metyrapone has been researched along with Asthma in 37 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two corticosteroid regimens, alternate-day prednisone and inhaled beclomethasone dipropionate, have been more acceptable than daily oral corticosteroids for treatment of chronic asthma." | 9.04 | Effects of inhaled beclomethasone dipropionate and alternate-day prednisone on pituitary-adrenal function in children with chronic asthma. ( Sherman, B; Waschek, J; Weinberger, M; Wyatt, R, 1978) |
| "Treatment with metyrapone significantly increased eosinophil infiltration (17." | 5.29 | Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse. ( De Bie, JJ; Hessel, EM; Hofman, G; Nijkamp, FP; Van Ark, I; Van Esch, B; Van Oosterhout, AJ, 1996) |
| "Growth, pulmonary, and adrenal-pituitary function were assessed in 20 steroid-dependent asthmatic children and adolescents while they were on daily prednisone therapy." | 5.04 | Growth, pulmonary, and endocrine function in chronic asthma patients on daily and alternate-day adrenocorticosteroid therapy. ( Bierman, CW; Kelley, VC; Pierson, WE; Shapiro, GG; Tattoni, DS, 1976) |
| "Two corticosteroid regimens, alternate-day prednisone and inhaled beclomethasone dipropionate, have been more acceptable than daily oral corticosteroids for treatment of chronic asthma." | 5.04 | Effects of inhaled beclomethasone dipropionate and alternate-day prednisone on pituitary-adrenal function in children with chronic asthma. ( Sherman, B; Waschek, J; Weinberger, M; Wyatt, R, 1978) |
| " Maternal treatment with dexamethasone on day 15 of pregnancy mimicked the stress effect and reproduced the AI and AHR outcomes, whereas blockade of the stress-induced corticosterone surge with metyrapone pretreatment of pregnant mice abrogated the effect." | 3.80 | Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids. ( Fedulov, AV; Kobzik, L; Lim, R, 2014) |
| "Hypothalamic-pituitary-adrenal function in a well-defined, carefully selected group of 25 patients with extrinsic asthma was assessed by measuring plasma levels of adrenocorticotropic hormone (ACTH) and of 11-deoxycorticol after administration of metyrapone and by measuring the level of cortisol following stimulation with cosyntropin." | 3.66 | Hypothalamic-pituitary-adrenal function in extrinsic asthma. ( Aaron, TH; Crockford, PM; Morrish, DW; Outhet, D; Sproule, BJ, 1979) |
| "Metyrapone test was performed if the serum cortisol was > 83 nmol/L (> 3 microg/dL)." | 1.37 | Hypothalamic-pituitary-adrenal axis suppression in asthmatic children on inhaled and nasal corticosteroids--more common than expected? ( Galal, U; Hough, S; Irusen, E; Lombard, C; Weinberg, E; Zöllner, EW, 2011) |
| "Metyrapone treatment prolonged the acute release of histamine, and this was seen together with a prolonged acute bronchoconstrictor response." | 1.29 | Allergen-induced late-phase airways obstruction in the pig: mediator release and eosinophil recruitment. ( Alving, K; Fornhem, C; Kumlin, M; Lundberg, JM, 1995) |
| "Treatment with metyrapone significantly increased eosinophil infiltration (17." | 1.29 | Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse. ( De Bie, JJ; Hessel, EM; Hofman, G; Nijkamp, FP; Van Ark, I; Van Esch, B; Van Oosterhout, AJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (64.86) | 18.7374 |
| 1990's | 6 (16.22) | 18.2507 |
| 2000's | 3 (8.11) | 29.6817 |
| 2010's | 4 (10.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lim, R | 1 |
| Fedulov, AV | 1 |
| Kobzik, L | 1 |
| Priftis, KN | 1 |
| Papadimitriou, A | 1 |
| Nicolaidou, P | 1 |
| Chrousos, GP | 1 |
| Kumlien Georén, S | 1 |
| Olgart Hoglund, C | 1 |
| Tcacencu, I | 1 |
| Wikstrom, AC | 2 |
| Stierna, P | 2 |
| Zöllner, EW | 3 |
| Lombard, C | 2 |
| Galal, U | 3 |
| Hough, S | 2 |
| Irusen, E | 2 |
| Weinberg, E | 3 |
| Lombard, CJ | 1 |
| Hough, FS | 1 |
| Irusen, EM | 1 |
| ANDERSSON, E | 1 |
| Georén, S | 1 |
| Ahnblad, P | 1 |
| Stjärne, P | 1 |
| Goldstein, DE | 1 |
| König, P | 1 |
| Fornhem, C | 2 |
| Kumlin, M | 1 |
| Lundberg, JM | 1 |
| Alving, K | 1 |
| Niimi, A | 1 |
| Amitani, R | 1 |
| Yamada, K | 1 |
| Tanaka, K | 1 |
| Kuze, F | 1 |
| De Bie, JJ | 1 |
| Hessel, EM | 1 |
| Van Ark, I | 1 |
| Van Esch, B | 1 |
| Hofman, G | 1 |
| Nijkamp, FP | 1 |
| Van Oosterhout, AJ | 1 |
| Kaufman, H | 1 |
| Bruderman, I | 1 |
| Gelbard, C | 1 |
| Schey, G | 1 |
| Shapiro, GG | 1 |
| Tattoni, DS | 1 |
| Kelley, VC | 1 |
| Pierson, WE | 1 |
| Bierman, CW | 1 |
| Morrish, DW | 1 |
| Sproule, BJ | 1 |
| Aaron, TH | 1 |
| Outhet, D | 1 |
| Crockford, PM | 1 |
| Wyatt, R | 1 |
| Waschek, J | 1 |
| Weinberger, M | 1 |
| Sherman, B | 1 |
| Ohrui, T | 1 |
| Sekizawa, K | 1 |
| Aikawa, T | 2 |
| Yamauchi, K | 1 |
| Sasaki, H | 2 |
| Takishima, T | 2 |
| Suda, H | 1 |
| Nagai, H | 1 |
| Iwama, T | 1 |
| Koda, A | 2 |
| Yanai, M | 1 |
| Shimura, S | 1 |
| Okayama, H | 1 |
| Sasaki, T | 1 |
| Nelson, JK | 1 |
| Mackay, JS | 1 |
| Sheridan, B | 1 |
| Weaver, JA | 1 |
| Numano, A | 1 |
| Abbasy, AS | 1 |
| Fahmy, MS | 1 |
| Kantoush, MM | 1 |
| Ferrari, E | 1 |
| Bossolo, PA | 1 |
| Pallavicini, S | 1 |
| Personeni, G | 1 |
| Sako, Y | 1 |
| Lass, N | 1 |
| Laurian, L | 1 |
| Balas, L | 1 |
| Knol, K | 1 |
| Sundberg, M | 1 |
| Jakobson, T | 1 |
| Benos, SA | 1 |
| Koutsoukos, A | 1 |
| Braouzi, H | 1 |
| Georgopoulos, A | 1 |
| Pavlatos, FC | 1 |
| Tuft, L | 2 |
| Horiuchi, Y | 1 |
| Kenny, FM | 1 |
| Chachaj, W | 2 |
| Janukowicz-Lorenz, H | 2 |
| Malolepszy, J | 2 |
| Plamieniak, L | 2 |
| Marks, AD | 1 |
| Channick, BJ | 1 |
| Morris, HG | 1 |
| Jorgensen, JR | 1 |
1 review available for metyrapone and Asthma
| Article | Year |
|---|---|
[Control of drug allergy].
Topics: Asthma; Cromolyn Sodium; Drug Hypersensitivity; Flavonoids; Histamine Release; Humans; Hypersensitiv | 1987 |
3 trials available for metyrapone and Asthma
| Article | Year |
|---|---|
Growth, pulmonary, and endocrine function in chronic asthma patients on daily and alternate-day adrenocorticosteroid therapy.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Age Determination by Skel | 1976 |
Effects of inhaled beclomethasone dipropionate and alternate-day prednisone on pituitary-adrenal function in children with chronic asthma.
Topics: Administration, Oral; Adolescent; Aerosols; Asthma; Beclomethasone; Child; Clinical Trials as Topic; | 1978 |
Comparison of pituitary-adrenocortical function in asthmatic patients given long-term corticosteroid therapy and in asthmatics who have not received adrenal steroids.
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aged; Asthma | 1969 |
33 other studies available for metyrapone and Asthma
| Article | Year |
|---|---|
Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Corticosterone; Disease Susceptibility; Female; Glucocor | 2014 |
Testing for hypothalamic-pituitary-adrenal axis suppression in asthmatic children.
Topics: Adolescent; Adrenal Cortex Function Tests; Anti-Asthmatic Agents; Asthma; Contraindications; Cosyntr | 2008 |
Timing-dependent effects of restraint stress on eosinophilic airway inflammation in mice.
Topics: Animals; Asthma; Bronchi; Corticosterone; Enzyme Inhibitors; Eosinophils; Hypothalamo-Hypophyseal Sy | 2008 |
Hypothalamic-pituitary-adrenal axis suppression in asthmatic children on inhaled and nasal corticosteroids: is the early-morning serum adrenocorticotropic hormone (ACTH) a useful screening test?
Topics: Administration, Inhalation; Administration, Intranasal; Adolescent; Adrenal Cortex Hormones; Adrenal | 2011 |
Hypothalamic-pituitary-adrenal axis suppression in asthmatic children on inhaled and nasal corticosteroids--more common than expected?
Topics: Administration, Inhalation; Administration, Intranasal; Adolescent; Adrenal Cortex Hormones; Adrenal | 2011 |
Hypothalamic-pituitary-adrenal axis suppression in asthmatic school children.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocortic | 2012 |
PITUITARY FUNCTION IN PATIENTS WITH BRONCHIAL ASTHMA MEASURED INDIRECTLY BY METHOPYRAPONE (SU 4885).
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Asthma; Metyrapone; Mineralocorticoid Receptor Antagon | 1964 |
Significance of endogenous glucocorticoid sensitivity for airway eosinophilia in a murine model of allergy.
Topics: Administration, Intranasal; Airway Resistance; Animals; Asthma; Bone Marrow; Bronchi; Disease Models | 2005 |
Effect of inhaled beclomethasone dipropionate on hypothalamic-pituitary-adrenal axis function in children with asthma.
Topics: 17-Hydroxycorticosteroids; Adolescent; Asthma; Beclomethasone; Blood Glucose; Child; Child, Preschoo | 1983 |
Allergen-induced late-phase airways obstruction in the pig: mediator release and eosinophil recruitment.
Topics: Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchoconstr | 1995 |
Late respiratory response and associated eosinophilic inflammation induced by repeated exposure to toluene diisocyanate in guinea pigs.
Topics: Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Enzyme Inhibitors; Eosinophils; Guinea Pigs; | 1996 |
Allergen-induced late airways reactions in the pig. Influence of endogenous and exogenous glucocorticoids.
Topics: Allergens; Amino Acid Sequence; Animals; Antimicrobial Cationic Peptides; Ascaris suum; Asthma; Bloo | 1995 |
Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; | 1996 |
Evaluation of pituitary-adrenal function in patients with chronic bronchial asthma following substitution of steroid treatment with disodium cromoglycate (Lomudal).
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Adult; Aged; Asthma; Cromolyn Sodium; Dexame | 1976 |
Hypothalamic-pituitary-adrenal function in extrinsic asthma.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Asthma; Cortodoxone; Fema | 1979 |
Vascular permeability and airway narrowing during late asthmatic response in dogs treated with Metopirone.
Topics: Airway Obstruction; Airway Resistance; Animals; Antigens; Asthma; Blood Vessels; Capillary Permeabil | 1992 |
Effects of NZ-107 on bronchoconstriction in guinea pigs.
Topics: Albuterol; Animals; Asthma; Bronchoconstriction; Cromolyn Sodium; Disease Models, Animal; Guinea Pig | 1992 |
Late asthmatic response to Ascaris antigen challenge in dogs treated with metyrapone.
Topics: Airway Resistance; Allergens; Animals; Antigens, Helminth; Ascaris; Asthma; Bronchoalveolar Lavage F | 1987 |
Intermittent therapy with corticotrophin.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Arthritis, Rheumato | 1966 |
[Study of urinary excretion of total 17-hydroxycorticosteroids among children. 3. Variations in urinary excretion of total 17-hydroxycorticosteroids by ACTH and metopirone loading in normal children and those with various diseases].
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Asthma; Child, Preschool; Humans; Infant; Me | 1966 |
The adrenal cortical glucocorticoid function in asthmatic children.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Asthma; Child; Child, Preschool; Eosinophils | 1967 |
[Corticotropo-corticoadrenal dynamics in prolonged cortisone treatment].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotr | 1967 |
[Clinical studies on the stimulation and suppression of the pituitary-adrenocortical system. 3. Studies on the pituitary adrenocortical suppression after long-term glucocorticoid treatment].
Topics: 17-Hydroxycorticosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aged; Arthriti | 1968 |
Evaluation of metopiron and ACTH tests in prolonged corticosteroid treatment of chronic asthma.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; | 1969 |
The function of the adrenal glands during prolonged corticosteroid therapy.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adrenal Insufficiency; Adren | 1969 |
A synthetic polypeptide--beta 1-24 corticotropin--in the depot form. I. Adrenocorticotropic and pituitary responsiveness following long-term intermittent administration.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Asthma; Delayed-Act | 1969 |
Corticosteroids in the unresponsive asthmatic patient.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aminophylline; Asthma; Child; Child, Preschool | 1971 |
[Bronchial asthma and anti-inflammatory steroid].
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Inflammatory A | 1971 |
Use of corticosteroids.
Topics: Addison Disease; Administration, Oral; Adolescent; Adrenocortical Hyperfunction; Age Factors; Asthma | 1974 |
[Functional pituitary reserve in patients with bronchial asthma in the light of metopyrone test].
Topics: 17-Hydroxycorticosteroids; Adolescent; Adult; Asthma; Humans; Metyrapone; Middle Aged; Pituitary Gla | 1969 |
Pituitary functional reserve in patients with bronchial asthma in the light of the results of the methopyrone test.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adult; Asthma; Bronchial Diseases; Humans; Metyrapone; Middle | 1970 |
Long-term corticosteroid therapy in chronic intractable asthmatic patients.
Topics: 17-Hydroxycorticosteroids; Adult; Aged; Asthma; Blood Coagulation Tests; Blood Glucose; Body Weight; | 1971 |
Recovery of endogenous pituitary-adrenal function in corticosteroid-treated children.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Glands; Asthma; Child; Female; Humans; Hydrocortisone | 1971 |