metyrapone has been researched along with Carcinoma, Anaplastic in 22 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To analyse the clinical and biochemical effects of metyrapone in the treatment of Cushing's syndrome." | 7.68 | Short and long-term responses to metyrapone in the medical management of 91 patients with Cushing's syndrome. ( Besser, GM; Grossman, AB; Howlett, TA; Perry, L; Rees, LH; Trainer, PJ; Verhelst, JA; Wass, JA, 1991) |
| "Aldosterone excretion was high, normal, or low in each of the three types of Cushing's syndrome." | 5.26 | Deoxycorticosterone and aldosterone excretion in Cushing's syndrome. ( Cassar, J; Joplin, GF; Kelly, WF; Loizou, S; Mashiter, K, 1980) |
| " by metyrapone test or by congenital adrenal hyperplasia resulting from 11 beta-hydroxylase deficiency." | 3.69 | An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione. ( Auzéby, A; Bogdan, A; Touitou, Y, 1995) |
| "To analyse the clinical and biochemical effects of metyrapone in the treatment of Cushing's syndrome." | 3.68 | Short and long-term responses to metyrapone in the medical management of 91 patients with Cushing's syndrome. ( Besser, GM; Grossman, AB; Howlett, TA; Perry, L; Rees, LH; Trainer, PJ; Verhelst, JA; Wass, JA, 1991) |
| "Metyrapone inhibition was associated with a concomitant increase in the formation of androgens (androstenedione and testosterone) from pregnenolone." | 1.31 | Biosynthesis and metabolism of steroid hormones by human adrenal carcinomas. ( Brown, JW; Fishman, LM, 2000) |
| "Aminoglutethimide was examined only for effects on CYP11A activity and was shown to inhibit pregnenolone formation (20 microM: 61 +/- 4% of control)." | 1.31 | Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line. ( Johansson, MK; Lund, BO; Sanderson, JT, 2002) |
| "Aldosterone excretion was high, normal, or low in each of the three types of Cushing's syndrome." | 1.26 | Deoxycorticosterone and aldosterone excretion in Cushing's syndrome. ( Cassar, J; Joplin, GF; Kelly, WF; Loizou, S; Mashiter, K, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (72.73) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mahesh, VB | 1 |
| McDonough, PG | 1 |
| Greenblatt, RB | 1 |
| Bertagna, C | 1 |
| Orth, DN | 2 |
| Cassar, J | 2 |
| Loizou, S | 2 |
| Kelly, WF | 2 |
| Mashiter, K | 2 |
| Joplin, GF | 3 |
| Freeman, DA | 1 |
| Auzéby, A | 1 |
| Bogdan, A | 1 |
| Touitou, Y | 1 |
| Brown, JW | 1 |
| Fishman, LM | 1 |
| Johansson, MK | 1 |
| Sanderson, JT | 1 |
| Lund, BO | 1 |
| Besser, GM | 2 |
| Jeffcoate, WJ | 1 |
| Birkenhäger, JC | 1 |
| Upton, GV | 1 |
| Seldenrath, HJ | 1 |
| Krieger, DT | 1 |
| Tashjian, AH | 1 |
| Barnes, AJ | 1 |
| White, M | 1 |
| Welbourn, RB | 1 |
| McElduff, A | 1 |
| Clifton-Bligh, P | 1 |
| Posen, S | 1 |
| Verhelst, JA | 1 |
| Trainer, PJ | 1 |
| Howlett, TA | 1 |
| Perry, L | 1 |
| Rees, LH | 1 |
| Grossman, AB | 1 |
| Wass, JA | 1 |
| Nomura, H | 1 |
| Azuma, S | 1 |
| Soma, R | 1 |
| Fujii, S | 1 |
| Koni, I | 1 |
| Nakabayashi, H | 1 |
| Tofuku, Y | 1 |
| Takeda, R | 1 |
| Blunt, SB | 1 |
| Pirmohamed, M | 1 |
| Chatterjee, VK | 1 |
| Burrin, JM | 1 |
| Allison, DJ | 1 |
| Smilo, RP | 2 |
| Earll, JM | 1 |
| Forsham, PH | 2 |
| Coll, R | 1 |
| Horner, I | 1 |
| Kraiem, Z | 1 |
| Gafni, J | 1 |
| Donahower, GF | 1 |
| Schumacher, OP | 1 |
| Hazard, JB | 1 |
| Sparks, LL | 1 |
| Pavlatos, FC | 1 |
| Liddle, GW | 1 |
| Yamada, S | 1 |
| Loridan, L | 1 |
| Senior, B | 1 |
1 trial available for metyrapone and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Experience with a rapid oral metyrapone test and the plasma ACTH content in determining the cause of Cushing's syndrome.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adolescent; Adrenal Gland Diseases; Adrenal Gla | 1969 |
21 other studies available for metyrapone and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Endocrine studies in a patient with virilism, ovarian stromal hyperplasia, and endometrial carcinoma.
Topics: Adult; Androgens; Carcinoma; Dexamethasone; Endometrium; Estrogens; Female; Humans; Hyperplasia; Hys | 1967 |
Clinical and laboratory findings and results of therapy in 58 patients with adrenocortical tumors admitted to a single medical center (1951 to 1978).
Topics: Adenoma; Adolescent; Adrenal Cortex Function Tests; Adrenal Cortex Neoplasms; Adrenocorticotropic Ho | 1981 |
Deoxycorticosterone and aldosterone excretion in Cushing's syndrome.
Topics: Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenal Glands; Adult; Aged; Aldosterone; Carcinoma; | 1980 |
Adrenal carcinoma.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aminoglutethimide; Carcinoma; Cushing Syndrome; Dia | 1994 |
An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adult | 1995 |
Biosynthesis and metabolism of steroid hormones by human adrenal carcinomas.
Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Buclade | 2000 |
Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.
Topics: Adrenal Cortex Neoplasms; Aminoglutethimide; Carcinoma; Chromatography, High Pressure Liquid; Colfor | 2002 |
Endocrine and metabolic diseases. Adrenal diseases.
Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Insuffici | 1976 |
[Paradoxical response of adrenal glands to dexamethasone in a case of adrenal carcinoma].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotr | 1975 |
Medullary thyroid carcinoma: ectopic production of peptides with ACTH-like, corticotrophin releasing factor-like and prolactin production-stimulating activities.
Topics: Adrenocorticotropic Hormone; Antigens; Biological Assay; Calcitonin; Carcinoma; Corticotropin-Releas | 1976 |
Cushing's syndrome due to adrenocortical carcinoma - a comphrensive clinical and biochemical study of patients treated by surgery and chemotherapy.
Topics: 17-Ketosteroids; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Carcinoma; Cort | 1979 |
Metastatic medullary carcinoma of the thyroid complicated by Cushing's syndrome.
Topics: Adult; Aminoglutethimide; Carcinoma; Cushing Syndrome; Dexamethasone; Drug Therapy, Combination; Hum | 1979 |
Short and long-term responses to metyrapone in the medical management of 91 patients with Cushing's syndrome.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; | 1991 |
[A case of familial medullary carcinoma of the thyroid complicated with Cushing's syndrome].
Topics: Adrenocorticotropic Hormone; Carcinoma; Circadian Rhythm; Cushing Syndrome; Dexamethasone; Humans; M | 1991 |
Use of adrenal arterial embolization in severe ACTH-dependent Cushing's syndrome.
Topics: ACTH Syndrome, Ectopic; Adrenal Glands; Carcinoma; Combined Modality Therapy; Cushing Syndrome; Embo | 1989 |
Suppression of tumorous adrenal hyperfunction by aminoglutethimide.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenocortical Hyperfu | 1967 |
Successful metyrapone therapy of the ectopic ACTH syndrome.
Topics: Adolescent; Adrenocorticotropic Hormone; Biopsy; Carcinoma; Cushing Syndrome; Cyclophosphamide; Horm | 1968 |
Medullary carcinoma of the thyroid--a cause of Cushing's syndrome: report of two cases.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Carci | 1968 |
Results of treatment in 108 patients with Cushing's syndrome.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Age | 1971 |
[Urinary 6beta-hydroxycortisol. II. Urinary 6beta-hydroxycortisol in different diseases and after administration of drugs].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Carcinoma; Cushing Syndrome; F | 1973 |
Cushing's syndrome in infancy.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abnormalities, Multiple; Adenoma; Adrenal Gland Neoplasm | 1969 |