metyrapone has been researched along with Chronic Disease in 14 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Growth, pulmonary, and adrenal-pituitary function were assessed in 20 steroid-dependent asthmatic children and adolescents while they were on daily prednisone therapy." | 5.04 | Growth, pulmonary, and endocrine function in chronic asthma patients on daily and alternate-day adrenocorticosteroid therapy. ( Bierman, CW; Kelley, VC; Pierson, WE; Shapiro, GG; Tattoni, DS, 1976) |
| "Chronic hypertension has been produced in mongrel dogs by the long-term oral administration of metyrapone (100 mg/kg per day)." | 3.65 | Multifactorial analysis of chronic hypertension induced by electrolyte-active steroids in trained, unanesthetized dogs. ( Bravo, EL; Dustan, HP; Tarazi, RC, 1977) |
| "Striking parallels exist between the neurochemical and toxic effects of stress and methamphetamine." | 1.35 | Chronic stress enhances methamphetamine-induced extracellular glutamate and excitotoxicity in the rat striatum. ( Tata, DA; Yamamoto, BK, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (71.43) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Biala, G | 1 |
| Pekala, K | 1 |
| Boguszewska-Czubara, A | 1 |
| Michalak, A | 1 |
| Kruk-Slomka, M | 1 |
| Grot, K | 1 |
| Budzynska, B | 1 |
| Tata, DA | 1 |
| Yamamoto, BK | 1 |
| Conrad, CD | 1 |
| Mauldin-Jourdain, ML | 1 |
| Hobbs, RJ | 1 |
| Ford, LR | 1 |
| Willi, SM | 1 |
| Hollis, BW | 1 |
| Wright, NM | 1 |
| Shapiro, GG | 1 |
| Tattoni, DS | 1 |
| Kelley, VC | 1 |
| Pierson, WE | 1 |
| Bierman, CW | 1 |
| Gerdes, H | 1 |
| Turpin, G | 1 |
| Heshmati, HM | 1 |
| Roger, M | 1 |
| Legrand, S | 1 |
| Guillemant, S | 1 |
| de Gennes, JL | 1 |
| Parnham, MJ | 1 |
| Bravo, EL | 1 |
| Tarazi, RC | 1 |
| Dustan, HP | 1 |
| Rinne, UK | 1 |
| Tăpălăgă, D | 2 |
| Fodor, O | 1 |
| Szantay, I | 2 |
| Szabo, P | 2 |
| Tamas, S | 2 |
| Clary, JJ | 1 |
| Hopper, CR | 1 |
| Stokinger, HE | 1 |
| Ferrari, E | 1 |
| Tronconi, L | 1 |
| Bossolo, PA | 1 |
| Pallavicini, S | 1 |
| Baldrighi, V | 1 |
1 review available for metyrapone and Chronic Disease
| Article | Year |
|---|---|
Glucocorticoid and mineralocorticoid hormones in chronic liver diseases.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Chronic Disease; Circadian Rhythm; Cortiso | 1979 |
1 trial available for metyrapone and Chronic Disease
| Article | Year |
|---|---|
Growth, pulmonary, and endocrine function in chronic asthma patients on daily and alternate-day adrenocorticosteroid therapy.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Age Determination by Skel | 1976 |
12 other studies available for metyrapone and Chronic Disease
| Article | Year |
|---|---|
Behavioral and Biochemical Impact of Chronic Unpredictable Mild Stress on the Acquisition of Nicotine Conditioned Place Preference in Rats.
Topics: Animals; Behavior, Animal; Choice Behavior; Chronic Disease; Conditioning, Classical; Imipramine; Ma | 2018 |
Chronic stress enhances methamphetamine-induced extracellular glutamate and excitotoxicity in the rat striatum.
Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Chronic Disease; Dopamine; Dopamin | 2008 |
Metyrapone reveals that previous chronic stress differentially impairs hippocampal-dependent memory.
Topics: Animals; Atrophy; Behavior, Animal; Chronic Disease; Conditioning, Psychological; Corticosterone; Cu | 2001 |
Suppression and recovery of the neonatal hypothalamic-pituitary-adrenal axis after prolonged dexamethasone therapy.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Chronic Disease; Corticotropin-Releasing Horm | 1997 |
[Adrenocortical function in hyperprolactinemia. The study of glucocorticoids, mineralocorticoids and androgens in chronic and acute hyperprolactinemias (author's transl)].
Topics: Acute Disease; Adenoma; Adrenal Cortex; Adrenocorticotropic Hormone; Androgens; Chronic Disease; Fem | 1979 |
Metyrapone: a possible tool in investigating the role of endogenous corticosteroids in inflammation.
Topics: Adrenal Cortex Hormones; Animals; Chronic Disease; Female; In Vitro Techniques; Inflammation; Metyra | 1977 |
Multifactorial analysis of chronic hypertension induced by electrolyte-active steroids in trained, unanesthetized dogs.
Topics: Acebutolol; Aldosterone; Animals; Chronic Disease; Clonidine; Corticosterone; Diet, Sodium-Restricte | 1977 |
Corticotrophin secretion capacity in multiple sclerosis.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acute Disease; Adrenocorticotropic Hormone; Adult; Chron | 1968 |
[Urinary cortisol excretion in chronic hepatitis].
Topics: Adrenocorticotropic Hormone; Adult; Chronic Disease; Hepatitis; Humans; Hydrocortisone; Injections, | 1971 |
[Urinary cortisol analysis in chronic hepatitis. In vitro test with H 3-cortisol].
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Chronic Disease; Hepatitis; Humans; Hydrocortiso | 1972 |
Altered adrenal function as an inducer of latent chronic beryllium disease.
Topics: Adrenal Glands; Alkaline Phosphatase; Animals; Berylliosis; Beryllium; Body Weight; Bone and Bones; | 1972 |
[The functional state of the pituitary-adrenal system in chronic coronary insufficiency].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Aged; Angiography; Chronic Disease; Coronary Dise | 1968 |