metyrapone has been researched along with Alcohol Drinking in 7 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metyrapone treatment was not found to reduce alcohol consumption more than placebo." | 6.70 | No effect of the cortisol-synthesis inhibitor metyrapone on alcohol drinking: a pilot study. ( Balldin, J; Berggren, U; Eriksson, M; Fahlke, C; Hansen, S; Mårin, P, 2001) |
| "Metyrapone treatment was not found to reduce alcohol consumption more than placebo." | 2.70 | No effect of the cortisol-synthesis inhibitor metyrapone on alcohol drinking: a pilot study. ( Balldin, J; Berggren, U; Eriksson, M; Fahlke, C; Hansen, S; Mårin, P, 2001) |
| "Treatment with corticosterone (0." | 1.29 | Metyrapone-induced suppression of corticosterone synthesis reduces ethanol consumption in high-preferring rats. ( Engel, JA; Fahlke, C; Hansen, S; Hård, E; Thomasson, R, 1994) |
| "The impact of chronic alcohol abuse on the hypothalamic-pituitary-adrenal (HPA) axis was investigated in actively drinking, nondepressed alcoholics with no evidence of liver disease." | 1.28 | Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics. ( Dobs, AS; Wand, GS, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Callaghan, MJ | 1 |
| Croft, AP | 1 |
| Jacquot, C | 1 |
| Little, HJ | 1 |
| Fahlke, C | 2 |
| Hård, E | 1 |
| Thomasson, R | 1 |
| Engel, JA | 1 |
| Hansen, S | 3 |
| Nebbia, C | 1 |
| Dacasto, M | 1 |
| Ceppa, L | 1 |
| Bosia, S | 1 |
| Burdino, E | 1 |
| Witkamp, RF | 1 |
| Ugazio, G | 1 |
| Söderpalm, AH | 1 |
| Eriksson, M | 1 |
| Berggren, U | 1 |
| Mårin, P | 1 |
| Balldin, J | 1 |
| Wand, GS | 1 |
| Dobs, AS | 1 |
| Verdy, M | 1 |
| Brouillet, J | 1 |
1 trial available for metyrapone and Alcohol Drinking
| Article | Year |
|---|---|
No effect of the cortisol-synthesis inhibitor metyrapone on alcohol drinking: a pilot study.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Analysis of Variance; Enzyme Inhibitors; Humans; Hydrocor | 2001 |
6 other studies available for metyrapone and Alcohol Drinking
| Article | Year |
|---|---|
The hypothalamopituitary-adrenal axis and alcohol preference.
Topics: Adrenocorticotropic Hormone; Alcohol Drinking; Animals; Animals, Newborn; Behavior, Animal; Central | 2005 |
Metyrapone-induced suppression of corticosterone synthesis reduces ethanol consumption in high-preferring rats.
Topics: Alcohol Drinking; Animals; Corticosterone; Drinking; Ethanol; Male; Metyrapone; Rats; Rats, Wistar | 1994 |
Gender differences in ethanol oxidation and cytochrome P4502E1 content and functions in hepatic microsomes from alcohol-preferring and non-preferring rats.
Topics: Alcohol Drinking; Animals; Blotting, Western; Carbon Tetrachloride Poisoning; Cytochrome P-450 CYP2E | 1996 |
Alcohol alliesthesia: food restriction increases the palatability of alcohol through a corticosterone-dependent mechanism.
Topics: Adrenalectomy; Alcohol Drinking; Animals; Circadian Rhythm; Corticosterone; Enzyme Inhibitors; Food | 1999 |
Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics.
Topics: Alcohol Drinking; Alcoholism; Corticotropin-Releasing Hormone; Cosyntropin; Hormones; Humans; Hypoth | 1991 |
Alcohol and adrenocortical function. Negative effect on ACTH reserve in man by metyrapone test.
Topics: Adrenocorticotropic Hormone; Adult; Alcohol Drinking; Ethanol; Female; Humans; Hydrocortisone; Infus | 1970 |