metyrapone has been researched along with Brain Edema in 3 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metyrapone was able to confer similar neuroprotection as G-CSF while dexamethasone reversed the effects of G-CSF." | 1.38 | Role of the pituitary–adrenal axis in granulocyte-colony stimulating factor-induced neuroprotection against hypoxia–ischemia in neonatal rats. ( Charles, MS; Duris, K; Manaenko, A; Ostrowski, RP; Tang, J; Zhang, JH, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Charles, MS | 1 |
| Ostrowski, RP | 1 |
| Manaenko, A | 1 |
| Duris, K | 1 |
| Zhang, JH | 1 |
| Tang, J | 1 |
| Bouzarth, WF | 1 |
| Shenkin, HA | 1 |
| Feldman, W | 1 |
| Christensen, BE | 1 |
3 other studies available for metyrapone and Brain Edema
| Article | Year |
|---|---|
Role of the pituitary–adrenal axis in granulocyte-colony stimulating factor-induced neuroprotection against hypoxia–ischemia in neonatal rats.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; bcl-2-Associated X Protein; Brain; Brain Ede | 2012 |
Adrenocortical response to craniocerebral trauma.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic | 1968 |
[Metyrapone incombination with spironolactone and prednisone in the therapy of severe edema].
Topics: Aged; Brain Edema; Drug Synergism; Edema; Female; Humans; Hyperkalemia; Hyponatremia; Metyrapone; Mi | 1968 |