Page last updated: 2024-10-31

metyrapone and Brain Ischemia

metyrapone has been researched along with Brain Ischemia in 8 studies

Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models."5.31Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001)
"Metyrapone (200 mg/kg) was administered either 30 min before or 1, 12 and 24 h after MCA occlusion."5.30Infarct volume and functional outcome after pre- and postoperative administration of metyrapone, a steroid synthesis inhibitor, in focal brain ischemia in the rat. ( Johansson, BB; Nordborg, C; Risedal, A, 1999)
"Cerebral ischemia and seizures can induce considerable GC secretion."5.29Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures. ( Brooke, SM; Craddock, SD; Mattson, MP; Pettigrew, LC; Phares, C; Sapolsky, RM; Smith-Swintosky, VL, 1996)
"Rats exposed to forebrain ischemia have reduced injury when anesthetized with isoflurane versus fentanyl + N(2)O."3.70The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat. ( Mackensen, GB; Massey, G; Nellgård, B; Pearlstein, RD; Warner, DS, 2000)
"They induced stress in rats by cerebral ischemia, collected blood samples at various intervals using both the drop method and the plasma extraction method and then quantified corticosterone by radioimmunoassay."1.38A refined blood collection method for quantifying corticosterone. ( James, JS; Merali, Z; Milot, MR; Plamondon, H, 2012)
"In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models."1.31Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001)
"Metyrapone (200 mg/kg) was administered either 30 min before or 1, 12 and 24 h after MCA occlusion."1.30Infarct volume and functional outcome after pre- and postoperative administration of metyrapone, a steroid synthesis inhibitor, in focal brain ischemia in the rat. ( Johansson, BB; Nordborg, C; Risedal, A, 1999)
"Cerebral ischemia and seizures can induce considerable GC secretion."1.29Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures. ( Brooke, SM; Craddock, SD; Mattson, MP; Pettigrew, LC; Phares, C; Sapolsky, RM; Smith-Swintosky, VL, 1996)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (50.00)18.2507
2000's3 (37.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Milot, MR1
James, JS1
Merali, Z1
Plamondon, H1
Smith-Swintosky, VL1
Pettigrew, LC1
Sapolsky, RM1
Phares, C1
Craddock, SD1
Brooke, SM1
Mattson, MP1
Krugers, HJ3
Kemper, RH1
Korf, J3
Ter Horst, GJ1
Knollema, S1
Risedal, A1
Nordborg, C1
Johansson, BB1
Maslam, S2
Van Vuuren, SM1
Joëls, M2
Holsboer, F1
Nellgård, B1
Mackensen, GB1
Massey, G1
Pearlstein, RD1
Warner, DS1
Schurr, A1
Payne, RS1
Miller, JJ1
Tseng, MT1

Other Studies

8 other studies available for metyrapone and Brain Ischemia

ArticleYear
A refined blood collection method for quantifying corticosterone.
    Lab animal, 2012, Volume: 41, Issue:3

    Topics: Animals; Blood Specimen Collection; Brain Ischemia; Cerebrum; Corticosterone; Male; Metyrapone; Radi

2012
Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:4

    Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Glucocorticoids; Hippocampus; Male; Metyrapone; Neu

1996
Metyrapone reduces rat brain damage and seizures after hypoxia-ischemia: an effect independent of modulation of plasma corticosterone levels?
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1998, Volume: 18, Issue:4

    Topics: Animals; Blood Glucose; Body Temperature; Brain Damage, Chronic; Brain Ischemia; Corticosterone; Epi

1998
Infarct volume and functional outcome after pre- and postoperative administration of metyrapone, a steroid synthesis inhibitor, in focal brain ischemia in the rat.
    European journal of neurology, 1999, Volume: 6, Issue:4

    Topics: Animals; Behavior, Animal; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Glial Fibrillary Ac

1999
Postischemic steroid modulation: effects on hippocampal neuronal integrity and synaptic plasticity.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1999, Volume: 19, Issue:10

    Topics: Action Potentials; Animals; Brain Ischemia; Corticosterone; Dexamethasone; Electrophysiology; Epilep

1999
The corticosterone synthesis inhibitor metyrapone prevents hypoxia/ischemia-induced loss of synaptic function in the rat hippocampus.
    Stroke, 2000, Volume: 31, Issue:5

    Topics: Animals; Brain Ischemia; Corticosterone; Hippocampus; Hypoxia; Male; Metyrapone; Rats; Rats, Wistar;

2000
The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:1

    Topics: Anesthetics; Animals; Brain Ischemia; Corticosterone; Fentanyl; Interleukin-6; Isoflurane; Metyrapon

2000
Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental.
    Journal of neuroscience research, 2001, Dec-01, Volume: 66, Issue:5

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Glucose; Brain Ischemia; Corticostero

2001