metyrapone has been researched along with Alcoholism in 6 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metyrapone treatment was not found to reduce alcohol consumption more than placebo." | 6.70 | No effect of the cortisol-synthesis inhibitor metyrapone on alcohol drinking: a pilot study. ( Balldin, J; Berggren, U; Eriksson, M; Fahlke, C; Hansen, S; Mårin, P, 2001) |
| "Metyrapone treatment was not found to reduce alcohol consumption more than placebo." | 2.70 | No effect of the cortisol-synthesis inhibitor metyrapone on alcohol drinking: a pilot study. ( Balldin, J; Berggren, U; Eriksson, M; Fahlke, C; Hansen, S; Mårin, P, 2001) |
| "Treatment with metyrapone or o,p'-DDD can always induce a clinical remission but not a cure, and neurotransmitter therapy may be effective in a minority of cases." | 2.37 | Cushing's syndrome. ( Besser, GM; Howlett, TA; Rees, LH, 1985) |
| "The impact of chronic alcohol abuse on the hypothalamic-pituitary-adrenal (HPA) axis was investigated in actively drinking, nondepressed alcoholics with no evidence of liver disease." | 1.28 | Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics. ( Dobs, AS; Wand, GS, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jenkins, RM | 1 |
| Page, MM | 1 |
| Eriksson, M | 1 |
| Fahlke, C | 1 |
| Hansen, S | 1 |
| Berggren, U | 1 |
| Mårin, P | 1 |
| Balldin, J | 1 |
| Wand, GS | 1 |
| Dobs, AS | 1 |
| von Bardeleben, U | 1 |
| Holsboer, F | 1 |
| Howlett, TA | 1 |
| Rees, LH | 1 |
| Besser, GM | 1 |
| Lundberg, PO | 1 |
| Osterman, PO | 1 |
| Wide, L | 1 |
2 reviews available for metyrapone and Alcoholism
| Article | Year |
|---|---|
Human corticotropin releasing hormone: clinical studies in patients with affective disorders, alcoholism, panic disorder and in normal controls.
Topics: Adrenocorticotropic Hormone; Alcoholism; Aldosterone; Corticotropin-Releasing Hormone; Depression; D | 1988 |
Cushing's syndrome.
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Alcoho | 1985 |
1 trial available for metyrapone and Alcoholism
| Article | Year |
|---|---|
No effect of the cortisol-synthesis inhibitor metyrapone on alcohol drinking: a pilot study.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Analysis of Variance; Enzyme Inhibitors; Humans; Hydrocor | 2001 |
3 other studies available for metyrapone and Alcoholism
| Article | Year |
|---|---|
Atypical case of alcohol-induced Cushingoid syndrome.
Topics: Alcoholism; Cushing Syndrome; Female; Humans; Metyrapone; Middle Aged | 1981 |
Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics.
Topics: Alcohol Drinking; Alcoholism; Corticotropin-Releasing Hormone; Cosyntropin; Hormones; Humans; Hypoth | 1991 |
Vasopressin test in cases of optic atrophy and optic neuritis.
Topics: Adolescent; Adult; Aged; Alcoholism; Amblyopia; Circadian Rhythm; Female; Humans; Hydrocortisone; Hy | 1971 |