Compounds > metyrapone
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metyrapone and Central Hypothyroidism

metyrapone has been researched along with Central Hypothyroidism in 23 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Research Excerpts

ExcerptRelevanceReference
"A 58-yr-old woman had frequent hypoglycemic attacks, undetectable levels of plasma cortisol, ACTH, and beta-lipotropin, and deficient responses of these hormones after insulin induced-hypoglycemia and metyrapone."3.66Anaphylactic shock after synthetic adrenocorticotropin-(1-18) in a patient with isolated adrenocorticotropin and beta-lipotropin deficiency. ( Hashimoto, K; Ofuji, T; Takahara, J; Takaya, Y; Yunoki, S, 1980)
"Subnormal plasma 11-deoxycortisol (compound S) responses to metyrapone were found in patients with adrenal insufficiency or with Cushing syndrome caused by adrenal tumors and in those receiving long-term glucocorticoid or diphenylhydantoin sodium therapy."3.65Single-dose metyrapone test: review of a four-year experience. ( Jubiz, W; Meikle, AW; Spiger, M; Tylor, FH; West, CD, 1975)
"Hypothyroidism is known to lead to a certain degree of functional insufficiency of the adrenal gland by affecting both the hypophyseal axis and peripheral metabolism of cortisol."1.29[Hypothalamic-pituitary-adrenal function in primary hypothyroidism]. ( Bakiri, F; Benmiloud, M, 1994)
" Responses of LH and FSH to LH-RH improved markedly after a long term administration of LH-RH for a period of one month in 2 patients with gonadotropin deficiency."1.25Hypothalamic-pituitary functions in patients with idiopathic pituitary dwarfism. ( Demura, H; Demura, R; Jujo, K; Maeda, T; Odagiri, E; Shizume, K; Suda, T; Takano, K, 1975)
"In 17 patients with primary hypothyroidism, plasma TSH levels fell significantly during treatment to a mean of 54% of control (range 23-96%)."1.25The effect of glucocorticoids on thyrotropin secretion. ( Utiger, RD; Wilber, JF, 1969)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199022 (95.65)18.7374
1990's1 (4.35)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
MESTMAN, JH1
NELSON, DH1
BLIZZARD, RM1
TOUYABOGGIANO, JJ1
MEDOC, J1
SARVER, ME1
SABEH, G1
FETTERMAN, GH1
WALD, N1
DANOWSKI, TS1
Davison, K1
Roth, M1
Gibson, A1
KAPLAN, NM1
Hashimoto, K1
Takahara, J1
Takaya, Y1
Yunoki, S1
Ofuji, T1
Yoshida, T1
Arai, T1
Sugano, J1
Yarita, H1
Yanagisawa, H1
Bakiri, F1
Benmiloud, M1
Weiss, RB1
Yamamoto, T1
Ogihara, T1
Miyai, K1
Kumahara, Y1
Hirata, Y1
Demura, R1
Jujo, K1
Takano, K1
Odagiri, E1
Maeda, T1
Suda, T1
Demura, H1
Shizume, K1
Croxson, MS1
Hall, TD1
Kletzky, OA1
Jaramillo, JE1
Nicoloff, JT1
Spiger, M1
Jubiz, W1
Meikle, AW1
West, CD1
Tylor, FH1
Siegel, ET1
Kubo, N1
Hasui, K1
Spark, RF1
Minozzi, M1
Faggiano, M1
Lombardi, G1
Carella, C1
Criscuolo, T1
Oliver, C1
Vague, P1
Zachmann, M1
Völlmin, JA1
Zagalak, M1
Kley, HK1
Krüskemper, HL1
Wilber, JF1
Utiger, RD1
Blunck, W1
Bierich, JR1

Other Studies

23 other studies available for metyrapone and Central Hypothyroidism

ArticleYear
INHIBITION BY ESTROGEN ADMINISTRATION OF ADRENAL-PITUITARY RESPONSE TO METHOPYRAPONE.
    The Journal of clinical investigation, 1963, Volume: 42

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Diabetes Mellitus; Estrogens; Hypothyroidism; Ketones;

1963
THE DIFFERENTIAL DIAGNOSIS AND TREATMENT OF SHORT STATURE AT ADOLESCENCE.
    Journal of the Iowa Medical Society, 1964, Volume: 54

    Topics: Adolescent; Body Height; Bone and Bones; Child; Diagnosis, Differential; Dwarfism; Estrogens; Glucos

1964
[HYPOPHYSARY COMA IN SHEEHAN'S SYNDROME. ANATOMOCLINICAL STUDY].
    Anales de la Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay, 1963, Volume: 48

    Topics: Adrenal Insufficiency; Coma; Desoxycorticosterone; Diagnosis, Differential; Female; Humans; Hydrocor

1963
FRACTIONAL HYPOPITUITARISM WITH GIANTISM AND NORMAL SELLA TURCICA.
    The New England journal of medicine, 1964, Dec-17, Volume: 271

    Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Chromosome Aberrations; Fluids and Secretions; G

1964
PREMATURELY AGED APPEARANCE AND SIMULATED ENDOCRINE DISORDER IN CHRONIC ANXIETY.
    Acta psychiatrica Scandinavica, 1964, Volume: 40, Issue:2

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Anxi

1964
METHOPYRAPONE TEST IN PRIMARY HYPOTHYROIDISM.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Diagnosis, Differential; Hypothyroidism; Keton

1965
Anaphylactic shock after synthetic adrenocorticotropin-(1-18) in a patient with isolated adrenocorticotropin and beta-lipotropin deficiency.
    The Journal of clinical endocrinology and metabolism, 1980, Volume: 51, Issue:5

    Topics: Adrenocorticotropic Hormone; Anaphylaxis; beta-Lipotropin; Female; Humans; Hydrocortisone; Hypoglyce

1980
Isolated ACTH deficiency accompanied by 'primary hypothyroidism' and hyperprolactinaemia.
    Acta endocrinologica, 1983, Volume: 104, Issue:4

    Topics: Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Gonadotropin-Releasing Hormone; Humans

1983
[Hypothalamic-pituitary-adrenal function in primary hypothyroidism].
    Presse medicale (Paris, France : 1983), 1994, Feb-19, Volume: 23, Issue:7

    Topics: Adrenocorticotropic Hormone; Adult; Autoimmune Diseases; Cosyntropin; Female; Humans; Hydrocortisone

1994
Primary empty sella syndrome.
    The West Virginia medical journal, 1975, Volume: 71, Issue:3

    Topics: Adrenocorticotropic Hormone; Cerebrospinal Fluid Rhinorrhea; Humans; Hypopituitarism; Hypothyroidism

1975
Co-existent primary hypothyroidism and isolated ACTH deficiency.
    Acta endocrinologica, 1976, Volume: 82, Issue:3

    Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Follicle Stimulating Hormone; Gonadotropin-Releasing H

1976
Hypothalamic-pituitary functions in patients with idiopathic pituitary dwarfism.
    Endocrinologia japonica, 1975, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Arginine; Child; Cortodoxone; Dwarfism, Pituitary; Follicle Stimulating Hormone;

1975
Decreased serum thyrotropin induced by fasting.
    The Journal of clinical endocrinology and metabolism, 1977, Volume: 45, Issue:3

    Topics: 17-Hydroxycorticosteroids; Adult; Fasting; Female; Humans; Hydrocortisone; Hypothyroidism; Iodine; M

1977
Single-dose metyrapone test: review of a four-year experience.
    Archives of internal medicine, 1975, Volume: 135, Issue:5

    Topics: Adenoma, Chromophobe; Adolescent; Adrenal Cortex Neoplasms; Adrenal Gland Diseases; Adrenal Glands;

1975
Assessment of pituitary-adrenal gland function in the dog.
    American journal of veterinary research, 1968, Volume: 29, Issue:1

    Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenocorticotropic Hormone; Animals; Diabetes Mellitus; Do

1968
[Fractional determination of 4 types of neutral steroid glucuronides (11-deoxy-C-19 steroid, 11-deoxy-C-21 steroid, 11-oxy-C-19 steroid, 11-oxy-C-21 steroid) and 3 types of steroid glucuronides (11-deoxy-neutral steroid, pregnanediol, 11-oxy-neutral stero
    Nihon Naibunpi Gakkai zasshi, 1969, Jan-20, Volume: 44, Issue:10

    Topics: Adrenal Insufficiency; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Adult; Castration;

1969
[Diurnal variation of plasma cortisol concentration in patients with various diseases and negative feedback mechanism of the pituitary-adrenal axis].
    Nihon Naibunpi Gakkai zasshi, 1969, Sep-20, Volume: 45, Issue:6

    Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Central Nervous Sys

1969
Simplified assessment of pituitary-adrenal reserve. Measurement of serum 11-deoxycortisol and cortisol after metyrapone.
    Annals of internal medicine, 1971, Volume: 75, Issue:5

    Topics: Acromegaly; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Biotransformation; Child; Child, P

1971
Somatotrophic and corticotrophic functions in primary hypothyroidism before and after thyroxine treatment.
    Acta endocrinologica, 1973, Volume: 74, Issue:3

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arginine; Child; Female; Growth Ho

1973
Urinary steroid dynamics after a single dose of metyrapone.
    Acta endocrinologica, 1974, Volume: 77, Issue:2

    Topics: 17-Ketosteroids; Administration, Oral; Adolescent; Adrenocorticotropic Hormone; Adult; Child; Child,

1974
[Performance and interpretation of a shortened metyrapone test].
    Klinische Wochenschrift, 1972, Nov-15, Volume: 50, Issue:22

    Topics: 11-Hydroxycorticosteroids; Acromegaly; Adolescent; Adult; Aged; Circadian Rhythm; Diabetes Mellitus;

1972
The effect of glucocorticoids on thyrotropin secretion.
    The Journal of clinical investigation, 1969, Volume: 48, Issue:11

    Topics: Animals; Depression, Chemical; Dexamethasone; Humans; Hydrocortisone; Hypothyroidism; Metyrapone; Mi

1969
[Differentiated evaluation of metopirone test by thin layer chromatography].
    Klinische Wochenschrift, 1968, Feb-15, Volume: 46, Issue:4

    Topics: Addison Disease; Adrenal Cortex Hormones; Adult; Child; Child, Preschool; Chromatography, Thin Layer

1968