metyrapone has been researched along with Depression in 9 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clinical trial with a steroid suppressive agent, metyrapone, was carried out in 6 patients with treatment-resistant depression (3 patients with major depression and 3 with bipolar disorder)." | 5.08 | [Clinical effects of cortisol synthesis inhibition on treatment-resistant depression]. ( Iizuka, H; Kishimoto, A; Mizukawa, R; Nakamura, J, 1996) |
| "Treatment with metyrapone or o,p'-DDD can always induce a clinical remission but not a cure, and neurotransmitter therapy may be effective in a minority of cases." | 2.37 | Cushing's syndrome. ( Besser, GM; Howlett, TA; Rees, LH, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shishkina, GT | 2 |
| Bulygina, VV | 2 |
| Dygalo, NN | 2 |
| Kalinina, TS | 1 |
| Lanshakov, DA | 1 |
| Babluk, EV | 1 |
| Takatsu-Coleman, AL | 1 |
| Patti, CL | 1 |
| Zanin, KA | 1 |
| Zager, A | 1 |
| Carvalho, RC | 1 |
| Borçoi, AR | 1 |
| Ceccon, LM | 1 |
| Berro, LF | 1 |
| Tufik, S | 1 |
| Andersen, ML | 1 |
| Frussa-Filho, R | 1 |
| Iizuka, H | 1 |
| Kishimoto, A | 1 |
| Nakamura, J | 1 |
| Mizukawa, R | 1 |
| von Bardeleben, U | 1 |
| Holsboer, F | 1 |
| Howlett, TA | 1 |
| Rees, LH | 1 |
| Besser, GM | 1 |
| Stancáková, A | 1 |
| Durindová, Z | 1 |
| Stancák, A | 1 |
| Vujosevic, K | 1 |
| Palmar, I | 1 |
| Romano, M | 1 |
| Kapor, G | 1 |
| Jakobson, T | 1 |
| Stenbäck, A | 1 |
| Strandström, L | 1 |
| Rimón, R | 1 |
2 reviews available for metyrapone and Depression
| Article | Year |
|---|---|
Human corticotropin releasing hormone: clinical studies in patients with affective disorders, alcoholism, panic disorder and in normal controls.
Topics: Adrenocorticotropic Hormone; Alcoholism; Aldosterone; Corticotropin-Releasing Hormone; Depression; D | 1988 |
Cushing's syndrome.
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Alcoho | 1985 |
1 trial available for metyrapone and Depression
| Article | Year |
|---|---|
[Clinical effects of cortisol synthesis inhibition on treatment-resistant depression].
Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Depression; Depression, Chemical; | 1996 |
6 other studies available for metyrapone and Depression
| Article | Year |
|---|---|
Behavioral effects of glucocorticoids during the first exposures to the forced swim stress.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Dexamethasone; Enzyme | 2015 |
Anti-Apoptotic Protein Bcl-xL Expression in the Midbrain Raphe Region Is Sensitive to Stress and Glucocorticoids.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Depression; Dexamethasone; Glucoco | 2015 |
Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: mood-congruent memory in male mice?
Topics: Affect; Animals; Avoidance Learning; Behavior, Animal; Corticosterone; Crowding; Depression; Discrim | 2013 |
[Influence of ACTH and metopirone on the excretion of cortisol metabolites in endogenous depression during thioridazine administration].
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Depression; Female; Humans; Hydrocortisone; Male | 1972 |
[Function of the pituitary-adrenal system in depression].
Topics: 17-Hydroxycorticosteroids; Depression; Humans; Metyrapone; Pituitary-Adrenal System | 1973 |
The excretion of urinary 11-deoxy- and 11-oxy-17-hydroxy-corticosteroids in depressive patients during basal conditions and during the administration of methopyrapone.
Topics: Adrenal Cortex Hormones; Antidepressive Agents; Chromatography, Thin Layer; Depression; Electroconvu | 1966 |