metyrapone has been researched along with Bronchial Hyperreactivity in 6 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigates the role of adrenal-derived catecholamines and corticosterone on the inhibition by rolipram, a phosphodiesterase (PDE)-4 inhibitor, of pulmonary eosinophilia and airway hyperresponsiveness (AHR) in allergic mice." | 7.70 | Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines. ( Chapman, RW; Crawley, Y; Kreutner, W; Kung, TT; Luo, B; Young, S, 2000) |
| "Treatment with metyrapone significantly increased eosinophil infiltration (17." | 5.29 | Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse. ( De Bie, JJ; Hessel, EM; Hofman, G; Nijkamp, FP; Van Ark, I; Van Esch, B; Van Oosterhout, AJ, 1996) |
| " Maternal treatment with dexamethasone on day 15 of pregnancy mimicked the stress effect and reproduced the AI and AHR outcomes, whereas blockade of the stress-induced corticosterone surge with metyrapone pretreatment of pregnant mice abrogated the effect." | 3.80 | Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids. ( Fedulov, AV; Kobzik, L; Lim, R, 2014) |
| "This study investigates the role of adrenal-derived catecholamines and corticosterone on the inhibition by rolipram, a phosphodiesterase (PDE)-4 inhibitor, of pulmonary eosinophilia and airway hyperresponsiveness (AHR) in allergic mice." | 3.70 | Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines. ( Chapman, RW; Crawley, Y; Kreutner, W; Kung, TT; Luo, B; Young, S, 2000) |
| " In ovalbumin-sensitized guinea pigs, challenged with low doses of ovalbumin, we observed an immediate bronchoconstriction, a late-phase bronchopulmonary eosinophilia but no late-phase bronchoconstriction." | 3.68 | Chasing the elusive animal model of late-phase bronchoconstriction: studies in dogs, guinea pigs and rats. ( Fidler, SF; Griffin, RL; Reid, MS; Richards, IM; Shields, SK, 1992) |
| "Treatment with metyrapone significantly increased eosinophil infiltration (17." | 1.29 | Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse. ( De Bie, JJ; Hessel, EM; Hofman, G; Nijkamp, FP; Van Ark, I; Van Esch, B; Van Oosterhout, AJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lim, R | 1 |
| Fedulov, AV | 1 |
| Kobzik, L | 1 |
| Arimura, A | 1 |
| Asanuma, F | 1 |
| Yagi, H | 1 |
| Kurosawa, A | 1 |
| Harada, M | 1 |
| De Bie, JJ | 1 |
| Hessel, EM | 1 |
| Van Ark, I | 1 |
| Van Esch, B | 1 |
| Hofman, G | 1 |
| Nijkamp, FP | 1 |
| Van Oosterhout, AJ | 1 |
| Kung, TT | 1 |
| Crawley, Y | 1 |
| Luo, B | 1 |
| Young, S | 1 |
| Kreutner, W | 1 |
| Chapman, RW | 1 |
| Richards, IM | 1 |
| Griffin, RL | 1 |
| Shields, SK | 1 |
| Reid, MS | 1 |
| Fidler, SF | 1 |
| Nagai, H | 1 |
| Tsuji, F | 1 |
| Shimazawa, T | 1 |
| Goto, S | 1 |
| Yoshitake, K | 1 |
| Koda, A | 1 |
6 other studies available for metyrapone and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Corticosterone; Disease Susceptibility; Female; Glucocor | 2014 |
Involvement of thromboxane A2 in bronchial hyperresponsiveness but not lung inflammation induced by bacterial lipopolysaccharide in guinea pigs.
Topics: Animals; Bridged Bicyclo Compounds; Bronchial Hyperreactivity; Cytokines; Fatty Acids, Monounsaturat | 1993 |
Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; | 1996 |
Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines.
Topics: Animals; Antihypertensive Agents; Bronchial Hyperreactivity; Bronchoalveolar Lavage; Catecholamines; | 2000 |
Chasing the elusive animal model of late-phase bronchoconstriction: studies in dogs, guinea pigs and rats.
Topics: Animals; Ascaris; Bronchi; Bronchial Hyperreactivity; Disease Models, Animal; Dogs; Guinea Pigs; Met | 1992 |
Participation of collagenase and elastase in LPS-induced airway hyperresponsiveness in guinea pigs.
Topics: Acetylcholine; Airway Obstruction; Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; | 1991 |