metyrapone has been researched along with Argentaffinoma in 10 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cushing's syndrome due to bronchial carcinoid tumors that secrete adrenocorticotropin (ACTH) may be difficult to distinguish from pituitary Cushing's disease, since the responses to dexamethasone and metyrapone are sometimes similar." | 7.67 | Ectopic ACTH syndrome caused by a bronchial carcinoid tumor responsive to dexamethasone, metyrapone, and corticotropin-releasing factor. ( Abboud, C; Carey, RM; Carney, JA; Malchoff, CD; Orth, DN; Pairolero, PC, 1988) |
| "Cushing's syndrome due to bronchial carcinoid tumors that secrete adrenocorticotropin (ACTH) may be difficult to distinguish from pituitary Cushing's disease, since the responses to dexamethasone and metyrapone are sometimes similar." | 3.67 | Ectopic ACTH syndrome caused by a bronchial carcinoid tumor responsive to dexamethasone, metyrapone, and corticotropin-releasing factor. ( Abboud, C; Carey, RM; Carney, JA; Malchoff, CD; Orth, DN; Pairolero, PC, 1988) |
| " Conservative treatment with metyrapone suppressed the Cushing syndrome." | 3.66 | [Successful conservative treatment of bronchial carcinoid with Cushing's syndrome due to ectopic ACTH production]. ( Euler, HH; Herrlinger, JD; Kirmse, L; Kleine, L; Löffler, H; Müller-Hermelink, HK, 1983) |
| "Why some bronchial carcinoid tumours are responsive is unknown but it could be because of co-secretion of corticotrophin releasing factor (CRF) and/or expression of glucocorticoid receptors." | 1.29 | Glucocorticoid responsive ACTH secreting bronchial carcinoid tumours contain high concentrations of glucocorticoid receptors. ( Donald, RA; Espiner, EA; Florkowski, CM; Lewis, JG; Wittert, GA, 1994) |
| "The Cushing's syndrome was controlled medically, and when the patient deteriorated clinically she received treatment with a combination of BCNU, adriamycin, and ftorafur." | 1.26 | Successful therapy of an ACTH-producing gastric carcinoid APUD tumor: report of a case and review of the literature. ( Callen, PW; Churg, A; Friedman, MA; Harbour, J; Marcus, FS, 1980) |
| "Six patients with actively secreting carcinoid tumors responded to standard metyrapone testing with a mean increment of 22." | 1.25 | Adrenal function in the carcinoid syndrome: effects of the serotonin antagonist cyproheptadine. ( Feldman, JM; Plank, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (80.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mizoguchi, Y | 1 |
| Kajiume, T | 1 |
| Miyagawa, S | 1 |
| Okada, S | 1 |
| Nishi, Y | 1 |
| Kobayashi, M | 1 |
| Marcus, FS | 1 |
| Friedman, MA | 1 |
| Callen, PW | 1 |
| Churg, A | 1 |
| Harbour, J | 1 |
| Herrlinger, JD | 1 |
| Euler, HH | 1 |
| Kleine, L | 1 |
| Kirmse, L | 1 |
| Müller-Hermelink, HK | 1 |
| Löffler, H | 1 |
| Florkowski, CM | 1 |
| Wittert, GA | 1 |
| Lewis, JG | 1 |
| Donald, RA | 1 |
| Espiner, EA | 1 |
| Plank, J | 1 |
| Feldman, JM | 1 |
| Malchoff, CD | 1 |
| Orth, DN | 1 |
| Abboud, C | 1 |
| Carney, JA | 1 |
| Pairolero, PC | 1 |
| Carey, RM | 1 |
| Schteingart, DE | 1 |
| Lloyd, RV | 1 |
| Akil, H | 1 |
| Chandler, WF | 1 |
| Ibarra-Perez, G | 1 |
| Rosen, SG | 1 |
| Ogletree, R | 1 |
| Steel, K | 1 |
| Baerg, RD | 1 |
| Adams, DO | 1 |
| Jones, JE | 1 |
| Shane, SR | 1 |
| Gilbert, E | 1 |
| Flink, EB | 1 |
| Schein, PS | 1 |
1 review available for metyrapone and Argentaffinoma
| Article | Year |
|---|---|
Chemotherapeutic management of the hormone-secreting endocrine malignancies.
Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Aminoglutethimide; Aniline Compounds; Antibiotics, Ant | 1972 |
9 other studies available for metyrapone and Argentaffinoma
| Article | Year |
|---|---|
Steroid-dependent ACTH-produced thymic carcinoid: regulation of POMC gene expression by cortisol via methylation of its promoter region.
Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Antimetabolites; Carcinoid Tumor; Child; DNA Me | 2007 |
Successful therapy of an ACTH-producing gastric carcinoid APUD tumor: report of a case and review of the literature.
Topics: Adrenocorticotropic Hormone; Apudoma; Carcinoid Tumor; Cushing Syndrome; Cytoplasmic Granules; Femal | 1980 |
[Successful conservative treatment of bronchial carcinoid with Cushing's syndrome due to ectopic ACTH production].
Topics: ACTH Syndrome, Ectopic; Bronchial Neoplasms; Carcinoid Tumor; Cushing Syndrome; Cyclophosphamide; Do | 1983 |
Glucocorticoid responsive ACTH secreting bronchial carcinoid tumours contain high concentrations of glucocorticoid receptors.
Topics: ACTH Syndrome, Ectopic; Adolescent; Adult; Bronchial Neoplasms; Carcinoid Tumor; Corticotropin-Relea | 1994 |
Adrenal function in the carcinoid syndrome: effects of the serotonin antagonist cyproheptadine.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Aged; Carcinoid Tumor; Circadian Rhythm; Cyproheptadine; | 1975 |
Ectopic ACTH syndrome caused by a bronchial carcinoid tumor responsive to dexamethasone, metyrapone, and corticotropin-releasing factor.
Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; Bronchial Neoplasms; Carcinoid Tumor; Co | 1988 |
Cushing's syndrome secondary to ectopic corticotropin-releasing hormone-adrenocorticotropin secretion.
Topics: ACTH Syndrome, Ectopic; Bronchial Neoplasms; Carcinoid Tumor; Corticotropin-Releasing Hormone; Cushi | 1986 |
Cushing's syndrome in association with a carcinoid tumor of the lung.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Carcinoid Tumor; Cushing Sy | 1967 |
Cushing's syndrome induced by the ectopic production of ACTH by a bronchial carcinoid.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Aged; Bronchial Neoplasms; | 1969 |