metyrapone has been researched along with Aldosteronism in 33 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We characterized the pharmacokinetic/pharmacodynamic relationships of a prototypical ASI, (+)-(5R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile hydrochloride (CGS020286A, FAD286, FAD) and compared these profiles to those of the 11beta-hydroxylase inhibitor metyrapone (MET) in two rodent models of secondary hyperaldosteronism and corticosteronism." | 7.76 | Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone. ( Beil, M; Fu, F; Hu, CW; Jeng, AY; Liang, G; Rigel, DF, 2010) |
| "The effect of 5 to 9 days of metyrapone administration (400 mg/m2 every 4 h) on aldosterone, deoxycorticosterone, plasma renin activity, electrolyte balance, and blood pressure was investigated in 2 normotensive siblings (one of whom showed limited ACTH reserve), in 3 patients with hypertension and dexamethasone-suppressible hyperaldosteronism, and in a hypertensive patient with primary hyperaldosteronism due to bilateral adrenal hyperplasia." | 7.66 | Mineralocorticoid and metabolic response to metyrapone on normotensive children and children with dexamethasone-suppressible and primary hyperaldosteronism. ( Levine, LS; New, MI; Sonino, N, 1981) |
| " We characterized the pharmacokinetic/pharmacodynamic relationships of a prototypical ASI, (+)-(5R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile hydrochloride (CGS020286A, FAD286, FAD) and compared these profiles to those of the 11beta-hydroxylase inhibitor metyrapone (MET) in two rodent models of secondary hyperaldosteronism and corticosteronism." | 3.76 | Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone. ( Beil, M; Fu, F; Hu, CW; Jeng, AY; Liang, G; Rigel, DF, 2010) |
| " by metyrapone test or by congenital adrenal hyperplasia resulting from 11 beta-hydroxylase deficiency." | 3.69 | An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione. ( Auzéby, A; Bogdan, A; Touitou, Y, 1995) |
| "The effect of 5 to 9 days of metyrapone administration (400 mg/m2 every 4 h) on aldosterone, deoxycorticosterone, plasma renin activity, electrolyte balance, and blood pressure was investigated in 2 normotensive siblings (one of whom showed limited ACTH reserve), in 3 patients with hypertension and dexamethasone-suppressible hyperaldosteronism, and in a hypertensive patient with primary hyperaldosteronism due to bilateral adrenal hyperplasia." | 3.66 | Mineralocorticoid and metabolic response to metyrapone on normotensive children and children with dexamethasone-suppressible and primary hyperaldosteronism. ( Levine, LS; New, MI; Sonino, N, 1981) |
| "The blood pressure elevation of primary aldosteronism is caused by excessive production of the known mineralocorticoid, aldosterone." | 2.64 | Are there unknown mineralocorticoids in low-renin essential hypertension? ( Hollifield, JW; Island, DP; Liddle, GW; Sennett, JA; Slaton, PE; Wilson, HM; Yarbro, L, 1977) |
| "The hypothesis that hyperaldosteronism is not the sole cause of hypertension in dexamethasone-suppressible hyperaldosteronsim was tested in an 18-year-old male." | 1.26 | Evidence for an unidentified ACTH-induced steroid hormone causing hypertension. ( Levine, LS; New, MI; Peterson, RE; Saenger, P, 1976) |
| "The hypertension was alleviated by the administeration of dexamethasone in 2 of 3 patients with 17 alpha-hydroxylase deficiency." | 1.26 | Hypertension induced by adrenocortical dysfunction--hypertension in 17 alpha-hydroxylase deficiency and metopirone-induced hypertension. ( Kato, E; Kitajima, W; Kondo, K; Konishi, K; Matsuki, S; Nakamura, R; Ohguro, T; Oka, M; Ozawa, Y; Saito, I; Saruta, T; Yamagami, K, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (90.91) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (3.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rigel, DF | 1 |
| Fu, F | 1 |
| Beil, M | 1 |
| Hu, CW | 1 |
| Liang, G | 1 |
| Jeng, AY | 1 |
| PECORINI, V | 1 |
| CERIANI, R | 1 |
| GARCIA DEL RIO, H | 1 |
| WELSH, P | 1 |
| RUBIANES, C | 1 |
| GUILLEMAN, P | 1 |
| OGAWA, K | 1 |
| WATANABE, Y | 1 |
| KUNII, Y | 1 |
| HOFFMEISTER, W | 1 |
| MINDER, E | 1 |
| MARKOFF, NG | 1 |
| NEHER, R | 1 |
| KAHNT, FW | 1 |
| FISHER, DA | 1 |
| MORRIS, MD | 1 |
| KUMAGAI, H | 1 |
| CRANE, MG | 1 |
| HARRIS, JJ | 1 |
| HERBER, R | 1 |
| Nomura, K | 2 |
| Naruse, M | 1 |
| Naruse, K | 1 |
| Demura, H | 2 |
| Shizume, K | 1 |
| Sonino, N | 1 |
| Levine, LS | 2 |
| New, MI | 3 |
| Auzéby, A | 1 |
| Bogdan, A | 1 |
| Touitou, Y | 1 |
| Besser, GM | 1 |
| Jeffcoate, WJ | 1 |
| Peterson, RE | 2 |
| Saenger, P | 1 |
| Saruta, T | 1 |
| Nakamura, R | 1 |
| Saito, I | 1 |
| Kondo, K | 1 |
| Ohguro, T | 1 |
| Yamagami, K | 1 |
| Kitajima, W | 1 |
| Oka, M | 1 |
| Konishi, K | 1 |
| Ozawa, Y | 1 |
| Kato, E | 1 |
| Matsuki, S | 1 |
| Hollifield, JW | 1 |
| Slaton, PE | 1 |
| Wilson, HM | 1 |
| Sennett, JA | 1 |
| Yarbro, L | 1 |
| Island, DP | 1 |
| Liddle, GW | 1 |
| Beierwaltes, WH | 1 |
| Wieland, DM | 1 |
| Mosley, ST | 1 |
| Swanson, DP | 1 |
| Sarkar, SD | 1 |
| Freitas, JE | 1 |
| Thrall, JH | 1 |
| Herwig, KR | 1 |
| Loewenstein, JE | 1 |
| Ujihara, M | 1 |
| Minato, M | 1 |
| Honda, M | 1 |
| Hatano, M | 1 |
| Takeda, R | 1 |
| Matsuda, T | 1 |
| Tucci, JR | 1 |
| Espiner, EA | 1 |
| Jagger, PI | 1 |
| Lauler, DP | 1 |
| Brackett, NC | 1 |
| Koppel, M | 1 |
| Randall, RE | 1 |
| Nixon, WP | 1 |
| Pasqualini, JR | 1 |
| Beuve-Méry, P | 1 |
| Meyer, P | 1 |
| Miura, K | 1 |
| Miura, S | 1 |
| Hasui, K | 1 |
| Hellman, L | 1 |
| Bradlow, HL | 1 |
| Zumoff, B | 1 |
| Igarashi, Y | 1 |
| Imai, M | 1 |
| Egi, S | 1 |
| Kawato, H | 1 |
| Suwa, S | 1 |
| Siegal, EJ | 1 |
| Streeten, DH | 1 |
| Speller, PJ | 1 |
| Werning, C | 1 |
| Siegenthaler, W | 1 |
| Torikai, T | 1 |
5 reviews available for metyrapone and Aldosteronism
| Article | Year |
|---|---|
[Clinical studies on a disorder of mineralocorticoid metabolism].
Topics: Aldosterone; Humans; Hyperaldosteronism; Kanamycin; Ketoconazole; Metyrapone; Mineralocorticoids; Mi | 1986 |
[New endocrine disorders attracting current interest--adrenal system].
Topics: Addison Disease; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocorticotropic Ho | 1969 |
Recent advances in human steroid metabolism.
Topics: Adrenocorticotropic Hormone; Aldosterone; Carbon Isotopes; Dexamethasone; Estriol; Etiocholanolone; | 1970 |
[Glucocorticoid responsive aldosteronism: our pediatric cases and presentation of concepts].
Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Child; Dexamethas | 1971 |
[Aspect of hormones and hypertension].
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Age Factors; Aged; Aldosterone; Blood Pressure; Catechol | 1969 |
2 trials available for metyrapone and Aldosteronism
| Article | Year |
|---|---|
Are there unknown mineralocorticoids in low-renin essential hypertension?
Topics: Aminoglutethimide; Blood Pressure; Clinical Trials as Topic; Humans; Hyperaldosteronism; Hypertensio | 1977 |
The effect of metyrapone on aldosterone secretion in man.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Adult; Aldosterone; Body We | 1967 |
26 other studies available for metyrapone and Aldosteronism
| Article | Year |
|---|---|
Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11beta-hydroxylase inhibitor metyrapone.
Topics: Adrenal Glands; Aldosterone; Animals; Blood Pressure; Blood Proteins; Chromatography, Liquid; Cortic | 2010 |
[Syndrome of secondary hyperaldosteronism treated with Metopirone].
Topics: Hyperaldosteronism; Ketones; Metyrapone; Pyridines; Syndrome | 1962 |
[TREATMENT OF STATES OF HYPERALDOSTERONISM. THERAPEUTIC INDICATIONS OF SPIRONOLACTONE].
Topics: Humans; Hyperaldosteronism; Ketones; Metyrapone; Mineralocorticoid Receptor Antagonists; Propiopheno | 1963 |
[CASE OF PRIMARY HYPERALDOSTERONISM AND THE EFFECT OF VARIOUS DRUGS].
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Benzothiadiazines; Chlorothiazide; Desoxycorticosterone; | 1964 |
[PATHOPHYSIOLOGY AND CLINICAL ASPECTS OF SECONDARY ALDOSTERONISM AND ITS TREATMENT].
Topics: Adrenocorticotropic Hormone; Aldosterone; Ascites; Body Fluids; Classification; Dexamethasone; Extra | 1964 |
[A SURGICALLY TREATED CASE OF CONN'S SYNDROME. CLINICAL, HISTOLOGICAL AND BIOCHEMICAL FINDINGS].
Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Alkalosis; Humans; Hyperal | 1964 |
IDIOPATHIC EDEMA ND HYPERALDOSTERONURIA: POSTURAL VENOUS PLASMA POOLING.
Topics: Adolescent; Aldosterone; Angiotensins; Blood Pressure; Body Weight; Drug Therapy; Edema; Ephedrine; | 1965 |
[STUDIES ON THE DIAGNOSTIC USE OF METOPIRONE (11-BETA-HYDROXYLASE INHIBITOR) IN DISEASES OF THE PITUITARY AND ADRENAL CORTEX].
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Blo | 1964 |
PRIMARY ALDOSTERONISM DUE TO AN ADRENAL CARCINOMA.
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Alkalosis; Blood; Drug Therapy; Hyperaldosteronism | 1965 |
In vivo evidence of cortisol secretion by aldosterone-producing adenomas.
Topics: Adenoma; Adrenocorticotropic Hormone; Aldosterone; Humans; Hydrocortisone; Hyperaldosteronism; Metyr | 1984 |
Mineralocorticoid and metabolic response to metyrapone on normotensive children and children with dexamethasone-suppressible and primary hyperaldosteronism.
Topics: Aldosterone; Child; Desoxycorticosterone; Electrolytes; Female; Humans; Hyperaldosteronism; Hyperten | 1981 |
An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adult | 1995 |
Endocrine and metabolic diseases. Adrenal diseases.
Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Insuffici | 1976 |
Evidence for an unidentified ACTH-induced steroid hormone causing hypertension.
Topics: 18-Hydroxydesoxycorticosterone; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aldoste | 1976 |
Hypertension induced by adrenocortical dysfunction--hypertension in 17 alpha-hydroxylase deficiency and metopirone-induced hypertension.
Topics: Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Animals; Cushing Syndrome; Deso | 1978 |
Imaging the adrenal glands with radiolabeled inhibitors of enzymes: concise communication.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Animals; Breast Neoplasms; Dogs; Enzyme Inhibitors; Humans; | 1978 |
Testing adrenal function--1975.
Topics: Adolescent; Adrenal Cortex Function Tests; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal | 1975 |
[Inhibitors of thyroid hormone-, steroid hormone-, and catecholamine-synthesis].
Topics: Antithyroid Agents; Autoimmunity; Catecholamines; Dihydrotestosterone; Humans; Hyperaldosteronism; I | 1991 |
[Clinical significance of serum and urinary 18-hydroxycorticosterone analysis in endocrine tests of the adrenal cortex].
Topics: 18-Hydroxycorticosterone; Addison Disease; Adrenal Cortex Function Tests; Adrenocorticotropic Hormon | 1989 |
[Clinical studies on the effects of aldosterone and anti-aldosterone compounds on water and electrolyte metabolism. II. Clinical studies on the effects of compounds which inhibit aldosterone synthesis on water and electrolyte metabolism].
Topics: Adrenal Glands; Adult; Aged; Butanones; Female; Glucocorticoids; Heparinoids; Humans; Hyperaldostero | 1967 |
Hyperplasia of the juxtaglomerular complex with secondary aldosteronism without hypertension (Bartter's syndrome).
Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Aldosterone; Ammonium Chloride; Angiotensin II; Bicarb | 1968 |
[Production and excretion of corticosteroids in primary hyperaldosteronism].
Topics: Adenoma; Adrenal Cortex Hormones; Angiotensin II; Carbon Isotopes; Dexamethasone; Humans; Hyperaldos | 1968 |
[Diurnal variation of plasma cortisol concentration in patients with various diseases and negative feedback mechanism of the pituitary-adrenal axis].
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Central Nervous Sys | 1969 |
Dexamethasone-suppressible hyperaldosteronism.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Aldosterone; Co | 1973 |
The role of mineralocorticoids in the pathogenesis of hypokalemic periodic paralysis.
Topics: Adult; Aldosterone; Angiotensin II; Desoxycorticosterone; Humans; Hydrocortisone; Hyperaldosteronism | 1974 |
[Therapy of secondary hyperaldosteronism].
Topics: Aminoglutethimide; Butanones; Heparin; Humans; Hyperaldosteronism; Metyrapone; Mineralocorticoid Rec | 1973 |