metyrapone has been researched along with Age-Related Memory Disorders in 13 studies
Metyrapone: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
metyrapone : An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The metyrapone treated hypoxic animals performed better in the Morris Water Maze." | 5.38 | Corticosterone synthesis inhibitor metyrapone ameliorates chronic hypobaric hypoxia induced memory impairment in rat. ( Baitharu, I; Barhwal, K; Deep, SN; Hota, SK; Ilavazhagan, G; Jain, V; Malhotra, AS; Prasad, D, 2012) |
| "The metyrapone treated hypoxic animals performed better in the Morris Water Maze." | 1.38 | Corticosterone synthesis inhibitor metyrapone ameliorates chronic hypobaric hypoxia induced memory impairment in rat. ( Baitharu, I; Barhwal, K; Deep, SN; Hota, SK; Ilavazhagan, G; Jain, V; Malhotra, AS; Prasad, D, 2012) |
| "To evaluate whether paradoxical sleep deprivation-induced memory impairments are due to release of glucocorticoids, by means of corticosterone inhibition with metyrapone." | 1.35 | Glucocorticoids are not responsible for paradoxical sleep deprivation-induced memory impairments. ( Oliveira, MG; Rossi, VC; Suchecki, D; Tiba, PA; Tufik, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Faucher, P | 1 |
| Huguet, C | 1 |
| Mons, N | 1 |
| Micheau, J | 1 |
| Keller, SM | 1 |
| Schreiber, WB | 1 |
| Stanfield, BR | 1 |
| Knox, D | 1 |
| Maćkowiak, M | 1 |
| Grzegorzewska, M | 1 |
| Budziszewska, B | 1 |
| Chocyk, A | 1 |
| Hess, G | 1 |
| Wedzony, K | 1 |
| Tronche, C | 1 |
| Piérard, C | 1 |
| Coutan, M | 1 |
| Chauveau, F | 1 |
| Liscia, P | 1 |
| Béracochéa, D | 1 |
| Rimmele, U | 1 |
| Meier, F | 1 |
| Lange, T | 1 |
| Born, J | 1 |
| Milot, MR | 1 |
| Plamondon, H | 1 |
| Baitharu, I | 1 |
| Deep, SN | 1 |
| Jain, V | 1 |
| Barhwal, K | 1 |
| Malhotra, AS | 1 |
| Hota, SK | 1 |
| Prasad, D | 1 |
| Ilavazhagan, G | 1 |
| Lupien, SJ | 1 |
| Wilkinson, CW | 1 |
| Brière, S | 1 |
| Ng Ying Kin, NM | 1 |
| Meaney, MJ | 1 |
| Nair, NP | 1 |
| Pedersen, WA | 1 |
| McMillan, PJ | 1 |
| Kulstad, JJ | 1 |
| Leverenz, JB | 1 |
| Craft, S | 1 |
| Haynatzki, GR | 1 |
| Mesripour, A | 1 |
| Hajhashemi, V | 1 |
| Rabbani, M | 1 |
| Tiba, PA | 1 |
| Oliveira, MG | 1 |
| Rossi, VC | 1 |
| Tufik, S | 1 |
| Suchecki, D | 1 |
| Wang, XY | 1 |
| Zhao, M | 1 |
| Ghitza, UE | 1 |
| Li, YQ | 1 |
| Lu, L | 1 |
| Tsutsumi, S | 1 |
| Akaike, M | 1 |
| Arimitsu, H | 1 |
| Imai, H | 1 |
| Kato, N | 1 |
2 trials available for metyrapone and Age-Related Memory Disorders
| Article | Year |
|---|---|
Suppressing the morning rise in cortisol impairs free recall.
Topics: Adolescent; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Emotions; Enzyme Inhibitors; | 2010 |
Acute modulation of aged human memory by pharmacological manipulation of glucocorticoids.
Topics: Aged; Aging; Anti-Inflammatory Agents; Enzyme Inhibitors; Humans; Hydrocortisone; Memory; Memory Dis | 2002 |
11 other studies available for metyrapone and Age-Related Memory Disorders
| Article | Year |
|---|---|
Acute pre-learning stress selectively impairs hippocampus-dependent fear memory consolidation: Behavioral and molecular evidence.
Topics: Animals; Corticosterone; Emotions; Fear; Hippocampus; Learning; Male; Memory Consolidation; Memory D | 2022 |
Inhibiting corticosterone synthesis during fear memory formation exacerbates cued fear extinction memory deficits within the single prolonged stress model.
Topics: Animals; Conditioning, Psychological; Corticosterone; Cues; Disease Models, Animal; Enzyme Inhibitor | 2015 |
Cocaine decreases the expression of PSA-NCAM protein and attenuates long-term potentiation via glucocorticoid receptors in the rat dentate gyrus.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Cocaine; Cocaine-Related Disorders; Cort | 2008 |
Increased stress-induced intra-hippocampus corticosterone rise associated with memory impairments in middle-aged mice.
Topics: Age Factors; Aging; Animals; Antimetabolites; Corticosterone; Discrimination, Psychological; Glucoco | 2010 |
How right is the righting reflex? The risk of false positives in neuroprotection studies using behavioral measures to certify forebrain ischemia.
Topics: Animals; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Memory Disor | 2010 |
Corticosterone synthesis inhibitor metyrapone ameliorates chronic hypobaric hypoxia induced memory impairment in rat.
Topics: Altitude Sickness; Animals; Antioxidants; Corticosterone; Drug Interactions; Glucose; Glucose Transp | 2012 |
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Behavior, Anim | 2006 |
Metyrapone and mifepristone reverse recognition memory loss induced by spontaneous morphine withdrawal in mice.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Glucocorticoids; Hormone Antagonists; Injections | 2008 |
Glucocorticoids are not responsible for paradoxical sleep deprivation-induced memory impairments.
Topics: Adrenocorticotropic Hormone; Animals; Conditioning, Psychological; Corticosterone; Drug Administrati | 2008 |
Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala.
Topics: Amygdala; Analgesics, Opioid; Androstanols; Animals; Association Learning; Behavior, Animal; Conditi | 2008 |
Circulating corticosterone alters the rate of neuropathological and behavioral changes induced by trimethyltin in rats.
Topics: Adrenalectomy; Animals; Behavior, Animal; Cell Count; Corticosterone; Enzyme Inhibitors; Hippocampus | 2002 |