metyrapone has been researched along with Depression, Involutional in 9 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Depression, Involutional: Form of depression in those MIDDLE AGE with feelings of ANXIETY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Many patients with major depressive disorder have treatment-resistant depression, defined as no adequate response to two consecutive courses of antidepressants." | 2.82 | Antidepressant augmentation with metyrapone for treatment-resistant depression (the ADD study): a double-blind, randomised, placebo-controlled trial. ( Anderson, IM; Ferrier, IN; Finkelmeyer, A; Gallagher, P; Grunze, HC; Haddad, PM; Hughes, T; Lloyd, AJ; Mamasoula, C; McAllister-Williams, RH; McColl, E; Pearce, S; Siddiqi, N; Sinha, BN; Steen, N; Wainwright, J; Watson, S; Winter, FH, 2016) |
| "Metyrapone treatment was well tolerated without serious adverse effects." | 2.71 | Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial. ( Jahn, H; Kellner, M; Kiefer, F; Schick, M; Wiedemann, K; Yassouridis, A, 2004) |
| "Major depressive disorder affects a substantial percentage of the U." | 2.45 | Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus? ( Coleman, VH; Kling, MA; Schulkin, J, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McAllister-Williams, RH | 2 |
| Smith, E | 1 |
| Anderson, IM | 2 |
| Barnes, J | 1 |
| Gallagher, P | 2 |
| Grunze, HC | 2 |
| Haddad, PM | 2 |
| House, AO | 1 |
| Hughes, T | 2 |
| Lloyd, AJ | 2 |
| McColl, EM | 1 |
| Pearce, SH | 1 |
| Siddiqi, N | 2 |
| Sinha, B | 1 |
| Speed, C | 1 |
| Steen, IN | 1 |
| Wainright, J | 1 |
| Watson, S | 2 |
| Winter, FH | 2 |
| Ferrier, IN | 2 |
| Finkelmeyer, A | 1 |
| Mamasoula, C | 1 |
| McColl, E | 1 |
| Pearce, S | 1 |
| Sinha, BN | 1 |
| Steen, N | 1 |
| Wainwright, J | 1 |
| Kling, MA | 1 |
| Coleman, VH | 1 |
| Schulkin, J | 1 |
| Carroll, BJ | 1 |
| Iranmanesh, A | 1 |
| Keenan, DM | 1 |
| Cassidy, F | 1 |
| Wilson, WH | 1 |
| Veldhuis, JD | 1 |
| Young, EA | 2 |
| Altemus, M | 1 |
| Lopez, JF | 1 |
| Kocsis, JH | 1 |
| Schatzberg, AF | 1 |
| DeBattista, C | 1 |
| Zubieta, JK | 1 |
| Jahn, H | 1 |
| Schick, M | 1 |
| Kiefer, F | 1 |
| Kellner, M | 1 |
| Yassouridis, A | 1 |
| Wiedemann, K | 1 |
| Hui, X | 1 |
| Zhou, CH | 1 |
| Wang, MW | 1 |
| Young, AH | 1 |
| Ribeiro, SC | 1 |
| Ye, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression.[NCT03491696] | Phase 4 | 14 participants (Anticipated) | Interventional | 2018-12-22 | Recruiting | ||
| Double-Blind, Placebo Controlled Trial of Metyrapone as Augmenting Agent in the Treatment of Major Depression[NCT00125554] | Phase 2 | 63 participants | Interventional | 1998-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metyrapone and Depression, Involutional
| Article | Year |
|---|---|
Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus?
Topics: Adrenal Glands; Aminoglutethimide; Anti-Inflammatory Agents; Corticotropin-Releasing Hormone; Depres | 2009 |
Glucocorticoid receptor and treatment of psychotic major depression.
Topics: Animals; Brain; Dehydroepiandrosterone; Depressive Disorder, Major; Humans; Metyrapone; Mifepristone | 2005 |
Antiglucocoticoid treatments for depression.
Topics: Adrenocortical Hyperfunction; Dehydroepiandrosterone; Depressive Disorder, Major; Enzyme Inhibitors; | 2006 |
5 trials available for metyrapone and Depression, Involutional
| Article | Year |
|---|---|
Study protocol for the randomised controlled trial: antiglucocorticoid augmentation of anti-Depressants in Depression (The ADD Study).
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Clinical Protocols; Depressive Disorder, Major; Depr | 2013 |
Antidepressant augmentation with metyrapone for treatment-resistant depression (the ADD study): a double-blind, randomised, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Tre | 2016 |
HPA axis activation in major depression and response to fluoxetine: a pilot study.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Antidepressive Agents, Second-Generation; Circadian | 2004 |
Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial.
Topics: Adrenocorticotropic Hormone; Adult; Antidepressive Agents; Cortodoxone; Dehydroepiandrosterone; Depr | 2004 |
Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial.
Topics: Adrenocorticotropic Hormone; Adult; Antidepressive Agents; Cortodoxone; Dehydroepiandrosterone; Depr | 2004 |
Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial.
Topics: Adrenocorticotropic Hormone; Adult; Antidepressive Agents; Cortodoxone; Dehydroepiandrosterone; Depr | 2004 |
Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial.
Topics: Adrenocorticotropic Hormone; Adult; Antidepressive Agents; Cortodoxone; Dehydroepiandrosterone; Depr | 2004 |
Sex differences in ACTH pulsatility following metyrapone blockade in patients with major depression.
Topics: Adrenocorticotropic Hormone; Adult; Analysis of Variance; Area Under Curve; Case-Control Studies; Ci | 2007 |
1 other study available for metyrapone and Depression, Involutional
| Article | Year |
|---|---|
Pathophysiology of hypercortisolism in depression: pituitary and adrenal responses to low glucocorticoid feedback.
Topics: Adrenocorticotropic Hormone; Adult; Case-Control Studies; Cushing Syndrome; Depressive Disorder, Maj | 2012 |