Issue:7

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aldosterone; Blood Proteins; Corticosterone; C

1967
[Endoccinological changes as a result of obesity in juveniles].
    Der Internist, 1968, Volume: 9, Issue:4

    Topics: Adolescent; Adrenocorticotropic Hormone; Age Factors; Blood Glucose; Body Height; Body Weight; Cushi

1968
ACTH-excess and increased urinary pressor activity.
    Experimental medicine and surgery, 1967, Volume: 25, Issue:1

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Biological Assay; Catechola

1967
[Diurnal variation of plasma cortisol concentration in patients with various diseases and negative feedback mechanism of the pituitary-adrenal axis].
    Nihon Naibunpi Gakkai zasshi, 1969, Sep-20, Volume: 45, Issue:6

    Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Central Nervous Sys

1969
Delay of hormonally induced diabetes by amino-glutethimide and metyrapone in partially pancreatectomized rats bearing transplantable pituitary tumors. Concomitant failure to prevent splanchnomegaly.
    Endocrinology, 1970, Volume: 86, Issue:1

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Aniline Compounds; Animals; Anticonv

1970
[Pituitary function test using synthetic lysine-8-vasopressin--comparison with metopirone test and insulin stress test].
    Naika. Internal medicine, 1971, Volume: 28, Issue:1

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anorexia Nervosa; Craniopharyngioma; Cushing S

1971
Adrenocortical activity in complicated and uncomplicated diabetes.
    Israel journal of medical sciences, 1972, Volume: 8, Issue:6

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Diabetes Co

1972
[Lipoatrophic diabetes. A case description].
    Vutreshni bolesti, 1973, Volume: 12, Issue:1

    Topics: Adrenocorticotropic Hormone; Adult; Atrophy; Blood Glucose; Diabetes Mellitus; Eye Manifestations; F

1973
The Mauriac syndrome.
    Clinical pediatrics, 1974, Volume: 13, Issue:9

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Child; Depression, Chemical; Dexamethasone; Diabetes Mel

1974
[Performance and interpretation of a shortened metyrapone test].
    Klinische Wochenschrift, 1972, Nov-15, Volume: 50, Issue:22

    Topics: 11-Hydroxycorticosteroids; Acromegaly; Adolescent; Adult; Aged; Circadian Rhythm; Diabetes Mellitus;

1972
Effect of metyrapone on insulin, cortisol, and glucose tolerance test responses in diabetes.
    New York state journal of medicine, 1970, Sep-15, Volume: 70, Issue:18

    Topics: Adult; Diabetes Mellitus; Female; Glucose Tolerance Test; Humans; Hydrocortisone; Insulin; Metyrapon

1970
[Functional aspects of the pituitary gland and adrenal cortex in diabetic retinopathy].
    Minerva medica, 1971, Jan-31, Volume: 62, Issue:9

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adult; Age Factors; Aged; Circadian Rhyt

1971
Hyperresponsiveness to metyrapone.
    Experimental medicine and surgery, 1967, Volume: 25, Issue:1

    Topics: Adrenal Cortex Hormones; Anorexia Nervosa; Diabetes Mellitus; Growth; Growth Disorders; Humans; Hypo

1967
[Analysis of the simultaneous manifestation of the granulocytopenic and antidiabetogenic effect based on studies with SU-4885-Metopirone(CIBA) on diabetics].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1965, Volume: 25, Issue:1

    Topics: Adult; Agranulocytosis; Diabetes Mellitus; Female; Glucocorticoids; Humans; Lymphocytosis; Male; Met

1965