metyrapone has been researched along with Delayed Effects, Prenatal Exposure in 12 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Maternal treatment with dexamethasone on day 15 of pregnancy mimicked the stress effect and reproduced the AI and AHR outcomes, whereas blockade of the stress-induced corticosterone surge with metyrapone pretreatment of pregnant mice abrogated the effect." | 3.80 | Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids. ( Fedulov, AV; Kobzik, L; Lim, R, 2014) |
| "To determine whether prenatal dietary protein deprivation results in a reduction in nephron number and hypertension in offspring by exposure to maternal glucocorticoids, we administered metyrapone to rats fed either a 6% or 20% protein diet to inhibit glucocorticoid production and compared the offspring to rats that were the product of mothers fed either a 6% or 20% protein diet during the last half of pregnancy." | 3.77 | Evidence that prenatal programming of hypertension by dietary protein deprivation is mediated by fetal glucocorticoid exposure. ( Baum, M; Gattineni, J; Habib, S; Twombley, K, 2011) |
| "Maternal food restriction (MFR) causes intrauterine growth restriction, a known risk factor for developing chronic lung disease." | 1.42 | Metyrapone alleviates deleterious effects of maternal food restriction on lung development and growth of rat offspring. ( Khorram, O; Li, Y; Paek, DS; Rehan, VK; Sakurai, R; Saraswat, A; Torday, JS, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Nemoto, T | 1 |
| Nakakura, T | 1 |
| Kakinuma, Y | 1 |
| Chuang, TD | 1 |
| Sakurai, R | 3 |
| Gong, M | 1 |
| Khorram, O | 4 |
| Rehan, VK | 3 |
| Li, Y | 2 |
| Corral, J | 1 |
| Saraswat, A | 2 |
| Husain, S | 1 |
| Dhar, A | 1 |
| Torday, JS | 2 |
| Durrant, LM | 1 |
| Buchholz, JN | 1 |
| Pearce, WJ | 1 |
| Lim, R | 1 |
| Fedulov, AV | 1 |
| Kobzik, L | 1 |
| Paek, DS | 1 |
| Leret, ML | 1 |
| Rua, C | 1 |
| Garcia-Montojo, M | 1 |
| Lecumberri, M | 1 |
| González, JC | 1 |
| Erhuma, A | 1 |
| McMullen, S | 2 |
| Langley-Evans, SC | 2 |
| Bennett, AJ | 1 |
| Bogdarina, I | 1 |
| Haase, A | 1 |
| Langley-Evans, S | 1 |
| Clark, AJ | 1 |
| Habib, S | 1 |
| Gattineni, J | 1 |
| Twombley, K | 1 |
| Baum, M | 1 |
| Peruzović, M | 1 |
| Milković, K | 1 |
12 other studies available for metyrapone and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Elevated blood pressure in high-fat diet-exposed low birthweight rat offspring is most likely caused by elevated glucocorticoid levels due to abnormal pituitary negative feedback.
Topics: Animals; Birth Weight; Blood Pressure; Corticosterone; Diet, High-Fat; Feedback, Physiological; Fema | 2020 |
Role of miR-29 in mediating offspring lung phenotype in a rodent model of intrauterine growth restriction.
Topics: Animals; Extracellular Matrix Proteins; Female; Fetal Growth Retardation; Glucocorticoids; Lung; Mal | 2018 |
Metyrapone blocks maternal food restriction-induced changes in female rat offspring lung development.
Topics: Age Factors; Animal Nutritional Physiological Phenomena; Animals; Caloric Restriction; Female; Gesta | 2014 |
Maternal food restriction modulates cerebrovascular structure and contractility in adult rat offspring: effects of metyrapone.
Topics: Age Factors; Animals; Calcium; Caloric Restriction; Cardiovascular Diseases; Cerebrovascular Circula | 2014 |
Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Corticosterone; Disease Susceptibility; Female; Glucocor | 2014 |
Metyrapone alleviates deleterious effects of maternal food restriction on lung development and growth of rat offspring.
Topics: Age Factors; Animals; Bronchopulmonary Dysplasia; Caloric Restriction; Cell Differentiation; Cells, | 2015 |
Influence of metyrapone treatment during pregnancy on the development and maturation of brain monoaminergic systems in the rat.
Topics: Animals; Brain; Brain Chemistry; Corticosterone; Dopamine; Enzyme Inhibitors; Female; Male; Metyrapo | 2009 |
Feeding pregnant rats a low-protein diet alters the hepatic expression of SREBP-1c in their offspring via a glucocorticoid-related mechanism.
Topics: Adrenalectomy; Animals; Cells, Cultured; Dexamethasone; Diet, Protein-Restricted; Dietary Proteins; | 2009 |
Glucocorticoid effects on the programming of AT1b angiotensin receptor gene methylation and expression in the rat.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Blood Pressure; Dexamethasone | 2010 |
Evidence that prenatal programming of hypertension by dietary protein deprivation is mediated by fetal glucocorticoid exposure.
Topics: Animals; Blood Pressure; Dexamethasone; Diet, Protein-Restricted; Female; Fetus; Hypertension; Kidne | 2011 |
Maternal low-protein diet in rat pregnancy programs blood pressure through sex-specific mechanisms.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Blood Pressure; Corticosterone; Diet, Protein- | 2005 |
Prenatal ACTH and corticosteroids, development and behavior in rat.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Avoidance Learning; Behavior, Animal; | 1986 |