metyrapone has been researched along with Blood Poisoning in 4 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used the overnight metyrapone stimulation test to investigate the diagnostic value of the standard cosyntropin stimulation test, and the prevalence of sepsis-associated adrenal insufficiency." | 3.73 | Diagnosis of adrenal insufficiency in severe sepsis and septic shock. ( Abe, E; Alvarez, JC; Annane, D; Boudou, P; Ibrahim, F; Maxime, V, 2006) |
| " For example, a marked fall in systemic blood pressure and dynamic lung compliance is seen in both models, but in the present gram-positive sepsis model, much less interleukin-8 and tumor necrosis factor-alpha are produced." | 3.70 | Synergistic septicemic action of the gram-positive bacterial cell wall components peptidoglycan and lipoteichoic acid in the pig in vivo. ( Alving, K; Middelveld, RJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Annane, D | 1 |
| Maxime, V | 1 |
| Ibrahim, F | 1 |
| Alvarez, JC | 1 |
| Abe, E | 1 |
| Boudou, P | 1 |
| Middelveld, RJ | 1 |
| Alving, K | 1 |
| Grant, JM | 1 |
| Yeo, JD | 1 |
| Loridan, L | 1 |
| Senior, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Total, Salivary and Calculated Free Cortisol Levels in Patients With Severe Sepsis[NCT02589431] | 46 participants (Actual) | Observational | 2009-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for metyrapone and Blood Poisoning
| Article | Year |
|---|---|
Diagnosis of adrenal insufficiency in severe sepsis and septic shock.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Aged; Cosyntropin; Female; Humans; Hydrocortison | 2006 |
Synergistic septicemic action of the gram-positive bacterial cell wall components peptidoglycan and lipoteichoic acid in the pig in vivo.
Topics: Animals; Drug Synergism; Endothelin-1; Endotoxins; Female; Hydrocortisone; Interleukin-8; Leukocyte | 2000 |
Studies o the levels of 17 hydroxy-corticoids in 24-hour specimens of urine from five quadriplegic patients and two paraplegic patients admitted to the Royal North Shore Hospital, Sydney.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Female; H | 1968 |
Cushing's syndrome in infancy.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Abnormalities, Multiple; Adenoma; Adrenal Gland Neoplasm | 1969 |