metyrapone has been researched along with Depression, Endogenous in 38 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The metyrapone test was applied to groups of patients suffering from major depressive illness with melancholia, mania or schizophrenia, before and after treatment." | 7.67 | The metyrapone test in affective disorders and schizophrenia II. Changes upon treatment. ( Carson, SW; Fava, GA; Jusko, WJ; Molnar, G; Morphy, MA; Perini, GI, 1984) |
| "The metyrapone test was applied to patients suffering from major depressive illness with melancholia, from mania, and from schizophrenia." | 7.67 | The metyrapone test in affective disorders and schizophrenia. ( Carson, SW; Fava, GA; Jusko, WJ; Molnar, G; Morphy, MA; Perini, GI, 1984) |
| "The metyrapone test was applied to groups of patients suffering from major depressive illness with melancholia, mania or schizophrenia, before and after treatment." | 3.67 | The metyrapone test in affective disorders and schizophrenia II. Changes upon treatment. ( Carson, SW; Fava, GA; Jusko, WJ; Molnar, G; Morphy, MA; Perini, GI, 1984) |
| "The metyrapone test was applied to patients suffering from major depressive illness with melancholia, from mania, and from schizophrenia." | 3.67 | The metyrapone test in affective disorders and schizophrenia. ( Carson, SW; Fava, GA; Jusko, WJ; Molnar, G; Morphy, MA; Perini, GI, 1984) |
| "Treatment with metyrapone resulted in greatly increased urinary excretion of 11-deoxy corticosteroids, including the GABA-modulatory steroid tetrahydro-11-deoxycorticosterone (from 68 +/- 34 to 219 +/- 75 micrograms/24 h, p < ." | 2.68 | The relationship between the effects of metyrapone treatment on depressed mood and urinary steroid profiles. ( Checkley, SA; O'Dwyer, AM; Raven, PW; Taylor, NF, 1996) |
| "Adult male mice underwent middle cerebral artery occlusion (MCAO), and were recovered 7 days." | 1.33 | Role of IL-1 in poststroke depressive-like behavior in mice. ( Craft, TK; DeVries, AC, 2006) |
| "Metyrapone has multiple effects on extra-adrenal corticosteroid metabolism and is the only agent we know of which selectively inhibits 11-oxoreductase." | 1.29 | Extra-adrenal effects of metyrapone include inhibition of the 11-oxoreductase activity of 11 beta-hydroxysteroid dehydrogenase: a model for 11-HSD I deficiency. ( Checkley, SA; Raven, PW; Taylor, NF, 1995) |
| "Metyrapone 750 mg was given 4-hourly for 24 h and samples were taken for cortisol and ACTH." | 1.28 | Effect of metyrapone on the pituitary-adrenal axis in depression: relation to dexamethasone suppressor status. ( Besser, GM; Clare, AW; Dinan, TG; Grossman, A; McLoughlin, L; O'Keane, V; Rees, LH; Turner, TH; Ur, E, 1992) |
| "This study defines the pituitary B-endorphin (BE) secretory response to a low dosage (0." | 1.28 | B-endorphin response to a low dosage of human corticotropin releasing hormone during metyrapone administration in depression. ( Brazis, M; Dorin, R; Hauger, R; Lisansky, J; Meikle, AW; Qualls, C; Strassman, R; Turkin, A, 1992) |
| "If metyrapone was given during the time of day when hypothalamic pituitary adrenal activity was otherwise low, the relative increase in the corticotropin concentration was small." | 1.28 | Augmented pituitary corticotropin response to a threshold dosage of human corticotropin-releasing hormone in depressives pretreated with metyrapone. ( Britton, D; Fava, GA; Hochla, P; Lisansky, J; Meikle, AW; Peake, GT; Qualls, C; Risch, SC; Strassman, RJ; Zownir-Brazis, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (31.58) | 18.7374 |
| 1990's | 21 (55.26) | 18.2507 |
| 2000's | 5 (13.16) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rogóz, Z | 1 |
| Budziszewska, B | 1 |
| Kubera, M | 1 |
| Basta-Kaim, A | 1 |
| Jaworska-Feil, L | 1 |
| Skuza, G | 1 |
| Lasoń, W | 1 |
| Craft, TK | 1 |
| DeVries, AC | 1 |
| Broadley, AJ | 1 |
| Korszun, A | 1 |
| Abdelaal, E | 1 |
| Moskvina, V | 1 |
| Deanfield, J | 1 |
| Jones, CJ | 1 |
| Frenneaux, MP | 1 |
| Young, EA | 3 |
| Ribeiro, SC | 1 |
| Obinata, D | 1 |
| Yamaguchi, K | 1 |
| Hirano, D | 1 |
| Yoshida, T | 1 |
| Soma, M | 1 |
| Takahashi, S | 1 |
| Perini, GI | 4 |
| Fava, GA | 8 |
| Morphy, MA | 7 |
| Carson, SW | 3 |
| Molnar, G | 4 |
| Jusko, WJ | 3 |
| Wetterberg, L | 1 |
| O'Dwyer, AM | 2 |
| Lightman, SL | 1 |
| Marks, MN | 1 |
| Checkley, SA | 3 |
| Akil, H | 2 |
| Haskett, RF | 1 |
| Watson, SJ | 2 |
| Ghadirian, AM | 3 |
| Engelsmann, F | 1 |
| Dhar, V | 3 |
| Filipini, D | 1 |
| Keller, R | 2 |
| Chouinard, G | 2 |
| Murphy, BE | 4 |
| Báez, M | 1 |
| Volosin, M | 1 |
| Gaitan, D | 1 |
| Loosen, PT | 1 |
| Orth, DN | 1 |
| Raven, PW | 2 |
| Taylor, NF | 2 |
| Lopez, JF | 1 |
| Murphy-Weinberg, V | 1 |
| Rupprecht, R | 3 |
| Ströhle, A | 1 |
| Hermann, B | 1 |
| di Michele, F | 1 |
| Spalletta, G | 1 |
| Pasini, A | 1 |
| Holsboer, F | 3 |
| Romeo, E | 1 |
| Ur, E | 1 |
| Dinan, TG | 1 |
| O'Keane, V | 1 |
| Clare, AW | 1 |
| McLoughlin, L | 1 |
| Rees, LH | 1 |
| Turner, TH | 1 |
| Grossman, A | 1 |
| Besser, GM | 1 |
| Starkman, MN | 1 |
| Schteingart, DE | 1 |
| Schork, MA | 1 |
| Lisansky, J | 3 |
| Hauger, R | 1 |
| Strassman, R | 1 |
| Dorin, R | 1 |
| Meikle, AW | 2 |
| Brazis, M | 1 |
| Qualls, C | 2 |
| Turkin, A | 1 |
| Pedersen, RC | 3 |
| Zielezny, M | 3 |
| Sonino, N | 3 |
| Brownie, AC | 2 |
| Rothschild, AJ | 1 |
| Schatzberg, AF | 1 |
| Kornhuber, J | 2 |
| Wodarz, N | 2 |
| Lugauer, J | 1 |
| Göbel, C | 1 |
| Haack, D | 1 |
| Beck, G | 1 |
| Müller, OA | 3 |
| Riederer, P | 2 |
| Beckmann, H | 2 |
| Wild, K | 1 |
| Schmitz, B | 1 |
| Braner, HU | 1 |
| Peake, GT | 1 |
| Strassman, RJ | 1 |
| Risch, SC | 1 |
| Zownir-Brazis, M | 1 |
| Hochla, P | 1 |
| Britton, D | 1 |
| Stokes, PE | 2 |
| Sikes, CR | 2 |
| von Bardeleben, U | 1 |
| Stalla, GK | 1 |
| Kramlinger, KG | 1 |
| Peterson, GC | 1 |
| Watson, PK | 1 |
| Leonard, LL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression.[NCT03491696] | Phase 4 | 14 participants (Anticipated) | Interventional | 2018-12-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metyrapone and Depression, Endogenous
| Article | Year |
|---|---|
The relationship between the pineal gland and the pituitary--adrenal axis in health, endocrine and psychiatric conditions.
Topics: Adenoma; Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Circadian Rhythm; Cushing Syndr | 1983 |
The hypothalamic-pituitary-adrenocortical axis in major depression.
Topics: Adrenocorticotropic Hormone; Body Fluids; Corticotropin-Releasing Hormone; Depressive Disorder; Estr | 1988 |
The hypothalamic-pituitary-adrenocortical axis in major depression.
Topics: Adrenocorticotropic Hormone; Brain; Corticotropin-Releasing Hormone; Depressive Disorder; Estrenes; | 1988 |
8 trials available for metyrapone and Depression, Endogenous
| Article | Year |
|---|---|
Metyrapone improves endothelial dysfunction in patients with treated depression.
Topics: Adult; Antidepressive Agents; Brachial Artery; Coronary Disease; Depressive Disorder; Double-Blind M | 2006 |
Treatment of major depression with metyrapone and hydrocortisone.
Topics: Adult; Analysis of Variance; Cross-Over Studies; Depressive Disorder; Drug Therapy, Combination; Fem | 1995 |
Evidence against changes in corticotroph CRF receptors in depressed patients.
Topics: Adrenocorticotropic Hormone; Adult; beta-Endorphin; beta-Lipotropin; Bipolar Disorder; Circadian Rhy | 1995 |
The relationship between the effects of metyrapone treatment on depressed mood and urinary steroid profiles.
Topics: Adult; Affect; Antidepressive Agents; Depressive Disorder; Female; Humans; Hydrocortisone; Metyrapon | 1996 |
Normal pituitary response to metyrapone in the morning in depressed patients: implications for circadian regulation of corticotropin-releasing hormone secretion.
Topics: Adrenocorticotropic Hormone; Adult; beta-Endorphin; Circadian Rhythm; Corticotropin-Releasing Hormon | 1997 |
Neuroendocrine responses to inhibitors of steroid biosynthesis in patients with major depression resistant to antidepressant therapy.
Topics: Adult; Aminoglutethimide; Analysis of Variance; Androgen Antagonists; Antidepressive Agents; Dehydro | 1998 |
Response to steroid suppression in major depression resistant to antidepressant therapy.
Topics: Adult; Aminoglutethimide; Antidepressive Agents; Dehydroepiandrosterone; Depressive Disorder; Dexame | 1991 |
Treatment of major depression with steroid suppressive drugs.
Topics: Adrenocortical Hyperfunction; Adult; Aged; Aminoglutethimide; Cushing Syndrome; Depressive Disorder; | 1991 |
27 other studies available for metyrapone and Depression, Endogenous
| Article | Year |
|---|---|
Effect of combined treatment with imipramine and metyrapone on the immobility time, the activity of hypothalamo-pituitary-adrenocortical axis and immunological parameters in the forced swimming test in the rat.
Topics: Animals; Corticosterone; Depressive Disorder; Drug Therapy, Combination; Hypothalamo-Hypophyseal Sys | 2005 |
Role of IL-1 in poststroke depressive-like behavior in mice.
Topics: Animals; Antimetabolites; Depressive Disorder; Drinking Behavior; Glucocorticoids; Hormone Antagonis | 2006 |
Sex differences in the ACTH response to 24H metyrapone in depression.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Antimetabolites; Circadian Rhythm; Depressive Di | 2006 |
Preoperative management of Cushing's syndrome with metyrapone for severe psychiatric disturbances.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Depressive Disorder; Female; Humans; Metyrapone; Mi | 2008 |
The metyrapone test in affective disorders and schizophrenia II. Changes upon treatment.
Topics: Adult; Aged; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Cortodoxone; Depressive | 1984 |
The metyrapone test in affective disorders and schizophrenia.
Topics: Adult; Aged; Bipolar Disorder; Cortodoxone; Depressive Disorder; Dexamethasone; Female; Humans; Hydr | 1984 |
Simultaneous analysis of cortexolone and cortisol by high-performance liquid chromatography for use in the metyrapone test.
Topics: 17-Hydroxycorticosteroids; Chromatography, High Pressure Liquid; Cortodoxone; Depressive Disorder; H | 1984 |
The psychotropic effects of inhibitors of steroid biosynthesis in depressed patients refractory to treatment.
Topics: Adrenal Cortex Hormones; Adult; Aminoglutethimide; Bipolar Disorder; Depressive Disorder; Dose-Respo | 1995 |
Corticosterone influences forced swim-induced immobility.
Topics: Animals; Behavior, Animal; Corticosterone; Depressive Disorder; Dose-Response Relationship, Drug; Ma | 1994 |
Two patients with Cushing's disease in a kindred with multiple endocrine neoplasia type I.
Topics: Adolescent; Adult; Cushing Syndrome; Depressive Disorder; Dexamethasone; Female; Humans; Hyperparath | 1993 |
Extra-adrenal effects of metyrapone include inhibition of the 11-oxoreductase activity of 11 beta-hydroxysteroid dehydrogenase: a model for 11-HSD I deficiency.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adult; Anti-Inflammatory Agents; Depressive Disorder; Drug Th | 1995 |
Neuroactive steroid concentrations following metyrapone administration in depressed patients and healthy volunteers.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Antidepressive Agents, Second-Generation; Brain; Case-Cont | 1998 |
Effect of metyrapone on the pituitary-adrenal axis in depression: relation to dexamethasone suppressor status.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Corticotropin-Releasing Hormone; Depres | 1992 |
Discordant changes in plasma ACTH and beta-lipotropin/beta-endorphin levels in Cushing's disease patients with depression.
Topics: Adrenocorticotropic Hormone; Adult; Aged; beta-Endorphin; beta-Lipotropin; Cushing Syndrome; Depress | 1992 |
B-endorphin response to a low dosage of human corticotropin releasing hormone during metyrapone administration in depression.
Topics: Adrenal Glands; beta-Endorphin; Corticotropin-Releasing Hormone; Depressive Disorder; Female; Humans | 1992 |
Beta-endorphin responses to metyrapone and dexamethasone in depressed patients.
Topics: beta-Endorphin; Depressive Disorder; Dexamethasone; Humans; Hypothalamo-Hypophyseal System; Male; Me | 1992 |
Theoretical basis for response to steroid suppression in major depression.
Topics: Aminoglutethimide; Depressive Disorder; Dopamine; Humans; Hydrocortisone; Ketoconazole; Metyrapone | 1992 |
Disturbed glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressives pretreated with metyrapone.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; beta-Endorphin; Bipolar Disorder; Depressive D | 1991 |
In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Bipolar Disorder; Depressive Disorder; Dexamet | 1991 |
Effects of metyrapone and dexamethasone on pro-gamma-MSH and ACTH levels in depressed patients.
Topics: Adrenocorticotropic Hormone; Adult; Depressive Disorder; Dexamethasone; Humans; Male; Metyrapone; Pe | 1990 |
Effects of metyrapone and dexamethasone upon pro-gamma-MSH plasma levels in depressed patients and healthy controls.
Topics: Adrenocorticotropic Hormone; Adult; Depressive Disorder; Dexamethasone; Humans; Hydrocortisone; Hypo | 1990 |
Augmented pituitary corticotropin response to a threshold dosage of human corticotropin-releasing hormone in depressives pretreated with metyrapone.
Topics: Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Corticotropin-Releasing Hormone; Cortodoxone; | 1989 |
Blunting of ACTH response to human CRH in depressed patients is avoided by metyrapone pretreatment.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Corticotropin-Releasing Hormone; Depressive Disorder; Fema | 1988 |
Adrenocortical steroid secretion and 11-beta-steroid hydroxylase activity after pituitary-adrenocortical probes in depression.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Bipolar Disorder; Corticosterone; Corticotropi | 1985 |
The dexamethasone suppression and metyrapone tests in depression.
Topics: 17-Hydroxycorticosteroids; Adult; Cortodoxone; Depressive Disorder; Dexamethasone; Female; Humans; H | 1985 |
Metyrapone for depression and delirium secondary to Cushing's syndrome.
Topics: Cushing Syndrome; Delirium; Depressive Disorder; Humans; Male; Metyrapone; Middle Aged | 1985 |
The metyrapone test in depressed males.
Topics: Addison Disease; Adult; Cortodoxone; Depressive Disorder; Dexamethasone; Humans; Hydrocortisone; Hyp | 1985 |