metyrapone has been researched along with Bipolar Disorder in 10 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The metyrapone test was applied to groups of patients suffering from major depressive illness with melancholia, mania or schizophrenia, before and after treatment." | 7.67 | The metyrapone test in affective disorders and schizophrenia II. Changes upon treatment. ( Carson, SW; Fava, GA; Jusko, WJ; Molnar, G; Morphy, MA; Perini, GI, 1984) |
| "The metyrapone test was applied to patients suffering from major depressive illness with melancholia, from mania, and from schizophrenia." | 7.67 | The metyrapone test in affective disorders and schizophrenia. ( Carson, SW; Fava, GA; Jusko, WJ; Molnar, G; Morphy, MA; Perini, GI, 1984) |
| "The metyrapone test was applied to groups of patients suffering from major depressive illness with melancholia, mania or schizophrenia, before and after treatment." | 3.67 | The metyrapone test in affective disorders and schizophrenia II. Changes upon treatment. ( Carson, SW; Fava, GA; Jusko, WJ; Molnar, G; Morphy, MA; Perini, GI, 1984) |
| "The metyrapone test was applied to patients suffering from major depressive illness with melancholia, from mania, and from schizophrenia." | 3.67 | The metyrapone test in affective disorders and schizophrenia. ( Carson, SW; Fava, GA; Jusko, WJ; Molnar, G; Morphy, MA; Perini, GI, 1984) |
| "Treatment with metyrapone led to a swift improvement of the patient's symptoms." | 1.42 | [Cushing's syndrome in a manic patient with a long-standing bipolar disorder: cause or coincidence?]. ( Bartel, M; de Witte, LD; Kleijweg, M; Smits, RB; Valk, GD; Vergeer, M; Vinkers, CH, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Witte, LD | 1 |
| Smits, RB | 1 |
| Bartel, M | 1 |
| Kleijweg, M | 1 |
| Valk, GD | 1 |
| Vinkers, CH | 1 |
| Vergeer, M | 1 |
| Perini, GI | 3 |
| Fava, GA | 3 |
| Morphy, MA | 3 |
| Carson, SW | 3 |
| Molnar, G | 3 |
| Jusko, WJ | 3 |
| Young, EA | 1 |
| Akil, H | 1 |
| Haskett, RF | 1 |
| Watson, SJ | 1 |
| Ghadirian, AM | 1 |
| Engelsmann, F | 1 |
| Dhar, V | 1 |
| Filipini, D | 1 |
| Keller, R | 1 |
| Chouinard, G | 1 |
| Murphy, BE | 1 |
| Rupprecht, R | 2 |
| Kornhuber, J | 2 |
| Wodarz, N | 2 |
| Lugauer, J | 1 |
| Göbel, C | 1 |
| Haack, D | 1 |
| Beck, G | 1 |
| Müller, OA | 2 |
| Riederer, P | 2 |
| Beckmann, H | 2 |
| Wild, K | 1 |
| Schmitz, B | 1 |
| Braner, HU | 1 |
| Holsboer, F | 1 |
| De Martinis, C | 1 |
| Doglio, R | 1 |
| Fonzo, D | 1 |
| Gandiglio, G | 1 |
1 trial available for metyrapone and Bipolar Disorder
| Article | Year |
|---|---|
Evidence against changes in corticotroph CRF receptors in depressed patients.
Topics: Adrenocorticotropic Hormone; Adult; beta-Endorphin; beta-Lipotropin; Bipolar Disorder; Circadian Rhy | 1995 |
9 other studies available for metyrapone and Bipolar Disorder
| Article | Year |
|---|---|
[Cushing's syndrome in a manic patient with a long-standing bipolar disorder: cause or coincidence?].
Topics: Aged; Bipolar Disorder; Cushing Syndrome; Diagnosis, Differential; Female; Humans; Metyrapone | 2015 |
The metyrapone test in affective disorders and schizophrenia II. Changes upon treatment.
Topics: Adult; Aged; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Cortodoxone; Depressive | 1984 |
The metyrapone test in affective disorders and schizophrenia.
Topics: Adult; Aged; Bipolar Disorder; Cortodoxone; Depressive Disorder; Dexamethasone; Female; Humans; Hydr | 1984 |
The metyrapone test in manic patients and healthy subjects.
Topics: 17-Hydroxycorticosteroids; Adult; Bipolar Disorder; Cortodoxone; Dexamethasone; Female; Humans; Hydr | 1984 |
The psychotropic effects of inhibitors of steroid biosynthesis in depressed patients refractory to treatment.
Topics: Adrenal Cortex Hormones; Adult; Aminoglutethimide; Bipolar Disorder; Depressive Disorder; Dose-Respo | 1995 |
Disturbed glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressives pretreated with metyrapone.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; beta-Endorphin; Bipolar Disorder; Depressive D | 1991 |
In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Bipolar Disorder; Depressive Disorder; Dexamet | 1991 |
Adrenocortical steroid secretion and 11-beta-steroid hydroxylase activity after pituitary-adrenocortical probes in depression.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Bipolar Disorder; Corticosterone; Corticotropi | 1985 |
[Studies on relations between the central nervous system and adrenal cortex activity. I. Adrenal cortex function in manic-depressive psychoses].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Bipolar Disorder; Cr | 1965 |