metyrapone has been researched along with Cancer of Prostate in 8 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Androgens are well-known to stimulate prostate cancer (PC) growth." | 1.36 | Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. ( Hartmann, RW; Haupenthal, J; Hille, UE; Hu, Q; Jagusch, C, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, Q | 1 |
| Jagusch, C | 1 |
| Hille, UE | 1 |
| Haupenthal, J | 1 |
| Hartmann, RW | 1 |
| TAKENAKA, I | 1 |
| Ohashi, T | 1 |
| Morioka, M | 1 |
| Akaeda, T | 1 |
| Mitsuhata, N | 1 |
| Takeda, K | 1 |
| Ohmori, H | 1 |
| Saito, T | 1 |
| Takami, T | 1 |
| Kanbegawa, A | 1 |
| Stathem, BN | 1 |
| Pardoe, TH | 1 |
| Mir, MA | 1 |
| Levitt, M | 1 |
| Sharma, RN | 1 |
| Faiman, C | 1 |
| Kitahara, K | 1 |
| Newmark, SR | 1 |
| Dluhy, RG | 1 |
| Bennett, AH | 1 |
| Blackard, CE | 1 |
| Doe, RP | 1 |
| Seal, US | 1 |
2 trials available for metyrapone and Cancer of Prostate
| Article | Year |
|---|---|
Normal metyrapone response after 1 month of high-dose methylprednisolone in cancer patients: a phase I study.
Topics: Adenocarcinoma; Aged; Clinical Trials as Topic; Colonic Neoplasms; Cortodoxone; Female; Humans; Hydr | 1979 |
Serum corticosteroid-binding globulin, cortisol, and nonprotein-bound cortisol levels in patients receiving estrogen for carcinoma of the prostate.
Topics: Adenocarcinoma; Adrenal Glands; Binding, Competitive; Blood Protein Electrophoresis; Carbon Isotopes | 1973 |
6 other studies available for metyrapone and Cancer of Prostate
| Article | Year |
|---|---|
Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer.
Topics: Androgen Antagonists; Animals; Biphenyl Compounds; Cell Line; Cricetinae; Cricetulus; Humans; Imidaz | 2010 |
[EXPERIMENTAL STUDIES OF PROSTATIC TUMORS. 3. EFFECTS OF PITUITARY AND ADRENOCORTICAL HORMONES].
Topics: Cortisone; Gonadotropins; Gonadotropins, Pituitary; Humans; Ketones; Male; Metabolism; Metyrapone; M | 1964 |
[Plasma 11-deoxycortisol response to single dose metyrapone in prostatic cancer patients (author's transl)].
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Adult; Aged; Cortodoxone; Humans; Hydrocorti | 1981 |
Response of ectopic prostatic ACTH production to metyrapone.
Topics: Adenocarcinoma; Adrenocorticotropic Hormone; Humans; Male; Metyrapone; Middle Aged; Prostate; Prosta | 1981 |
[A study of radiation hypophysectomy for prostatic cancer. 2. Endocrine function and clinical effect after raiation hypophysectomy].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Ag | 1972 |
Ectopic adrenocorticotropin syndrome with prostatic carcinoma.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenocorticotropic Hormone; Blood Gluco | 1973 |