metyrapone has been researched along with Aging in 27 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with metyrapone inhibited the increase in plasma corticosterone levels induced by the bite-raised condition, and also attenuated the reduction in cell proliferation." | 1.35 | Chewing under restraint stress inhibits the stress-induced suppression of cell birth in the dentate gyrus of aged SAMP8 mice. ( Karasawa, N; Kubo, KY; Ono, Y; Onozuka, M; Sasaguri, K; Takahashi, T; Watanabe, K; Yamamoto, T, 2009) |
| "The metyrapone treatment produced no changes in GAD activity at PN23, but induced an important increase in this activity at PN90." | 1.34 | Role of maternal corticosterone in the development and maturation of the aminoacidergic systems of the rat brain. ( Garcia-Montojo, M; González, JC; Lecumberri, M; Leret, ML, 2007) |
| "Pretreatment with metyrapone, which suppresses the stress-induced rise in plasma corticosterone levels, prevented the molarless condition-induced increase in plasma corticosterone levels, reduction in CA1 pyramidal neuron numbers, and impairment of spatial learning." | 1.31 | Evidence for involvement of glucocorticoid response in the hippocampal changes in aged molarless SAMP8 mice. ( Fujita, M; Onozuka, M; Saito, S; Tonosaki, K; Watanabe, K, 2002) |
| "As phenobarbital treatment in young rats enhanced the symptoms of nephrotoxicity and metyrapone treatment in adult rats decreased the symptoms of nephrotoxicity, age-dependent differences in chromate nephrotoxicity may be linked to an increase in the enzymatic reduction of Cr(VI) with age." | 1.28 | Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats. ( Appenroth, D; Bräunlich, H; Friese, KH; Gambaryan, S, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (55.56) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kubo, KY | 1 |
| Sasaguri, K | 1 |
| Ono, Y | 1 |
| Yamamoto, T | 1 |
| Takahashi, T | 1 |
| Watanabe, K | 2 |
| Karasawa, N | 1 |
| Onozuka, M | 2 |
| Tronche, C | 1 |
| Piérard, C | 1 |
| Coutan, M | 1 |
| Chauveau, F | 1 |
| Liscia, P | 1 |
| Béracochéa, D | 1 |
| Lupien, SJ | 1 |
| Wilkinson, CW | 3 |
| Brière, S | 1 |
| Ng Ying Kin, NM | 1 |
| Meaney, MJ | 1 |
| Nair, NP | 1 |
| LACROIX, L | 1 |
| STRUMIA, E | 1 |
| Leret, ML | 1 |
| Lecumberri, M | 1 |
| Garcia-Montojo, M | 1 |
| González, JC | 1 |
| de Peretti, E | 2 |
| Mappus, E | 1 |
| Parandoosh, Z | 1 |
| Franklin, MR | 1 |
| Coupland, RE | 1 |
| Bustami, F | 1 |
| Zulkifli, I | 1 |
| Siegel, HS | 1 |
| Mashaly, MM | 1 |
| Dunnington, EA | 1 |
| Siegel, PB | 1 |
| Hayes, TB | 1 |
| Wu, TH | 1 |
| Vacchio, MS | 1 |
| Papadopoulos, V | 1 |
| Ashwell, JD | 1 |
| Wright, MC | 1 |
| Wang, XJ | 1 |
| Pimenta, M | 1 |
| Ribeiro, V | 1 |
| Paine, AJ | 1 |
| Lechner, MC | 1 |
| Peskind, ER | 2 |
| Raskind, MA | 2 |
| Petrie, EC | 1 |
| Murray, SR | 1 |
| Colasurdo, EA | 1 |
| Fujita, M | 1 |
| Tonosaki, K | 1 |
| Saito, S | 1 |
| Blicher-Toft, M | 2 |
| Hummer, L | 2 |
| Baverstock, PR | 1 |
| Bradshaw, SD | 1 |
| Appenroth, D | 1 |
| Gambaryan, S | 1 |
| Friese, KH | 1 |
| Bräunlich, H | 1 |
| Forest, MG | 1 |
| Loras, B | 1 |
| Morel, Y | 1 |
| David, M | 1 |
| François, R | 1 |
| Bertrand, J | 1 |
| Coe, CL | 1 |
| Cassayre, P | 1 |
| Levine, S | 1 |
| Rosenberg, LT | 1 |
| Sapolsky, RM | 1 |
| Mott, GE | 1 |
| Arvay, A | 1 |
| Takács, J | 1 |
| Pallone, E | 1 |
| Micheli, G | 1 |
| Saba, GC | 1 |
| Lenzi, S | 1 |
| Abate, G | 1 |
| Bernardi, P | 1 |
| Montini, T | 1 |
| Jensen, HK | 1 |
| Blichert-Toft, M | 1 |
| Ferrari, E | 1 |
| Bossolo, PA | 1 |
2 trials available for metyrapone and Aging
| Article | Year |
|---|---|
Acute modulation of aged human memory by pharmacological manipulation of glucocorticoids.
Topics: Aged; Aging; Anti-Inflammatory Agents; Enzyme Inhibitors; Humans; Hydrocortisone; Memory; Memory Dis | 2002 |
Decreased hypothalamic-pituitary-adrenal axis sensitivity to cortisol feedback inhibition in human aging.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Aging; Cortodoxone; Enzyme Inhibitors; Fee | 1997 |
25 other studies available for metyrapone and Aging
| Article | Year |
|---|---|
Chewing under restraint stress inhibits the stress-induced suppression of cell birth in the dentate gyrus of aged SAMP8 mice.
Topics: Aging; Animals; Cell Proliferation; Corticosterone; Dentate Gyrus; Male; Mastication; Metyrapone; Mi | 2009 |
Increased stress-induced intra-hippocampus corticosterone rise associated with memory impairments in middle-aged mice.
Topics: Age Factors; Aging; Animals; Antimetabolites; Corticosterone; Discrimination, Psychological; Glucoco | 2010 |
[BEHAVIOR OF THE ADRENAL CORTEX IN OLD MEN, IN NORMAL CONDITIONS AND AFTER CORTICOTROPIN STIMULATION].
Topics: 17-Ketosteroids; Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormon | 1964 |
Role of maternal corticosterone in the development and maturation of the aminoacidergic systems of the rat brain.
Topics: Aging; Amino Acids; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Corticost | 2007 |
Pattern of plasma pregnenolone sulfate levels in humans from birth to adulthood.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aging; Child; Child, Preschool; Chorionic Gonadotrop | 1983 |
Developmental changes in rabbit pulmonary cytochrome P-450 subpopulations.
Topics: Aging; Amphetamines; Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Female; Lung; Male; Met | 1983 |
Influence of drugs affecting the pituitary adrenal axis on chromaffin cells.
Topics: Adrenal Medulla; Aging; Animals; Chromaffin Granules; Cyproterone; Epinephrine; Male; Metyrapone; Mi | 1980 |
Inhibition of adrenal steroidogenesis, neonatal feed restriction, and pituitary-adrenal axis response to subsequent fasting in chickens.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aging; Animals; Chickens; Corticosterone; Food Deprivat | 1995 |
Interdependence of corticosterone and thyroid hormones in toad larvae (Bufo boreas). II. Regulation of corticosterone and thyroid hormones.
Topics: Aging; Analysis of Variance; Animals; Bufonidae; Corticosterone; Drug Interactions; Homeostasis; Lar | 1995 |
Steroid production in the thymus: implications for thymocyte selection.
Topics: Aging; Animals; Cells, Cultured; Cholesterol Side-Chain Cleavage Enzyme; Corticosterone; Cytochrome | 1994 |
Glucocorticoid receptor-independent transcriptional induction of cytochrome P450 3A1 by metyrapone and its potentiation by glucocorticoid.
Topics: Aging; Animals; Binding Sites; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Syst | 1996 |
Human glucocorticoid feedback inhibition is reduced in older individuals: evening study.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aging; Circadian Rhythm; Cortodoxone; Feedback; Female; Gl | 2001 |
Evidence for involvement of glucocorticoid response in the hippocampal changes in aged molarless SAMP8 mice.
Topics: Aging; Animals; Cell Count; Darkness; Escape Reaction; Glucocorticoids; Hippocampus; Light; Metyrapo | 2002 |
Immunoreactive corticotrophin reserve in old age in man during and after surgical stress.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aging; Antigens; Female; Humans; Male; Metyrapone; Middle | 1976 |
Serum immunoreactive corticotrophin and response to metyrapone in old age in man.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aging; Circadian Rhythm; Feedback; Female; Humans; Male; M | 1977 |
Variation in rate of growth and adrenal corticosteroidogenesis in field and laboratory populations of the lizard Amphibolurus ornatus.
Topics: Acclimatization; Adaptation, Physiological; Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; | 1975 |
Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats.
Topics: Aging; Animals; Chromates; Chromium; Cromolyn Sodium; Female; Kidney; Kidney Diseases; Kidney Tubule | 1990 |
Usefulness of plasma pregnenolone sulfate in testing pituitary-adrenal function in children.
Topics: Adolescent; Adrenal Gland Diseases; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aging; Child | 1986 |
Effects of age, sex, and psychological disturbance on immunoglobulin levels in the squirrel monkey.
Topics: Aging; Animals; Arousal; Cebidae; Complement C3; Complement C4; Dexamethasone; Immunoglobulin G; Imm | 1988 |
Social subordinance in wild baboons is associated with suppressed high density lipoprotein-cholesterol concentrations: the possible role of chronic social stress.
Topics: Aging; Animals; Animals, Wild; Cholesterol, HDL; Dexamethasone; Dominance-Subordination; Male; Metyr | 1987 |
The influence of hormone changes during pregnancy on the velocity of collagen aging.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Castration; Chorionic Gonadotropin; Collagen; Estradiol | 1965 |
[Some aspects of adrenal cortex physiology in the senile age].
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Aging; Dexamethasone; Female; Humans; Male; Me | 1966 |
[Functional study of the glycoactive adrenal gland in the aged patient. II. Functional tests with metopirone, dexamethasone and bacterial pyretogen].
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Aged; Aging; Dexamethasone; | 1968 |
Pituitary-adrenal function in old age evaluated by the intravenous metyrapone test.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aging; Female; Humans; Hydrocortisone; Injections, Intrave | 1970 |
[ACTH-cortisol system in the third life-period].
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Aged; Aging; Dexamethasone; Female; Humans; | 1973 |