metyrapone has been researched along with Brain Ischemia in 8 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models." | 5.31 | Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001) |
| "Metyrapone (200 mg/kg) was administered either 30 min before or 1, 12 and 24 h after MCA occlusion." | 5.30 | Infarct volume and functional outcome after pre- and postoperative administration of metyrapone, a steroid synthesis inhibitor, in focal brain ischemia in the rat. ( Johansson, BB; Nordborg, C; Risedal, A, 1999) |
| "Cerebral ischemia and seizures can induce considerable GC secretion." | 5.29 | Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures. ( Brooke, SM; Craddock, SD; Mattson, MP; Pettigrew, LC; Phares, C; Sapolsky, RM; Smith-Swintosky, VL, 1996) |
| "Rats exposed to forebrain ischemia have reduced injury when anesthetized with isoflurane versus fentanyl + N(2)O." | 3.70 | The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat. ( Mackensen, GB; Massey, G; Nellgård, B; Pearlstein, RD; Warner, DS, 2000) |
| "They induced stress in rats by cerebral ischemia, collected blood samples at various intervals using both the drop method and the plasma extraction method and then quantified corticosterone by radioimmunoassay." | 1.38 | A refined blood collection method for quantifying corticosterone. ( James, JS; Merali, Z; Milot, MR; Plamondon, H, 2012) |
| "In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models." | 1.31 | Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001) |
| "Metyrapone (200 mg/kg) was administered either 30 min before or 1, 12 and 24 h after MCA occlusion." | 1.30 | Infarct volume and functional outcome after pre- and postoperative administration of metyrapone, a steroid synthesis inhibitor, in focal brain ischemia in the rat. ( Johansson, BB; Nordborg, C; Risedal, A, 1999) |
| "Cerebral ischemia and seizures can induce considerable GC secretion." | 1.29 | Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures. ( Brooke, SM; Craddock, SD; Mattson, MP; Pettigrew, LC; Phares, C; Sapolsky, RM; Smith-Swintosky, VL, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Milot, MR | 1 |
| James, JS | 1 |
| Merali, Z | 1 |
| Plamondon, H | 1 |
| Smith-Swintosky, VL | 1 |
| Pettigrew, LC | 1 |
| Sapolsky, RM | 1 |
| Phares, C | 1 |
| Craddock, SD | 1 |
| Brooke, SM | 1 |
| Mattson, MP | 1 |
| Krugers, HJ | 3 |
| Kemper, RH | 1 |
| Korf, J | 3 |
| Ter Horst, GJ | 1 |
| Knollema, S | 1 |
| Risedal, A | 1 |
| Nordborg, C | 1 |
| Johansson, BB | 1 |
| Maslam, S | 2 |
| Van Vuuren, SM | 1 |
| Joëls, M | 2 |
| Holsboer, F | 1 |
| Nellgård, B | 1 |
| Mackensen, GB | 1 |
| Massey, G | 1 |
| Pearlstein, RD | 1 |
| Warner, DS | 1 |
| Schurr, A | 1 |
| Payne, RS | 1 |
| Miller, JJ | 1 |
| Tseng, MT | 1 |
8 other studies available for metyrapone and Brain Ischemia
| Article | Year |
|---|---|
A refined blood collection method for quantifying corticosterone.
Topics: Animals; Blood Specimen Collection; Brain Ischemia; Cerebrum; Corticosterone; Male; Metyrapone; Radi | 2012 |
Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Glucocorticoids; Hippocampus; Male; Metyrapone; Neu | 1996 |
Metyrapone reduces rat brain damage and seizures after hypoxia-ischemia: an effect independent of modulation of plasma corticosterone levels?
Topics: Animals; Blood Glucose; Body Temperature; Brain Damage, Chronic; Brain Ischemia; Corticosterone; Epi | 1998 |
Infarct volume and functional outcome after pre- and postoperative administration of metyrapone, a steroid synthesis inhibitor, in focal brain ischemia in the rat.
Topics: Animals; Behavior, Animal; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Glial Fibrillary Ac | 1999 |
Postischemic steroid modulation: effects on hippocampal neuronal integrity and synaptic plasticity.
Topics: Action Potentials; Animals; Brain Ischemia; Corticosterone; Dexamethasone; Electrophysiology; Epilep | 1999 |
The corticosterone synthesis inhibitor metyrapone prevents hypoxia/ischemia-induced loss of synaptic function in the rat hippocampus.
Topics: Animals; Brain Ischemia; Corticosterone; Hippocampus; Hypoxia; Male; Metyrapone; Rats; Rats, Wistar; | 2000 |
The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat.
Topics: Anesthetics; Animals; Brain Ischemia; Corticosterone; Fentanyl; Interleukin-6; Isoflurane; Metyrapon | 2000 |
Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Glucose; Brain Ischemia; Corticostero | 2001 |