Page last updated: 2024-10-31

metyrapone and Diabetes Mellitus, Adult-Onset

metyrapone has been researched along with Diabetes Mellitus, Adult-Onset in 7 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Research Excerpts

ExcerptRelevanceReference
"Treatment with metyrapone thus appears a good therapy for AIMAH, but its effectiveness has not, to our knowledge, been studied."5.31Rational, effective metyrapone treatment of ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH). ( Nomura, K; Obara, T; Omori, K; Omori, N; Takano, K, 2001)
"Among this population with Type 2 diabetes high liver fat was associated with hyperinsulinemia, higher fasting glucose levels, peripheral and hepatic insulin resistance, and impaired suppression of FFA oxidation and FFA and glycerol turnover during hyperinsulinemia."2.79Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with Type 2 diabetes with and without fatty liver. ( Andrew, R; Bastin, ME; Gray, CD; Iredale, JP; Macfarlane, DP; Marshall, I; Preston, T; Raubenheimer, PJ; Walker, BR, 2014)
"Treatment with metyrapone thus appears a good therapy for AIMAH, but its effectiveness has not, to our knowledge, been studied."1.31Rational, effective metyrapone treatment of ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH). ( Nomura, K; Obara, T; Omori, K; Omori, N; Takano, K, 2001)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Rose, M1
Filiatreault, A1
Williams, A1
Guénette, J1
Thomson, EM1
Delivanis, DA1
Athimulam, S1
Bancos, I1
Macfarlane, DP1
Raubenheimer, PJ1
Preston, T1
Gray, CD1
Bastin, ME1
Marshall, I1
Iredale, JP1
Andrew, R1
Walker, BR1
Schiemer, R1
Latibeaudiere, M1
Close, C1
Fox, R1
Takeshita, N1
Yoshino, T1
Mutoh, S1
Omori, N1
Nomura, K1
Omori, K1
Takano, K1
Obara, T1
Atiea, JA1
Aslan, SM1
Owens, DR1
Luzio, S1

Trials

1 trial available for metyrapone and Diabetes Mellitus, Adult-Onset

ArticleYear
Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with Type 2 diabetes with and without fatty liver.
    American journal of physiology. Gastrointestinal and liver physiology, 2014, Oct-01, Volume: 307, Issue:7

    Topics: Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Energy Metabolism

2014

Other Studies

6 other studies available for metyrapone and Diabetes Mellitus, Adult-Onset

ArticleYear
Modulation of insulin signaling pathway genes by ozone inhalation and the role of glucocorticoids: A multi-tissue analysis.
    Toxicology and applied pharmacology, 2023, 06-15, Volume: 469

    Topics: Animals; Diabetes Mellitus, Type 2; Glucocorticoids; Insulin; Male; Metyrapone; Ozone; Rats; Rats, I

2023
Modern Management of Mild Autonomous Cortisol Secretion.
    Clinical pharmacology and therapeutics, 2019, Volume: 106, Issue:6

    Topics: 14-alpha Demethylase Inhibitors; Adrenal Cortex Neoplasms; Adrenal Insufficiency; Adrenalectomy; Adr

2019
Type 2 diabetes identified in pregnancy secondary to Cushing's syndrome.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2011, Volume: 31, Issue:6

    Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Cushing Syndrome; Diabetes Mellitus, Type 2

2011
Possible involvement of corticosterone in bone loss of genetically diabetic db/db mice.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2000, Volume: 32, Issue:4

    Topics: Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Calcium; Corticosterone; Diabetes Mell

2000
Rational, effective metyrapone treatment of ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH).
    Endocrine journal, 2001, Volume: 48, Issue:6

    Topics: Adrenal Glands; Cushing Syndrome; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Humans; Hydrocortiso

2001
Early morning hyperglycaemia "dawn phenomenon" in non-insulin dependent diabetes mellitus (NIDDM): effects of cortisol suppression by metyrapone.
    Diabetes research (Edinburgh, Scotland), 1990, Volume: 14, Issue:4

    Topics: Aged; Blood Glucose; C-Peptide; Circadian Rhythm; Diabetes Mellitus, Type 2; Epinephrine; Female; Gl

1990