metyrapone has been researched along with Breast Neoplasms in 18 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the effect of inducers on the major enzymes responsible for metabolising the quinone antitumor agent mitoxantrone, and on its cytotoxicity in MCF 7 human breast cancer cells." | 7.69 | The activity of xenobiotic enzymes and the cytotoxicity of mitoxantrone in MCF 7 human breast cancer cells treated with inducing agents. ( Grant, MH; Li, SJ; Rodgers, EH, 1995) |
| " A partial adrenal insufficiency was found during Synacthen stimulation, confirmed by a slight increase of 11-desoxycortisol after metyrapone, despite a sufficient rise in ACTH levels." | 7.67 | Mechanism of adrenal suppression by high-dose medroxyprogesterone acetate in breast cancer patients. ( Doorenbos, H; Sleijfer, DT; Sluiter, WJ; van der Ploeg, E; van Veelen, H; Willemse, PH, 1985) |
| "This study investigated the effect of inducers on the major enzymes responsible for metabolising the quinone antitumor agent mitoxantrone, and on its cytotoxicity in MCF 7 human breast cancer cells." | 3.69 | The activity of xenobiotic enzymes and the cytotoxicity of mitoxantrone in MCF 7 human breast cancer cells treated with inducing agents. ( Grant, MH; Li, SJ; Rodgers, EH, 1995) |
| " A partial adrenal insufficiency was found during Synacthen stimulation, confirmed by a slight increase of 11-desoxycortisol after metyrapone, despite a sufficient rise in ACTH levels." | 3.67 | Mechanism of adrenal suppression by high-dose medroxyprogesterone acetate in breast cancer patients. ( Doorenbos, H; Sleijfer, DT; Sluiter, WJ; van der Ploeg, E; van Veelen, H; Willemse, PH, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (72.22) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| POMMATAU, E | 1 |
| POULAIN, S | 1 |
| COLON, J | 1 |
| DITZEL, J | 1 |
| HANSEN, PF | 1 |
| RISKAER, N | 1 |
| RIVADENEYRA, J | 1 |
| COLE, VW | 1 |
| MANNHEIMER, IH | 1 |
| MCCULLAGH, EP | 1 |
| FELDSTEIN, MA | 1 |
| TWEED, DC | 1 |
| DOHN, DF | 1 |
| BLEASEL, K | 1 |
| LAZARUS, L | 1 |
| Lin, CH | 1 |
| Lin, PH | 1 |
| Konishi, Y | 1 |
| Li, SJ | 1 |
| Rodgers, EH | 1 |
| Grant, MH | 1 |
| Suda, T | 1 |
| Tozawa, F | 1 |
| Dobashi, I | 1 |
| Horiba, N | 1 |
| Ohmori, N | 1 |
| Yamakado, M | 1 |
| Yamada, M | 1 |
| Demura, H | 1 |
| Chen, L | 1 |
| Waxman, DJ | 1 |
| Chen, D | 1 |
| Kufe, DW | 1 |
| Critselis, AN | 1 |
| Rettura, G | 1 |
| Levenson, SM | 1 |
| Seifter, E | 1 |
| Beierwaltes, WH | 1 |
| Wieland, DM | 1 |
| Mosley, ST | 1 |
| Swanson, DP | 1 |
| Sarkar, SD | 1 |
| Freitas, JE | 1 |
| Thrall, JH | 1 |
| Herwig, KR | 1 |
| Shiiki, S | 1 |
| Fuchimoto, S | 1 |
| Orita, K | 1 |
| van Veelen, H | 1 |
| Willemse, PH | 1 |
| Sleijfer, DT | 1 |
| van der Ploeg, E | 1 |
| Sluiter, WJ | 1 |
| Doorenbos, H | 1 |
| van Kampen, EJ | 1 |
| Hoek, W | 1 |
| Metcalf, MG | 1 |
| Beaven, DW | 1 |
| Wilson, LD | 1 |
| Oldham, SB | 1 |
| Harding, BW | 1 |
18 other studies available for metyrapone and Breast Neoplasms
| Article | Year |
|---|---|
[THE METOPIRONE TEST IN BREAST CANCER OF AN ADVANCED STAGE, BEFORE AND AFTER PITUITARY IMPLANTATION OF YTTRIUM].
Topics: Adrenal Cortex Hormones; Breast Neoplasms; Cortisone; Follicle Stimulating Hormone; Humans; Ketones; | 1963 |
PITUITARY-ADRENAL FUNCTION FOLLOWING HYPOPHYSECTOMY IN MAN.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Blood Chemical Analysis; Breast Neoplasms; Gonadotropins; | 1964 |
[INVESTIGATION OF THE BIOLOGICAL ACTIVITIES OF TRIAMCINOLONE DIACETATE IN PATIENTS WITH ADRENAL INSUFFICIENCY].
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenalectomy; Aldosterone; Blood; Blood Pressure; B | 1964 |
URINARY PORTER-SILBER CHROMOGENS FOLLOWING INTRAVENOUS METHOPYRAPONE AND ACTH IN PATIENTS WITH BREAST CANCER.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Breast Neoplasms; Drug Therapy; Geriatrics; | 1965 |
A STUDY OF PITUITARY FUNCTION AFTER INTRASELLAR IMPLANTATION OF 90YTTRIUM.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Acromegaly; Basal Metabolism; Breast Neoplasms; Cushing | 1965 |
CRYOGENIC HYPOPHYSECTOMY.
Topics: Acromegaly; Betamethasone; Breast Neoplasms; Cryosurgery; Diabetic Retinopathy; Drug Therapy; Humans | 1965 |
Induction of ROS formation, poly(ADP-ribose) polymerase-1 activation, and cell death by PCB126 and PCB153 in human T47D and MDA-MB-231 breast cancer cells.
Topics: Benzoflavones; Breast Neoplasms; Catalase; Cell Line, Tumor; Cell Survival; Chelating Agents; Cytoch | 2006 |
Effects of tamoxifen, stilbestrol and metyrapone on binding of various steroids to cytosol receptors in human breast cancer cytosols.
Topics: Breast Neoplasms; Cytosol; Diethylstilbestrol; Female; Humans; In Vitro Techniques; Metyrapone; Rece | 1981 |
The activity of xenobiotic enzymes and the cytotoxicity of mitoxantrone in MCF 7 human breast cancer cells treated with inducing agents.
Topics: Benz(a)Anthracenes; Breast Neoplasms; Cell Death; Cytochrome P-450 Enzyme System; Dexamethasone; Dic | 1995 |
Corticotropin-releasing hormone, proopiomelanocortin, and glucocorticoid receptor gene expression in adrenocorticotropin-producing tumors in vitro.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenoma; Adrenocorticotropic Hormone; Adult; Aged; Arginine | 1993 |
Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.
Topics: Adenoviridae; Animals; Antineoplastic Agents, Alkylating; Body Weight; Breast Neoplasms; Cell Cycle; | 1996 |
Inhibitory effect of metyrapone and deoxycorticosterone on C3H breast adenocarcinoma.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Desoxycorticosterone; Immunosuppression Therapy; Metyrapo | 1977 |
Imaging the adrenal glands with radiolabeled inhibitors of enzymes: concise communication.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Animals; Breast Neoplasms; Dogs; Enzyme Inhibitors; Humans; | 1978 |
A comparison of the antitumor effects of natural human tumor necrosis factors alpha and beta: the roles of arachidonic acid metabolism and intracellular cAMP.
Topics: Arachidonic Acid; Arachidonic Acids; Breast Neoplasms; Colforsin; Colonic Neoplasms; Cyclic AMP; Dex | 1990 |
Mechanism of adrenal suppression by high-dose medroxyprogesterone acetate in breast cancer patients.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Insufficiency; Aged; Androstenedione; Breast Neoplasms; Cosynt | 1985 |
Urinary steroid spectrum by gas chromatography.
Topics: 17-Ketosteroids; Addison Disease; Adrenocorticotropic Hormone; Androgens; Breast Neoplasms; Chemistr | 1967 |
The metopirone test of pituitary corticotrophin release. Evaluation of 101 tests.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Br | 1968 |
Cytochrome P450 and steroid 11beta-hydroxylation in mitochondria from human adrenal cortex.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Antimycin A; Breast Neoplasms; Carbon Monoxide; Cushing S | 1968 |