metyrapone has been researched along with Arthritis, Rheumatoid in 22 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Estimate the contribution of monocytes/macrophages to the disease process in rheumatoid arthritis (RA), by measuring the serum levels of the leucocyte-derived granular proteins: lysozyme, myeloperoxidase (MPO), lactoferrin and human neutrophil lipocalin (HNL)." | 3.70 | Serum lysozyme: a potential marker of monocyte/macrophage activity in rheumatoid arthritis. ( Arvidson, NG; Gudbjörnsson, B; Hâkansson, L; Hällgren, R; Torsteinsdóttir, I; Venge, P, 1999) |
| "Pregnanetriol excretion was lower (P less than ." | 2.37 | Low adrenal androgenic-anabolic steroids in women with rheumatoid arthritis (RA): gas-liquid chromatographic studies of RA patients and matched normal control women indicating decreased 11-deoxy-17-ketosteroid excretion. ( Jefferson, WE; Josipović, DB; Masi, AT, 1984) |
| "Metyrapone treatment increased the surface expression of CD35 and CD49f on eosinophils, but did not affect surface expression on neutrophils." | 1.30 | Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids. ( Arvidson, NG; Håkansson, L; Hällgren, R; Torsteinsdóttir, I, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (86.36) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| KAPLAN, NM | 1 |
| DeANDRADE, JR | 1 |
| LOUYOT, P | 2 |
| GAUCHER, A | 2 |
| BENOIT, P | 2 |
| MONTET, Y | 1 |
| KERNOHAN, RJ | 1 |
| GOTH, E | 2 |
| GOERGENYI, G | 1 |
| FOEVENYI, J | 1 |
| SZANTO, E | 2 |
| SHIOKAWA, Y | 1 |
| FLEISHMAN, EV | 1 |
| KALLIOMAKI, JL | 1 |
| KARKI, NT | 1 |
| SAARIMAA, HA | 1 |
| TALA, E | 1 |
| Jasani, MK | 2 |
| Boyle, JA | 1 |
| Greig, WR | 1 |
| Dalakos, TG | 2 |
| Browning, MC | 1 |
| Thompson, A | 1 |
| Buchanan, WW | 2 |
| Masi, AT | 1 |
| Josipović, DB | 1 |
| Jefferson, WE | 1 |
| Torsteinsdóttir, I | 3 |
| Arvidson, NG | 3 |
| Hällgren, R | 3 |
| Håkansson, L | 3 |
| Gudbjörnsson, B | 1 |
| Venge, P | 1 |
| Giacovazzo, M | 3 |
| Nelson, JK | 1 |
| Mackay, JS | 1 |
| Sheridan, B | 1 |
| Weaver, JA | 1 |
| Ruvalcaba, RH | 1 |
| Waxman, SH | 1 |
| Tippit, DF | 1 |
| Kelley, VC | 1 |
| Görgényi, G | 1 |
| Fövényi, J | 1 |
| Sako, Y | 1 |
| Diver, MJ | 1 |
| Bell, AM | 1 |
| Ippolito, A | 2 |
| Babalamenti, G | 1 |
| Pagliari, M | 1 |
1 review available for metyrapone and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Low adrenal androgenic-anabolic steroids in women with rheumatoid arthritis (RA): gas-liquid chromatographic studies of RA patients and matched normal control women indicating decreased 11-deoxy-17-ketosteroid excretion.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Anab | 1984 |
21 other studies available for metyrapone and Arthritis, Rheumatoid
| Article | Year |
|---|---|
ASSESSMENT OF PITUITARY ACTH SECRETORY CAPACITY WITH METOPIRONE: II. COMPARISON WITH OTHER TESTS.
Topics: Acromegaly; Adenoma; Adenoma, Chromophobe; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Art | 1963 |
PITUITARY-ADRENOCORTICAL RESERVE DURING CORTICOSTEROID THERAPY: A REPORT ON THE METHOPYRAPONE TEST IN TEN PATIENTS TAKING LONG-CONTINUED SMALL DOSES.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Biomedical Research; Met | 1964 |
[EXAMINATION OF THE HYPOTHALAMUS AND ADRENAL GLANDS IN THE COURSE OF CHRONIC POLYARTHRITIS FOLLOWING PROLONGED CORTICOTHERAPY].
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Arthritis; Ar | 1964 |
[HYPOTHALAMO-HYPOPHYSO-ADRENAL FUNCTION FOLLOWING PROLONGED CORTICOTHERAPY STUDIED WITH THE METOPIRONE TEST].
Topics: Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Cortisone; Humans; Hypothalamo-Hypoph | 1964 |
METYRAPONE AND ACUTE ADRENAL INSUFFICIENCY.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Insufficiency; Arthritis; Arthritis, Rheumatoid; F | 1964 |
[ADRENOCORTICAL AND PITUITARY FUNCTION FOLLOWING PROTRACTED PREDNISOLONE TREATMENT].
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Biomedical Research; | 1964 |
ACTIVATION OF SUBCLINICAL RHEUMATIC ACTIVITY BY METOPIRONE ADMINISTRATION IN RHEUMATIC HEART DISEASE AND RHEUMATOID ARTHRITIS.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Arthritis, Rheumatoid; Conjunctiva; Diagnosis; Erythrocyte | 1964 |
[USE OF THE METOPIRONE TEST FOR THE INVESTIGATION OF THE PITUITARY AND CORTICO-ADRENAL FUNCTION IN PATIENTS UNDERGOING PROLONGED CORTICOSTEROID THERAPY].
Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Drug Therapy; Metyrapone; Mineralocortico | 1965 |
Pituitary corticotrophin (ACTH) production in rheumatoid arthritis tested indirectly with Metopiron (Su 4885).
Topics: Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Humans; Metyrapone | 1961 |
Corticosteroid-induced suppression of the hypothalamo-pituitary-adrenal axis: observations on patients given oral corticosteroids for rheumatoid arthritis.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Adult; Arthritis, Rheumatoid; Blood Glucose; Female; Gluc | 1967 |
Monocyte activation in rheumatoid arthritis (RA): increased integrin, Fc gamma and complement receptor expression and the effect of glucocorticoids.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; CD18 Antigens; Female; Glucocorticoids; Human | 1999 |
Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD; Antigens, Neoplasm; Arthritis, Rheumatoid; Cell Adhesi | 1999 |
Serum lysozyme: a potential marker of monocyte/macrophage activity in rheumatoid arthritis.
Topics: Acute-Phase Proteins; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Arthritis, Rheumatoi | 1999 |
[Treatment of rheumatoid arthritis].
Topics: Adrenal Glands; Adrenal Insufficiency; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antimalarial | 1975 |
Intermittent therapy with corticotrophin.
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Arthritis, Rheumato | 1966 |
Response to metyrapone in children with rheumatic diseases.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Arthritis, Rheu | 1966 |
Adrenocortical and pituitary function following long-term prednisolone treatment.
Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aged; Arthritis, Rheumatoid; Female; Huma | 1966 |
[Clinical studies on the stimulation and suppression of the pituitary-adrenocortical system. 3. Studies on the pituitary adrenocortical suppression after long-term glucocorticoid treatment].
Topics: 17-Hydroxycorticosteroids; Adrenal Insufficiency; Adrenocorticotropic Hormone; Adult; Aged; Arthriti | 1968 |
Some clinical observations on the diurnal rhythm of plasma cortisol (11-OHCS) in patients with rheumatoid arthritis treated with oral corticosteroid drugs.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Aged; Arthritis, Rheumatoid; Circadian Rhythm; | 1974 |
[Use of metopirone in the diagnosis of latent immuno-allergic disorders].
Topics: Arthritis, Rheumatoid; Humans; Hypersensitivity; Metyrapone | 1964 |
[Metopirone in the treatment of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Humans; Metyrapone | 1965 |